DK2405893T3 - Præparat på oliebasis indeholdende anti-protozoiske triaziner og anthelmintiske cyclodepsipeptider - Google Patents
Præparat på oliebasis indeholdende anti-protozoiske triaziner og anthelmintiske cyclodepsipeptider Download PDFInfo
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- DK2405893T3 DK2405893T3 DK10707228.2T DK10707228T DK2405893T3 DK 2405893 T3 DK2405893 T3 DK 2405893T3 DK 10707228 T DK10707228 T DK 10707228T DK 2405893 T3 DK2405893 T3 DK 2405893T3
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- toltrazuril
- emodepside
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Paints Or Removers (AREA)
Claims (12)
1. Midler indeholdende triazin, som er virksom mod parasitiske protozoer, med en kornstørrelse d(90) < 15 ym og et anthelmintisk cyclodepsipeptid i en oliebasis.
2. Middel ifølge krav 1, hvori triazinen er en forbindelse med formlerne (I) eller (II)
(D eller
(Π), hvor R1 står for R3-SC>2- eller R3-S-, R2 står for alkyl, alkoxy, halogen eller SC>2N(CH3)2, og R3 står for halogenalkyl, R4 og R5 uafhængigt af hinanden står for hydrogen eller Cl, og R6 står for fluor eller chlor samt deres fysiologisk forligelige salte.
3. Middel ifølge et af de foregående krav, hvori triazinen er toltrazuril, ponazuril eller diclazuril.
4. Middel ifølge et af de foregående krav, hvori det cykliske depsipeptid er et 24-leddet octacyclodepsipeptid.
5. Middel ifølge krav 4, hvori det cykliske depsipeptid er emodepsid.
6. Middel ifølge krav 4, hvori det cykliske depsipeptid er PF 1022.
7. Middel ifølge et af de foregående krav indeholdende et fortykningsmiddel, navnlig en glycerolester.
8. Middel ifølge krav 7 indeholdende en glyceroldiester med C12-C24-fedtsyrer som fortykningsmiddel.
9. Middel ifølge krav 8 indeholdende glyceroldibehenat som fortykningsmiddel.
10. Middel ifølge krav 9 indeholdende: 2-4 vægt-% toltrazuril 0,1 - 0,2 vægt-% emodepsid 2-5 vægt-% glyceryldibehenat 0,05 - 0,5 vægt-% butylhydroxytoluen 0,02 - 0,1 vægt-% sorbinsyre ad 100 vægt-% solsikkeolie
11. Anvendelse af midler ifølge et af de foregående krav til fremstilling af lægemidler til bekæmpelse af parasitære protozoer og endoparasitter hos mennesker og dyr.
12. Middel ifølge et af de foregående krav til bekæmpelse af parasitære protozoer og endoparasitter hos dyr.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009012423A DE102009012423A1 (de) | 2009-03-10 | 2009-03-10 | Zubereitung auf Ölbasis |
| PCT/EP2010/001396 WO2010102762A1 (de) | 2009-03-10 | 2010-03-05 | Zubereitung auf ölbasis enthaltend anti-protozoische triazine und anthelmintische cyclodepsipeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2405893T3 true DK2405893T3 (da) | 2015-07-27 |
Family
ID=42105958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10707228.2T DK2405893T3 (da) | 2009-03-10 | 2010-03-05 | Præparat på oliebasis indeholdende anti-protozoiske triaziner og anthelmintiske cyclodepsipeptider |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20120141546A1 (da) |
| EP (1) | EP2405893B1 (da) |
| JP (2) | JP5845092B2 (da) |
| KR (1) | KR101779618B1 (da) |
| CN (2) | CN102348454A (da) |
| AR (1) | AR075629A1 (da) |
| AU (1) | AU2010223539B2 (da) |
| BR (1) | BRPI1009434A2 (da) |
| CA (1) | CA2754623C (da) |
| DE (1) | DE102009012423A1 (da) |
| DK (1) | DK2405893T3 (da) |
| ES (1) | ES2542552T3 (da) |
| HR (1) | HRP20150780T1 (da) |
| MX (1) | MX2011009113A (da) |
| NZ (1) | NZ595050A (da) |
| PL (1) | PL2405893T3 (da) |
| PT (1) | PT2405893E (da) |
| SI (1) | SI2405893T1 (da) |
| TW (1) | TW201043234A (da) |
| WO (1) | WO2010102762A1 (da) |
| ZA (1) | ZA201106349B (da) |
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| MX368209B (es) | 2011-12-21 | 2019-09-24 | Bayer Pharma Ag Star | Preparaciones que comprenden emodepsido amorfo. |
| CN110292561A (zh) * | 2019-07-12 | 2019-10-01 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一种具有抗球虫作用的口服药物溶液配方及制备 |
| EP3888684A1 (en) | 2020-03-31 | 2021-10-06 | Bayer Animal Health GmbH | Composition having improved voluntary acceptance |
