DK2867361T3 - Omfangsrig parallel kombinatorisk genetik - Google Patents
Omfangsrig parallel kombinatorisk genetikInfo
- Publication number
- DK2867361T3 DK2867361T3 DK13734638.3T DK13734638T DK2867361T3 DK 2867361 T3 DK2867361 T3 DK 2867361T3 DK 13734638 T DK13734638 T DK 13734638T DK 2867361 T3 DK2867361 T3 DK 2867361T3
- Authority
- DK
- Denmark
- Prior art keywords
- genetics
- extensive parallel
- parallel combinatory
- combinatory
- extensive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666081P | 2012-06-29 | 2012-06-29 | |
| PCT/US2013/048619 WO2014005042A2 (en) | 2012-06-29 | 2013-06-28 | Massively parallel combinatorial genetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2867361T3 true DK2867361T3 (da) | 2018-01-29 |
Family
ID=48747811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13734638.3T DK2867361T3 (da) | 2012-06-29 | 2013-06-28 | Omfangsrig parallel kombinatorisk genetik |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9315806B2 (da) |
| EP (1) | EP2867361B1 (da) |
| JP (1) | JP6401700B2 (da) |
| CN (1) | CN104508130B (da) |
| AU (1) | AU2013282323B2 (da) |
| CA (1) | CA2877962C (da) |
| DK (1) | DK2867361T3 (da) |
| ES (1) | ES2663424T3 (da) |
| NO (1) | NO2897610T3 (da) |
| PL (1) | PL2867361T3 (da) |
| PT (1) | PT2867361T (da) |
| SG (1) | SG11201408736SA (da) |
| WO (1) | WO2014005042A2 (da) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| WO2014100400A1 (en) * | 2012-12-19 | 2014-06-26 | Helge Zieler | Compositions and methods for creating altered and improved cells and organisms |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| CA2954360C (en) * | 2014-07-07 | 2022-11-22 | Johan ELF | Phenotypic characterization and in situ genotyping of a library of genetically different cells |
| CA2954791A1 (en) * | 2014-07-14 | 2016-01-21 | The Regents Of The University Of California | Crispr/cas transcriptional modulation |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3212789B1 (en) * | 2014-10-31 | 2020-04-22 | Massachusetts Institute of Technology | Massively parallel combinatorial genetics for crispr |
| US20170369878A1 (en) * | 2015-01-12 | 2017-12-28 | Massachusetts Institute Of Technology | Microrna combinations for anti-cancer therapeutics |
| US10738087B2 (en) | 2015-07-30 | 2020-08-11 | Massachusetts Eye And Ear Infirmary | Ancestral virus sequences and uses thereof |
| WO2017070633A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Evolved cas9 proteins for gene editing |
| CN109072233A (zh) * | 2016-04-26 | 2018-12-21 | 麻省理工学院 | 可扩展的重组酶级联 |
| JP7093310B2 (ja) | 2016-05-18 | 2022-06-29 | アミリス， インコーポレイテッド | 外因性ランディングパッドへの核酸のゲノム組込みのための組成物および方法 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| JP7201153B2 (ja) | 2016-08-09 | 2023-01-10 | プレジデント アンド フェローズ オブ ハーバード カレッジ | プログラム可能ｃａｓ９－リコンビナーゼ融合タンパク質およびその使用 |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN107784198B (zh) * | 2016-08-26 | 2021-06-15 | 深圳华大基因科技服务有限公司 | 一种二代序列和三代单分子实时测序序列联合组装方法和系统 |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| IL266197B2 (en) | 2016-10-24 | 2024-03-01 | Geneinfosec Inc | Hiding information contained within nucleic acids |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR102687373B1 (ko) | 2017-03-23 | 2024-07-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US11293018B2 (en) | 2017-06-09 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Manipulation of nuclear architecture |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| EP3697906A1 (en) | 2017-10-16 | 2020-08-26 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3775266A4 (en) | 2018-04-05 | 2021-06-30 | Massachusetts Eye and Ear Infirmary | METHOD OF MANUFACTURING AND USING COMBINATIONAL BAR-CODED NUCLEIC ACID LIBRARIES WITH DEFINED VARIATION |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| CN112955549B (zh) | 2018-09-19 | 2024-12-20 | 香港大学 | 改进的高通量组合基因修饰系统和优化的Cas9酶变体 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN109801679B (zh) * | 2019-01-15 | 2021-02-02 | 广州柿宝生物科技有限公司 | 一种用于长链分子的数学序列重建方法 |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN114174499A (zh) * | 2019-02-08 | 2022-03-11 | 利兰斯坦福初级大学董事会 | 具有组合基因修饰的工程化细胞的生产和跟踪 |
