DK3041926T3 - Indretning til in-vitro-modellering af in-vivo-væv af organer - Google Patents
Indretning til in-vitro-modellering af in-vivo-væv af organer Download PDFInfo
- Publication number
- DK3041926T3 DK3041926T3 DK14758977.4T DK14758977T DK3041926T3 DK 3041926 T3 DK3041926 T3 DK 3041926T3 DK 14758977 T DK14758977 T DK 14758977T DK 3041926 T3 DK3041926 T3 DK 3041926T3
- Authority
- DK
- Denmark
- Prior art keywords
- bodies
- vivo tissue
- vitro modeling
- modeling
- vitro
- Prior art date
Links
- 238000000338 in vitro Methods 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
- C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Mechanical Engineering (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183063 | 2013-09-05 | ||
| PCT/EP2014/068921 WO2015032889A1 (en) | 2013-09-05 | 2014-09-05 | Device for in-vitro modelling in-vivo tissues of organs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3041926T3 true DK3041926T3 (da) | 2020-06-08 |
Family
ID=49117711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14758977.4T DK3041926T3 (da) | 2013-09-05 | 2014-09-05 | Indretning til in-vitro-modellering af in-vivo-væv af organer |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10066198B2 (da) |
| EP (2) | EP3663388B1 (da) |
| CN (2) | CN105593358B (da) |
| DK (1) | DK3041926T3 (da) |
| ES (2) | ES2795974T3 (da) |
| PL (2) | PL3663388T3 (da) |
| PT (1) | PT3041926T (da) |
| WO (1) | WO2015032889A1 (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
| EP3132019A1 (en) | 2014-04-16 | 2017-02-22 | The Charles Stark Draper Laboratory, Inc. | Microfluidic tissue model |
| US10564148B2 (en) * | 2014-09-24 | 2020-02-18 | Triad National Security, Llc | Multi-organ media compositions and methods of their use |
| SG11201703500XA (en) | 2014-10-29 | 2017-05-30 | Corning Inc | Perfusion bioreactor platform |
| CN107109328B (zh) | 2014-10-29 | 2021-02-05 | 康宁股份有限公司 | 细胞培养插入件 |
| JP2017532971A (ja) | 2014-10-29 | 2017-11-09 | コーニング インコーポレイテッド | 細胞培養集合体を生成するためのマイクロウェル設計および製造 |
| GB2554818A (en) * | 2015-04-01 | 2018-04-11 | Harvard College | Respiration device for analysis of a response to shear stress and foreign agents on cells |
| NL2014840B1 (en) * | 2015-05-21 | 2017-01-31 | Intecrypt B V | Microfluidic device for in vitro 3D cell culture experimentation. |
| JP6480285B2 (ja) * | 2015-08-04 | 2019-03-06 | 豊田合成株式会社 | 細胞培養器具およびその製造方法 |
| EP3334531B1 (de) | 2015-08-12 | 2020-07-22 | Meon Medical Solutions GmbH & Co. KG | Vorrichtung und verfahren zur bestimmung der migrationsfähigkeit amöboid beweglicher zellen |
| ES2615512B1 (es) * | 2015-11-06 | 2018-03-15 | Universidad De Zaragoza | Dispositivo y sistema microfluídico para el estudio de cultivos celulares |
| EP3231860A1 (en) * | 2016-04-14 | 2017-10-18 | Technische Universität Wien | Microfluidic device |
| RU2741806C2 (ru) * | 2016-06-15 | 2021-01-28 | Миметас Б.В. | Устройство и способы для культивирования клеток |
| US11001796B2 (en) | 2016-11-23 | 2021-05-11 | The Charles Stark Draper Laboratory, Inc. | Bi-layer multi-well cell culture platform |
| EP3545077A1 (en) * | 2016-11-24 | 2019-10-02 | AlveoliX AG | Cell culturing system and method |
| CN106929403A (zh) * | 2017-04-14 | 2017-07-07 | 西安医学院 | 一种用于药物高通量筛选的血脑屏障模拟装置 |
| WO2019014636A1 (en) | 2017-07-14 | 2019-01-17 | Corning Incorporated | CONTAINER FOR CELL CULTURE |
| US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
