DK2992888T3 - Anvendelse af pentacyklisk triterpenoid saponinforbindelse fra szechuan melandium-rod til fremstilling af hypoglykæmisk lægemiddel - Google Patents
Anvendelse af pentacyklisk triterpenoid saponinforbindelse fra szechuan melandium-rod til fremstilling af hypoglykæmisk lægemiddel Download PDFInfo
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- DK2992888T3 DK2992888T3 DK14866552.4T DK14866552T DK2992888T3 DK 2992888 T3 DK2992888 T3 DK 2992888T3 DK 14866552 T DK14866552 T DK 14866552T DK 2992888 T3 DK2992888 T3 DK 2992888T3
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- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229930005346 hydroxycinnamic acid Natural products 0.000 description 1
- 235000010359 hydroxycinnamic acids Nutrition 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 201000008980 hyperinsulinism Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002473 insulinotropic effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 description 1
- 229960003243 phenformin Drugs 0.000 description 1
- 229960005095 pioglitazone Drugs 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 229960004586 rosiglitazone Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- DSUMGVHMUUADBM-VXUDCIMKSA-N stachysterone A Chemical compound C([C@H]1C(=O)C=C23)[C@@H](O)[C@@H](O)C[C@]1(C)[C@H]3CC=C1[C@]2(C)CC[C@@H]1[C@@](C)(O)[C@H](O)CCC(C)(O)C DSUMGVHMUUADBM-VXUDCIMKSA-N 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 229940100613 topical solution Drugs 0.000 description 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-N trans-4-coumaric acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (2)
1. Forbindelse af Wacao-saponiner til anvendelse til behandling af diabetes, hvilken forbindelse er udvalgt blandt forbindelserne med følgende formler:
2. Forbindelser til anvendelse ifølge krav 1, hvor forbindelserne anvendes alene, i en blanding af to eller flere 5 eller blandet med andre materialer til fremstilling af midler som injektioner, topiske opløsninger, salver, pastaer, plastre, dråber, gurglevand, suppositorier, sublinguale tabletter, pastafilm, aerosolmidler, brusetabletter og piller.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310627408.7A CN103599117B (zh) | 2013-11-28 | 2013-11-28 | 瓦草五环三萜皂苷类化合物制备降血糖药物的用途 |
| PCT/CN2014/075471 WO2015078133A1 (zh) | 2013-11-28 | 2014-04-16 | 瓦草五环三萜皂苷类化合物制备降血糖药物的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2992888T3 true DK2992888T3 (da) | 2017-05-08 |
Family
ID=50117426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14866552.4T DK2992888T3 (da) | 2013-11-28 | 2014-04-16 | Anvendelse af pentacyklisk triterpenoid saponinforbindelse fra szechuan melandium-rod til fremstilling af hypoglykæmisk lægemiddel |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160082024A1 (da) |
| EP (1) | EP2992888B1 (da) |
| JP (1) | JP6386550B2 (da) |
| CN (1) | CN103599117B (da) |
| DK (1) | DK2992888T3 (da) |
| WO (1) | WO2015078133A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599117B (zh) * | 2013-11-28 | 2015-04-22 | 王学勇 | 瓦草五环三萜皂苷类化合物制备降血糖药物的用途 |
| CN104013636B (zh) * | 2014-06-16 | 2016-06-08 | 王学勇 | 瓦草五环三萜皂苷类化合物抗肿瘤的药物用途 |
| CN105147710B (zh) * | 2015-09-11 | 2018-09-14 | 中国科学院西双版纳热带植物园 | 一种降血糖药物及其制备方法和应用 |
| WO2020113128A1 (en) * | 2018-11-29 | 2020-06-04 | January, Inc. | Systems, methods, and devices for biophysical modeling and response prediction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817862A (zh) * | 2009-02-26 | 2010-09-01 | 中国药科大学 | 熊果酸-3-O-β-D-吡喃葡萄糖醛酸苷及其衍生物、其制备方法及医药用途 |
| CN103599117B (zh) * | 2013-11-28 | 2015-04-22 | 王学勇 | 瓦草五环三萜皂苷类化合物制备降血糖药物的用途 |
-
2013
- 2013-11-28 CN CN201310627408.7A patent/CN103599117B/zh active Active
-
2014
- 2014-04-16 JP JP2016524659A patent/JP6386550B2/ja not_active Expired - Fee Related
- 2014-04-16 EP EP14866552.4A patent/EP2992888B1/en active Active
- 2014-04-16 US US14/890,564 patent/US20160082024A1/en not_active Abandoned
- 2014-04-16 WO PCT/CN2014/075471 patent/WO2015078133A1/zh not_active Ceased
- 2014-04-16 DK DK14866552.4T patent/DK2992888T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015078133A1 (zh) | 2015-06-04 |
| EP2992888B1 (en) | 2017-02-01 |
| JP6386550B2 (ja) | 2018-09-05 |
| EP2992888A1 (en) | 2016-03-09 |
| US20160082024A1 (en) | 2016-03-24 |
| CN103599117B (zh) | 2015-04-22 |
| JP2016526559A (ja) | 2016-09-05 |
| CN103599117A (zh) | 2014-02-26 |
| EP2992888A4 (en) | 2016-03-16 |
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