DK2660599T3 - Forudsigelse af risiko for større uønskede hjertehændelser - Google Patents
Forudsigelse af risiko for større uønskede hjertehændelser Download PDFInfo
- Publication number
- DK2660599T3 DK2660599T3 DK13179055.2T DK13179055T DK2660599T3 DK 2660599 T3 DK2660599 T3 DK 2660599T3 DK 13179055 T DK13179055 T DK 13179055T DK 2660599 T3 DK2660599 T3 DK 2660599T3
- Authority
- DK
- Denmark
- Prior art keywords
- subject
- macers
- level
- time
- treatment
- Prior art date
Links
- 230000002411 adverse Effects 0.000 title claims description 17
- 238000000034 method Methods 0.000 claims description 92
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims description 70
- 102400001263 NT-proBNP Human genes 0.000 claims description 64
- 238000011282 treatment Methods 0.000 claims description 38
- 108020001621 Natriuretic Peptide Proteins 0.000 claims description 33
- 102000004571 Natriuretic peptide Human genes 0.000 claims description 33
- 239000000692 natriuretic peptide Substances 0.000 claims description 33
- 230000000747 cardiac effect Effects 0.000 claims description 25
- 206010019280 Heart failures Diseases 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 19
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 210000002966 serum Anatomy 0.000 claims description 10
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 230000002829 reductive effect Effects 0.000 claims description 5
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 4
- 201000006370 kidney failure Diseases 0.000 claims description 4
- 235000009421 Myristica fragrans Nutrition 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 239000001115 mace Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 1
- 230000034994 death Effects 0.000 description 35
- 231100000517 death Toxicity 0.000 description 35
- 238000004458 analytical method Methods 0.000 description 30
- 239000000090 biomarker Substances 0.000 description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 23
- 201000010099 disease Diseases 0.000 description 22
- 238000005259 measurement Methods 0.000 description 19
- 239000000523 sample Substances 0.000 description 16
- 208000000059 Dyspnea Diseases 0.000 description 15
- 206010013975 Dyspnoeas Diseases 0.000 description 15
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 13
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 description 13
- 206010008479 Chest Pain Diseases 0.000 description 13
- 102400000667 Brain natriuretic peptide 32 Human genes 0.000 description 12
- 238000003745 diagnosis Methods 0.000 description 12
- 238000013517 stratification Methods 0.000 description 12
- 230000004083 survival effect Effects 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 10
- 208000010125 myocardial infarction Diseases 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 230000001154 acute effect Effects 0.000 description 8
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 8
- 210000002381 plasma Anatomy 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000004364 calculation method Methods 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 238000004393 prognosis Methods 0.000 description 5
- 230000002685 pulmonary effect Effects 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 206010002383 Angina Pectoris Diseases 0.000 description 4
- 101710187802 Natriuretic peptides B Proteins 0.000 description 4
- 102100036836 Natriuretic peptides B Human genes 0.000 description 4
- 208000010378 Pulmonary Embolism Diseases 0.000 description 4
- 238000011256 aggressive treatment Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229940109239 creatinine Drugs 0.000 description 4
- -1 i.e. Proteins 0.000 description 4
- 230000003908 liver function Effects 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 102000002723 Atrial Natriuretic Factor Human genes 0.000 description 3
- 101800001288 Atrial natriuretic factor Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 101000852968 Homo sapiens Interleukin-1 receptor-like 1 Proteins 0.000 description 3
- 102100036706 Interleukin-1 receptor-like 1 Human genes 0.000 description 3
- 208000019693 Lung disease Diseases 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 238000000611 regression analysis Methods 0.000 description 3
- 208000013220 shortness of breath Diseases 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 2
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 2
- 208000020446 Cardiac disease Diseases 0.000 description 2
- 206010008469 Chest discomfort Diseases 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 206010015137 Eructation Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 108700003107 Interleukin-1 Receptor-Like 1 Proteins 0.000 description 2
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 2
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 206010033307 Overweight Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 101150095505 ST2 gene Proteins 0.000 description 2
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000024924 glomerular filtration Effects 0.000 description 2
