DK2683361T3 - Fremgangsmåde til fremstilling af en levothyroxinopløsning - Google Patents
Fremgangsmåde til fremstilling af en levothyroxinopløsning Download PDFInfo
- Publication number
- DK2683361T3 DK2683361T3 DK11711688.9T DK11711688T DK2683361T3 DK 2683361 T3 DK2683361 T3 DK 2683361T3 DK 11711688 T DK11711688 T DK 11711688T DK 2683361 T3 DK2683361 T3 DK 2683361T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparing
- levothyroxine solution
- levothyroxine
- solution
- Prior art date
Links
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 title 1
- 229950008325 levothyroxine Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2011/051015 WO2012120338A1 (en) | 2011-03-10 | 2011-03-10 | Method for the preparaton of a levothyroxine solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2683361T3 true DK2683361T3 (da) | 2016-02-01 |
Family
ID=44625617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11711688.9T DK2683361T3 (da) | 2011-03-10 | 2011-03-10 | Fremgangsmåde til fremstilling af en levothyroxinopløsning |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9050307B2 (da) |
| EP (1) | EP2683361B2 (da) |
| CY (1) | CY1117151T1 (da) |
| DK (1) | DK2683361T3 (da) |
| ES (1) | ES2559818T5 (da) |
| HR (1) | HRP20151421T1 (da) |
| HU (1) | HUE028423T2 (da) |
| PL (1) | PL2683361T5 (da) |
| PT (1) | PT2683361E (da) |
| RS (1) | RS54524B1 (da) |
| SI (1) | SI2683361T1 (da) |
| WO (1) | WO2012120338A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9345772B1 (en) * | 2015-02-27 | 2016-05-24 | Nilesh Parikh | Liquid levothyroxine formulations |
| DE112016005058T5 (de) | 2015-11-04 | 2018-07-19 | Leiutis Pharmaceuticals Pvt Ltd | Neue Levothyroxin-Formulierungen zur oralen Anwendung |
| NL2017110B1 (en) * | 2016-07-05 | 2018-01-12 | Emp Levo Gmbh | Methods for the preparation of a levothyroxine solution |
| WO2018069805A2 (en) | 2016-10-10 | 2018-04-19 | Ftf Pharma Private Limited | Method for preparation of liquid oral composition of l-thyroxin |
| EP3311844A1 (en) | 2016-10-18 | 2018-04-25 | Altergon S.A. | High-stability packaged solutions of t4 thyroid hormone |
| US9782376B1 (en) | 2016-12-01 | 2017-10-10 | Fresenius Kabi Usa Llc | Levothyroxine liquid formulations |
| US11241382B2 (en) | 2019-03-01 | 2022-02-08 | Altergon Sa | Administration regimen of compositions of T4 thyroid hormone with high oral absorption |
| GR1009815B (el) * | 2019-07-25 | 2020-09-15 | Ιουλια Κλεωνος Τσετη | Μη αλκοολουχο ελευθερο απο συντηρητικα και καταλληλο για απο του στοματος χορηγηση πολυδοσικο διαλυμα λεβοθυροξινης για την αντιμετωπιση του υποθυρεοειδισμου |
| WO2021100063A1 (en) | 2019-11-22 | 2021-05-27 | Wockhardt Limited | Oral film composition comprising levothyroxine |
| WO2024227895A2 (en) * | 2023-05-02 | 2024-11-07 | Labomed Pharmaceutical Company S.A. | Oral solution comprising liothyronine sodium |
| GR1010807B (el) | 2023-09-15 | 2024-10-24 | Ιουλια Κλεωνος Τσετη | Σφραγισμενος μονοδοσικος περιεκτης υδατικου διαλυματος λεβοθυροξινης καταλληλος για απο του στοματος χορηγηση |
| CN117919171B (zh) * | 2024-03-22 | 2024-05-31 | 泊诺(天津)创新医药研究有限公司 | 一种左甲状腺素钠口服液的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3035974A (en) * | 1960-02-18 | 1962-05-22 | Israel Murray | Compositions and method for the parenteral administration of thyroxine |
| CN1011118B (zh) | 1986-06-13 | 1991-01-09 | 天津医学院附属医院 | 治疗白内障的眼药水的制药方法 |
| GB9401891D0 (en) | 1994-02-01 | 1994-03-30 | Boots Co Plc | Therapeutic agents |
| US20050059574A1 (en) | 2000-12-21 | 2005-03-17 | Irwin Klein | Compositions of stable T3 and methodes of use thereof |
| US20070045951A1 (en) † | 2003-02-21 | 2007-03-01 | Robertson Phillip J | Video game mask |
| US8318712B2 (en) | 2006-01-06 | 2012-11-27 | Intervet International B.V. | Concentrated liquid thyroid hormone composition |
-
2011
- 2011-03-10 HU HUE11711688A patent/HUE028423T2/en unknown
- 2011-03-10 DK DK11711688.9T patent/DK2683361T3/da active
- 2011-03-10 PT PT117116889T patent/PT2683361E/pt unknown
- 2011-03-10 HR HRP20151421T patent/HRP20151421T1/hr unknown
- 2011-03-10 RS RS20150872A patent/RS54524B1/sr unknown
- 2011-03-10 EP EP11711688.9A patent/EP2683361B2/en active Active
- 2011-03-10 WO PCT/IB2011/051015 patent/WO2012120338A1/en not_active Ceased
- 2011-03-10 ES ES11711688T patent/ES2559818T5/es active Active
- 2011-03-10 US US14/003,598 patent/US9050307B2/en active Active
- 2011-03-10 SI SI201130713T patent/SI2683361T1/sl unknown
- 2011-03-10 PL PL11711688.9T patent/PL2683361T5/pl unknown
-
2016
- 2016-01-21 CY CY20161100064T patent/CY1117151T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2683361A1 (en) | 2014-01-15 |
| RS54524B1 (sr) | 2016-06-30 |
| SI2683361T1 (sl) | 2016-02-29 |
| HUE028423T2 (en) | 2016-12-28 |
| ES2559818T5 (es) | 2024-06-27 |
| HRP20151421T1 (hr) | 2016-03-25 |
| CY1117151T1 (el) | 2017-04-05 |
| US9050307B2 (en) | 2015-06-09 |
| WO2012120338A1 (en) | 2012-09-13 |
| US20140073695A1 (en) | 2014-03-13 |
| EP2683361B1 (en) | 2015-11-25 |
| PL2683361T5 (pl) | 2024-09-09 |
| PT2683361E (pt) | 2016-02-22 |
| PL2683361T3 (pl) | 2016-04-29 |
| ES2559818T3 (es) | 2016-02-16 |
| EP2683361B2 (en) | 2023-11-29 |
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