DK2536451T3 - Autoinjektor med en torsionsfjeder - Google Patents
Autoinjektor med en torsionsfjeder Download PDFInfo
- Publication number
- DK2536451T3 DK2536451T3 DK11703888.5T DK11703888T DK2536451T3 DK 2536451 T3 DK2536451 T3 DK 2536451T3 DK 11703888 T DK11703888 T DK 11703888T DK 2536451 T3 DK2536451 T3 DK 2536451T3
- Authority
- DK
- Denmark
- Prior art keywords
- housing
- syringe
- auto
- injector
- needle
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
- A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (14)
1. Autoinjektor (1) til administration af en dosis af et væskeformigt medikament (M), som omfatter: - et aflangt hus (2), der er indrettet til at indeholde en sprøjte (7) med en hul kanyle (9) og en prop (10) til forsegling af sprøjten (7) og forskydning af medikamentet (M) , hvilket aflange hus (2) har en distal ende (D) og en proksimal ende (P) med en åbning, der er beregnet til at blive ført mod et injektionssted, hvor sprøjten (7) er glidbart anbragt i forhold til huset (2), - et fjedermiddel (14), der er i stand til ved aktivering at skubbe kanylen (9) fra en dækket position inde i huset (2) til en fremskudt position gennem åbningen og forbi den proksimale ende (P) samt drive sprøjten (7) til at dispensere dosen af medikament (M), et aktiveringsmiddel (4), der er indrettet til at låse fjedermidlet (14) i en trykpåført tilstand før manuel betjening og i stand til ved manuel betjening at frigøre fjedermidlet (14) til injektion, hvor fjedermidlet (14) er en torsionsfjeder (14), der er fastgjort i den ene ende i huset (2) og i den anden ende i en første geardel (15), der kan rotere omkring en længdeakse, men er aksialt fikseret, hvor den første geardel (15) ved rotation er indrettet til translativ bevægelse af en anden geardel (11), hvilken anden geardel (11) er forhindret i at rotere i forhold til huset og er koblet til proppen (10), så den skubbes mod den proksimale ende (P) , hvor den første geardel (15) er i indgreb med aktiveringsmidlet (4) før manuel betjening på en måde til forhindring af rotation og afkobles fra aktiveringsmidlet (4) ved manuel betjening, hvor en i det væsentlige rørformet kanyleafskærmning (3) er anbragt omkring sprøjten (7) i huset (2), hvilken kanyleafskærmning (3) kan glide mellem mindst en tilbagetrukket position, hvor kanyleafskærmningen (3) er næsten skjult inde i huset (2), og en fremskudt position, hvor kanyleafskærmningen (3) stikker frem fra den proksimale ende (P) og dækker den hule kanyle (9) i dens fremskudte position, hvor kanyleafskærmningen (3) påvirkes af et andet fjedermiddel (12) mod den fremskudte position, der er kendetegnet ved, at kanyleafskærmningen (3) er låst i den tilbagetrukne position ved hjælp af et låsemiddel, der kan frigøres ved hjælp af rotationsbevægelse, der overføres fra den første geardel (15) via en koblingsmekanisme, der går i indgreb med den anden geardel (11), kort før den anden geardel (11) er fuldt fremskudt under et indsprøjtningsslag.
2. Autoinjektor (1) ifølge krav 1, der er kendetegnet ved, at en indgrebsmekanisme er indrettet til at låse aktiveringsmidlet (4) og forhindre, at det betjenes manuelt, hvor indgrebsmekanismen er koblet til kanyleafskærmningen (3) , hvor indgrebsmekanismen kan frigøres ved at skubbe kanyleafskærmningen (3) et lille stykke ind i huset (2) fra kanyleafskærmningens (3) tilbagetrukne position.
3. Autoinjektor (1) ifølge et af ovennævnte krav, der er kendetegnet ved, at aktiveringsmidlet (4) er en udløserknap (4), der er anbragt lateralt på huset (2) og kan betjenes, ved at den trykkes i tværgående retning i forhold til længdeaksen.
