DK2951754T3 - Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter - Google Patents
Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter Download PDFInfo
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- DK2951754T3 DK2951754T3 DK14746677.5T DK14746677T DK2951754T3 DK 2951754 T3 DK2951754 T3 DK 2951754T3 DK 14746677 T DK14746677 T DK 14746677T DK 2951754 T3 DK2951754 T3 DK 2951754T3
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- G—PHYSICS
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- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C10/00—Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/10—Design of libraries
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/20—Probabilistic models
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/50—Molecular design, e.g. of drugs
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Library & Information Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physiology (AREA)
- Computing Systems (AREA)
- Crystallography & Structural Chemistry (AREA)
- Probability & Statistics with Applications (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Ecology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759276P | 2013-01-31 | 2013-01-31 | |
| US201361799377P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/013666 WO2014120819A1 (en) | 2013-01-31 | 2014-01-29 | Methods, systems, and software for identifying bio-molecules with interacting components |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2951754T3 true DK2951754T3 (da) | 2024-04-15 |
Family
ID=51223867
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14746677.5T DK2951754T3 (da) | 2013-01-31 | 2014-01-29 | Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter |
| DK14746406.9T DK2951579T3 (da) | 2013-01-31 | 2014-01-29 | Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14746406.9T DK2951579T3 (da) | 2013-01-31 | 2014-01-29 | Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9665694B2 (da) |
| EP (4) | EP4398255A3 (da) |
| JP (4) | JP6377078B2 (da) |
| KR (3) | KR102215219B1 (da) |
| CN (3) | CN105144190B (da) |
| AU (2) | AU2014212430B2 (da) |
| BR (2) | BR112015018454B1 (da) |
| CA (2) | CA2899859C (da) |
| DK (2) | DK2951754T3 (da) |
| ES (2) | ES2979018T3 (da) |
| FI (2) | FI2951754T3 (da) |
| HU (2) | HUE066735T2 (da) |
| IL (2) | IL240056A0 (da) |
| LT (2) | LT2951754T (da) |
| NZ (2) | NZ710299A (da) |
| RU (2) | RU2695146C2 (da) |
| SG (2) | SG11201505977RA (da) |
| WO (2) | WO2014120821A1 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014212430B2 (en) | 2013-01-31 | 2019-06-20 | Codexis, Inc. | Methods, systems, and software for identifying bio-molecules with interacting components |
| WO2014171898A2 (en) | 2013-04-17 | 2014-10-23 | Agency For Science, Technology And Research | Method for generating extended sequence reads |
| EP2911075A1 (de) * | 2014-02-25 | 2015-08-26 | LTS LOHMANN Therapie-Systeme AG | System zur Bestimmung einer Eignung eines Wirkstoffs für die transdermale oder transmukosale Applikation sowie entsprechendes Verfahren |
| HUE053363T2 (hu) | 2014-11-25 | 2021-06-28 | Codexis Inc | Módosított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására |
| US20170372005A1 (en) * | 2014-12-22 | 2017-12-28 | Board Of Regents Of The University Of Texas System | Systems and methods for processing sequence data for variant detection and analysis |
| AU2015370125B2 (en) | 2014-12-22 | 2022-02-03 | Codexis, Inc. | Human alpha-galactosidase variants |
| EP3298524A4 (en) | 2015-05-22 | 2019-03-20 | CSTS Health Care Inc. | THERMODYNAMIC MEASURES ON PROTEIN-PROTEIN INTERACTION NETWORKS FOR CANCER THERAPY |
| FR3047013A1 (fr) * | 2016-01-22 | 2017-07-28 | Univ Montpellier | Procede de classification d'un echantillon biologique. |
| CA3022907C (en) * | 2016-05-04 | 2024-04-02 | Deep Genomics Incorporated | Methods and systems for producing an expanded training set for machine learning using biological sequences |
