DK2732289T3 - ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS - Google Patents

ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS Download PDF

Info

Publication number: DK2732289T3
Authority: DK; Denmark
Prior art keywords: ser; gly; antibody; thr; oligomers
Prior art date: 2011-07-13

Application number

DK12737445.2T

Other languages

Danish (da)

English (en)

Inventor

William F Goure

Alexander Mccampbell

Mary J Savage

Paul J Shughrue

Fubao Wang

Weirong Wang

Abigail L Wolfe

Ningyan Zhang

Wei-Qin Zhao

Renee C Gaspar

Min Xu

Original Assignee

Acumen Pharmaceuticals Inc

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-07-13

Filing date

2012-07-09

Publication date

2018-05-22

2011-07-13 Priority claimed from PCT/US2011/043866 external-priority patent/WO2012009442A2/fr

2012-07-09 Application filed by Acumen Pharmaceuticals Inc, Merck Sharp & Dohme filed Critical Acumen Pharmaceuticals Inc

2018-05-22 Application granted granted Critical

2018-05-22 Publication of DK2732289T3 publication Critical patent/DK2732289T3/en

Links

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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
General Physics & Mathematics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
Neurosurgery (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

DK12737445.2T 2011-07-13 2012-07-09 ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS DK2732289T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201161507332P	2011-07-13	2011-07-13
PCT/US2011/043866 WO2012009442A2 (fr)	2010-07-14	2011-07-13	Anticorps monoclonal anti-addl et ses utilisations
PCT/US2012/045956 WO2013009703A2 (fr)	2011-07-13	2012-07-09	Anticorps, trousse et procédé de détection d'oligomères bêta-amyloïdes

Publications (1)

Publication Number	Publication Date
DK2732289T3 true DK2732289T3 (en)	2018-05-22

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ID=47506433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK12737445.2T DK2732289T3 (en)	2011-07-13	2012-07-09	ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS

Country Status (13)

Country	Link
US (2)	US20130052670A1 (fr)
EP (2)	EP2732286A4 (fr)
JP (1)	JP2014521089A (fr)
KR (1)	KR20140072019A (fr)
CN (1)	CN103782171B (fr)
AU (1)	AU2012282825B2 (fr)
BR (1)	BR112014000671A2 (fr)
CA (1)	CA2840976A1 (fr)
DK (1)	DK2732289T3 (fr)
ES (1)	ES2666840T3 (fr)
MX (1)	MX2014000480A (fr)
RU (1)	RU2014105172A (fr)
WO (2)	WO2013009703A2 (fr)

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KR20200047790A (ko)	2009-06-17	2020-05-07	바이오젠 엠에이 인코포레이티드	대상에게서 ｓｍｎ２ 스플라이싱을 조정하기 위한 조성물 및 방법
US9320793B2 (en) *	2010-07-14	2016-04-26	Acumen Pharmaceuticals, Inc.	Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
EP2943225A4 (fr)	2013-01-09	2016-07-13	Ionis Pharmaceuticals Inc	Compositions et procédés pour la modulation de l'épissage de smn2 chez un sujet
WO2015077473A1 (fr) *	2013-11-20	2015-05-28	University Of Iowa Research Foundation	Procédés et compositions pour le traitement de dépôts de substance amyloïde
US20170044538A1 (en)	2014-04-17	2017-02-16	Biogen Ma Inc.	Compositions and Methods for Modulation of SMN2 Splicing in a Subject
WO2015175769A1 (fr)	2014-05-15	2015-11-19	Biogen Ma Inc.	Procédés de détection d'oligomères bêta-amyloïdes dans des échantillons biologiques
WO2016040748A1 (fr) *	2014-09-12	2016-03-17	Ionis Pharmaceuticals, Inc.	Compositions et procédés de détection d'une protéine smn chez un patient et traitement d'un patient
MA41480A (fr) *	2014-10-17	2017-12-19	Glenmark Pharmaceuticals Sa	Anticorps qui se lient au ccr6 et leurs utilisations
PT3341725T (pt) *	2015-08-25	2021-09-21	Prothena Biosciences Ltd	Métodos para detetar alfa-sinucleína fosforilada
WO2017138497A1 (fr)	2016-02-08	2017-08-17	シスメックス株式会社	Méthode de détection d'analyte et kit de réactifs permettant de détecter un analyte
EP3471779A4 (fr)	2016-06-16	2020-07-08	Ionis Pharmaceuticals, Inc.	Combinaisons pour la modulation de l'expression de smn
JP7299566B2 (ja) *	2019-07-05	2023-06-28	株式会社島津製作所	アミロイドベータに対するモノクローナル抗体、及びその抗体を用いるアミロイドベータ関連ペプチドの測定方法
CA3173034A1 (fr)	2020-02-28	2021-09-02	Ionis Pharmaceuticals, Inc.	Composes et procedes de modulation de smn2
KR102798206B1 (ko) *	2021-06-25	2025-04-22	장재원	동적 형광 또는 x-선의 표준편차와 자기상관을 활용한 조기 진단 시스템
JP2024534269A (ja) *	2021-08-30	2024-09-18	ザブリガムアンドウィメンズホスピタルインコーポレイテッド	神経変性疾患を治療するための方法および物質
EP4562427A2 (fr) *	2022-07-27	2025-06-04	Durin Life Sciences, Inc.	Détection précoce et surveillance de maladies neurodégénératives à l'aide d'une plateforme de diagnostic à maladies multiples
CN117589996A (zh) *	2022-08-09	2024-02-23	深圳智源生物医药有限公司	强毒性淀粉样蛋白寡聚体的诊断用途

