DK2625502T3 - Fremgangsmåde og system til effektiv behandling af biologiske prøver - Google Patents
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Claims (17)
- PAT E NT K RAV1. Fremgangsmåde til effektiv prøvebehandling, omfattende trinene: at tilvejebringe en prøve (1) understøttet af et prøveunderstøtningselement (2); at tilvejebringe prøveunderstøtningselementet (2) med en hydrofil overflade; at tilvejebringe en bevægelig stav (4) anbragt over prøveunderstøtningselementet (2), hvor staven (4) har en i det væsentlige flad hydrofob overflade (15); at påføre en væske (3) på prøven (1) understøttet af prøveunderstøtningselementet (2); vedholdende at oscillere staven (4) frem og tilbage over prøven (1) understøttet af prøveunderstøtningselementet (2), idet der skabes en vedholdende oscillerende stavbevægelse (5); med væsken (3) at danne en i det væsentlige indesluttet væskebro (6), der bevæger sig fluidisk, mellem staven (4) og prøveunderstøtningselementet (2); vedholdende at oscillere den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, frem og tilbage over prøven (1) med den vedholdende oscillerende stavbevægelse (5) mellem stavens (4) i det væsentlige flade hydrofobe overflade (15) og prøveunderstøtningselementet (2); dynamisk at bringe den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, i kontakt med prøven (1); og at behandle prøven (1) understøttet af prøveunderstøtningselementet (2).
- 2. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor trinet vedholdende at oscillere en stav (4) frem og tilbage over prøven (1) understøttet af prøveunderstøtningselementet (2) omfatter trinet vedholdende at oscillere en ufleksibel stav frem og tilbage over prøven med den vedholdende oscillerende stavbevægelse.
- 3. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor trinet vedholdende at oscillere en stav (4) frem og tilbage over prøven (1) understøttet af prøveunderstøtningselementet (2) omfatter et trin valgt blandt en gruppe bestående af: - kontinuerligt at bevæge staven frem og tilbage over prøven; - ensartet at bevæge staven frem og tilbage over prøven; - at bevæge staven frem og tilbage over prøven med konstant hastighed; og - at bevæge staven frem og tilbage over prøven med variabel hastighed.
- 4. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor trinet vedholdende at oscillere den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, mellem staven (4) og prøveunderstøtningselementet (2) frem og tilbage over prøven (1) med den vedholdende oscillerende stavbevægelse (5) omfatter et trin valgt blandt en gruppe bestående af: - vedholdende at oscillere den i det væsentlige indesluttede væskebro, der bevæger sig fluidisk, langs en bredde af prøveunderstøtningselementet; - vedholdende at oscillere den i det væsentlige indesluttede væskebro, der bevæger sig fluidisk, langs en længde af prøveunderstøtningselementet; - vedholdende at oscillere den i det væsentlige indesluttede væskebro, der bevæger sig fluidisk, således at hver bevægelse dækker hele prøven; - vedholdende at oscillere den i det væsentlige indesluttede væskebro, der bevæger sig fluidisk, diagonalt på tværs af prøveunderstøtningselementet; og - en hvilken som helst kombination deraf.
- 5. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor trinet at danne en i det væsentlige indesluttet væskebro (6), der bevæger sig fluidisk, med væsken (3) mellem staven (4) og prøveunderstøtningselementet (2) omfatter trinet at holde i det væsentlige hele væsken i den i det væsentlige indesluttede væskebro, der bevæger sig fluidisk.
- 6. Fremgangsmåde til effektiv prøvebehandling ifølge krav 5, hvor trinet at holde i det væsentlige hele væsken i den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, omfatter trinet at tilbringe en menisk (18) ved hver ende af den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk.
- 7. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor prøven (1) er valgt blandt en gruppe bestående af en biologisk prøve, biologisk materiale, væv, testprøve, antigenudvundet væv, epitopudvundet væv, afparaffineret væv, histologisk prøve, celler, celletestprøver, cellelinjer, proteiner, cellemembraner, syntetiske peptider, cellepræparater, blod, kropsvæske, knoglemarv, cytologiske testprøver, blodudstrygning, tyndlagspræparater, mikroarrayprøver, mikroskopiske objektglasbaserede biologiske prøver, formalinfikserede paraffin indstøbte vævsprøver, konserveret prøve og en hvilken som helst kombination deraf.
- 8. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor trinet at påføre en væske (3) på prøven (1) omfatter trinet at tilvejebringe mindst en komponent i væsken.
- 9. Fremgangsmåde til effektiv prøvebehandling ifølge krav 8, hvor den mindst ene komponent er valgt blandt en gruppe bestående af et antistof, en DNA-sonde, en RNA-sonde, en partikel, en nanopartikel, en mikropartikel, et salt, et primært antistof, et sekundært antistof, et tertiært antistof, et kromogent substrat, en kontrafarvning, der er kompatibel med et antistofenzymkonjugat, et overfladeaktivt stof, en komponent, der er i stand til at reducere overfladespænding af en vandbaseret reagens, en hvilken som helst kombination deraf.