- 102000055002 human IL1RL1 Human genes 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 208000013433 lightheadedness Diseases 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 230000004199 lung function Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 230000000414 obstructive effect Effects 0.000 description 2
- 208000008494 pericarditis Diseases 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 206010042772 syncope Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000000779 thoracic wall Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 101800001890 Atrial natriuretic peptide Proteins 0.000 description 1
- 206010007556 Cardiac failure acute Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 208000029147 Collagen-vascular disease Diseases 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 description 1
- 206010052337 Diastolic dysfunction Diseases 0.000 description 1
- 208000002251 Dissecting Aneurysm Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 201000000628 Gas Gangrene Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 101000680096 Homo sapiens Transmembrane emp24 domain-containing protein 1 Proteins 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 101710187800 Natriuretic peptides A Proteins 0.000 description 1
- 102100034296 Natriuretic peptides A Human genes 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010030180 Oesophageal pain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010071436 Systolic dysfunction Diseases 0.000 description 1
- 206010044003 Tonsillar hypertrophy Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000013211 curve analysis Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 208000000122 hyperventilation Diseases 0.000 description 1
- 230000000870 hyperventilation Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 206010028320 muscle necrosis Diseases 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 210000004898 n-terminal fragment Anatomy 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 206010035653 pneumoconiosis Diseases 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 230000012495 positive regulation of renal sodium excretion Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- IJZIXCZIZHENJV-ONCBQHFTSA-N sabatine Chemical compound O[C@@H]([C@H]1CC[C@H]2[C@]3(O)C[C@H](O)[C@]4(O)[C@]5(C)O)[C@@H](OC(C)=O)CC[C@]1(C)[C@H]2C[C@@]3(O)[C@@H]4CN1[C@H]5CC[C@H](C)C1 IJZIXCZIZHENJV-ONCBQHFTSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Electrotherapy Devices (AREA)
Claims (15)
- FORUDSIGELSE AF RISIKO FOR STØRRE UØNSKEDE HJERTEHÆNDELSER PATENTKRAV1. Fremgangsmåde til udvælgelse af en behandling til et individ, hvilken fremgangsmåde omfatter: bestemmelse af en risikoscore for større uønskede hjertehændelser (MACERS) for et individ baseret på, mindst delvist, forholdet mellem et andet niveau af opløseligt vækststimuleringsudtrykt gen 2 (ST2) hos individet på et andet tidspunkt (ST2 TI) og et første niveau af opløseligt ST2 hos individet på et første tidspunkt (ST2 TO), foruden en vægtet naturlig logaritme for et niveau af N-terminalt natriuretisk peptid af cerebraltypen (NT-proBNP) hos individet på et andet tidspunkt (NP TI) i henhold til følgende formel: MACERS = (ST2 T1/ST2 TO) + <xln(NP TI), hvor α er en vægtningsfaktor; sammenligning af MACERS med en reference-MACERS; og udvælgelse af: (a) initial hospitalisering, forsat behandling på hospitalet, eller hjertekateterisation for et individ, der har en forhøjet MACERS sammenlignet med reference-MACERS’en, (2) en alternativ behandling af et individ, der modtager en behandling og som har en forhøjet MACERS sammenlignet med reference-MACERS’en, eller (3) forsat behandling eller afbrydning af behandling, såsom hospitaludskrivelse, for et individ, der modtager en behandling og som har en nedsat MACERS sammenlignet med reference-MACERS’en.
- 2. Fremgangsmåde ifølge krav 1, hvor initial hospitalisering, forsat behandling på hospitalet, eller hjertekateterisation udvælges for et individ, der har en forhøjet MACERS sammenlignet med reference-MACERS’en.
- 3. Fremgangsmåde ifølge krav 1, hvor en alternativ behandling udvælges til et individ, der modtager en behandling, og som har en nedsat MACERS sammenlignet med reference-MACERS’en.
- 4. Fremgangsmåde ifølge krav 1, hvor forsat behandling eller afbrydning af behandling, såsom hospitaludskrivelse, udvælges for et individ, der modtager behandling og som har en nedsat MACERS sammenlignet med reference-MACERS’en.
- 5. Fremgangsmåde ifølge krav 1, hvor reference-MACERS’en repræsenterer en score, der svarer til en lav risiko for en uønsket hændelse inden for et år.
- 6. Fremgangsmåde ifølge krav 1, hvor fremgangsmåden omfatter: opnåelse af et første niveau af opløseligt ST2 hos individet på det første tidspunkt til bestemmelse af ST2 TO; opnåelse af et andet niveau af opløseligt ST2 hos individet på det andet tidspunkt til bestemmelse af ST2T1; og opnåelse af et niveau af NT-proBNP hos individet på det andet tidspunkt til bestemmelse af NP TI.
