DK26378A - PROCEDURE FOR MAKING ARGIN COMPOUNDS - Google Patents

PROCEDURE FOR MAKING ARGIN COMPOUNDS

Info

Publication number: DK26378A
Authority: DK; Denmark
Prior art keywords: argin; compounds; procedure; making; making argin
Prior art date: 1977-01-19

Application number

DK26378A

Other languages

Danish (da)

Other versions

DK150521C (en

DK150521B (en

Inventor

S Okamoto

R Kikumoto

Y Tamao

K Ohkubo

T Trezuka

S Tonomura

A Hijikato

Original Assignee

Mitsubishi Chem Ind

S Okamoto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-01-19

Filing date

1978-01-18

Publication date

1978-07-20

1977-01-19 Priority claimed from US05/760,745 external-priority patent/US4066773A/en

1977-01-19 Priority claimed from US05/760,668 external-priority patent/US4073913A/en

1977-01-19 Priority claimed from US05/760,672 external-priority patent/US4093712A/en

1977-01-19 Priority claimed from US05/760,929 external-priority patent/US4101653A/en

1977-01-19 Priority claimed from US05/760,676 external-priority patent/US4097472A/en

1977-03-10 Priority claimed from US05/776,195 external-priority patent/US4097591A/en

1977-06-06 Priority claimed from JP6650877A external-priority patent/JPS6010028B2/en

1977-06-07 Priority claimed from US05/804,331 external-priority patent/US4140681A/en

1977-06-07 Priority claimed from US05/804,368 external-priority patent/US4131673A/en

1978-01-18 Application filed by Mitsubishi Chem Ind, S Okamoto filed Critical Mitsubishi Chem Ind

1978-07-20 Publication of DK26378A publication Critical patent/DK26378A/en

1987-03-16 Publication of DK150521B publication Critical patent/DK150521B/en

1987-10-19 Application granted granted Critical

1987-10-19 Publication of DK150521C publication Critical patent/DK150521C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK026378A 1977-01-19 1978-01-18 METHOD OF ANALOGUE FOR THE PREPARATION OF N2-ARYLSULPHONYL-L-ARGININAMIDES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK150521C (en)

Applications Claiming Priority (18)

Application Number	Priority Date	Filing Date	Title
US05/760,929 US4101653A (en)	1974-11-08	1977-01-19	N2 -arylsulfonyl-argininamides and the pharmaceutically acceptable salts thereof
US76092977		1977-01-19
US05/760,668 US4073913A (en)	1974-11-08	1977-01-19	N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US76067677		1977-01-19
US05/760,672 US4093712A (en)	1974-11-08	1977-01-19	N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US76067277		1977-01-19
US05/760,676 US4097472A (en)	1974-11-08	1977-01-19	N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
US76074577		1977-01-19
US05/760,745 US4066773A (en)	1974-11-08	1977-01-19	N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US76066877		1977-01-19
US05/776,195 US4097591A (en)	1974-11-08	1977-03-10	N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US77619577		1977-03-10
JP6650877A JPS6010028B2 (en)	1977-06-06	1977-06-06	N↑2-arylsulfonyl-L-argininamides and pharmaceutically acceptable salts thereof
JP6650877		1977-06-06
US05/804,331 US4140681A (en)	1974-11-08	1977-06-07	N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US80433177		1977-06-07
US80436877		1977-06-07
US05/804,368 US4131673A (en)	1974-11-08	1977-06-07	N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof

Publications (3)

Publication Number	Publication Date
DK26378A true DK26378A (en)	1978-07-20
DK150521B DK150521B (en)	1987-03-16
DK150521C DK150521C (en)	1987-10-19

Family

ID=27577127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK026378A DK150521C (en)	1977-01-19	1978-01-18	METHOD OF ANALOGUE FOR THE PREPARATION OF N2-ARYLSULPHONYL-L-ARGININAMIDES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (17)

