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DK2853593T3 - Hydrolaser, nukleinsyrer, der koder for disse, og fremgangsmåder til fremstilling og anvendelse heraf - Google Patents

Hydrolaser, nukleinsyrer, der koder for disse, og fremgangsmåder til fremstilling og anvendelse heraf Download PDF

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Publication number
DK2853593T3
DK2853593T3 DK14187967.6T DK14187967T DK2853593T3 DK 2853593 T3 DK2853593 T3 DK 2853593T3 DK 14187967 T DK14187967 T DK 14187967T DK 2853593 T3 DK2853593 T3 DK 2853593T3
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seq
polypeptide
disclosure
sequence
nucleic acid
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DK14187967.6T
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English (en)
Inventor
Uwe T Bornscheuer
David Paul Weiner
Tim Hitchman
Jonathan Lyon
Sirirung Wongsakul
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Dsm Ip Assets Bv
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
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Claims (18)

1. Nukleinsyre, der koder for et polypeptid med lipaseaktivitet, hvor nukleinsyren er en sekvens med mindst 85 %, 86 %, 87 %, 88 %, 89 %, 90 %, 91 %, 92 %, 93 %, 94 %, 95 %, 96 %, 97 %, 98 %, 99 % eller 100 % sekvensidentitet med SEQ ID NO: 15.
2. Ekspressionskassette, vektor eller kloningsvehikel, der omfatter nukleinsyresekvensen ifølge krav 1.
3. Transformeret ikke-human celle, der omfatter ekspressionskassetten ifølge krav 2, hvor den transformerede ikke-humane celle er en bakteriecelle, en mammaliacelle, en svampecelle, en gærcelle, en insektcelle eller en plantecelle.
4. Isoleret eller rekombinant polypeptid med lipaseaktivitet, hvor polypeptidet er valgt blandt: (i) en aminosyresekvens, der har mindst 85 %, 86 %, 87 %, 88 %, 89 %, 90 %, 91 %, 92 %, 93 %, 94 %, 95 %, 96 %, 97 %, 98 %, 99 % eller 100 % sekvensidentitet med SEQ ID NO: 16 eller (ii) kodes af nukleinsyren ifølge krav 1.
5. Proteinpræparat, der omfatter et polypeptid ifølge krav 4, hvor proteinpræparatet omfatter en væske, et faststof eller en gel.
6. Fodertilskud til et dyr, der omfatter polypeptidet ifølge krav 4.
7. Fremgangsmåde til fremstilling af det rekombinante polypeptid ifølge krav 4, som omfatter: (a) tilvejebringelse af nukleinsyren ifølge krav 1, der er operabelt koblet til en promotor; og (b) ekspression af nukleinsyren fra trin (a) under betingelser, der åbner mulighed for ekspression af polypeptidet, til derved fremstilling af det rekombinante polypeptid ifølge krav 4.
8. Fremgangsmåde til hydrolysering af en triacylglycerol (TAG), en diacylglycerol (DAG) eller en monoacylglycerol (MAG), som omfatter følgende trin: (a) tilvejebringelse af polypeptidet ifølge krav 4; (b) tilvejebringelse af en sammensætning, der omfatter en triacylglycerol (TAG), en diacylglycerol (DAG) eller en monoacylglycerol (MAG); og (c) etablering af kontakt mellem polypeptidet fra trin (a) og sammensætningen fra trin (b) under betingelser, hvor polypeptidet hydrolyserer triacylglycerol (TAG), diacylglycerol (DAG) eller monoacylglycerol (MAG).
9. Detergentsammensætning, der omfatter polypeptidet ifølge krav 4.
10. Detergentsammensætning ifølge krav 9, hvor polypeptidet er en ikke-overfladeaktiv hydrolase eller en overfladeaktiv hydrolase.
11. Detergentsammensætning ifølge krav 9, hvor polypeptidet er formuleret i en ikke-vandig væskeformig sammensætning, et støbt faststof, en granulatform, en partikulær form, en sammenpresset tablet, en gelform, en pasta eller en opslemmet form.
12. Fremgangsmåde til raffinering af et smøremiddel, som omfatter følgende trin: (a) tilvejebringelse af polypeptidet ifølge krav 4; (b) tilvejebringelse af et smøremiddel; og (c) behandling af smøremidlet med polypeptidet fra (a) under betingelser, hvor polypeptidet selektivt kan hydrolysere olier i smøremidlet, til derved raffinering af det.
13. Fremgangsmåde til behandling af et tekstil, som omfatter følgende trin: (a) tilvejebringelse af polypeptidet ifølge krav 4; (b) tilvejebringelse af et tekstil; og (c) behandling af tekstilet med polypeptidet fra (a) under betingelser, hvor polypeptidet selektivt kan hydrolysere carboxylestere til derved behandling af tekstilet.
14. Fremgangsmåde ifølge krav 13, hvor behandling af tekstilet omfatter forbedring af følelsen og draperingsevnen af det endelige tekstil, farvning, opnåelse af flammehæmmende egenskaber, opnåelse af vandafvisning, opnåelse af optisk blegning eller opnåelse af harpiksfinish.
15. Fremgangsmåde til fjernelse eller reducering af omfanget af en fødevare-eller olieplet, som omfatter etablering af kontakt mellem polypeptidet ifølge krav 4 og fødevare- eller oliepletten under betingelser, hvor polypeptidet kan hydrolysere fødevare- eller oliepletten.
16. Fremgangsmåde ifølge krav 15, hvor polypeptidet ifølge krav 4 har en forøget stabilitet over for denaturering af overfladeaktive stoffer og oer for varmedeaktivering.
17. Kostsammensætning, der omfatter polypeptidet ifølge krav 4 .
18. Fremgangsmåde til reducering af fedtindholdet i mælkeeller plantebaserede kostsammensætninger, som omfatter følgende trin: (a) tilvejebringelse af polypeptidet ifølge krav 4; (b) tilvejebringelse af en sammensætning, der omfatter mælk eller en planteolie, og (c) behandling af sammensætningen fra trin (b) med polypeptidet fra (a) under betingelser, hvor polypeptidet kan hydrolysere olien eller fedtet i sammensætning fra (b), til derved reducering af dens fedtindhold.
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