- 7. Fremgangsmåde til evaluering af effektiviteten af en behandling hos et individ, hvilken fremgangsmåde omfatter: bestemmelse af en første MACE-risikoscore (MACERS) for et individ baseret på, mindst delvist, forholdet mellem et andet niveau af opløseligt vækststimuleringsudtrykt gen 2 (ST2) hos individet på et andet tidspunkt (ST2 TI) og et første niveau af opløseligt ST2 hos individet på et første tidspunkt (ST2 TO), foruden en vægtet naturlig logaritme for et niveau af N-terminalt natriuretisk peptid af cerebraltypen (NT-proBNP) hos individet på et andet tidspunkt (NP TI) i henhold til følgende formel: første MACERS = (ST2 T1/ST2 TO) + aln(NP TI), hvor a er en vægtningsfaktor; bestemmelse af en anden MACE-risikoscore (MACERS) for et individ baseret på, mindst delvist, forholdet mellem et tredje niveau af opløseligt ST2 hos individet på et tredje tidspunkt (ST2 T2) og det første niveau af opløseligt ST2 hos individet på det første tidspunkt (ST2 TO), foruden en vægtet naturlig logaritme af et niveau af NT-proBNP hos individet på det tredje tidspunkt (NP T2) i henhold til følgende formel: anden MACERS = (ST2 T2/ST2 TO) + aln(NP T2), hvor a er en vægtningsfaktor; sammenligning af den anden MACERS med den første MACERS; og bestemmelse af, om behandlingen er effektiv hos et individ, der har en anden MACERS, der er nedsat sammenlignet med den første MACERS, eller om behandlingen ikke var effektiv hos et individ, der har en anden MACERS, der er lig med eller forhøjet sammenlignet med den første MACERS.
- 8. Fremgangsmåde ifølge krav 7, hvor behandlingen fastslås at være effektiv hos et individ, der har en anden MACERS, der er nedsat sammenlignet med den første MACERS.
- 9. Fremgangsmåde ifølge krav 7, hvor behandlingen fastslås ikke at være effektiv hos et individ, der har en anden MACERS, der er lig med eller forhøjet sammenlignet med den første MACERS.
- 10. Fremgangsmåde ifølge krav 7, hvor fremgangsmåde omfatter: opnåelse af et første niveau af opløseligt ST2 hos individet på det første tidspunkt til bestemmelse af ST2 TO; opnåelse af et andet niveau af opløseligt ST2 hos individet på det andet tidspunkt til bestemmelse af ST2T1; opnåelse af et tredje niveau af opløseligt ST2 hos individet på det tredje tidspunkt til bestemmelse af ST2 T2; opnåelse af et niveau af NT-proBNP hos individet på det andet tidspunkt til bestemmelse af NP Ti; Og opnåelse af et niveau af NT-proBNP hos individet på det tredje tidspunkt til bestemmelse af NP T2.
- 11. Fremgangsmåde ifølge krav 1 eller 7, hvor vægtningsfaktoren α er omkring 0,33.
- 12. Fremgangsmåde ifølge krav 1 eller 7, hvor det første tidspunkt er inden for 1-7 dage fra indtræden af symptomer hos individet.
- 13. Fremgangsmåde ifølge krav 1 eller 7, hvor det andet tidspunkt er 2-14 dage efter det første tidspunkt.
- 14. Fremgangsmåde ifølge krav 1 eller 7, hvor individet er blevet diagnosticeret med hjertefejl, eller har en BMI på 25-29, en BMI på > 30 eller nyreinsufficiens.