4. Autoinjektor (1) ifølge krav 3, der er kendetegnet ved, at udløserknappen (4) har en låsestift (18), der kan gå i indgreb med mindst én stoptand (19), der er tilvejebragt på den første geardel (15), til forhindring af rotation deraf, så fjedermidlet (14) låses i dets trykpåførte tilstand.
5. Autoinjektor (1) ifølge et af kravene 1 til 4, der er kendetegnet ved, at låsemidlet har form af en bajonetlås mellem kanyleafskærmningen (3) og et udvendigt bagenderør (13) , der er anbragt omkring torsionsfjederen (14), hvor kanyleafskærmningen (3) styres i huset (2) på en måde, der forhindrer relativ rotation, og hvor det udvendige bagenderør (13) er koblet til koblingsmekanismen, hvor bajonetlåsen omfatter en bajonetstift (32), der er anbragt på det ene af det udvendige bagenderør (13) eller kanyleafskærmningen (3), og et stiftspor (33) , der er anbragt på det andet af det udvendige bagenderør (13) eller kanyleafskærmningen (3).
6. Autoinjektor (1) ifølge et af ovennævnte krav, der er kendetegnet ved, at den anden geardel (11) er en stempelstang (11) med et udvendigt ledeskruegevind (16), hvilken stempelstang (11) har et aksialt hul til glidbar anbringelse af stempelstangen (11) på en aksel (21), der er fastgjort til huset (2), hvor det aksiale hul og akslen (21) har tilsvarende ikke-cirkulære profiler, hvor den første geardel (15) er en ledemøtrik (15) , der er i indgreb med det udvendige ledeskruegevind (16).
7. Autoinjektor (1) ifølge krav 6, der er kendetegnet ved, at det udvendige ledeskruegevind (16) har en variabel stigning.
8. Autoinjektor (1) ifølge et af kravene 3 til 7, der er kendetegnet ved, at indgrebsmekanismen omfatter respektive gribere (24, 25), der er tilvejebragt på kanyleafskærmningen (3) og udløserknappen (4).
9. Autoinjektor (1) ifølge et af kravene 1 til 8, der er kendetegnet ved, at sprøjten (7) er anbragt i en sprøjtemedbringer (8) og understøttet af sprøjtemedbringeren (8) i en proksimal ende, hvor sprøjtemedbringeren (8) er glidbart anbragt i kanyleafskærmningen (3) , og hvor der er tilvejebragt et modhold i kanyleafskærmningen (3), der definerer en maksimal fremadposition for sprøjtemedbringeren (8) .
10. Autoinjektor (1) ifølge et af kravene 1 til 7, der er kendetegnet ved, at koblingsmekanismen omfatter en rundtgående ansats (28), der er anbragt på den anden geardel (11), og mindst én elastisk koblingsfinger (29) med en respektiv skrå indre overflade, der er anbragt i en distal ende af den første geardel (15), hvor ansatsen (28) er indrettet til at udøve et stigende tryk mod den skrå overflade til derved udadbøjning af koblingsfingrene (29) tæt på slutningen af et indsprøjtningsslag, hvor koblingsmekanismen yderligere omfatter et indvendigt bagenderør (20), der er anbragt omkring koblingsfingrene (29) inde i torsionsfjederen (14) og fastgjort til det udvendige bagenderør (13) i deres distale ender, idet det indvendige bagenderør (14) har et antal indre længdegående noter (31) til at gå i indgreb med de udadbøjede koblingsfingre (29) .
11. Autoinjektor (1) ifølge krav 10, der er kendetegnet ved, at de indre længdegående noter (31) er anbragt på en måde, så de danner en klinkehage, når de er i indgreb med koblingsfingrene (29) .
12. Autoinjektor (1) ifølge et af kravene 1 til 11, der er kendetegnet ved, at der er tilvejebragt en låsemekanisme til låsning af kanyleafskærmningen (3) i dens fremskudte position.
13. Autoinjektor (1) ifølge et af ovennævnte krav, der er kendetegnet ved, at der er tilvejebragt mindst ét vindue (6) i huset (2) til inspektion af sprøjten (7).
