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DK2963031T3 - Prodrug af tetrahydrocannabinol, sammensætninger omfattende prodrug af tetrahydrocannabinol og fremgangsmåder til anvendelse af samme - Google Patents

Prodrug af tetrahydrocannabinol, sammensætninger omfattende prodrug af tetrahydrocannabinol og fremgangsmåder til anvendelse af samme Download PDF

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Publication number
DK2963031T3
DK2963031T3 DK15172043.0T DK15172043T DK2963031T3 DK 2963031 T3 DK2963031 T3 DK 2963031T3 DK 15172043 T DK15172043 T DK 15172043T DK 2963031 T3 DK2963031 T3 DK 2963031T3
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compound
pharmaceutical composition
pain
syndrome
dermatitis
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DK15172043.0T
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Miroslaw Jerzy Golinski
Dana Carmel Hammell
Jeffry Lynn Howard
Audra Lynn Stinchcomb
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Zynerba Pharmaceuticals Inc
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    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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Claims (14)

  1. PRODRUG AF TETRAHYDROCANNABINOL, SAMMENSÆTNINGER OMFATTENDE PRODRUG AF TETRAHYDROCANNABINOL OG FREMGANGSMÅDER TIL ANVENDELSE AF SAMME
    1. Forbindelse med formlen der er valgt blandt:
    eller et farmaceutisk acceptabelt salt deraf.
  2. 2. Farmaceutisk sammensætning der omfatter: (a) forbindelsen ifølge krav 1; og (b) en farmaceutisk acceptabel excipiens.
  3. 3. Anvendelse af forbindelsen ifølge krav 1 til fremstilling af et medikament til behandling af en medicinsk tilstand hos et pattedyr, hvilken anvendelse er udvalgt fra gruppen der består af: anoreksi, kvalme, opkastning, smerte, wasting-syndrom, HIV-wasting, kemoterapi-induceret kvalme og opkastning, alkoholforstyrrelser, antitumor, amyotro-fisk lateralsklerose, glioblastom multiforme, gliom, øget intraokulært tryk, glaukom, cannabisbrugsforstyrrelser, Tourettes syndrom, dystoni, multipel sklerose, inflammatoriske tarmsygdomme, arthritis, dermatitis, reumatoid arthritis, systemisk lupus erythematosus, antiinflammatorisk, antikonvulsiv, antipsykotisk, antioxidant, neuroprotektiv, anticancer, immunmodulerende virkninger, perifer neuropatisk smerte, neuropatisk smerte forbundet med post-herpetisk neuralgi, diabetisk neuropati, helvedesild, forbrændinger, aktinisk keratose, mundhulesår og mavesår, post-episiotomi smerter, psoriasis, pruritis, kontaktdermatitis, eksem, bullous dermatitis herpetiformis, eksfoliativ dermatitis, mycosis fungoider,
    pemphigus, alvorlig erythema multiforme (fx Stevens-Johnsons syndrom), se-borrheisk dermatitis, ankyloserende spondylitis, psoriatisk arthritis, Reiter's syndrom, gigt, chondrocalcinose, ledsmerter sekundær til dysmenorré, fibromyalgi, muskuloskeletale smerter, neuropatiske post-operative komplikationer, polymyositis, akut uspecifik tenosynovitis, bursitis, epicondylitis, post-traumatisk artrose, synovitis og juvenil reumatoid arthritis.
  4. 4. Anvendelsen ifølge krav 3, hvor den medicinske tilstand er Tourettes syndrom.
  5. 5. Anvendelse af forbindelsen ifølge krav 1 til fremstilling af et medikament til indgivelse til et pattedyr, hvilken indgivelse omfatter trinnene: (a) at kombinere forbindelsen ifølge krav 1 med et farmaceutisk exci-piens til dannelse af en farmaceutisk sammensætning; (b) at skabe en doseringsform der er egnet til administration til et pattedyr fra den farmaceutiske sammensætning; og (c) at administrere doseringsformen til et pattedyr.
  6. 6. Anvendelse ifølge et hvilket som helst af kravene 3 til 5, hvor forbindelsen ifølge krav 3 eller den farmaceutiske sammensætning ifølge krav 5 administreres ad en vej, som er valgt fra gruppen der består af: transdermal, topisk, oral, bukkal, sublingual, intravenøs, intramuskulær, vaginal, rektal, okulær, nasal og follikulær.