| WO2019014635A1 (en) | 2017-07-14 | 2019-01-17 | Corning Incorporated | 3D CELL CULTURE CONTAINERS FOR MANUAL OR AUTOMATIC EXCHANGE |
| EP3652292B1 (en) | 2017-07-14 | 2025-06-18 | Corning Incorporated | Cell culture vessel for 3d culture and methods of culturing 3d cells |
| LU100595B1 (en) * | 2017-12-27 | 2019-06-28 | Luxembourg Inst Science & Tech List | Cell bio-incubator with a variable internal pressure |
| CN108660076A (zh) * | 2018-05-21 | 2018-10-16 | 中国科学院苏州生物医学工程技术研究所 | 一种仿真肺芯片模型 |
| CN111051493B (zh) | 2018-07-13 | 2023-11-03 | 康宁股份有限公司 | 具有稳定器装置的细胞培养容器 |
| CN111032851B (zh) | 2018-07-13 | 2024-03-29 | 康宁股份有限公司 | 具有包含液体介质传递表面的侧壁的微腔皿 |
| EP3649227A1 (en) | 2018-07-13 | 2020-05-13 | Corning Incorporated | Fluidic devices including microplates with interconnected wells |
| NL2022085B1 (en) | 2018-11-28 | 2020-06-25 | Mimetas B V | Device for assessing mechanical strain induced in or by cells |
| US11007524B2 (en) * | 2019-01-18 | 2021-05-18 | National Tsing Hua University | Automatic microfluidic system for rapid personalized drug screening and testing method for personalized antibiotic susceptibility |
| CN119875798A (zh) * | 2019-03-26 | 2025-04-25 | 株式会社村田制作所 | 微生物培养装置及微生物培养方法 |
| US20210340477A1 (en) * | 2020-05-01 | 2021-11-04 | The Charles Stark Draper Laboratory Inc. | Microfluidic cell culture plate for air-liquid interface and 3d cultured tissue applications |
| CN111909838B (zh) * | 2020-09-02 | 2025-08-26 | 安徽骆华生物科技有限公司 | 一种细胞功能检测的微流控芯片 |
| CN112080425A (zh) * | 2020-09-07 | 2020-12-15 | 中国科学院上海微系统与信息技术研究所 | 一种器官芯片、上皮/内皮屏障模型器件及其制作方法 |
| CN112635022B (zh) * | 2020-11-27 | 2023-07-25 | 易波 | 用于吸持生物组织的亲水界面的评价方法及系统 |
| CN112890822B (zh) * | 2021-01-21 | 2022-02-08 | 北京理工大学 | 一种胎儿心电仿体 |
| CN113528338A (zh) * | 2021-07-19 | 2021-10-22 | 中国医科大学 | 一种用于药物筛选的专用组合模具及其使用方法 |
| CN115703992A (zh) * | 2021-08-04 | 2023-02-17 | 刘承贤 | 肺呼吸晶片与细胞拉伸培养平台及其运作方法 |
| US20230113710A1 (en) * | 2021-10-08 | 2023-04-13 | Shanghai Ruiyu Biotech Co., Ltd. | Culture devices |
| CN114989937B (zh) * | 2022-05-17 | 2024-09-06 | 厦门大学 | 一种集成机械激励的器官芯片、芯片阵列和制作方法 |
| CN115820415A (zh) * | 2022-07-21 | 2023-03-21 | 北京大橡科技有限公司 | 培养单元、培养组件、芯片以及类器官共培养模型及其构建方法和构建装置以及应用 |
| DE102023125347B3 (de) * | 2023-09-19 | 2025-02-06 | Technische Universität Hamburg, Körperschaft des öffentlichen Rechts | Mikrosystembauelement |
| WO2025065103A1 (en) * | 2023-09-27 | 2025-04-03 | The Governing Council Of The University Of Toronto | Microfluidic device and related systems and methods |
| DE102024100350B3 (de) | 2024-01-08 | 2024-12-19 | Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts | Zelldehnungsvorrichtung, Verfahren zur Durchführung von Zelldehnungsuntersuchungen und System dafür |
| WO2025190809A2 (en) | 2024-03-13 | 2025-09-18 | Universität Bern | Advanced device and process for mimicking tissues in vitro |
| TWI890456B (zh) * | 2024-05-24 | 2025-07-11 | 達運精密工業股份有限公司 | 仿生器官裝置 |
| CN119326549B (zh) * | 2024-10-30 | 2025-09-12 | 中国科学院杭州医学研究所 | 一种预应力血管芯片 |
| CN119464051A (zh) * | 2024-11-11 | 2025-02-18 | 清华大学 | 三维仿生肺芯片及其制备方法 |
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| US4789601A (en) * | 1987-05-04 | 1988-12-06 | Banes Albert J | Biocompatible polyorganosiloxane composition for cell culture apparatus |
| US5470743A (en) * | 1991-03-06 | 1995-11-28 | Becton, Dickinson And Company | Transmembrane cell culture device |
| US6472200B1 (en) * | 1999-07-23 | 2002-10-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Device and method for performing a biological modification of a fluid |
