DK2849748T3 - Farmaceutisk sammensætning omfattende (1r,4r)-6'-fluor-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyklohexan-1,1'-pyran[3,4,b]indol]-4-amin og et gabapentinoid - Google Patents
Farmaceutisk sammensætning omfattende (1r,4r)-6'-fluor-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyklohexan-1,1'-pyran[3,4,b]indol]-4-amin og et gabapentinoid Download PDFInfo
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- DK2849748T3 DK2849748T3 DK13726111.1T DK13726111T DK2849748T3 DK 2849748 T3 DK2849748 T3 DK 2849748T3 DK 13726111 T DK13726111 T DK 13726111T DK 2849748 T3 DK2849748 T3 DK 2849748T3
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- active ingredient
- pain
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (13)
1. Farmaceutisk sammensætning til anvendelse i forebyggelse eller behandling af smerte, omfattende: a) en første farmakologisk virksom bestanddel udvalgt fra forbindelsen ifølge den kemiske formel (I) og de fysiologisk acceptable salte deraf
(I) og b) en anden farmakologisk virksom bestanddel udvalgt blandt gabapentinoider og de fysiologisk acceptable salte deraf.
2. Farmaceutisk sammensætning til anvendelse i forebyggelse eller behandling af smerte ifølge krav 1, hvor den første farmakologisk virksomme bestanddel er forbindelsen ifølge den kemiske formel (I)
(I)
3. Farmaceutisk sammensætning til anvendelse i forebyggelse eller behandling af smerte ifølge krav 1 eller 2, hvor den anden farmakologisk virksomme bestanddel er udvalgt fra gruppen bestående af pregabalin, gabapentin, vigabatrin og de fysiologisk acceptable salte deraf.
4. Farmaceutisk sammensætning til anvendelse i forebyggelse eller behandling af smerte ifølge et hvilket som helst af de foregående krav, som indeholder den første og den anden farmakologisk virksomme bestanddel i et sådant vægtforhold, at de vil udøve en synergistisk terapeutisk virkning efter indgift til en patient.
5. Farmaceutisk sammensætning til anvendelse i forebyggelse eller behandling af smerte ifølge et hvilket som helst af de foregående krav, hvor det relative vægtforhold af den første farmakologisk virksomme bestanddel og den anden farmakologisk virksomme bestanddel ligger i området fra 1:30 til 1:1000.000.
6. Farmaceutisk sammensætning til anvendelse i forebyggelse eller behandling af smerte ifølge krav 5, hvor smerten er: - perifær smerte, central smerte eller muskel-skelet-smerte; og/eller - akut, subakut eller kronisk smerte; og/eller - moderat til stærk smerte; og/elller - neuropatisk eller psykogen eller nociceptiv eller blandet smerte; og/eller - lændesmerter, visceral smerte eller hovedpine; og/eller - postoperativ (postkirurgisk) smerte, cancersmerte eller inflammationssmerte.
7. Farmaceutisk doseringsform til anvendelse i forebyggelse eller behandling af smerte omfattende den farmaceutiske sammensætning ifølge et hvilket som helst af de foregående krav.
8. Farmaceutisk doseringsform til anvendelse i forebyggelse eller behandling af smerte ifølge krav 7, som indeholder den første farmakologisk virksomme bestanddel i en dosis på 10 til 1200 pg.
9. Farmaceutisk doseringsform til anvendelse i forebyggelse eller behandling af smerte ifølge krav 7 eller 8, som indeholder den anden farmakologisk virksomme bestanddel i en dosis fra 0,05 til 5 g.
10. Farmaceutisk doseringsform til anvendelse i forebyggelse eller behandling af smerte ifølge et hvilket som helst af kravene 7 til 9, hvor dosen af den første farmakologisk virksomme bestanddel er inden for området fra 1:20 til 20:1 af mængden, som har ækvivalent virkning med dosen af den anden farmakologisk vrksomme bestanddel.
11. Farmaceutisk doseringsform til anvendelse i forebyggelse eller behandling af smerte ifølge et hvilket som helst af kravene 7 til 10, som er til oral, intravenøs, intraperitoneal, transdermal, intratekal, intramuskulær, intranasal, transmukosal, subkutan eller rektal indgift.
12. Sæt til anvendelse i forebyggelse eller behandling af smerte omfattende en første farmaceutisk doseringsform omfattende den første farmakologisk virksomme bestanddel som defineret i krav 1 eller 2, og en anden farmaceutisk doseringsform omfattende den anden farmakologisk virksomme bestanddel som defineret i krav 1 eller 3.
