DK2941484T3 - Fremgangsmåde til at opnå immunsuppressive dendritriske celler - Google Patents

Fremgangsmåde til at opnå immunsuppressive dendritriske celler Download PDF

Info

Publication number: DK2941484T3
Authority: DK; Denmark
Prior art keywords: immunsuppressive; procedure; obtaining; dendritric cells; dendritric
Prior art date: 2013-01-03

Application number

DK14700050.9T

Other languages

English (en)

Inventor

Karsten Henco

Günter Bauer

Justin Duckworth

Adrian Hayday

Richard Edelson

Robert Tigelaar

Michael Girardi

Original Assignee

Transimmune Ag

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-01-03

Filing date

2014-01-02

Publication date

2020-06-02

2014-01-02 Application filed by Transimmune Ag, Univ Yale filed Critical Transimmune Ag

2020-06-02 Application granted granted Critical

2020-06-02 Publication of DK2941484T3 publication Critical patent/DK2941484T3/da

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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
- C12N5/064—Immunosuppressive dendritic cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/115—Platelets, megakaryocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
- C12N2529/10—Stimulation by light

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Emergency Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK14700050.9T 2013-01-03 2014-01-02 Fremgangsmåde til at opnå immunsuppressive dendritriske celler DK2941484T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361748550P	2013-01-03	2013-01-03
GBGB1300052.6A GB201300052D0 (en)	2013-01-03	2013-01-03	Method for obtaining immuno-suppressive dendritic cells
PCT/EP2014/050012 WO2014106631A1 (en)	2013-01-03	2014-01-02	Method for obtaining immuno-suppressive dendritic cells

Publications (1)

Publication Number	Publication Date
DK2941484T3 true DK2941484T3 (da)	2020-06-02

Family

ID=47747914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK14700050.9T DK2941484T3 (da)	2013-01-03	2014-01-02	Fremgangsmåde til at opnå immunsuppressive dendritriske celler

Country Status (12)

Country	Link
US (2)	US20160130552A1 (da)
EP (2)	EP3719118A1 (da)
JP (3)	JP2016509474A (da)
KR (3)	KR20200106217A (da)
CN (2)	CN104955940A (da)
AU (1)	AU2014204346B2 (da)
CA (1)	CA2897113C (da)
DK (1)	DK2941484T3 (da)
ES (1)	ES2795927T3 (da)
GB (1)	GB201300052D0 (da)
PL (1)	PL2941484T3 (da)
WO (1)	WO2014106631A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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JP6219832B2 (ja)	2011-10-17	2017-10-25	マサチューセッツインスティテュートオブテクノロジー	細胞内送達
PL3033184T3 (pl)	2013-08-16	2021-09-20	Massachusetts Institute Of Technology	Selektywne dostarczanie materiału do komórek
GB201413665D0 (en) *	2014-07-03	2014-09-17	Transimmune Ag And Yale University	Method for obtaining globally activated monocytes
JP7523203B2 (ja)	2014-10-31	2024-07-26	マサチューセッツインスティテュートオブテクノロジー	生体分子の免疫細胞への送達
US10526573B2 (en)	2014-11-14	2020-01-07	Massachusetts Institute Of Technology	Disruption and field enabled delivery of compounds and compositions into cells
EP3245294A4 (en)	2015-01-12	2018-05-30	Massachusetts Institute of Technology	Gene editing through microfluidic delivery
GB201513278D0 (en) *	2015-07-03	2015-09-09	Transimmune Ag And Yale University	Device and method for obtaining immunostimulatory antigen-presenting cells
JP6925984B2 (ja)	2015-07-09	2021-08-25	マサチューセッツインスティテュートオブテクノロジー	無核細胞への物質の送達
ES2924071T3 (es)	2015-09-02	2022-10-04	Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd	Anticuerpos específicos para inmunoglobulina de células T humanas y dominio ITIM (TIGIT)
EP3518942A4 (en) *	2016-09-29	2020-05-27	Hadasit Medical Research Services&Development Ltd.	DENDRITIC CELL PREPARATIONS, COMPOSITIONS AND METHODS OF USE
US12331320B2 (en)	2018-10-10	2025-06-17	The Research Foundation For The State University Of New York	Genome edited cancer cell vaccines
CN109701019B (zh) *	2019-01-04	2021-07-16	中国人民解放军第二军医大学	一种新的长链非编码RNA即lnc-Dpf3、其序列、免疫效应及用途
MX2021008022A (es)	2019-01-07	2021-08-05	Shattuck Labs Inc	Proteínas heterodiméricas para modular células t gamma delta.
US11098093B2 (en)	2019-01-07	2021-08-24	Shattuck Labs, Inc.	Heterodimeric proteins for modulating gamma delta T cells
WO2023283514A1 (en) *	2021-07-06	2023-01-12	Vanderbilt University	Fluid shear stress for ex vivo activation of immune effector cells
US20250084370A1 (en)	2021-07-29	2025-03-13	Transimmune Ag	Methods for selectively reducing immunogenicity in a transplant
KR20240040111A (ko) *	2021-07-29	2024-03-27	트랜스이뮨 아게	선택적 관용화 - 관용성 수지상 세포를 선택적으로 생성하는 방법
WO2024227807A1 (en)	2023-05-01	2024-11-07	Yale University	Antigen-specific physiologic dendritic cells for vaccination
AU2024265076A1 (en)	2023-05-01	2025-11-06	Emory University	Antigen-specific physiologic dendritic cells for therapy
CN118256609B (zh) *	2024-02-06	2024-08-30	湖北文理学院	Tm9sf1标志物在监测自身免疫性疾病病程中的应用

Family Cites Families (3)