- 15. Fremgangsmåde ifølge krav 1 eller 7, hvor prøven omfatter serum, blod eller plasma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4615808P | 2008-04-18 | 2008-04-18 | |
| EP09731842.2A EP2269063B1 (en) | 2008-04-18 | 2009-04-17 | Predicting risk of major adverse cardiac events |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2660599T3 true DK2660599T3 (da) | 2014-12-08 |
Family
ID=41199760
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13179055.2T DK2660599T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
| DK14177846.4T DK2827152T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
| DK16166093.1T DK3093663T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
| DK09731842.2T DK2269063T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14177846.4T DK2827152T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
| DK16166093.1T DK3093663T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
| DK09731842.2T DK2269063T3 (da) | 2008-04-18 | 2009-04-17 | Forudsigelse af risiko for større uønskede hjertehændelser |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8090562B2 (da) |
| EP (5) | EP2269063B1 (da) |
| JP (6) | JP5526122B2 (da) |
| AU (3) | AU2009236109B2 (da) |
| CA (1) | CA2720674A1 (da) |
| DK (4) | DK2660599T3 (da) |
| ES (4) | ES2590213T3 (da) |
| HR (2) | HRP20131100T1 (da) |
| HU (2) | HUE039963T2 (da) |
| PL (4) | PL2827152T3 (da) |
| PT (4) | PT2660599E (da) |
| SI (4) | SI3093663T1 (da) |
| WO (1) | WO2009129454A2 (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432060B2 (en) | 2000-11-09 | 2008-10-07 | The Brigham And Women's Hospital, Inc. | Methods for diagnosis of cardiovascular disease |
| CN102533972B (zh) | 2002-05-09 | 2014-07-02 | 布赖汉姆妇女医院 | 作为心血管病的标志和治疗靶的1l1rl-1 |
| ES2378314T3 (es) | 2006-04-24 | 2012-04-11 | Critical Care Diagnostics, Inc. | Predicción de la mortalidad y detección de enfermedades graves. |
| ATE517341T1 (de) * | 2006-04-27 | 2011-08-15 | Critical Care Diagnostics Inc | Interleukin-33 (il-33) zur diagnose und vorhersage von herz-gefäss-erkrankungen |
| AU2007248160B2 (en) | 2006-05-01 | 2011-03-24 | Critical Care Diagnostics, Inc. | Diagnosis of cardiovascular disease |
| ES2542343T3 (es) * | 2006-05-02 | 2015-08-04 | Critical Care Diagnostics, Inc. | Diagnóstico diferencial entre enfermedad pulmonar y cardiovascular |
| US9968266B2 (en) | 2006-12-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Risk stratification based heart failure detection algorithm |
| WO2009129454A2 (en) | 2008-04-18 | 2009-10-22 | Critical Care Diagnostics, Inc. | Predicting risk of major adverse cardiac events |
| ES2795003T3 (es) * | 2008-10-07 | 2020-11-20 | Brahms Gmbh | Biomarcador para la predicción de los primeros eventos adversos |
| US9561006B2 (en) * | 2008-10-15 | 2017-02-07 | The United States Of America As Represented By The Secretary Of The Navy | Bayesian modeling of pre-transplant variables accurately predicts kidney graft survival |
| US8417541B1 (en) * | 2009-08-27 | 2013-04-09 | Cerner Innovation, Inc. | Multi-stage model for predicting probabilities of mortality in adult critically ill patients |
| EP2480129B1 (en) * | 2009-09-25 | 2019-11-06 | Volcano Corporation | Device for determining the likelihood of a patient having a clinically silent event based on ascertained physiological parameters |
| PL2556090T3 (pl) | 2010-04-09 | 2017-07-31 | Critical Care Diagnostics, Inc. | Rozpuszczalne ludzkie przeciwciała st-2 i metody analityczne ich oznaczania |
| US10943676B2 (en) | 2010-06-08 | 2021-03-09 | Cerner Innovation, Inc. | Healthcare information technology system for predicting or preventing readmissions |
| CN103718046B (zh) | 2011-03-17 | 2016-10-12 | 重症监护诊断股份有限公司 | 预测不良临床结果的风险的方法 |
| CA2842072A1 (en) | 2011-07-18 | 2013-01-24 | James V. Snider | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
| EP2637023A1 (en) * | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| AU2013262515B2 (en) | 2012-05-18 | 2018-03-15 | Cardiac Pacemakers, Inc. | Methods for treating or predicting risk of a ventricular tachyarrhythmia event |