- 10. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1 og endvidere omfattende trinet at tilvejebringe en farvet prøve.
- 11. Fremgangsmåde til effektiv prøvebehandling ifølge krav 10, hvor trinet at tilvejebringe en farvet prøve omfatter trinet at tilvejebringe en farvet prøve med en egenskab valgt blandt en gruppe bestående af en skarp farve, frisk farve, en farvet prøve med i det væsentlige ingen baggrund, en farvet prøve med i det væsentlige ingen ikke-specifik farvning og en farvet prøve med i det væsentlige ingen farvetone på prøveunderstøtningselementet.
- 12. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1 og endvidere omfattende trinene: på spids måde at bringe den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, i kontakt med prøveunderstøtningselementet (2) i en spids væske-til-prøveunderstøtningselement-kontaktvinkel, på stump måde at bringe den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, i kontakt med staven (4) i en stump væske-ti l-stav-kontaktvinkel; på dynamisk måde at bringe den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, i kontakt med prøven (1).
- 13. Fremgangsmåde til effektiv prøvebehandling ifølge krav 1, hvor den hydrofobe overflade omfatter en nanostruktureret ru hydrofob overflade.
- 14. Fremgangsmåde til effektiv prøvebehandling ifølge krav 13 og endvidere omfattende trinet at coate staven (4) med et lag af selvdannet monolag af phosphonater.
- 15. Fremgangsmåde til effektiv prøvebehandling ifølge krav 13, hvor trinet på spids måde at bringe den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, i kontakt med prøveunderstøtningselementet (2) i en spids væske-til-prøveunderstøtningselement-kontaktvinkel omfatter trinet at tilvejebringe en klæbende kraft mellem den i det væsentlige indesluttede væskebro (6), der be- væger sig fluidisk, og prøveunderstøtningselementet (2), som er større end en kohæsionskraft i den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk.
- 16. Fremgangsmåde til effektiv prøvebehandling ifølge krav 13, hvor trinet på stump måde at bringe den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, i kontakt med staven (4) i en stump væske-til-stav-kontaktvinkel omfatter trinet at tilvejebringe en kohæsionskraft i den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, som er større end en klæbende kraft mellem den i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, og staven (4).
- 17. System til effektiv behandling af prøver, omfattende: et prøveunderstøtningselement (2) med en hydrofil overflade til understøtning af en prøve (1); en vedholdende styret bevægelig oscillerende stav (4) beliggende over prøveunderstøtningselementet (2), hvor staven (4) har en i det væsentlige flad hydrofob overflade (15); hvor systemet er indrettet til at danne en oscillerende i det væsentlige indesluttet væskebro (6), der bevæger sig fluidisk, beliggende mellem den vedholdende styrede oscillerende stav (4) og prøveunderstøtningselementet (2); og en dynamisk kontakt mellem den oscillerende i det væsentlige indesluttede væskebro (6), der bevæger sig fluidisk, og en prøve (1); hvor den bevægelige oscillerende stav (4) er i stand til at bevæge sig frem og tilbage over prøven (1) understøttet af prøveunderstøtningselementet (2).
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-
2011
- 2011-10-06 WO PCT/US2011/055161 patent/WO2012048154A1/en not_active Ceased
- 2011-10-06 EP EP11831630.6A patent/EP2625502B1/en not_active Not-in-force
- 2011-10-06 CA CA2851101A patent/CA2851101C/en not_active Expired - Fee Related
- 2011-10-06 ES ES11831630T patent/ES2699950T3/es active Active
- 2011-10-06 DK DK11831630.6T patent/DK2625502T3/da active
- 2011-10-06 CN CN201180058858.8A patent/CN103261872B/zh not_active Expired - Fee Related
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2012
- 2012-05-03 US US13/463,500 patent/US8501434B2/en active Active
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2013
- 2013-07-09 US US13/937,891 patent/US9442049B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8501434B2 (en) | 2013-08-06 |
| EP2625502A1 (en) | 2013-08-14 |
| EP2625502B1 (en) | 2018-09-05 |
| WO2012048154A1 (en) | 2012-04-12 |
| ES2699950T3 (es) | 2019-02-13 |
| US9442049B2 (en) | 2016-09-13 |
| CA2851101C (en) | 2017-02-14 |
| US20130309688A1 (en) | 2013-11-21 |
| CA2851101A1 (en) | 2012-04-12 |
| US20120214191A1 (en) | 2012-08-23 |
| CN103261872A (zh) | 2013-08-21 |
| EP2625502A4 (en) | 2014-12-03 |
| CN103261872B (zh) | 2016-08-24 |
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