| US10184117B2 (en) | 2016-06-09 | 2019-01-22 | Codexis, Inc. | Biocatalysts and methods for hydroxylation of chemical compounds |
| AU2017284104B2 (en) | 2016-06-15 | 2020-06-25 | Codexis, Inc. | Engineered beta-glucosidases and glucosylation methods |
| IL264686B2 (en) | 2016-08-26 | 2024-07-01 | Codexis Inc | Engineered imine reductases and methods for reversible amination of ketone and amine compounds |
| US10118610B2 (en) * | 2016-08-31 | 2018-11-06 | Ford Global Technologies, Llc | Autonomous vehicle using path prediction |
| TW202237833A (zh) | 2017-02-03 | 2022-10-01 | 美商克迪科思股份有限公司 | 經工程處理之醣基轉移酶及甜菊糖之葡萄糖苷化方法 |
| KR102573324B1 (ko) | 2017-02-13 | 2023-08-30 | 코덱시스, 인코포레이티드 | 조작된 페닐알라닌 암모니아 리아제 폴리펩티드 |
| CN108693787A (zh) * | 2017-03-29 | 2018-10-23 | 株式会社东芝 | 模型构建系统以及模型构建方法 |
| US10793841B2 (en) | 2017-06-30 | 2020-10-06 | Codexis, Inc. | T7 RNA polymerase variants |
| AU2018292104B2 (en) | 2017-06-30 | 2025-03-27 | Codexis, Inc. | T7 RNA polymerase variants |
| CN107677997B (zh) * | 2017-09-28 | 2021-06-29 | 杭州电子科技大学 | 基于GLMB滤波和Gibbs采样的扩展目标跟踪方法 |
| US20190108311A1 (en) * | 2017-10-06 | 2019-04-11 | Grail, Inc. | Site-specific noise model for targeted sequencing |
| AU2018350975B2 (en) | 2017-10-17 | 2023-11-23 | Invitae Corporation | Molecular evidence platform for auditable, continuous optimization of variant interpretation in genetic and genomic testing and analysis |
| WO2019118557A1 (en) | 2017-12-13 | 2019-06-20 | Codexis, Inc. | Carboxyesterase polypeptides for amide coupling |
| CN108281192B (zh) * | 2017-12-29 | 2022-03-22 | 一诺仪器(中国)有限公司 | 基于集成学习算法的人体成分预测方法及系统 |
| WO2020028039A1 (en) | 2018-07-30 | 2020-02-06 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| KR20210078510A (ko) * | 2018-10-11 | 2021-06-28 | 버클리 라잇츠, 인크. | 최적화된 단백질 생성의 확인을 위한 시스템 및 방법, 및 이를 위한 키트 |
| US11398297B2 (en) * | 2018-10-11 | 2022-07-26 | Chun-Chieh Chang | Systems and methods for using machine learning and DNA sequencing to extract latent information for DNA, RNA and protein sequences |
| EP3874033A4 (en) | 2018-10-29 | 2022-08-03 | Codexis, Inc. | ENGINEERED DNA POLYMERASE VARIANTS |
| JP2022513199A (ja) | 2018-12-14 | 2022-02-07 | コデクシス, インコーポレイテッド | 操作されたチロシンアンモニアリアーゼ |
| JP2022515742A (ja) | 2018-12-20 | 2022-02-22 | コデクシス, インコーポレイテッド | α-ガラクトシダーゼバリアント |
| CA3127602A1 (en) * | 2019-01-22 | 2020-07-30 | EMULATE, Inc. | High-content imaging of microfluidic devices |
| US12321837B2 (en) * | 2019-02-14 | 2025-06-03 | University Of Washington | Systems and methods for improved nanopore-based analysis of nucleic acids |
| CN109902389B (zh) * | 2019-03-01 | 2021-01-01 | 厦门大学 | 基于改进通用似然估计的不确定性有限元模型修正方法 |
| CN109979539B (zh) * | 2019-04-10 | 2020-10-02 | 电子科技大学 | 基因序列优化方法、装置及数据处理终端 |
| JP7387760B2 (ja) | 2019-05-02 | 2023-11-28 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 合成タンパク質の安定性を高めるためのシステムおよび方法 |
| JP7298284B2 (ja) * | 2019-05-09 | 2023-06-27 | 富士通株式会社 | 演算処理装置、演算処理プログラム、及び演算処理方法 |
| WO2020244775A1 (en) * | 2019-06-07 | 2020-12-10 | Leica Microsystems Cms Gmbh | A system and method for processing biology-related data, a system and method for controlling a microscope and a microscope |
| BR112021024915A2 (pt) * | 2019-06-12 | 2022-01-18 | Quantum Si Inc | Técnicas para a identificação de proteína ao usar aprendizagem de máquina e sistemas e métodos relacionados |
| JP7699107B2 (ja) | 2019-08-30 | 2025-06-26 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 操作されたリパーゼ改変体 |
| JP7438693B2 (ja) * | 2019-09-02 | 2024-02-27 | キヤノンメディカルシステムズ株式会社 | 診療支援装置 |
| AU2020344624A1 (en) * | 2019-09-13 | 2022-03-31 | The University Of Chicago | Method and apparatus using machine learning for evolutionary data-driven design of proteins and other sequence defined biomolecules |