| CN102830234A (zh) * | 2012-08-10 | 2012-12-19 | 杭州华得森生物技术有限公司 | 一种检测人心力衰竭新型标志物st2的快速诊断试剂盒 |
| US9523696B2 (en) | 2012-08-16 | 2016-12-20 | Critical Care Diagnostics, Inc. | Methods for predicting risk of developing hypertension |
| AU2013305829A1 (en) * | 2012-08-21 | 2015-03-05 | Critical Care Diagnostics, Inc. | Multimarker risk stratification |
| RU2510505C1 (ru) * | 2012-11-15 | 2014-03-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ определения вероятности выраженной сердечной недостаточности в клинической картине инфаркта миокарда |
| GB201310290D0 (en) * | 2013-06-10 | 2013-07-24 | Univ Manchester | Method for determining a probability of a major adverse cardiac event (MACE) |
| CN106461636A (zh) * | 2014-01-10 | 2017-02-22 | 重症监护诊断股份有限公司 | 用于测定心力衰竭风险的方法和系统 |
| EP3198023B1 (en) | 2014-09-26 | 2020-04-22 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| WO2016140958A1 (en) * | 2015-03-02 | 2016-09-09 | Estes Edward Harvey | Method and device to predict adverse cardiovascular events and mortality from an electrocardiogram-based validated risk score |
| EP4442200A3 (en) * | 2016-04-01 | 2024-12-04 | Cardiac Pacemakers, Inc. | Multi-disease patient management |
| AT518560B1 (de) | 2016-04-18 | 2018-01-15 | Trumpf Maschinen Austria Gmbh & Co Kg | Biegebalken für eine Schwenkbiegemaschine |
| EP3614908B1 (en) | 2017-04-29 | 2024-10-09 | Cardiac Pacemakers, Inc. | Heart failure event rate assessment |
| US20200074313A1 (en) * | 2018-08-29 | 2020-03-05 | Koninklijke Philips N.V. | Determining features to be included in a risk assessment instrument |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| JP2022532423A (ja) * | 2019-05-17 | 2022-07-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 心血管系リスクを減らすためのゲノムに基づく方法 |
| US11551817B2 (en) | 2020-01-14 | 2023-01-10 | International Business Machines Corporation | Assessing unreliability of clinical risk prediction |
| CN117099000A (zh) * | 2021-03-08 | 2023-11-21 | 赛诺菲 | 心血管疾病 |
| EP4430635A1 (en) * | 2021-11-11 | 2024-09-18 | Beckman Coulter, Inc. | Assessment of risk for major adverse cardiac event |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208479A (en) | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US5206140A (en) | 1988-06-24 | 1993-04-27 | Research Corporation Technologies, Inc. | Assay for soluble crosslinked fibrin polymers |
| US5217899A (en) | 1990-08-24 | 1993-06-08 | The General Hospital Corporation | Cell stretching apparatus |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| JP2732005B2 (ja) | 1992-12-14 | 1998-03-25 | 眞一 富永 | ヒトｓｔ２をコードするｄｎａ、該ｄｎａの発現産物、該ｄｎａを発現させることによる発現産物の製造方法 |
| JPH0731479A (ja) | 1993-02-23 | 1995-02-03 | Shinichi Tominaga | マウスｓｔ２ｌをコードするｄｎａ、該ｄｎａの発現産物、該ｄｎａを発現させることによる発現産物の製造方法 |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| WO1998007754A1 (en) | 1996-08-23 | 1998-02-26 | Human Genome Sciences, Inc. | T1 receptor-like ligand ii |
| WO1998038311A1 (en) | 1997-02-28 | 1998-09-03 | Human Genome Sciences, Inc. | T1/st2-receptor ligand iii |
| DE19711932A1 (de) | 1997-03-21 | 1998-09-24 | Anne Katrin Dr Werenskiold | In vitro-Verfahren zum Prognostizieren des Krankheitsverlaufs von Patienten mit Mammakarzinom und/oder zum Diagnostizieren eines Mammakarzinoms |
| ATE530180T1 (de) | 1997-04-02 | 2011-11-15 | Brigham & Womens Hospital | Verfahren zur ermittlung der individualen risikoprofile atherosklerotischen erkrankungen |
| EP0988552B1 (en) | 1997-06-10 | 2010-11-24 | Lpath, Inc. | Methods for early detection of heart disease |
| JP3516655B2 (ja) | 1997-09-11 | 2004-04-05 | 塩野義製薬株式会社 | Ｂｎｐの免疫測定法 |
| GB9727172D0 (en) | 1997-12-24 | 1998-02-25 | Univ Glasgow | Reagents specific for st2l and uses therefor |
| US6309888B1 (en) | 1998-09-04 | 2001-10-30 | Leuven Research & Development Vzw | Detection and determination of the stages of coronary artery disease |
