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DK2911650T3 - Hidtil ukendt reagens til gen-lægemiddel-terapeutika - Google Patents

Hidtil ukendt reagens til gen-lægemiddel-terapeutika Download PDF

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Publication number
DK2911650T3
DK2911650T3 DK13850878T DK13850878T DK2911650T3 DK 2911650 T3 DK2911650 T3 DK 2911650T3 DK 13850878 T DK13850878 T DK 13850878T DK 13850878 T DK13850878 T DK 13850878T DK 2911650 T3 DK2911650 T3 DK 2911650T3
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DK
Denmark
Prior art keywords
gen
pharmaceutical therapy
unknown reagent
unknown
reagent
Prior art date
Application number
DK13850878T
Other languages
English (en)
Inventor
Heng-Phon Too
Yoon Khei Ho
Lihan Zhou
Original Assignee
Agency Science Tech & Res
Nat Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res, Nat Univ Singapore filed Critical Agency Science Tech & Res
Application granted granted Critical
Publication of DK2911650T3 publication Critical patent/DK2911650T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5156Animal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
DK13850878T 2012-10-29 2013-10-29 Hidtil ukendt reagens til gen-lægemiddel-terapeutika DK2911650T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261719908P 2012-10-29 2012-10-29
PCT/SG2013/000464 WO2014070111A1 (en) 2012-10-29 2013-10-29 A novel reagent for gene-drug therapeutics

Publications (1)

Publication Number Publication Date
DK2911650T3 true DK2911650T3 (da) 2019-11-18

Family

ID=50627830

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13850878T DK2911650T3 (da) 2012-10-29 2013-10-29 Hidtil ukendt reagens til gen-lægemiddel-terapeutika

Country Status (7)

Country Link
US (1) US10100331B2 (da)
EP (1) EP2911650B1 (da)
JP (1) JP6342910B2 (da)
CN (1) CN105101951B (da)
DK (1) DK2911650T3 (da)
SG (1) SG11201503020TA (da)
WO (1) WO2014070111A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6342910B2 (ja) 2012-10-29 2018-06-13 エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ 遺伝子薬物療法のための新規試薬
JP6231709B1 (ja) 2016-05-31 2017-11-15 シスメックス株式会社 蛍光画像分析装置および分析方法
CN108611355B (zh) * 2018-05-04 2021-08-31 北京锦篮基因科技有限公司 X染色体连锁肌小管肌病的基因药物
SG10201902002SA (en) * 2019-03-06 2020-10-29 Nat Univ Singapore Non-viral modification of mesenchymal stem cells
GB201903873D0 (en) * 2019-03-21 2019-05-08 Univ Nottingham Enhanced transfection

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003709A1 (en) * 1991-08-16 1993-03-04 Vical, Inc. Composition and method for treating cystic fibrosis
CN1254234C (zh) * 2000-06-09 2006-05-03 莱古伦公司 质粒dna(lipogenestm)和含细胞核定位信号/促融合肽缀合物的治疗剂包封到定向脂质体复合体中
CN100558903C (zh) * 2000-11-29 2009-11-11 Pci生物技术联合股份有限公司 将分子输递进胞质溶胶的光化学内化法
US20060074124A1 (en) * 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
WO2006002538A1 (en) * 2004-07-02 2006-01-12 Protiva Biotherapeutics, Inc. Immunostimulatory sirna molecules and uses therefor
JP5561893B2 (ja) * 2004-07-12 2014-07-30 独立行政法人科学技術振興機構 核酸構造体
US20060051405A1 (en) * 2004-07-19 2006-03-09 Protiva Biotherapeutics, Inc. Compositions for the delivery of therapeutic agents and uses thereof
WO2007041341A2 (en) * 2005-09-29 2007-04-12 The Trustees Of Columbia University In The City Of New York Identification of anti-cancer compounds and compounds for treating huntington's disease and methods of treatment thereof
WO2007064163A1 (en) * 2005-11-30 2007-06-07 Jung Moon Kim Non-activated wnt inhibition polypeptides and method for preparing the same
JP4182449B2 (ja) * 2006-03-29 2008-11-19 東洋紡績株式会社 核酸導入時の細胞障害を低減する方法
WO2008103431A2 (en) * 2007-02-23 2008-08-28 Pronai Therapeutics, Inc. Dnai - liposomes
SG190562A1 (en) * 2008-04-18 2013-06-28 Vaxinnate Corp Deletion mutants of flagellin and methods of use
US8802138B2 (en) * 2009-10-12 2014-08-12 Jessie L.-S. Au Methods and compositions for improved deliver, expression or activity of RNA interference agents
WO2011097181A2 (en) * 2010-02-04 2011-08-11 Vivoscript,Inc. Compositions and methods for re-programming cells without genetic modification for treatment of neurological disorders
WO2011130624A2 (en) * 2010-04-16 2011-10-20 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
KR101242113B1 (ko) 2010-10-22 2013-03-19 고마바이오텍(주) 유전자 전달용 양이온성 센다이 f/hn 바이로좀 복합체
WO2013052053A1 (en) 2011-10-06 2013-04-11 Empire Technology Development Llc Transfection sheets and methods of use
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
JP6342910B2 (ja) 2012-10-29 2018-06-13 エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ 遺伝子薬物療法のための新規試薬

Also Published As

Publication number Publication date
CN105101951A (zh) 2015-11-25
WO2014070111A1 (en) 2014-05-08
EP2911650B1 (en) 2019-09-04
JP6342910B2 (ja) 2018-06-13
SG11201503020TA (en) 2015-05-28
CN105101951B (zh) 2021-08-03
EP2911650A1 (en) 2015-09-02
EP2911650A4 (en) 2016-05-04
JP2016503290A (ja) 2016-02-04
US10100331B2 (en) 2018-10-16
US20150361449A1 (en) 2015-12-17

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