| SG11202109882VA (en) | 2019-03-19 | 2021-10-28 | Broad Inst Inc | Methods and compositions for editing nucleotide sequences |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP4283295A3 (en) * | 2019-04-30 | 2024-03-06 | Gigagen, Inc. | Recombinant polyclonal proteins and methods of use thereof |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| KR20230019843A (ko) | 2020-05-08 | 2023-02-09 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물 |
| WO2021253002A1 (en) | 2020-06-12 | 2021-12-16 | Gigagen, Inc. | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| US20240398799A1 (en) | 2021-08-19 | 2024-12-05 | Engine Biosciences Pte. Ltd. | Compositions and methods for generating synthetic lethality in tumors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US211103A (en) | 1879-01-07 | Improvement in nut-locks | ||
| DE60141533D1 (de) * | 2000-12-08 | 2010-04-22 | Life Technologies Corp | Ukleinsäuremolekülen unter verwendung multipler erkennungsstellen |
| EP1660674B1 (en) | 2003-09-10 | 2010-03-17 | Althea Technologies, Inc. | Expression profiling using microarrays |
| US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
| US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| CA2744153C (en) * | 2008-11-19 | 2020-07-07 | Amyris, Inc. | Compositions and methods for the assembly of polynucleotides |
| US9255291B2 (en) | 2010-05-06 | 2016-02-09 | Bioo Scientific Corporation | Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing |
| WO2012019765A1 (en) | 2010-08-10 | 2012-02-16 | European Molecular Biology Laboratory (Embl) | Methods and systems for tracking samples and sample combinations |
-
2013
- 2013-06-28 EP EP13734638.3A patent/EP2867361B1/en active Active
- 2013-06-28 CA CA2877962A patent/CA2877962C/en active Active
- 2013-06-28 AU AU2013282323A patent/AU2013282323B2/en active Active
- 2013-06-28 PT PT137346383T patent/PT2867361T/pt unknown
- 2013-06-28 ES ES13734638.3T patent/ES2663424T3/es active Active
- 2013-06-28 US US14/411,628 patent/US9315806B2/en active Active
- 2013-06-28 WO PCT/US2013/048619 patent/WO2014005042A2/en not_active Ceased
- 2013-06-28 PL PL13734638T patent/PL2867361T3/pl unknown
- 2013-06-28 DK DK13734638.3T patent/DK2867361T3/da active
- 2013-06-28 JP JP2015520583A patent/JP6401700B2/ja active Active
- 2013-06-28 SG SG11201408736SA patent/SG11201408736SA/en unknown
- 2013-06-28 CN CN201380040777.4A patent/CN104508130B/zh active Active
- 2013-09-19 NO NO13839158A patent/NO2897610T3/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6401700B2 (ja) | 2018-10-10 |
| CN104508130B (zh) | 2016-09-28 |
| US20150141263A1 (en) | 2015-05-21 |
| NO2897610T3 (da) | 2018-06-09 |
| AU2013282323A1 (en) | 2015-02-19 |
| AU2013282323B2 (en) | 2018-05-10 |
| CN104508130A (zh) | 2015-04-08 |
| US9315806B2 (en) | 2016-04-19 |
| HK1210217A1 (en) | 2016-04-15 |
| WO2014005042A3 (en) | 2014-02-27 |
| CA2877962A1 (en) | 2014-01-03 |
| ES2663424T3 (es) | 2018-04-12 |
| CA2877962C (en) | 2018-06-05 |
| PT2867361T (pt) | 2018-02-07 |
| SG11201408736SA (en) | 2015-03-30 |
| EP2867361B1 (en) | 2017-11-01 |
| HK1207886A1 (en) | 2016-02-12 |
| JP2015521850A (ja) | 2015-08-03 |
| PL2867361T3 (pl) | 2018-07-31 |
| WO2014005042A2 (en) | 2014-01-03 |
| EP2867361A2 (en) | 2015-05-06 |
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