| GB9827348D0 (en) | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| EP1140137A2 (en) | 1998-12-18 | 2001-10-10 | Scios Inc. | Method for detection and use of differentially expressed genes in disease states |
| WO2000073498A1 (en) | 1999-06-02 | 2000-12-07 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| FR2795823B1 (fr) | 1999-07-01 | 2001-11-23 | Inst Nat Sante Rech Med | Methodes et kits pour le diagnostic ou le suivi d'une pathologie synoviale ou osteoarticulaire comprenant l'utilisation d'un marqueur specifique de la degradation du tissu synovial |
| CA2383252A1 (en) | 1999-08-24 | 2001-03-01 | Medicure International Inc. | Treatment of cardiovascular related pathologies |
| US6323334B1 (en) | 1999-09-24 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding a 103 gene product and uses therefor |
| AU2001218871A1 (en) | 2000-03-21 | 2001-10-03 | Takao Arai | Monoclonal antibody and method and kit for the immunoassay of soluble human st2 with the use of the same |
| FR2807170B1 (fr) | 2000-03-30 | 2002-06-28 | Sipal | Charniere elastique a frottement reduit |
| CA2388061A1 (en) | 2000-08-22 | 2002-02-28 | The Brigham And Women's Hospital, Inc | Diagnosis and treatment of cardiovascular conditions |
| US7432060B2 (en) | 2000-11-09 | 2008-10-07 | The Brigham And Women's Hospital, Inc. | Methods for diagnosis of cardiovascular disease |
| US6537221B2 (en) | 2000-12-07 | 2003-03-25 | Koninklijke Philips Electronics, N.V. | Strain rate analysis in ultrasonic diagnostic images |
| FI20010019L (fi) | 2001-01-05 | 2002-07-06 | Biohit Oyj | Menetelmä atrofisen diagnostisoimiseksi |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| EP2261669A1 (en) | 2001-05-04 | 2010-12-15 | Alere San Diego, Inc. | Diagnostic markers of acute coronary syndromes and methods of use thereof |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| WO2003022987A2 (en) | 2001-07-26 | 2003-03-20 | Eos Biotechnology, Inc. | Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection |
| US6810284B1 (en) | 2001-11-21 | 2004-10-26 | Pacesetter, Inc. | Implantable cardiac stimulation system and method for monitoring diastolic function |
| CN102533972B (zh) | 2002-05-09 | 2014-07-02 | 布赖汉姆妇女医院 | 作为心血管病的标志和治疗靶的1l1rl-1 |
| US20040005615A1 (en) | 2002-05-24 | 2004-01-08 | Jing Li | Amplification and overexpression of oncogenes |
| US8263325B2 (en) | 2002-11-15 | 2012-09-11 | Ottawa Heart Institute Research Corporation | Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis |
| CA2507415A1 (en) * | 2002-11-21 | 2004-06-03 | The University Of Leicester | Bodily fluid markers of tissue hypoxia |
| WO2004056868A2 (en) | 2002-12-19 | 2004-07-08 | Endocube Sas | Nf-hev compositions and methods of use |
| US20040133079A1 (en) | 2003-01-02 | 2004-07-08 | Mazar Scott Thomas | System and method for predicting patient health within a patient management system |
| US20040220155A1 (en) | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| WO2005041893A2 (en) | 2003-10-31 | 2005-05-12 | Queststar Medical, Inc. | Detection of acute myocardial infarction biomarkers |
| CA3048093A1 (en) | 2003-11-26 | 2005-06-23 | Celera Corporation | Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof |
| WO2005055810A2 (en) | 2003-12-05 | 2005-06-23 | The Cleveland Clinic Foundation | Risk markers for cardiovascular disease |
| US20050196817A1 (en) | 2004-01-20 | 2005-09-08 | Molecular Staging Inc. | Biomarkers for sepsis |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| JP2005291899A (ja) | 2004-03-31 | 2005-10-20 | Akira Matsumori | 心疾患の検査法 |
| WO2006066095A1 (en) | 2004-12-17 | 2006-06-22 | Clearwater Systems Corporation | Method and apparatus for treating fluids |
| ES2388795T3 (es) | 2005-01-24 | 2012-10-18 | F. Hoffmann-La Roche Ag | Utilización de péptidos de tipo Bnp para la evaluación del riesgo de sufrir insuficiencia cardiaca como consecuencia de la sobrecarga de volumen |
| EP1731910A1 (en) | 2005-06-07 | 2006-12-13 | F. Hoffmann-La Roche Ag | Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases |
