DK2893001T3 - Fremgangsmåde til dyrkning af mesenkymale stamceller - Google Patents
Fremgangsmåde til dyrkning af mesenkymale stamceller Download PDFInfo
- Publication number
- DK2893001T3 DK2893001T3 DK13833872T DK13833872T DK2893001T3 DK 2893001 T3 DK2893001 T3 DK 2893001T3 DK 13833872 T DK13833872 T DK 13833872T DK 13833872 T DK13833872 T DK 13833872T DK 2893001 T3 DK2893001 T3 DK 2893001T3
- Authority
- DK
- Denmark
- Prior art keywords
- mesenykymal
- cultivating
- procedure
- stem cells
- stem
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/16—Magnesium; Mg chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120097193A KR101532556B1 (ko) | 2012-09-03 | 2012-09-03 | 간엽줄기세포의 배양 방법 |
| PCT/KR2013/007891 WO2014035215A1 (en) | 2012-09-03 | 2013-09-02 | Method for culturing mesenchymal stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2893001T3 true DK2893001T3 (da) | 2019-12-02 |
Family
ID=50183937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13833872T DK2893001T3 (da) | 2012-09-03 | 2013-09-02 | Fremgangsmåde til dyrkning af mesenkymale stamceller |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9580687B2 (da) |
| EP (1) | EP2893001B1 (da) |
| JP (1) | JP6478243B2 (da) |
| KR (1) | KR101532556B1 (da) |
| CN (1) | CN104781394B (da) |
| AU (1) | AU2013309642B2 (da) |
| CA (1) | CA2884000C (da) |
| DK (1) | DK2893001T3 (da) |
| ES (1) | ES2755802T3 (da) |
| IN (1) | IN2015DN01737A (da) |
| PL (1) | PL2893001T3 (da) |
| PT (1) | PT2893001T (da) |
| WO (1) | WO2014035215A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3140417B1 (en) * | 2014-05-09 | 2021-04-21 | Reelabs Private Limited | Foetal polymix of mesenchymal stem cells under hypoxic conditions for the treatment of clinical disorders |
| JP6519727B2 (ja) * | 2014-09-17 | 2019-05-29 | 国立大学法人山口大学 | 間葉系幹細胞の培養方法、および肝機能障害用治療剤の製造方法 |
| US11000694B2 (en) | 2014-10-24 | 2021-05-11 | The Board Of Trustees Of The University Of Illinois | Use of lasers for treating and reversing fibrosis |
| SG11201703512QA (en) * | 2014-10-29 | 2017-06-29 | R Bio Co Ltd | Medium composition for culturing stem cells |
| CN105748514A (zh) * | 2015-01-05 | 2016-07-13 | 洪士杰 | 用于治疗肝脏疾病的间叶干细胞 |
| JP2018512061A (ja) * | 2015-02-20 | 2018-05-10 | ナショナル ヤン−ミン ユニバーシティ | 骨関節炎処置のための間葉幹細胞の使用 |
| EP3299023A4 (en) * | 2015-05-21 | 2019-03-20 | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences | OXYGEN ARM-TREATED MESENCHYMM STEM CELL AND ITS USE |
| CN109072190A (zh) * | 2016-03-09 | 2018-12-21 | 蔚山大学校产学协力团 | 将jak1抑制剂作为有效成分包含的用于干细胞的增殖、分化促进或老化抑制的组成物 |
| CA3019574C (en) * | 2016-03-31 | 2025-09-23 | Sanbio Inc | Medium, methods, cells and secreted factors for stem cell culture and therapy |
| TWI860974B (zh) * | 2017-06-05 | 2024-11-11 | 加州大學董事會 | 用來治療視網膜疾病之製劑的製造方法 |
| WO2019004293A1 (ja) | 2017-06-27 | 2019-01-03 | 味の素株式会社 | リボフラビン誘導体含有培地 |
| CN107384858A (zh) * | 2017-08-17 | 2017-11-24 | 成都康景生物科技有限公司 | 一种缺氧耐受型间充质干细胞的制备方法及其应用 |