13. Sæt til anvendelse i forebyggelse eller behandling af smerte ifølge krav 12, hvor den første og den anden farmaceutiske doseringsform er tilpasset samtidig eller på hinanden følgende indgift, enten ad samme eller forskellige indgiftsveje.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003940 | 2012-05-18 | ||
| PCT/EP2013/001465 WO2013170966A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a gabapentinoid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2849748T3 true DK2849748T3 (da) | 2017-12-04 |
Family
ID=48539081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13726111.1T DK2849748T3 (da) | 2012-05-18 | 2013-05-16 | Farmaceutisk sammensætning omfattende (1r,4r)-6'-fluor-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyklohexan-1,1'-pyran[3,4,b]indol]-4-amin og et gabapentinoid |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9320725B2 (da) |
| EP (1) | EP2849748B1 (da) |
| JP (1) | JP6116673B2 (da) |
| CN (1) | CN104284658A (da) |
| AU (1) | AU2013262072B2 (da) |
| BR (1) | BR112014028574A2 (da) |
| CA (1) | CA2873624A1 (da) |
| CY (1) | CY1119777T1 (da) |
| DK (1) | DK2849748T3 (da) |
| EA (1) | EA029766B1 (da) |
| ES (1) | ES2658218T3 (da) |
| HR (1) | HRP20171708T1 (da) |
| HU (1) | HUE034659T2 (da) |
| IL (1) | IL235658A (da) |
| LT (1) | LT2849748T (da) |
| MX (1) | MX356245B (da) |
| NO (1) | NO2849748T3 (da) |
| PL (1) | PL2849748T3 (da) |
| PT (1) | PT2849748T (da) |
| RS (1) | RS56799B1 (da) |
| SI (1) | SI2849748T1 (da) |
| WO (1) | WO2013170966A1 (da) |
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|---|---|---|---|---|
| US9320725B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid |
| EA201791662A1 (ru) | 2015-01-23 | 2017-12-29 | Грюненталь Гмбх | Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией |
| US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
| WO2017148595A1 (en) | 2016-02-29 | 2017-09-08 | Grünenthal GmbH | Titration of cebranopadol |
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| RU2638818C2 (ru) * | 2010-08-04 | 2017-12-15 | Грюненталь Гмбх | Лекарственная дозированная форма, которая содержит 6'-фтор-(n-метил-или n, n-диметил)-4-фенил-4', 9'-дигидро-3'н-спиро[циклогексан-1, 1'-пирано[3, 4, в]индол]-4-амин для лечения невропатической боли |
| TWI526445B (zh) * | 2010-08-04 | 2016-03-21 | 固朗索有限公司 | 含有６’－氟－（Ｎ－甲基－或Ｎ，Ｎ－二甲基－）－４－苯基－４’，９’－二氫－３’Ｈ－螺［環己烷－１，１’－哌喃並［３，４－ｂ］吲哚］－４－胺之藥學劑型 |
| US9320725B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid |
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2013
- 2013-05-13 US US13/892,968 patent/US9320725B2/en active Active
- 2013-05-16 BR BR112014028574A patent/BR112014028574A2/pt not_active IP Right Cessation
- 2013-05-16 RS RS20180083A patent/RS56799B1/sr unknown
- 2013-05-16 EA EA201401268A patent/EA029766B1/ru not_active IP Right Cessation
- 2013-05-16 WO PCT/EP2013/001465 patent/WO2013170966A1/en not_active Ceased
- 2013-05-16 PL PL13726111T patent/PL2849748T3/pl unknown
- 2013-05-16 DK DK13726111.1T patent/DK2849748T3/da active
- 2013-05-16 HR HRP20171708TT patent/HRP20171708T1/hr unknown
- 2013-05-16 CA CA2873624A patent/CA2873624A1/en not_active Abandoned
- 2013-05-16 AU AU2013262072A patent/AU2013262072B2/en not_active Ceased
- 2013-05-16 JP JP2015511952A patent/JP6116673B2/ja active Active
- 2013-05-16 NO NO13726111A patent/NO2849748T3/no unknown
- 2013-05-16 LT LTEP13726111.1T patent/LT2849748T/lt unknown
- 2013-05-16 ES ES13726111.1T patent/ES2658218T3/es active Active
- 2013-05-16 PT PT137261111T patent/PT2849748T/pt unknown
- 2013-05-16 CN CN201380025640.1A patent/CN104284658A/zh active Pending
- 2013-05-16 HU HUE13726111A patent/HUE034659T2/en unknown
- 2013-05-16 EP EP13726111.1A patent/EP2849748B1/en not_active Not-in-force
- 2013-05-16 SI SI201330920T patent/SI2849748T1/en unknown
- 2013-05-16 MX MX2014012764A patent/MX356245B/es active IP Right Grant
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2014
- 2014-11-12 IL IL235658A patent/IL235658A/en active IP Right Grant
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2016
- 2016-03-15 US US15/070,797 patent/US9629825B2/en active Active
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2018
- 2018-01-16 CY CY20181100050T patent/CY1119777T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20160193183A1 (en) | 2016-07-07 |
| IL235658A (en) | 2017-07-31 |
| ES2658218T3 (es) | 2018-03-08 |
| MX356245B (es) | 2018-05-21 |
| AU2013262072B2 (en) | 2018-01-18 |
| US20130310434A1 (en) | 2013-11-21 |
| EP2849748B1 (en) | 2017-11-01 |
| US9320725B2 (en) | 2016-04-26 |
| HUE034659T2 (en) | 2018-02-28 |
| MX2014012764A (es) | 2014-11-21 |
| WO2013170966A1 (en) | 2013-11-21 |
| NO2849748T3 (da) | 2018-03-31 |
| SI2849748T1 (en) | 2018-02-28 |
| CA2873624A1 (en) | 2013-11-21 |
| US9629825B2 (en) | 2017-04-25 |
| AU2013262072A1 (en) | 2015-01-22 |
| EP2849748A1 (en) | 2015-03-25 |
| EA201401268A1 (ru) | 2015-06-30 |
| PT2849748T (pt) | 2018-02-07 |
| CN104284658A (zh) | 2015-01-14 |
| PL2849748T3 (pl) | 2018-03-30 |
| BR112014028574A2 (pt) | 2017-06-27 |
| RS56799B1 (sr) | 2018-04-30 |
| IL235658A0 (en) | 2015-01-29 |
| EA029766B1 (ru) | 2018-05-31 |
| JP2015516446A (ja) | 2015-06-11 |
| HK1204943A1 (en) | 2015-12-11 |
| JP6116673B2 (ja) | 2017-04-19 |
| HRP20171708T1 (hr) | 2017-12-29 |
| LT2849748T (lt) | 2018-01-25 |
| CY1119777T1 (el) | 2018-06-27 |
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