14. Autoinjektor (1) ifølge et af kravene 6 til 13, der er kendetegnet ved, at ledemøtrikken (15) er forsynet med mindst én stift eller med et kugleleje (17) til at gå i indgreb med det udvendige ledeskruegevind (16).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10153985 | 2010-02-18 | ||
| US41208010P | 2010-11-10 | 2010-11-10 | |
| PCT/EP2011/052297 WO2011101375A1 (en) | 2010-02-18 | 2011-02-16 | Auto-injector with a torsion spring |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2536451T3 true DK2536451T3 (da) | 2018-07-16 |
Family
ID=42306756
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11703888.5T DK2536451T3 (da) | 2010-02-18 | 2011-02-16 | Autoinjektor med en torsionsfjeder |
| DK18151365.6T DK3338833T3 (da) | 2010-02-18 | 2011-02-16 | Autoinjektor med en torsionsfjeder |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18151365.6T DK3338833T3 (da) | 2010-02-18 | 2011-02-16 | Autoinjektor med en torsionsfjeder |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9636467B2 (da) |
| EP (2) | EP2536451B1 (da) |
| JP (1) | JP5805111B2 (da) |
| CA (1) | CA2789590A1 (da) |
| DK (2) | DK2536451T3 (da) |
| WO (1) | WO2011101375A1 (da) |
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| AU2003209095A1 (en) | 2002-02-11 | 2003-09-04 | Antares Pharma, Inc. | Intradermal injector |
| DK1850892T4 (da) | 2005-01-24 | 2023-06-06 | Antares Pharma Inc | Forfyldt nål-assisteret sprøjtejetinjektor |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
| US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
| EP3581224A1 (en) | 2008-08-05 | 2019-12-18 | Antares Pharma, Inc. | Multiple dosage injector |
| US12097357B2 (en) | 2008-09-15 | 2024-09-24 | West Pharma. Services IL, Ltd. | Stabilized pen injector |
| EP2408493B1 (en) | 2009-03-20 | 2024-07-24 | Antares Pharma, Inc. | Hazardous agent injection system |
| CA2768000A1 (en) * | 2009-04-30 | 2010-11-04 | Sanofi-Aventis Deutschland Gmbh | Axially adjustable connection of piston rod to piston for drive mechanism of a drug delivery device |
| AR078457A1 (es) * | 2009-09-30 | 2011-11-09 | Sanofi Aventis Deutschland | Mecanismo accionador para un dispositivo de descarga de farmacos |
| WO2011101376A1 (en) * | 2010-02-18 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Clutch mechanism |
| DK2536452T3 (da) | 2010-02-18 | 2019-01-02 | Sanofi Aventis Deutschland | Autoinjektor |
| EP2399635A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| EP2468333A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| USRE48593E1 (en) | 2010-12-21 | 2021-06-15 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
| EP2468330A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| EP2489385A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| EP2489389A1 (en) * | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Detent mechanism |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| EP2606925A1 (en) * | 2011-12-21 | 2013-06-26 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
| EP2606924A1 (en) * | 2011-12-21 | 2013-06-26 | Sanofi-Aventis Deutschland GmbH | Autoinjector having a retracting syringe carrier |
| KR20150003179A (ko) | 2012-03-06 | 2015-01-08 | 안타레스 팔마, 인코퍼레이티드 | 분리력 특징을 가진 사전충전형 주사기 |
| US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
| WO2013169804A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
| US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