| CN109666631A (zh) * | 2017-10-17 | 2019-04-23 | 澳门大学 | 增强干细胞活性的培养方法、应用以及用于治疗中枢神经疾病的制剂、制备方法及治疗方法 |
| CN109706115B (zh) * | 2017-10-26 | 2023-05-30 | 中国医科大学 | 一种小鼠骨髓间充质干细胞细胞系的构建方法 |
| CN108359637B (zh) * | 2018-02-14 | 2021-09-28 | 浙江生创精准医疗科技有限公司 | 一种宫血干细胞快速扩增的方法 |
| CN109517786B (zh) * | 2018-10-18 | 2022-06-17 | 广州元帅生物科技有限公司 | 一种具有修复功能的多能干细胞制剂及其应用 |
| CA3149572A1 (en) * | 2019-08-30 | 2021-03-04 | Ashlee WATTS | Xenogen-free mesenchymal stem cell compositions and methods of use |
| WO2022004938A1 (ko) * | 2020-06-30 | 2022-01-06 | 주식회사 미래셀바이오 | 유사 중간엽 줄기세포의 제조방법 |
| CN112147340B (zh) * | 2020-09-30 | 2024-03-08 | 北京银丰鼎诚生物工程技术有限公司 | 一种神经干细胞免疫调节功能的检测方法 |
| CN112375733B (zh) * | 2020-11-03 | 2022-09-02 | 中国人民解放军陆军军医大学第一附属医院 | 可增进间充质干细胞干细胞性的植物血凝素及其在间充质干细胞扩增培养中的应用 |
| KR102435452B1 (ko) * | 2020-11-11 | 2022-09-07 | 이엔셀 주식회사 | 노화가 감소되고 줄기세포능이 보존된 초기 중간엽 줄기세포, 및 그 배양방법 |
| CN113502261B (zh) * | 2021-07-16 | 2023-08-29 | 上海东方星际干细胞科技有限公司 | 一种能高效分化成脂的规模化3d低氧间充质干细胞培养体系 |
| CN116218770B (zh) * | 2022-12-30 | 2023-11-24 | 苏州科为康生物医药科技有限公司 | 一种间充质干细胞的制备方法和应用 |
| CN117660325B (zh) * | 2024-01-31 | 2024-04-19 | 苏州科为康生物医药科技有限公司 | 一种制备脐带血msc的培养基及其方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100494265B1 (ko) | 2001-08-14 | 2005-06-13 | 메디포스트(주) | 관절연골손상 치료용 조성물 |
| WO2003032735A1 (en) * | 2001-10-18 | 2003-04-24 | Lifecell Corporation | Remodeling of tissues and organs |
| DE60314602T2 (de) | 2002-02-19 | 2008-02-28 | Medipost, Co., Ltd. | Verfahren zur isolierung und kulturexpansion mesenchymaler stamm-/vorläuferzellen aus nabelschnurblut sowie verfahren zur differenzierung von aus nabelschnurblut stammenden mesenchymalen stamm-/vorläuferzellen in unterschiedliche mesenchymgewebe |
| WO2004012503A2 (en) * | 2002-07-30 | 2004-02-12 | Tigenix N.V. | Compositions comprising muscle progenitor cells and uses thereof |
| MXPA05013115A (es) * | 2003-06-06 | 2006-05-25 | Wyeth Corp | Metodos y materiales para identificar agentes que modulan la remodelacion de hueso y agentes identificados por los mismos. |
| JP2006055106A (ja) * | 2004-08-23 | 2006-03-02 | National Institute Of Advanced Industrial & Technology | ヒト血清培地を用いるヒト骨髄由来間葉系幹細胞培養法 |
| DK2471904T3 (da) * | 2005-12-29 | 2019-02-18 | Celularity Inc | Placentastamcellepopulationer |
| US20070178073A1 (en) * | 2006-02-01 | 2007-08-02 | Samsung Life Public Welfare Foundation | Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease |
| HRP20130765T1 (hr) * | 2007-02-12 | 2013-10-25 | Anthrogenesis Corporation | Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice |
| US8114668B2 (en) | 2007-05-14 | 2012-02-14 | Cardiac Pacemakers, Inc. | Composition for cold storage of stem cells |
| US8017390B2 (en) | 2007-07-20 | 2011-09-13 | Dongguk University Industry-Academic Cooperation Foundation | Method for the preparation of dermal papilla tissue employing mesenchymal stem cells |