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| DE2413722C3 (de) * | 1974-03-21 | 1982-04-08 | Bayer Ag, 5090 Leverkusen | Neue 1-(4-Phenoxy-phenyl)-1,3,5-triazin-Derivate, ein Verfahren zu ihrer Herstellung sowie ihre Anwendung als Arzneimittel |
| DE2718799A1 (de) | 1977-04-27 | 1978-11-09 | Bayer Ag | 1-(4-phenoxy-phenyl)-1,3,5-triazin- derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel und wachstumsfoerderer |
| DE3300793A1 (de) | 1983-01-12 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Coccidiosemittel |
| NO176766C (no) * | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
| JPH0570366A (ja) * | 1991-03-08 | 1993-03-23 | Meiji Seika Kaisha Ltd | 薬用組成物 |
| WO1993019053A1 (en) | 1992-03-17 | 1993-09-30 | Fujisawa Pharmaceutical Co., Ltd. | Depsipeptide derivative, production thereof and use thereof |
| DE4317458A1 (de) | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
| AU695021B2 (en) | 1993-02-19 | 1998-08-06 | Meiji Seika Kaisha Ltd. | PF1022 derivative cyclic depsipeptide |
| DE4317457A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| DE4317432A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| BR9407711A (pt) | 1993-09-06 | 1997-02-12 | Fujisawa Pharmaceutical Co | Composto de ciclopeptídeo processo para preparaçao de um composto de ciclopeptídeo e parasiticida |
| DE4342907A1 (de) | 1993-12-16 | 1995-06-22 | Bayer Ag | Neue cyclische Depsipeptide mit 18 Ringatomen und ihre Verwendung zur Bekämpfung von Endoparasiten |
| DE4400464A1 (de) | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| DE4401389A1 (de) | 1994-01-19 | 1995-07-20 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung |
| DE4406025A1 (de) | 1994-02-24 | 1995-08-31 | Bayer Ag | Milchsäure-haltige cyclische Depsipeptide mit 18 Ringatomen als endoparasitizide Mittel und Verfahren zu ihrer Herstellung |
| DE4412492A1 (de) | 1994-04-12 | 1995-10-19 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen |
| DE4437198A1 (de) | 1994-10-18 | 1996-04-25 | Bayer Ag | Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden |
| US5856436A (en) | 1995-06-30 | 1999-01-05 | Fujisawa Pharmaceutical Co., Ltd. | Depsipeptide derivative, process for production thereof, and novel intermediate therefor |
| HU228004B1 (en) | 1995-09-22 | 2012-08-28 | Bayer Animal Health Gmbh | Cyclic depsipeptide pf1022 derivatives |
| DE19545044A1 (de) * | 1995-12-02 | 1997-06-05 | Bayer Ag | Endoparasitizide Mittel |
| DE19545639A1 (de) | 1995-12-07 | 1997-06-12 | Bayer Ag | Verfahren zur Herstellung von substituierten Arylmilchsäure-haltigen Cyclodepsipeptiden mit 24 Ringatomen |
| WO1998037088A1 (en) | 1997-02-19 | 1998-08-27 | Meiji Seika Kaisha Ltd. | Derivatives of cyclodepsipeptide, pf1022 substance |
| DE19713626A1 (de) | 1997-04-02 | 1998-10-08 | Bayer Ag | Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung |
| BR9810412A (pt) | 1997-06-04 | 2000-08-22 | Bayer Ag | Desoxiciclodepsipeptìdios e seu emprego para o combate de endoparasitas |
| DE19811559A1 (de) | 1998-03-17 | 1999-09-23 | Bayer Ag | Cyclooctadepsipeptide |
| DE19824483A1 (de) | 1998-06-02 | 1999-12-09 | Bayer Ag | Halbfeste wäßrige Zubereitungen für orale Applikation von Toltrazuril-Sulfon |
| DE19828047A1 (de) | 1998-06-24 | 1999-12-30 | Bayer Ag | Substituierte Cyclooctadepsipeptide |
| DE19840320A1 (de) | 1998-09-04 | 2000-03-09 | Bayer Ag | Aza-Cyclodepsipeptide |
| US6150361A (en) * | 1998-12-22 | 2000-11-21 | Bayer Corporation | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
| US6194408B1 (en) | 1998-12-22 | 2001-02-27 | Bayer Corporation | Triazineone compounds for treating diseases due to Sarcocystis, Neospora and Toxoplasma |
| KR20010080571A (ko) * | 1998-12-22 | 2001-08-22 | 조지 제이. 리코스 | 사르코시스티스, 네오스포라 및 톡소플라즈마에 의한 질병치료용 트리아진온 화합물 |
| DE19958388A1 (de) | 1999-12-03 | 2001-06-07 | Bayer Ag | Triazinonverbindungen zur Behandlung von durch den Befall mit parasitischen Protozoen bedingten Krankheiten |
| DE19962147A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Ag | Schädlingsbekämpfungsmittel / PF 1022-221 |
| DE10008128A1 (de) | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