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US4665024A (en)	1984-10-01	1987-05-12	Becton, Dickinson And Company	Fluorescent gram stain
US6218506B1 (en)	1997-02-05	2001-04-17	Northwestern University	Amyloid β protein (globular assembly and uses thereof)
US6082205A (en)	1998-02-06	2000-07-04	Ohio State University	System and device for determining particle characteristics
EP1200470B1 (fr)	1999-08-04	2004-11-24	The University Of Southern California	Assemblage de proteine amyloide b globulaire et ses utilisations
CN1871517A (zh) *	2002-02-19	2006-11-29	免疫公司	快速有效分离循环癌细胞的方法和试剂
JP4824547B2 (ja)	2004-02-20	2011-11-30	インテレクトニュウロサイエンシス，インク．	モノクローナル抗体およびその利用
WO2005096730A2 (fr) *	2004-04-02	2005-10-20	Merck & Co., Inc.	Methodes de detection de substances se fixant a la proteine precurseur amyloide ou a des fragments $g(b) amyloides et composes de fixation
US7572640B2 (en)	2004-09-28	2009-08-11	Singulex, Inc.	Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US7780963B2 (en)	2004-10-25	2010-08-24	Merck & Co., Inc.	Anti-ADDL antibodies and uses thereof
WO2007050359A2 (fr) *	2005-10-21	2007-05-03	Merck & Co., Inc.	Anticorps monoclonal anti-addl et leur utilisation
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US8795664B2 (en) *	2010-06-04	2014-08-05	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin	Monoclonal antibodies targeting amyloid beta oligomers
US9320793B2 (en) *	2010-07-14	2016-04-26	Acumen Pharmaceuticals, Inc.	Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
WO2012009442A2 (fr) *	2010-07-14	2012-01-19	Merck Sharp & Dohme Corp.	Anticorps monoclonal anti-addl et ses utilisations

2012
- 2012-07-09 EP EP12811245.5A patent/EP2732286A4/fr not_active Withdrawn
- 2012-07-09 BR BR112014000671A patent/BR112014000671A2/pt not_active IP Right Cessation
- 2012-07-09 KR KR1020147003386A patent/KR20140072019A/ko not_active Withdrawn
- 2012-07-09 DK DK12737445.2T patent/DK2732289T3/en active
- 2012-07-09 JP JP2014520229A patent/JP2014521089A/ja active Pending
- 2012-07-09 EP EP12737445.2A patent/EP2732289B1/fr active Active
- 2012-07-09 RU RU2014105172/15A patent/RU2014105172A/ru not_active Application Discontinuation
- 2012-07-09 WO PCT/US2012/045956 patent/WO2013009703A2/fr not_active Ceased
- 2012-07-09 CA CA2840976A patent/CA2840976A1/fr not_active Abandoned
- 2012-07-09 CN CN201280044598.3A patent/CN103782171B/zh active Active
- 2012-07-09 AU AU2012282825A patent/AU2012282825B2/en active Active
- 2012-07-09 ES ES12737445.2T patent/ES2666840T3/es active Active
- 2012-07-09 MX MX2014000480A patent/MX2014000480A/es not_active Application Discontinuation
- 2012-07-09 WO PCT/US2012/045886 patent/WO2013009667A1/fr not_active Ceased
- 2012-07-09 US US13/544,554 patent/US20130052670A1/en not_active Abandoned
2013
- 2013-12-20 US US14/137,351 patent/US20140120037A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2840976A1 (fr)	2013-01-17
AU2012282825B2 (en)	2016-05-26
WO2013009703A8 (fr)	2014-01-23
CN103782171A (zh)	2014-05-07
US20130052670A1 (en)	2013-02-28
RU2014105172A (ru)	2015-08-20
MX2014000480A (es)	2014-06-23
US20140120037A1 (en)	2014-05-01
WO2013009703A3 (fr)	2013-03-21
EP2732286A1 (fr)	2014-05-21
AU2012282825A1 (en)	2014-01-16
ES2666840T3 (es)	2018-05-08
WO2013009667A1 (fr)	2013-01-17
CN103782171B (zh)	2016-12-14
EP2732289B1 (fr)	2018-04-11
BR112014000671A2 (pt)	2017-02-14
EP2732289A2 (fr)	2014-05-21
JP2014521089A (ja)	2014-08-25
WO2013009703A2 (fr)	2013-01-17
KR20140072019A (ko)	2014-06-12
EP2732286A4 (fr)	2015-02-25

Publication	Publication Date	Title
DK2732289T3 (en)	2018-05-22	ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS
EP2731969B1 (fr)	2018-10-17	Anticorps dirigés contre des agrégats de tau phosphorylée
KR102716144B1 (ko)	2024-10-10	신경퇴행을 검출하기 위한 분석
CA2584859C (fr)	2017-11-07	Anticorps anti-addl et leurs utilisations
US9310383B2 (en)	2016-04-12	Antibodies, kit and method for detecting amyloid beta oligomers
WO2012009442A2 (fr)	2012-01-19	Anticorps monoclonal anti-addl et ses utilisations
KR20210068408A (ko)	2021-06-09	가용성 bcma에 대한 항체
US20220017611A1 (en)	2022-01-20	New anti tau svqivykpv epitope single domain antibody
CA3207924A1 (fr)	2022-08-18	Methodes de detection de neurofilaments a chaine legere dans le plasma et le liquide cephalorachidien
WO2025137532A1 (fr)	2025-06-26	Méthode de quantification de protofibrilles bêta-amyloïdes
WO2025260029A1 (fr)	2025-12-18	Procédé de quantification de protofibrille bêta-amyloïde
WO2021032966A1 (fr)	2021-02-25	Détection d'oligomères a-bêta