| US20070021977A1 (en) | 2005-07-19 | 2007-01-25 | Witt Biomedical Corporation | Automated system for capturing and archiving information to verify medical necessity of performing medical procedure |
| JP4820192B2 (ja) | 2006-03-17 | 2011-11-24 | 一般財団法人化学及血清療法研究所 | 急性冠症候群でのａｄａｍｔｓ１３の測定と利用 |
| ES2378314T3 (es) | 2006-04-24 | 2012-04-11 | Critical Care Diagnostics, Inc. | Predicción de la mortalidad y detección de enfermedades graves. |
| ATE517341T1 (de) | 2006-04-27 | 2011-08-15 | Critical Care Diagnostics Inc | Interleukin-33 (il-33) zur diagnose und vorhersage von herz-gefäss-erkrankungen |
| AU2007248160B2 (en) * | 2006-05-01 | 2011-03-24 | Critical Care Diagnostics, Inc. | Diagnosis of cardiovascular disease |
| ES2542343T3 (es) | 2006-05-02 | 2015-08-04 | Critical Care Diagnostics, Inc. | Diagnóstico diferencial entre enfermedad pulmonar y cardiovascular |
| WO2007130627A2 (en) | 2006-05-04 | 2007-11-15 | The Brigham And Women's Hospital, Inc. | Il-33 in the treatment and diagnosis of diseases and disorders |
| WO2007146229A2 (en) * | 2006-06-07 | 2007-12-21 | Tethys Bioscience, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| RU2312591C1 (ru) | 2006-06-14 | 2007-12-20 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ прогнозирования развития риска внезапной смерти у больных с лево- и правожелудочковой экстрасистолией |
| US20080233191A1 (en) | 2007-03-22 | 2008-09-25 | Brent Blackburn | Use of ranolazine for elevated brain-type natriuretic peptide |
| JP2010526555A (ja) | 2007-05-11 | 2010-08-05 | タフツ・メディカル・センター | 加齢関連黄斑変性と関係するポリヌクレオチド及び患者のリスクを評価する方法 |
| GB0713404D0 (en) | 2007-07-11 | 2007-08-22 | Integra Sp Ipr Ltd | Altio graph |
| US20100267062A1 (en) | 2007-09-26 | 2010-10-21 | Norbert Frey | Osteopontin as Novel Prognostic Biomarker for Heart Failure |
| FR2923029B1 (fr) | 2007-10-26 | 2009-11-20 | Minima | Lunettes de type sans entourage a branches filaires |
| WO2009129454A2 (en) | 2008-04-18 | 2009-10-22 | Critical Care Diagnostics, Inc. | Predicting risk of major adverse cardiac events |
| WO2010025393A2 (en) * | 2008-08-28 | 2010-03-04 | The Regents Of The University Of California | Protein biomarkers and methods for diagnosing kawasaki disease |
| CN102317790B (zh) | 2008-11-11 | 2014-12-10 | B.R.A.H.M.S有限公司 | Adm在制备用于评估心力衰竭和/或呼吸短促的制剂中的应用 |
| EA201290311A1 (ru) | 2009-11-13 | 2012-12-28 | БиДжи МЕДИСИН, ИНК. | Факторы риска и прогнозирование инфаркта миокарда |
| US8258456B2 (en) | 2009-11-27 | 2012-09-04 | Himax Imaging, Inc. | Image sensor |
| PL2556090T3 (pl) | 2010-04-09 | 2017-07-31 | Critical Care Diagnostics, Inc. | Rozpuszczalne ludzkie przeciwciała st-2 i metody analityczne ich oznaczania |
| WO2012059477A1 (en) | 2010-11-01 | 2012-05-10 | B.R.A.H.M.S Gmbh | Prognosis and risk assessment of patients with non-specific complaints |
| RU2452394C1 (ru) | 2010-11-09 | 2012-06-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Ульяновский государственный университет | Способ прогнозирования риска смерти больных хронической сердечной недостаточностью |
| CN103718046B (zh) | 2011-03-17 | 2016-10-12 | 重症监护诊断股份有限公司 | 预测不良临床结果的风险的方法 |
| US8615387B2 (en) * | 2011-04-07 | 2013-12-24 | Invensys Systems, Inc. | Dynamic simulation of fluid filled vessels |
| CA2842072A1 (en) | 2011-07-18 | 2013-01-24 | James V. Snider | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
| AU2013262515B2 (en) | 2012-05-18 | 2018-03-15 | Cardiac Pacemakers, Inc. | Methods for treating or predicting risk of a ventricular tachyarrhythmia event |
| US9523696B2 (en) * | 2012-08-16 | 2016-12-20 | Critical Care Diagnostics, Inc. | Methods for predicting risk of developing hypertension |
| AU2013305829A1 (en) * | 2012-08-21 | 2015-03-05 | Critical Care Diagnostics, Inc. | Multimarker risk stratification |
| US9665593B2 (en) * | 2013-03-28 | 2017-05-30 | International Business Machines Corporation | Dynamically synching elements in file |
| JP6178687B2 (ja) | 2013-09-27 | 2017-08-09 | 富士機械工業株式会社 | グラビア塗工装置 |
| CN106461636A (zh) | 2014-01-10 | 2017-02-22 | 重症监护诊断股份有限公司 | 用于测定心力衰竭风险的方法和系统 |