| WO2021090182A1 (en) * | 2019-11-04 | 2021-05-14 | Oxford University Innovation Limited | Identification and characterisation of herbicides and plant growth regulators |
| WO2021119261A1 (en) * | 2019-12-10 | 2021-06-17 | Homodeus, Inc. | Generative machine learning models for predicting functional protein sequences |
| KR20220129547A (ko) | 2019-12-20 | 2022-09-23 | 코덱시스, 인코포레이티드 | 조작된 산성 알파-글루코시다제 변이체 |
| BR112022015139A2 (pt) | 2020-02-04 | 2022-10-11 | Codexis Inc | Polipeptídeo da leucina descarboxilase engenheirada, composição, sequência de polinucleotídeo engenheirado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da leucina descarboxilase engenheirada e para tratar e/ou prevenir os sintomas de doença da urina de xarope de bordo, composição, e, uso |
| US11188778B1 (en) * | 2020-05-05 | 2021-11-30 | Illumina, Inc. | Equalization-based image processing and spatial crosstalk attenuator |
| EP4038613A1 (en) * | 2020-07-06 | 2022-08-10 | Basf Se | Media, methods, and systems for protein design and optimization |
| CA3191900A1 (en) | 2020-08-28 | 2022-03-03 | Codexis, Inc. | Engineered amylase variants |
| JP2023539632A (ja) | 2020-08-28 | 2023-09-15 | コデクシス, インコーポレイテッド | 操作されたプロテアーゼバリアント |
| US11361194B2 (en) | 2020-10-27 | 2022-06-14 | Illumina, Inc. | Systems and methods for per-cluster intensity correction and base calling |
| US11898174B2 (en) | 2020-12-18 | 2024-02-13 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
| JP7577002B2 (ja) * | 2021-03-19 | 2024-11-01 | 日本放送協会 | 特徴抽出装置およびプログラム |
| US11439159B2 (en) | 2021-03-22 | 2022-09-13 | Shiru, Inc. | System for identifying and developing individual naturally-occurring proteins as food ingredients by machine learning and database mining combined with empirical testing for a target food function |
| CN112735535B (zh) * | 2021-04-01 | 2021-06-25 | 腾讯科技(深圳)有限公司 | 预测模型训练、数据预测方法、装置和存储介质 |
| CA3214975A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered cyclic gmp-amp synthase (cgas) variant enzymes |
| CA3214973A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered guanylate kinase variant enzymes |
| CA3215105A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered acetate kinase variant enzymes |
| CA3214972A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered adenylate kinase variant enzymes |
| TW202313969A (zh) | 2021-05-21 | 2023-04-01 | 美商克迪科思股份有限公司 | 經工程化的甲硫胺酸γ解離酶變異體 |
| WO2023003757A1 (en) | 2021-07-19 | 2023-01-26 | Illumina Software, Inc. | Intensity extraction with interpolation and adaptation for base calling |
| US11455487B1 (en) | 2021-10-26 | 2022-09-27 | Illumina Software, Inc. | Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling |
| CN118103501A (zh) | 2021-10-15 | 2024-05-28 | 科德克希思公司 | 工程化dna聚合酶变体 |
| EP4426185A1 (en) * | 2021-11-02 | 2024-09-11 | trinamiX GmbH | Measuring the human skin age through near-infrared spectroscopy |
| CN114913939B (zh) * | 2022-07-19 | 2022-11-15 | 北京科技大学 | 高通量平台和机器学习优化的药物组合设计方法及装置 |
| JP7775162B2 (ja) * | 2022-08-10 | 2025-11-25 | 株式会社東芝 | 情報処理装置、情報処理方法およびコンピュータプログラム |
| CN116884503B (zh) * | 2023-09-06 | 2023-12-26 | 北京齐碳科技有限公司 | 序列和后验矩阵的处理方法、装置和计算设备 |
| US12368503B2 (en) | 2023-12-27 | 2025-07-22 | Quantum Generative Materials Llc | Intent-based satellite transmit management based on preexisting historical location and machine learning |
| CN117935934B (zh) * | 2024-03-25 | 2024-07-02 | 中国科学院天津工业生物技术研究所 | 一种基于机器学习预测磷酸酶最佳催化温度的方法 |
| WO2025235589A1 (en) | 2024-05-08 | 2025-11-13 | Codexis, Inc. | Dna polymerase variants |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US6153410A (en) | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
| WO1999029902A1 (en) | 1997-12-08 | 1999-06-17 | California Institute Of Technology | Method for creating polynucleotide and polypeptide sequences |
| US20020048772A1 (en) | 2000-02-10 | 2002-04-25 | Dahiyat Bassil I. | Protein design automation for protein libraries |
| US7315786B2 (en) | 1998-10-16 | 2008-01-01 | Xencor | Protein design automation for protein libraries |