| CN103170038B (zh) * | 2013-02-22 | 2014-12-31 | 杭州金源生物技术有限公司 | 一种胰岛素注射笔 |
| EP3572108A1 (en) | 2013-03-11 | 2019-11-27 | Antares Pharma, Inc. | Dosage injector with pinion system |
| WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
| EP2823841A1 (en) | 2013-07-09 | 2015-01-14 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
| GB201313888D0 (en) | 2013-08-02 | 2013-09-18 | Consort Medical Plc | Assembly for an autoinjector device |
| AU354958S (en) * | 2013-09-20 | 2014-04-15 | Bayer Pharma AG | Electronic autoinjector |
| AU356724S (en) * | 2013-09-20 | 2014-08-01 | Bayer Pharma AG | Electronic autoinjector |
| USD729382S1 (en) * | 2013-09-30 | 2015-05-12 | Shl Group Ab | Trigger for a medical injector |
| TWI577410B (zh) | 2013-10-25 | 2017-04-11 | 卡貝歐洲有限公司 | 自動注射器的觸發機構 |
| EP2923714A1 (en) | 2014-03-28 | 2015-09-30 | Sanofi-Aventis Deutschland GmbH | Autoinjector triggered by skin contact |
| MX387194B (es) | 2014-06-03 | 2025-03-18 | Amgen Inc | Sistemas y metodos para procesar de manera remota datos recolectados por un dispositivo de suministro de farmaco. |
| GB201416985D0 (en) * | 2014-09-26 | 2014-11-12 | Ucb Biopharma Sprl And Bespak Europ Ltd | Housing part for an auto-injector |
| EP3689394A1 (en) | 2014-12-19 | 2020-08-05 | Amgen Inc. | Drug delivery device with live button or user interface field |
| US10799630B2 (en) * | 2014-12-19 | 2020-10-13 | Amgen Inc. | Drug delivery device with proximity sensor |
| US9415176B1 (en) | 2015-01-22 | 2016-08-16 | West Pharmaceutical Services, Inc. | Autoinjector having an end-of-dose visual indicator |
| KR102375765B1 (ko) * | 2015-04-24 | 2022-03-17 | 에스에이치엘 메디컬 아게 | 약물 전달 장치의 서브-조립체 및 약물 전달 장치 |
| TW201707738A (zh) | 2015-06-03 | 2017-03-01 | 賽諾菲阿凡提斯德意志有限公司 | 注射器支架及自動注射器（二） |
| JP6856840B2 (ja) | 2016-12-27 | 2021-04-14 | アクション メディカル テクノロジーズ，エルエルシーＡｃｔｉｏｎ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ，Ｌｌｃ | 注入器、および注入器を動作させる方法 |
| CN114191657B (zh) * | 2017-03-15 | 2023-07-14 | 欧文蒙福德有限公司 | 注入设备 |
| EP3651832B1 (en) | 2017-07-14 | 2023-12-13 | Amgen Inc. | Needle insertion-retraction system having dual torsion spring system |
| WO2019097076A1 (en) * | 2017-11-20 | 2019-05-23 | Novo Nordisk A/S | Power unit for drug delivery device |
| US10357619B1 (en) | 2018-02-08 | 2019-07-23 | Chalbourne Brasington | Auto-injection device |
| CN108744075B (zh) * | 2018-04-13 | 2020-10-30 | 中国人民解放军陆军军医大学第一附属医院 | 一种注射器引流用固定装置 |
| US11224696B2 (en) | 2018-07-10 | 2022-01-18 | Action Medical Technologies, Llc | Apparatuses and method for injecting medicaments |
| USD893712S1 (en) | 2019-02-15 | 2020-08-18 | Action Medical Technologies, Llc | Grip for autoinjectors |
| GB2592059A (en) * | 2020-02-14 | 2021-08-18 | Consort Medical Ltd | Improved injection device |
| WO2021195310A1 (en) | 2020-03-25 | 2021-09-30 | Action Medical Technolgies, Llc | Apparatuses and methods for injecting medicaments |
| US11759576B2 (en) | 2020-06-05 | 2023-09-19 | Action Medical Technologies, Llc | Parenteral injection apparatus |
| WO2022066863A1 (en) * | 2020-09-25 | 2022-03-31 | Becton, Dickinson And Company | Brake tower with biasing components and medical injection device including the same |
| CN115970096B (zh) * | 2022-12-23 | 2025-04-25 | 中国人民解放军西部战区总医院 | 一种护理用注射用保护装置 |
| WO2025132563A1 (en) * | 2023-12-21 | 2025-06-26 | Sanofi | Injector device |
| WO2025132624A1 (en) * | 2023-12-21 | 2025-06-26 | Sanofi | A medicament delivery device |
