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DK2670525T3 - Anordning og fremgangsmåde til at generere molekylære mikroarrays - Google Patents

Anordning og fremgangsmåde til at generere molekylære mikroarrays Download PDF

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Publication number
DK2670525T3
DK2670525T3 DK12703757.0T DK12703757T DK2670525T3 DK 2670525 T3 DK2670525 T3 DK 2670525T3 DK 12703757 T DK12703757 T DK 12703757T DK 2670525 T3 DK2670525 T3 DK 2670525T3
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Denmark
Prior art keywords
generating molecular
molecular microarrays
microarrays
generating
molecular
Prior art date
Application number
DK12703757.0T
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English (en)
Inventor
Jügen Burger
Günter Roth
Original Assignee
Biocopy Gmbh
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Publication of DK2670525T3 publication Critical patent/DK2670525T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00337—Valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00675—In-situ synthesis on the substrate
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
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    • B01L2300/0627—Sensor or part of a sensor is integrated
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
DK12703757.0T 2011-02-03 2012-02-03 Anordning og fremgangsmåde til at generere molekylære mikroarrays DK2670525T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011010307A DE102011010307A1 (de) 2011-02-03 2011-02-03 Vorrichtung und Verfahren zur Erzeugung von Protein-Mikroarrays
PCT/EP2012/051816 WO2012104399A2 (en) 2011-02-03 2012-02-03 Device and method for the generation of molecular microarrays

Publications (1)

Publication Number Publication Date
DK2670525T3 true DK2670525T3 (da) 2021-12-20

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DK12703757.0T DK2670525T3 (da) 2011-02-03 2012-02-03 Anordning og fremgangsmåde til at generere molekylære mikroarrays

Country Status (9)

Country Link
US (1) US9623394B2 (da)
EP (1) EP2670525B1 (da)
JP (1) JP5977259B2 (da)
CN (1) CN103338855B (da)
CA (1) CA2824221C (da)
DE (1) DE102011010307A1 (da)
DK (1) DK2670525T3 (da)
ES (1) ES2897738T3 (da)
WO (1) WO2012104399A2 (da)

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GB201108041D0 (en) 2011-05-13 2011-06-29 Univ Portsmouth Method
DK2852458T3 (da) 2012-05-23 2020-09-28 Univ Freiburg Albert Ludwigs Fremgangsmåde til detektion af realtiden for molekylærakkumulationer og/eller overvågning af fremstillingsprocessen for et molekyle-mikroarray
US20170312727A1 (en) * 2012-06-14 2017-11-02 Albert-Ludwigs-Universitaet Freiburg Analysis method on the basis of an array
US10376888B2 (en) 2014-07-03 2019-08-13 Centrillion Technology Holdings Corporation Device for storage and dispensing of reagents
EP3112018A1 (en) 2015-07-02 2017-01-04 Centrillion Technology Holdings Corporation Systems and methods to dispense and mix reagents
WO2019219757A1 (de) * 2018-05-15 2019-11-21 Albert-Ludwig-Universität Freiburg Mikroarray-transformer
EP3980789A4 (en) 2019-06-07 2023-02-22 Honeycomb Biotechnologies, Inc. CELLULAR CASSETTES FOR COLLECTING, STORING AND ANALYZING BIOLOGICAL SAMPLES
CN111250182B (zh) * 2020-02-11 2021-03-19 北京理工大学 一种高通量微流控电泳筛分芯片及其制备方法、应用方法
EP3872555A1 (en) * 2020-02-25 2021-09-01 Leica Instruments (Singapore) Pte. Ltd. Microscope stand and module and housing therefor
WO2022084748A1 (en) * 2020-10-23 2022-04-28 Spindle Biotech, Inc. Compositions and methods for rna synthesis
WO2022167396A1 (en) 2021-02-02 2022-08-11 Biocopy Gmbh Method for identifying emerging pathogen mutations enabling host cell entry and immune evasion
CN116008539B (zh) * 2022-09-02 2025-06-13 中国科学技术大学 一种分子开关及其应用
WO2025129663A1 (zh) * 2023-12-22 2025-06-26 深圳华大生命科学研究院 Rna-蛋白质互作的检测方法
JP2025125755A (ja) * 2024-02-16 2025-08-28 キヤノン株式会社 容器構造体

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WO2000027521A1 (en) * 1998-11-06 2000-05-18 Solexa Ltd. A method for reproducing molecular arrays
DE19854946C2 (de) * 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
EP1235932A2 (en) * 1999-10-08 2002-09-04 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
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US7037659B2 (en) * 2002-01-31 2006-05-02 Nimblegen Systems Inc. Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
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KR100552705B1 (ko) * 2004-01-07 2006-02-20 삼성전자주식회사 전기수력학적(Ｅｌｅｃｔｒｏｈｙｄｒｏｄｙｎａｍｉｃ)현상을 이용하여 기판 상에 생체분자를 프린팅하는 장치및 그 프린팅 방법
EP1763589A1 (en) * 2004-06-30 2007-03-21 RiNA Netzwerk RNA-Technologien GmbH Blueprint biochips
WO2006058246A2 (en) * 2004-11-29 2006-06-01 Rosser Roy J System and method for replicating a bio-molecular micro-array
GB0511717D0 (en) * 2005-06-09 2005-07-13 Babraham Inst Repeatable protein arrays
CN1995369A (zh) * 2006-12-14 2007-07-11 东南大学 一种固相制备核酸分子克隆的方法
CN102066579A (zh) * 2008-04-24 2011-05-18 纽约市哥伦比亚大学理事会 用于dna分子编排的几何图案和脂质双层以及它们的用途
DE102009012169B3 (de) 2009-03-06 2010-11-04 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zum Herstellen eines Replikats oder eines Derivats aus einem Array von Molekülen und Anwendungen derselben

Also Published As

Publication number Publication date
WO2012104399A3 (en) 2012-10-04
CA2824221C (en) 2020-07-07
EP2670525B1 (en) 2021-09-29
CA2824221A1 (en) 2012-08-09
CN103338855A (zh) 2013-10-02
WO2012104399A2 (en) 2012-08-09
DE102011010307A1 (de) 2012-08-09
US20140038854A1 (en) 2014-02-06
ES2897738T3 (es) 2022-03-02
JP2014505883A (ja) 2014-03-06
EP2670525A2 (en) 2013-12-11
JP5977259B2 (ja) 2016-08-24
CN103338855B (zh) 2015-11-25
US9623394B2 (en) 2017-04-18

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