| USD770057S1 (en) | 2014-04-14 | 2016-10-25 | Critical Care Diagnostics, Inc. | Blood test kit |
| US9934249B2 (en) | 2014-06-03 | 2018-04-03 | Conduent Business Machines Services, Llc | Systems and methods for context-aware and personalized access to visualizations of road events |
| USD800333S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| USD800332S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
-
2009
- 2009-04-17 WO PCT/US2009/040941 patent/WO2009129454A2/en not_active Ceased
- 2009-04-17 SI SI200931872T patent/SI3093663T1/sl unknown
- 2009-04-17 SI SI200930776T patent/SI2269063T1/sl unknown
- 2009-04-17 CA CA2720674A patent/CA2720674A1/en not_active Abandoned
- 2009-04-17 EP EP09731842.2A patent/EP2269063B1/en not_active Not-in-force
- 2009-04-17 AU AU2009236109A patent/AU2009236109B2/en not_active Ceased
- 2009-04-17 HU HUE16166093A patent/HUE039963T2/hu unknown
- 2009-04-17 SI SI200931045T patent/SI2660599T1/sl unknown
- 2009-04-17 PL PL14177846.4T patent/PL2827152T3/pl unknown
- 2009-04-17 DK DK13179055.2T patent/DK2660599T3/da active
- 2009-04-17 PL PL16166093T patent/PL3093663T3/pl unknown
- 2009-04-17 DK DK14177846.4T patent/DK2827152T3/da active
- 2009-04-17 EP EP18166387.3A patent/EP3378955A1/en not_active Withdrawn
- 2009-04-17 ES ES14177846.4T patent/ES2590213T3/es active Active
- 2009-04-17 PT PT131790552T patent/PT2660599E/pt unknown
- 2009-04-17 PL PL13179055T patent/PL2660599T3/pl unknown
- 2009-04-17 US US12/425,956 patent/US8090562B2/en active Active
- 2009-04-17 JP JP2011505224A patent/JP5526122B2/ja not_active Expired - Fee Related
- 2009-04-17 SI SI200931469A patent/SI2827152T1/sl unknown
- 2009-04-17 EP EP16166093.1A patent/EP3093663B1/en not_active Not-in-force
- 2009-04-17 DK DK16166093.1T patent/DK3093663T3/da active
- 2009-04-17 EP EP13179055.2A patent/EP2660599B1/en not_active Not-in-force
- 2009-04-17 DK DK09731842.2T patent/DK2269063T3/da active
- 2009-04-17 ES ES09731842.2T patent/ES2443125T3/es active Active
- 2009-04-17 HU HUE14177846A patent/HUE029880T2/en unknown
- 2009-04-17 PT PT16166093T patent/PT3093663T/pt unknown
- 2009-04-17 ES ES13179055.2T patent/ES2525029T3/es active Active
- 2009-04-17 PT PT141778464T patent/PT2827152T/pt unknown
- 2009-04-17 PT PT97318422T patent/PT2269063E/pt unknown
- 2009-04-17 PL PL09731842T patent/PL2269063T3/pl unknown
- 2009-04-17 ES ES16166093.1T patent/ES2687401T3/es active Active
- 2009-04-17 EP EP14177846.4A patent/EP2827152B1/en not_active Not-in-force
- 2009-04-17 HR HRP20131100AT patent/HRP20131100T1/hr unknown
-
2011
- 2011-11-18 US US13/299,612 patent/US20120065897A1/en not_active Abandoned
-
2013
- 2013-03-06 US US13/787,137 patent/US9886553B2/en not_active Expired - Fee Related
-
2014
- 2014-04-03 US US14/244,526 patent/US9965593B2/en active Active
- 2014-04-14 JP JP2014082442A patent/JP5873521B2/ja not_active Expired - Fee Related
- 2014-11-03 HR HRP20141056AT patent/HRP20141056T1/hr unknown
-
2016
- 2016-01-15 JP JP2016006007A patent/JP6200975B2/ja not_active Expired - Fee Related
- 2016-02-04 AU AU2016200697A patent/AU2016200697B2/en not_active Ceased
-
2017
- 2017-08-28 JP JP2017162932A patent/JP6484679B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-04 AU AU2018202350A patent/AU2018202350A1/en not_active Abandoned
- 2018-04-12 US US15/951,376 patent/US11170896B2/en active Active
-
2019
- 2019-02-18 JP JP2019026401A patent/JP6788050B2/ja not_active Expired - Fee Related
-
2020
- 2020-10-29 JP JP2020181010A patent/JP2021039108A/ja not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11170896B2 (en) | Predicting risk of major adverse cardiac events | |
| WO2007127749A2 (en) | Predicting mortality and detecting severe disease | |
| HK1231173A1 (en) | Predicting risk of major adverse cardiac events | |
| HK1206419B (en) | Predicting risk of major adverse cardiac events | |
| HK1185658B (en) | Predicting risk of major adverse cardiac events | |
| HK1152750B (en) | Predicting risk of major adverse cardiac events |