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Publication number	Priority date	Publication date	Assignee	Title
WO2000062818A1 (en)	1999-04-20	2000-10-26	Richard Leslie Edelson	Differentiation of monocytes into functional dendritic cells
US8524495B2 (en) *	2007-05-16	2013-09-03	Yale University	Methods for inducing the differentiation of blood monocytes into functional dendritic cells
AU2009317865A1 (en) *	2008-11-18	2011-06-23	Centre National De La Recherche Scientifique (Cnrs)	Peptide conjugates for suppressing an immune response, methods of making and uses therefor

2013
- 2013-01-03 GB GBGB1300052.6A patent/GB201300052D0/en not_active Ceased
2014
- 2014-01-02 DK DK14700050.9T patent/DK2941484T3/da active
- 2014-01-02 KR KR1020207025108A patent/KR20200106217A/ko not_active Ceased
- 2014-01-02 CN CN201480003942.3A patent/CN104955940A/zh active Pending
- 2014-01-02 EP EP20160436.0A patent/EP3719118A1/en active Pending
- 2014-01-02 US US14/759,016 patent/US20160130552A1/en not_active Abandoned
- 2014-01-02 CA CA2897113A patent/CA2897113C/en active Active
- 2014-01-02 CN CN202111008277.5A patent/CN114410581A/zh active Pending
- 2014-01-02 AU AU2014204346A patent/AU2014204346B2/en active Active
- 2014-01-02 KR KR1020187002019A patent/KR20180010345A/ko not_active Ceased
- 2014-01-02 JP JP2015551179A patent/JP2016509474A/ja active Pending
- 2014-01-02 WO PCT/EP2014/050012 patent/WO2014106631A1/en not_active Ceased
- 2014-01-02 EP EP14700050.9A patent/EP2941484B1/en active Active
- 2014-01-02 PL PL14700050T patent/PL2941484T3/pl unknown
- 2014-01-02 ES ES14700050T patent/ES2795927T3/es active Active
- 2014-01-02 KR KR1020157020667A patent/KR20150122639A/ko not_active Ceased
2017
- 2017-10-25 JP JP2017205758A patent/JP6599958B2/ja active Active
2019
- 2019-10-03 JP JP2019182703A patent/JP6804607B2/ja active Active
2021
- 2021-10-21 US US17/507,002 patent/US20220259556A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20160130552A1 (en)	2016-05-12
CN114410581A (zh)	2022-04-29
WO2014106631A1 (en)	2014-07-10
AU2014204346A1 (en)	2015-07-02
JP6804607B2 (ja)	2020-12-23
HK1210626A1 (en)	2016-04-29
CN104955940A (zh)	2015-09-30
EP2941484B1 (en)	2020-03-04
JP2018046837A (ja)	2018-03-29
KR20180010345A (ko)	2018-01-30
ES2795927T3 (es)	2020-11-25
US20220259556A1 (en)	2022-08-18
CA2897113A1 (en)	2014-07-10
EP2941484A1 (en)	2015-11-11
PL2941484T3 (pl)	2020-10-05
KR20200106217A (ko)	2020-09-11
JP6599958B2 (ja)	2019-10-30
JP2016509474A (ja)	2016-03-31
JP2020018315A (ja)	2020-02-06
KR20150122639A (ko)	2015-11-02
AU2014204346B2 (en)	2017-08-31
GB201300052D0 (en)	2013-02-20
EP3719118A1 (en)	2020-10-07
CA2897113C (en)	2024-03-12

Publication	Publication Date	Title
DK2941484T3 (da)	2020-06-02	Fremgangsmåde til at opnå immunsuppressive dendritriske celler
DK2941483T3 (da)	2020-06-02	Fremgangsmåde til at opnå immunstimulerende dendritriske celler
IL245573B (en)	2018-11-29	Cell
DK2996556T3 (da)	2021-05-31	System til billedstyret procedure
PT3017520T (pt)	2021-01-19	Conjunto de células solares
DK3042411T3 (da)	2021-05-10	Metalunderstøttet fastoxidbrændselscelle
IL242253A (en)	2017-12-31	Electro-chemical filter apparatus
DK3079836T3 (da)	2020-01-06	Fremgangsmåder til fremstilling af effektlag
DK2970951T3 (da)	2019-05-13	Fremgangsmåder til nukleinsyresekventering
DK3006568T3 (da)	2019-10-07	Fremgangsmåde til fremstilling af tagatose
DK3083540T3 (da)	2020-02-24	Fremgangsmåde til fremstilling af substituerede phenoxyphenylketoner
FI20176131L (fi)	2017-12-18	Menetelmä biopolttoaineen tai
EP3011599C0 (en)	2024-08-07	Photovoltaic devices
FR3003076B1 (fr)	2015-04-10	Supercondensateur electrochimique
AP2016008982A0 (en)	2016-01-31	Floating turbine
DK2992104T3 (da)	2019-07-15	Fremgangsmåde til ekspression
DK3234476T3 (da)	2020-03-02	Solfanger
DK2988659T3 (da)	2022-11-21	Forbedrede fremgangsmåder til vævskarakterisering
FI20135223L (fi)	2014-09-09	Prosessi bioöljyn konvertoimiseksi
DK2809782T3 (da)	2017-11-20	Forbedret fremgangsmåde til fremstilling af makrokugler
GB2527707B (en)	2020-02-26	Improved turbine
DK2872536T3 (da)	2019-11-25	Fremgangsmåde til ekstraktion af biomasse
FI20135224L (fi)	2014-09-09	Prosessi bioöljyn konvertoimiseksi
DK2837678T3 (da)	2019-12-09	Fremgangsmåde til forbedret afsmeltning
GB201312332D0 (en)	2013-08-21	Cell locations