| GB0715648D0 (en) * | 2007-08-10 | 2007-09-19 | Cambridge Silicon Radio Ltd | Channel decoding using similarity matching |
| ES2352046T3 (es) * | 2007-09-21 | 2011-02-15 | Universität Leipzig | Medio de cultivo celular y procedimiento de cultivo de células madre y células progenitor. |
| WO2010150094A1 (en) * | 2009-06-26 | 2010-12-29 | Life & Light Limited | Mesenchymal stem cells grown under hypoxic conditions: compositions, methods and uses therefor |
| WO2011043629A2 (ko) * | 2009-10-08 | 2011-04-14 | 서울대학교병원 | 인간 지방 줄기세포의 고활성을 유도하는 방법 및 배지 |
| SG187698A1 (en) * | 2010-08-03 | 2013-03-28 | Univ Sapporo Medical | Autoserum-containing bone marrow cell culture system, autoserum-containing bone marrow cell culture method, and method for producing medicinal composition comprising autoserum-containing cultured bone marrow cells as active ingredient |
| US20120052577A1 (en) * | 2010-08-31 | 2012-03-01 | The Regents Of The University Of California | Culture system for stem cell propagation and neural and oligodendrocyte specification |
-
2012
- 2012-09-03 KR KR1020120097193A patent/KR101532556B1/ko active Active
-
2013
- 2013-09-02 PT PT138338728T patent/PT2893001T/pt unknown
- 2013-09-02 CN CN201380045750.4A patent/CN104781394B/zh active Active
- 2013-09-02 JP JP2015529690A patent/JP6478243B2/ja active Active
- 2013-09-02 IN IN1737DEN2015 patent/IN2015DN01737A/en unknown
- 2013-09-02 US US14/425,220 patent/US9580687B2/en active Active
- 2013-09-02 WO PCT/KR2013/007891 patent/WO2014035215A1/en not_active Ceased
- 2013-09-02 AU AU2013309642A patent/AU2013309642B2/en active Active
- 2013-09-02 ES ES13833872T patent/ES2755802T3/es active Active
- 2013-09-02 DK DK13833872T patent/DK2893001T3/da active
- 2013-09-02 EP EP13833872.8A patent/EP2893001B1/en active Active
- 2013-09-02 PL PL13833872T patent/PL2893001T3/pl unknown
- 2013-09-02 CA CA2884000A patent/CA2884000C/en active Active
-
2017
- 2017-01-11 US US15/403,457 patent/US10294456B2/en active Active
-
2019
- 2019-03-29 US US16/370,102 patent/US11332715B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013309642B2 (en) | 2018-10-25 |
| EP2893001A4 (en) | 2016-03-09 |
| CN104781394A (zh) | 2015-07-15 |
| CA2884000C (en) | 2021-08-24 |
| JP2015532596A (ja) | 2015-11-12 |
| IN2015DN01737A (da) | 2015-05-29 |
| US20150284686A1 (en) | 2015-10-08 |
| CN104781394B (zh) | 2017-12-12 |
| KR101532556B1 (ko) | 2015-06-30 |
| US10294456B2 (en) | 2019-05-21 |
| JP6478243B2 (ja) | 2019-03-06 |
| CA2884000A1 (en) | 2014-03-06 |
| KR20140030703A (ko) | 2014-03-12 |
| PL2893001T3 (pl) | 2020-03-31 |
| PT2893001T (pt) | 2019-12-09 |
| US20170191036A1 (en) | 2017-07-06 |
| EP2893001A1 (en) | 2015-07-15 |
| US20190218517A1 (en) | 2019-07-18 |
| ES2755802T3 (es) | 2020-04-23 |
| WO2014035215A1 (en) | 2014-03-06 |
| US11332715B2 (en) | 2022-05-17 |
| US9580687B2 (en) | 2017-02-28 |
| EP2893001B1 (en) | 2019-10-30 |
| AU2013309642A1 (en) | 2015-03-26 |
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