| DE10031044A1 (de) * | 2000-06-26 | 2002-01-03 | Bayer Ag | Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere |
| DE10040174A1 (de) * | 2000-08-17 | 2002-02-28 | Bayer Ag | Verwendung von Triazintrion-Sulfonen zur Bekämpfung von Coccidiosen |
| DE10358525A1 (de) | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
| DE10359798A1 (de) * | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Cyclohexadepsipeptide zur Bekämpfung von Endoparasiten und ein Verfahren zu ihrer Herstellung |
| DE102004001558A1 (de) * | 2004-01-10 | 2005-08-18 | Bayer Healthcare Ag | Arzneimittel zur topischen Applikation bei Tieren |
| DE102005000746A1 (de) * | 2005-01-05 | 2006-07-13 | Bayer Healthcare Ag | Bekämpfung der Histomoniasis |
| DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
| DE102006038292A1 (de) * | 2006-08-16 | 2008-02-21 | Bayer Healthcare Ag | Transdermale Anwendung von Triazinen zur Bekämpfung von Coccidien-Infektionen |
| CA2661099C (en) * | 2006-08-30 | 2012-01-24 | Intervet International B.V. | Pharmaceutical compositions comprising cefquinome |
| PT2155699E (pt) * | 2007-05-15 | 2015-11-12 | Merial Inc | Compostos de ariloazol-2-il-cianoetilamino, método de fabrico e método de utilização |
| DE102007025908A1 (de) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulierungen enthaltend Triazinone und Eisen |
| DE102007026550A1 (de) * | 2007-06-08 | 2008-12-11 | Bayer Healthcare Ag | Extrudate mit verbesserter Geschmacksmaskierung |
-
2009
- 2009-03-10 DE DE102009012423A patent/DE102009012423A1/de not_active Withdrawn
-
2010
- 2010-02-26 AR ARP100100577A patent/AR075629A1/es unknown
- 2010-03-05 PL PL10707228T patent/PL2405893T3/pl unknown
- 2010-03-05 PT PT107072282T patent/PT2405893E/pt unknown
- 2010-03-05 BR BRPI1009434A patent/BRPI1009434A2/pt not_active Application Discontinuation
- 2010-03-05 EP EP10707228.2A patent/EP2405893B1/de active Active
- 2010-03-05 DK DK10707228.2T patent/DK2405893T3/da active
- 2010-03-05 KR KR1020117022850A patent/KR101779618B1/ko not_active Expired - Fee Related
- 2010-03-05 ES ES10707228.2T patent/ES2542552T3/es active Active
- 2010-03-05 CN CN2010800109593A patent/CN102348454A/zh active Pending
- 2010-03-05 WO PCT/EP2010/001396 patent/WO2010102762A1/de not_active Ceased
- 2010-03-05 MX MX2011009113A patent/MX2011009113A/es active IP Right Grant
- 2010-03-05 HR HRP20150780TT patent/HRP20150780T1/hr unknown
- 2010-03-05 AU AU2010223539A patent/AU2010223539B2/en active Active
- 2010-03-05 JP JP2011553335A patent/JP5845092B2/ja active Active
- 2010-03-05 CN CN201610193938.9A patent/CN105749248A/zh active Pending
- 2010-03-05 NZ NZ595050A patent/NZ595050A/xx unknown
- 2010-03-05 CA CA2754623A patent/CA2754623C/en not_active Expired - Fee Related
- 2010-03-05 SI SI201030980T patent/SI2405893T1/sl unknown
- 2010-03-05 US US13/202,739 patent/US20120141546A1/en not_active Abandoned
- 2010-03-09 TW TW099106692A patent/TW201043234A/zh unknown
-
2011
- 2011-08-30 ZA ZA2011/06349A patent/ZA201106349B/en unknown
-
2015
- 2015-07-09 JP JP2015137577A patent/JP2015212296A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015212296A (ja) | 2015-11-26 |
| ZA201106349B (en) | 2012-11-28 |
| TW201043234A (en) | 2010-12-16 |
| JP5845092B2 (ja) | 2016-01-20 |
| PL2405893T3 (pl) | 2015-10-30 |
| CN105749248A (zh) | 2016-07-13 |
| NZ595050A (en) | 2013-11-29 |
| CA2754623A1 (en) | 2010-09-16 |
| AU2010223539A1 (en) | 2011-09-22 |
| DE102009012423A1 (de) | 2010-09-16 |
| EP2405893B1 (de) | 2015-04-22 |
| PT2405893E (pt) | 2015-09-01 |
| CN102348454A (zh) | 2012-02-08 |
| SI2405893T1 (sl) | 2015-08-31 |
| US20120141546A1 (en) | 2012-06-07 |
| CA2754623C (en) | 2017-04-18 |
| KR101779618B1 (ko) | 2017-09-18 |
| HRP20150780T1 (hr) | 2015-08-28 |
| BRPI1009434A2 (pt) | 2016-03-01 |
| AR075629A1 (es) | 2011-04-20 |
| WO2010102762A1 (de) | 2010-09-16 |
| ES2542552T3 (es) | 2015-08-06 |
| EP2405893A1 (de) | 2012-01-18 |
| AU2010223539B2 (en) | 2015-06-11 |
| MX2011009113A (es) | 2011-09-26 |
| JP2012520244A (ja) | 2012-09-06 |
| KR20110126731A (ko) | 2011-11-23 |
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