Country	Link
CA (1)	CA1131621A (en)
CH (2)	CH648293A5 (en)
DD (1)	DD137352A5 (en)
DE (1)	DE2801478A1 (en)
DK (1)	DK150521C (en)
FI (1)	FI72316C (en)
GB (1)	GB1596971A (en)
GR (1)	GR60787B (en)
IL (1)	IL53685A (en)
IT (1)	IT1126229B (en)
NL (1)	NL187746C (en)
NO (1)	NO158681C (en)
NZ (1)	NZ186198A (en)
PH (1)	PH15913A (en)
SE (1)	SE452624B (en)
SU (1)	SU1181539A3 (en)
UA (1)	UA8370A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE48623B1 (en) *	1978-08-31	1985-03-20	Mitsubishi Chem Ind	Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
JPS5533499A (en) *	1978-08-31	1980-03-08	Mitsubishi Chem Ind Ltd	N2-arylsulfonyl-l-arginineamide and its pharmaceutically acceptable salt
GB9209032D0 (en) *	1992-04-25	1992-06-10	Ciba Geigy Ag	New peptide derivatives
FR2701480B1 (en) *	1993-02-15	1995-05-24	Sanofi Elf	Compounds with a sulfamoyl and amidino group, process for their preparation and pharmaceutical compositions containing them.
GB9426038D0 (en)	1994-12-22	1995-02-22	Iaf Biochem Int	Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) *	1995-12-21	2000-05-02	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors
FR2761065B1 (en) *	1997-03-20	2000-03-03	Synthelabo	N- (ARGINYL) BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN111961114A (en) *	2020-08-03	2020-11-20	扬州中宝药业股份有限公司	Argatroban intermediate and preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3978045A (en) *	1973-08-13	1976-08-31	Mitsubishi Chemical Industries Ltd.	N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof

1977
- 1977-12-16 CA CA293,199A patent/CA1131621A/en not_active Expired
- 1977-12-23 IL IL53685A patent/IL53685A/en unknown
- 1977-12-27 IT IT31297/77A patent/IT1126229B/en active
1978
- 1978-01-10 FI FI780073A patent/FI72316C/en not_active IP Right Cessation
- 1978-01-11 NZ NZ186198A patent/NZ186198A/en unknown
- 1978-01-13 DE DE19782801478 patent/DE2801478A1/en active Granted
- 1978-01-13 PH PH20660A patent/PH15913A/en unknown
- 1978-01-13 NL NLAANVRAGE7800448,A patent/NL187746C/en not_active IP Right Cessation
- 1978-01-17 SE SE7800512A patent/SE452624B/en not_active IP Right Cessation
- 1978-01-18 GB GB2063/78A patent/GB1596971A/en not_active Expired
- 1978-01-18 GR GR55191A patent/GR60787B/en unknown
- 1978-01-18 NO NO780191A patent/NO158681C/en unknown
- 1978-01-18 CH CH4530/82A patent/CH648293A5/en not_active IP Right Cessation
- 1978-01-18 CH CH51978A patent/CH633773A5/en not_active IP Right Cessation
- 1978-01-18 UA UA2776611A patent/UA8370A1/en unknown
- 1978-01-18 SU SU782566652A patent/SU1181539A3/en active
- 1978-01-18 DK DK026378A patent/DK150521C/en not_active IP Right Cessation
- 1978-01-19 DD DD78203302A patent/DD137352A5/en unknown