  7. 7. Anvendelsen ifølge krav 6, hvor forbindelsen ifølge krav 3 eller den farmaceutiske sammensætning ifølge krav 5 administreres ad en transdermal vej.
  8. 8. Anvendelsen ifølge krav 7, hvor forbindelsen ifølge krav 3 eller den farmaceutiske sammensætning ifølge krav 5 administreres som plastre, salver, cremer, suspensioner, lotioner, pastaer, geler, sprayer, skum eller olier.
  9. 9. Forbindelsen ifølge krav 1 eller den farmaceutiske sammensætning ifølge krav 2 til anvendelse i en fremgangsmåde til behandling af en medicinsk tilstand.
  10. 10. Forbindelse ifølge krav 1 eller den farmaceutiske sammensætning ifølge krav 2 til anvendelse i en fremgangsmåde til behandling afen medicinsk tilstand i et pattedyr, hvor den medicinske tilstand er, som er valgt fra gruppen der består af: anoreksi, kvalme, opkastning, smerte, wasting-syndrom, HIV-wasting, kemoterapi-induceret kvalme og opkastning, alkoholforstyrrelser, antitumor, amyotro-fisk lateralsklerose, glioblastom multiforme, gliom, øget intraokulært tryk, glaukom, cannabisbrugsforstyrrelser, Tourettes syndrom, dystoni, multipel sklerose, inflammatoriske tarmsygdomme, arthritis, dermatitis, reumatoid arthritis, systemisk lupus erythematosus, antiinflammatorisk, antikonvulsiv, antipsykotisk, antioxidant, neuroprotektiv, anticancer, immunmodulerende virkninger, perifer neuropatisk smerte, neuropatisk smerte forbundet med post-herpetisk neuralgi, diabetisk neuropati, helvedesild, forbrændinger, aktinisk keratose, mundhulesår og mavesår, post-episiotomi smerter, psoriasis, pruritis, kontaktdermatitis, eksem, bullous dermatitis herpetiformis, eksfoliativ dermatitis, mycosis fungoider, pemphigus, alvorlig erythema multiforme (fx Stevens-Johnsons syndrom), se-borrheisk dermatitis, ankyloserende spondylitis, psoriatisk arthritis, Reiter's syndrom, gigt, chondrocalcinose, ledsmerter sekundær til dysmenorré, fibromyalgi, muskuloskeletale smerter, neuropatiske post-operative komplikationer, polymyositis, akut uspecifik tenosynovitis, bursitis, epicondylitis, post-traumatisk artrose, synovitis og juvenil reumatoid arthritis.
  11. 11. Forbindelse til anvendelsen ifølge krav 10, hvor den medicinske tilstand er Tourettes syndrom.
  12. 12. Forbindelse til anvendelse eller det farmaceutiske præparat til anvendelse ifølge krav 10, hvor forbindelsen eller den farmaceutiske sammensætning administreres ad en vej, som er valgt fra gruppen, der består af: topisk, oral, buk- kal, sublingual, intravenøs, intramuskulær, vaginal, rektal , okulær, nasal og fol-likulær.
  13. 13. Forbindelse til anvendelse eller den farmaceutiske sammensætning til anvendelse ifølge krav 12, hvor forbindelsen eller den farmaceutiske sammensætning administreres ad en transdermal vej.
  14. 14. Forbindelse til anvendelse eller den farmaceutiske sammensætning til anvendelsen ifølge krav 13, hvor forbindelsen eller den farmaceutiske sammensætning administreres som plastre, salver, cremer, suspensioner, lotioner, pastaer, geler, sprayer, skum eller olier.
DK15172043.0T 2007-11-30 2008-12-01 Prodrug af tetrahydrocannabinol, sammensætninger omfattende prodrug af tetrahydrocannabinol og fremgangsmåder til anvendelse af samme DK2963031T3 (da)

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SI2215071T1 (sl) 2015-12-31
US20210047284A1 (en) 2021-02-18
EP2963031A2 (en) 2016-01-06
US20220194916A1 (en) 2022-06-23
US20240217942A1 (en) 2024-07-04
US20170088533A1 (en) 2017-03-30
CA2977722C (en) 2020-12-29
HK1219733A1 (en) 2017-04-13
PL2215071T3 (pl) 2015-12-31
US20240083866A1 (en) 2024-03-14
CA3099446A1 (en) 2009-06-11
EP2963031A3 (en) 2016-03-30
WO2009073633A1 (en) 2009-06-11
ES2547880T3 (es) 2015-10-09
SI2963031T1 (sl) 2019-04-30
US20090143462A1 (en) 2009-06-04
US9957246B2 (en) 2018-05-01
US20180208572A1 (en) 2018-07-26
US9695143B2 (en) 2017-07-04
JP6371263B2 (ja) 2018-08-08
US20200024248A1 (en) 2020-01-23
ES2716407T3 (es) 2019-06-12
DK2215071T3 (da) 2015-10-05
US20190233387A1 (en) 2019-08-01

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