| WO2025207905A1 (en) * | 2024-03-28 | 2025-10-02 | Genzyme Corporation | Needle shroud latch for injection devices |
| US12274871B1 (en) | 2024-03-28 | 2025-04-15 | Genzyme Corporation | Hold detent mechanism for injection devices |
| US12274866B1 (en) | 2024-03-28 | 2025-04-15 | Genzyme Corporation | Rotatable collar for injection devices |
| US12274875B1 (en) * | 2024-03-28 | 2025-04-15 | Genzyme Corporation | Needle shroud latch for injection devices |
| US12274872B1 (en) | 2024-03-28 | 2025-04-15 | Genzyme Corporation | Collar hold detent mechanism and lock for injection devices |
| US12427266B1 (en) | 2024-03-28 | 2025-09-30 | Genzyme Corporation | Needle shroud latch for injection devices |
| CN119112259B (zh) * | 2024-11-11 | 2025-04-01 | 上海畅德医疗科技有限公司 | 医用胶输送装置及其控制手柄 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001281753A1 (en) | 2000-08-29 | 2002-03-13 | Novo-Nordisk A/S | Automatic injection device with torsion function for retraction of needle |
| US20030105430A1 (en) * | 2001-11-30 | 2003-06-05 | Elan Pharma International Limited Wil House | Automatic injector |
| JP2006507061A (ja) | 2002-11-25 | 2006-03-02 | テクファーマ・ライセンシング・アクチェンゲゼルシャフト | リセット可能な解放安全装置を有する自動注射装置 |
| US7449012B2 (en) | 2004-08-06 | 2008-11-11 | Meridian Medical Technologies, Inc. | Automatic injector |
| DK2364742T4 (da) * | 2005-06-01 | 2025-08-18 | Shl Medical Ag | Anordning til afgivelse af lægemiddel |
| DE202005021773U1 (de) | 2005-06-01 | 2010-01-07 | Shl Group Ab | Medikamentenabgabevorrichtung |
| DE102005025424A1 (de) * | 2005-06-02 | 2006-12-07 | Tecpharma Licensing Ag | Injektionsvorrichtung mit einem Drehfederantrieb |
| WO2009007305A1 (en) | 2007-07-06 | 2009-01-15 | Novo Nordisk A/S | Automatic injection device |
| US8038649B2 (en) * | 2007-09-18 | 2011-10-18 | Shl Group Ab | Automatic injection device with needle insertion |
| GB0724944D0 (en) | 2007-12-20 | 2008-01-30 | Ucb Pharma Sa | Auto injector |
| GB0802351D0 (en) | 2008-02-08 | 2008-03-12 | Owen Mumford Ltd | Injection devices |
| GB2460398A (en) | 2008-05-20 | 2009-12-02 | Owen Mumford Ltd | Auto-injector having a magnetic injection indicator and a needle sheath retainer |
| GB2461088B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
| US8808250B2 (en) | 2010-02-18 | 2014-08-19 | Sanofi-Aventis Deutschland Gmbh | Auto-injector with a torsion spring |
-
2011
- 2011-02-16 EP EP11703888.5A patent/EP2536451B1/en active Active
- 2011-02-16 US US13/579,455 patent/US9636467B2/en active Active
- 2011-02-16 JP JP2012553299A patent/JP5805111B2/ja active Active
- 2011-02-16 EP EP18151365.6A patent/EP3338833B1/en active Active
- 2011-02-16 CA CA 2789590 patent/CA2789590A1/en not_active Abandoned
- 2011-02-16 WO PCT/EP2011/052297 patent/WO2011101375A1/en not_active Ceased
- 2011-02-16 DK DK11703888.5T patent/DK2536451T3/da active
- 2011-02-16 DK DK18151365.6T patent/DK3338833T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK3338833T3 (da) | 2020-10-19 |
| EP2536451B1 (en) | 2018-03-28 |
| CA2789590A1 (en) | 2011-08-25 |
| EP3338833A1 (en) | 2018-06-27 |
| EP3338833B1 (en) | 2020-07-29 |
| EP2536451A1 (en) | 2012-12-26 |
| US20130123710A1 (en) | 2013-05-16 |
| WO2011101375A1 (en) | 2011-08-25 |
| US9636467B2 (en) | 2017-05-02 |
| JP5805111B2 (ja) | 2015-11-04 |
| JP2013519471A (ja) | 2013-05-30 |
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