| ATE275625T1 (de) * | 2000-07-19 | 2004-09-15 | Technodop Ltd Soc De Droit Irl | Kulturraum und bioreaktor zur ausserkörperlichen tierzellenkultur |
| DE50211264D1 (de) * | 2002-09-16 | 2008-01-03 | Pan Biotech Gmbh | Einrichtung zur kultivierung von zellen, insbesondere menschlicher oder tierischer zellen |
| JP2006527093A (ja) | 2003-03-10 | 2006-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | プログラム可能な触覚アクチュエータを用いた集積化したマイクロ流体コントロール |
| WO2004094586A2 (en) * | 2003-04-18 | 2004-11-04 | Carnegie Mellon University | Three-dimentional, flexible cell growth substrate and related methods |
| JP2007537759A (ja) * | 2004-05-19 | 2007-12-27 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 灌流三次元細胞／組織疾患モデル |
| US8557582B2 (en) | 2007-09-28 | 2013-10-15 | Christopher MORAES | System, apparatus and method for applying mechanical force to a material |
| KR102140055B1 (ko) * | 2008-07-16 | 2020-07-31 | 칠드런'즈 메디컬 센터 코포레이션 | 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법 |
| US8748180B2 (en) * | 2009-07-29 | 2014-06-10 | Cornell University | Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof |
| TW201111501A (en) * | 2009-09-29 | 2011-04-01 | Univ Chang Gung | High throughput cell culture system capable of providing mechanical force pressing stimulation |
| WO2012063925A1 (ja) * | 2010-11-12 | 2012-05-18 | 独立行政法人農業生物資源研究所 | 細胞培養チャンバーとその製造方法、および、この細胞培養チャンバーを利用した組織モデルとその作製方法 |
| CA2828110C (en) * | 2011-02-28 | 2020-03-31 | President And Fellows Of Harvard College | Cell culture system |
| US20130143230A1 (en) * | 2011-12-02 | 2013-06-06 | The Trustees Of The Stevens Institute Of Technology | Microfluidic-based cell-culturing platform and method |
| JP6189787B2 (ja) | 2014-04-28 | 2017-08-30 | 豊田合成株式会社 | 細胞培養器具 |
-
2014
- 2014-09-05 US US14/916,026 patent/US10066198B2/en active Active
- 2014-09-05 EP EP20152403.0A patent/EP3663388B1/en active Active
- 2014-09-05 EP EP14758977.4A patent/EP3041926B1/en active Active
- 2014-09-05 PT PT147589774T patent/PT3041926T/pt unknown
- 2014-09-05 ES ES14758977T patent/ES2795974T3/es active Active
- 2014-09-05 WO PCT/EP2014/068921 patent/WO2015032889A1/en not_active Ceased
- 2014-09-05 ES ES20152403T patent/ES3030032T3/es active Active
- 2014-09-05 CN CN201480049253.6A patent/CN105593358B/zh active Active
- 2014-09-05 PL PL20152403.0T patent/PL3663388T3/pl unknown
- 2014-09-05 DK DK14758977.4T patent/DK3041926T3/da active
- 2014-09-05 PL PL14758977T patent/PL3041926T3/pl unknown
- 2014-09-05 CN CN202111517163.3A patent/CN114134042A/zh active Pending
-
2018
- 2018-07-31 US US16/051,201 patent/US11473045B2/en active Active
-
2022
- 2022-09-21 US US17/949,768 patent/US20230015127A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN105593358B (zh) | 2021-12-21 |
| US11473045B2 (en) | 2022-10-18 |
| EP3663388A1 (en) | 2020-06-10 |
| CN105593358A (zh) | 2016-05-18 |
| US20230015127A1 (en) | 2023-01-19 |
| ES2795974T3 (es) | 2020-11-25 |
| US10066198B2 (en) | 2018-09-04 |
| EP3663388C0 (en) | 2025-03-19 |
| PT3041926T (pt) | 2020-06-17 |
| WO2015032889A1 (en) | 2015-03-12 |
| PL3041926T3 (pl) | 2020-11-02 |
| PL3663388T3 (pl) | 2025-07-21 |
| EP3041926B1 (en) | 2020-03-04 |
| ES3030032T3 (en) | 2025-06-26 |
| US20180355299A1 (en) | 2018-12-13 |
| CN114134042A (zh) | 2022-03-04 |
| EP3041926A1 (en) | 2016-07-13 |
| EP3663388B1 (en) | 2025-03-19 |
| US20160194588A1 (en) | 2016-07-07 |
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