| WO2000042560A2 (en) | 1999-01-19 | 2000-07-20 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides |
| US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US20070065838A1 (en) | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| EP1266337A2 (en) * | 1999-11-22 | 2002-12-18 | Yissum Research Development Company of the Hebrew University of Jerusalem | System and method for searching a combinatorial space |
| US20010051855A1 (en) * | 2000-02-17 | 2001-12-13 | California Institute Of Technology | Computationally targeted evolutionary design |
| AU2001241939A1 (en) | 2000-02-28 | 2001-09-12 | Maxygen, Inc. | Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation |
| EP1272967A2 (en) | 2000-03-30 | 2003-01-08 | Maxygen, Inc. | In silico cross-over site selection |
| US20020045175A1 (en) | 2000-05-23 | 2002-04-18 | Zhen-Gang Wang | Gene recombination and hybrid protein development |
| US20030032059A1 (en) | 2000-05-23 | 2003-02-13 | Zhen-Gang Wang | Gene recombination and hybrid protein development |
| US20020155460A1 (en) | 2000-10-10 | 2002-10-24 | Genencor International Inc. | Information rich libraries |
| WO2002100428A1 (en) * | 2001-06-11 | 2002-12-19 | Transition Therapeutics Inc. | Combination therapies using vitamin b12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases |
| AU2003216507A1 (en) | 2002-03-01 | 2003-09-16 | Maxygen, Inc. | Methods, systems, and software for identifying functional bio-molecules |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US20050159896A1 (en) | 2002-04-04 | 2005-07-21 | Toshio Ishikawa | Apparatus and method for analyzing data |
| CN1672160B (zh) * | 2002-05-20 | 2010-06-09 | 埃博马可西斯公司 | 基于前导抗体的结构构建抗体文库的方法 |
| JP4042492B2 (ja) * | 2002-08-07 | 2008-02-06 | トヨタ自動車株式会社 | エンジン制御パラメータの適合方法及び適合システム |
| JP2004355174A (ja) * | 2003-05-28 | 2004-12-16 | Ishihara Sangyo Kaisha Ltd | データ解析方法及びそのシステム |
| CN1867584A (zh) * | 2003-10-08 | 2006-11-22 | E生物科学公司 | 天然免疫球蛋白结合试剂及其制造和使用方法 |
| US7529714B2 (en) * | 2004-12-14 | 2009-05-05 | International Business Machines Corporation | Cost management of software application portfolio |
| CN1763227A (zh) * | 2005-09-01 | 2006-04-26 | 南京工业大学 | 一种提高蛋白质生物学功能的方法 |
| CN101855242B (zh) | 2007-09-14 | 2014-07-30 | 阿迪马布有限责任公司 | 合理设计的合成抗体文库及其用途 |
| WO2009046445A1 (en) | 2007-10-04 | 2009-04-09 | Halcyon Molecular | Sequencing nucleic acid polymers with electron microscopy |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
| CN101353372A (zh) * | 2008-08-04 | 2009-01-28 | 林峻 | 一种新型蛋白质分子定向进化方法 |
| AU2009325069B2 (en) * | 2008-12-11 | 2015-03-19 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
| US8551096B2 (en) * | 2009-05-13 | 2013-10-08 | Boston Scientific Scimed, Inc. | Directional delivery of energy and bioactives |
| CN101792934A (zh) * | 2009-08-26 | 2010-08-04 | 青岛科技大学 | 一种基于组合原理和pcr建立超大容量基因文库的新方法 |
| JP5649424B2 (ja) * | 2010-02-03 | 2015-01-07 | 大和ハウス工業株式会社 | 防水シート診断方法および診断装置 |
| US20120115734A1 (en) | 2010-11-04 | 2012-05-10 | Laura Potter | In silico prediction of high expression gene combinations and other combinations of biological components |
| JP4839416B1 (ja) * | 2011-01-06 | 2011-12-21 | アクアエンタープライズ株式会社 | 移動過程予測システム、移動過程予測方法、移動過程予測装置及びコンピュータプログラム |
| US20120231447A1 (en) * | 2011-02-15 | 2012-09-13 | Howard Hughes Medical Institute | Surface Passivation Methods for Single Molecule Imaging of Biochemical Reactions |
| CN102206625A (zh) * | 2011-03-04 | 2011-10-05 | 东华大学 | 易错pcr/卡那霉素筛选系统定向进化蛋白质内含子 |
| US20130017540A1 (en) * | 2011-06-07 | 2013-01-17 | Yun Yen | Identification of mutation types associated with acquired resistance and methods for using same |
| AU2014212430B2 (en) | 2013-01-31 | 2019-06-20 | Codexis, Inc. | Methods, systems, and software for identifying bio-molecules with interacting components |
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