Also Published As

Publication number	Publication date
SE7800512L (en)	1978-07-20
NL187746B (en)	1991-08-01
IL53685A0 (en)	1978-03-10
SU1181539A3 (en)	1985-09-23
NO158681B (en)	1988-07-11
NZ186198A (en)	1980-12-19
DE2801478C2 (en)	1991-01-31
IL53685A (en)	1985-12-31
FI780073A7 (en)	1978-07-20
DE2801478A1 (en)	1978-07-20
CA1131621A (en)	1982-09-14
NO780191L (en)	1978-07-20
GB1596971A (en)	1981-09-03
DK150521C (en)	1987-10-19
CH648293A5 (en)	1985-03-15
UA8370A1 (en)	1996-03-29
PH15913A (en)	1983-04-22
NO158681C (en)	1988-10-19
FI72316C (en)	1987-05-11
NL187746C (en)	1992-01-02
CH633773A5 (en)	1982-12-31
DD137352A5 (en)	1979-08-29
NL7800448A (en)	1978-07-21
SE452624B (en)	1987-12-07
GR60787B (en)	1978-08-28
IT1126229B (en)	1986-05-14
DK150521B (en)	1987-03-16
FI72316B (en)	1987-01-30

Publication	Publication Date	Title
DK195378A (en)	1978-11-05	PROCEDURE FOR PREPARING POLYEN COMPOUNDS
DK188778A (en)	1978-11-11	PROCEDURE FOR MAKING ORGANIC COMPOUNDS
DK328978A (en)	1979-01-26	PROCEDURE FOR MAKING TRICYCLIC COMPOUNDS
DK81277A (en)	1977-08-26	PROCEDURE FOR MAKING BIS-PYRIDINIUM COMPOUNDS
DK155733C (en)	1989-09-25	PROCEDURE FOR PREPARING 4-HYDROXY-2-OXO-PYRROLIDE INGREDIATES
DK349478A (en)	1979-02-10	PROCEDURE FOR PREPARING OLIGOIMIDES
DK109578A (en)	1978-09-26	PROCEDURE FOR MAKING HETEROCYCLIC COMPOUNDS
DK155279C (en)	1989-07-24	PROCEDURE FOR PREPARING 4-HYDROXY-2-OXO-PYRROLIDE INGREDIATES
DK152516C (en)	1988-08-01	PROCEDURE FOR PROPAGING ROTAVIRUS
DK142989C (en)	1981-08-31	PROCEDURE FOR MANUFACTURING FUROKUMARINS
DK265978A (en)	1978-12-18	PROCEDURE FOR MAKING SUBSTITUTED GUANIDINS
DK158656C (en)	1990-12-03	PROCEDURE FOR DENITROUSING N-NITROSAMINES
DK398078A (en)	1979-03-09	PROCEDURE FOR THE PREPARATION OF SULPHONYLAMIDE COMPOUNDS
DK151078A (en)	1978-10-07	PROCEDURE FOR MAKING CYCLOBUTANONS
DK123277A (en)	1977-09-23	PROCEDURE FOR MAKING 3-HALOGENMETHYL-3-CEPHEM COMPOUNDS
DK7278A (en)	1978-07-08	PROCEDURE FOR MAKING SUBSTITUTED OXIMES
DK262678A (en)	1978-12-21	PROCEDURE FOR MAKING QUINOLINON DERIVATIVES
DK199578A (en)	1978-11-17	PROCEDURE FOR MAKING ORGANIC COMPOUNDS
DK226678A (en)	1978-11-24	PROCEDURE FOR THE PREPARATION OF HEXAHYDROGAMMA-CARBOLINE COMPOUNDS
DK20777A (en)	1977-07-29	PROCEDURE FOR MAKING PYRROLIDINE COMPOUNDS
DK26378A (en)	1978-07-20	PROCEDURE FOR MAKING ARGIN COMPOUNDS
DK302978A (en)	1979-01-14	PROCEDURE FOR MAKING ORGANIC COMPOUNDS
DK97578A (en)	1978-09-06	PROCEDURE FOR PREPARING BENZYLPYRIMIDINE COMPOUNDS
DK326778A (en)	1979-01-24	PROCEDURE FOR PREPARING 7 ALPHAMETHOXYCEPHALOSPORINE COMPOUNDS
DK31478A (en)	1978-07-23	PROCEDURE FOR MAKING ARALKYLANILINES

Legal Events

Date	Code	Title	Description
1998-02-23	PUP	Patent expired