DK2475368T3 - N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamin til anvendelse til behandling af cancer, som er resistent over for antimitotika - Google Patents
N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamin til anvendelse til behandling af cancer, som er resistent over for antimitotika Download PDFInfo
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- DK2475368T3 DK2475368T3 DK10755044T DK10755044T DK2475368T3 DK 2475368 T3 DK2475368 T3 DK 2475368T3 DK 10755044 T DK10755044 T DK 10755044T DK 10755044 T DK10755044 T DK 10755044T DK 2475368 T3 DK2475368 T3 DK 2475368T3
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Forbindelsen N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamin eller et farmaceutisk acceptabelt salt deraf til anvendelse til behandling af cancer hos et individ, hvor individets cancer er refraktær over for behandling med et anticancermiddel.
2. Forbindelse til anvendelse ifølge krav 1, hvor anticancermidlet er et kemo-terapeutikum.
3. Forbindelse til anvendelse ifølge krav 2, hvor kemoterapeutikummet er et middel valgt fra gruppen bestående af et antimitotikum og et anthracyclin.
4. Forbindelse til anvendelse ifølge krav 2, hvor kemoterapeutikummet er et middel valgt fra gruppen bestående af taxol, docetaxel, vineristin, vinblastin, vindesin og vinorelbin, daunorubicin, doxorubicin, idarubicin, epirubicin og mitoxantron.
5. Forbindelse til anvendelse ifølge krav 1, hvor anticancermidlet er AZD1152, PHA-739358, MK-0457 eller en kombination deraf.
6. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-5, hvor canceren er en eller flere af (a) en solid eller hæmatologisk afledt tumor valgt blandt blære-, bryst-, colon-, nyre-, lever-, lunge-, småcellet lunge-, øsofagus-, galdeblære-, ovarie-, pancreas-, mave-, cervix-, thyreoidea-, prostata- og hudcancer, (b) en hæmatopoietisk tumor af lymfoid oprindelse valgt blandt leukæmi, akut lymfatisk leukæmi, akut lymfoblastisk leukæmi, B-cellelymfom, T-cellelymfom, Flodgkins lymfom, non-Flodgkins lymfom, hårcellelymfom og Burkitts lymfom, (c) en hæmatopoietisk tumor af myeloid oprindelse valgt blandt akutte og kroniske myeloide leukæmier, myelodysplastisk syndrom og promyeloid leukæmi, (d) en tumor af mesenkymal oprindelse valgt blandt fibrosarkom og rhabdomyosarkom, (e) en tumor i centralnervesystemet og det perifere nervesystem valgt blandt astrocytom, neuroblastom, gliom og schwannom eller (f) et melanom, seminom, teratokarcinom, osteosarkom, xeroderma pigmentosum, keratoctanthom, follikulær thyreoideacancer eller Kaposis sarkom.
7. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-5, hvor canceren er en eller flere af en solid tumor valgt blandt blære-, bryst-, colon-, nyre-, lever-, lunge-, ikke-småcellet lunge-, hoved- og hals-, øsofagus-, ventrikel-, ovarie-, pancreas-, mave-, cervix-, thyreoidea- og prostatacancer eller et lymfom eller leukæmi.
8. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-5, hvor canceren er prostatacancer, ovariecancer, brystcancer, kolangiokarcinom, akut myeloid leukæmi, kronisk myeloid leukæmi eller en kombination deraf.
9. Anvendelse af forbindelsen N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1 -phthalazinamin eller et farmaceutisk acceptabelt salt deraf til fremstilling af et lægemiddel til behandling af cancer, som er refraktær over for behandling med et anticancermiddel.
10. Anvendelse af forbindelsen ifølge krav 9 til fremstilling af et lægemiddel til behandling af cancer valgt blandt blærecancer, brystcancer, coloncancer, nyrecancer, levercancer, lungecancer, ikke-småcellet lungecancer, hoved- og halscancer, øsofaguscancer, ventrikelcancer, ovariecancer, pancreascancer, mavecancer, cervixcancer, thyreoideacancer, prostatacancer, lymfom, leukæmi, myelomatose og en kombination deraf, hvor canceren er refraktær over for behandling med et anticancermiddel.
11. Anvendelse af forbindelsen ifølge krav 9 til reduktion af størrelsen af en solid tumor hos et individ, hvor individets tumor forinden var blevet behandlet med et kemoterapeutikum valgt fra gruppen bestående af paclitaxel, docetaxel, doxorubicin og et vincaalkaloid.
12. Anvendelse af forbindelsen ifølge krav 9, hvor anticancermidlet er et kemoterapeutikum valgt fra gruppen bestående af et antimitotikum og et anthracyclin.
13. Anvendelse af forbindelsen ifølge krav 9, hvor anticancermidlet er et kemoterapeutikum valgt fra gruppen bestående af taxol, docetaxel, vineristin, vinblastin, vindesin og vinorelbin, daunorubicin, doxorubicin, idarubicin, epirubicin og mitoxantron.
14. Anvendelse af forbindelsen ifølge krav 9, hvor anticancermidlet er AZDI 152, PHA-739358, MK-0457 eller en kombination deraf.
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| US24152709P | 2009-09-11 | 2009-09-11 | |
| PCT/US2010/048247 WO2011031842A1 (en) | 2009-09-11 | 2010-09-09 | N-4 ( - ( ( 3- ( 2 -amino-4 pyrimidinyl) -2 -pyridinyl) oxy) phenyl) -4- (4-methyl-2-thienyl) -1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer |
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| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| KR101701235B1 (ko) | 2013-09-30 | 2017-02-03 | 한국원자력의학원 | Ｈｒｐ-3 억제제를 포함하는 방사선 또는 약물내성 암의 치료용 약학 조성물 |
| MX378969B (es) | 2013-11-11 | 2025-03-11 | Amgen Inc | Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres. |
| JP6634016B2 (ja) * | 2013-12-03 | 2020-01-22 | アムジエン・インコーポレーテツド | Ｎ−（４−（（３−（２−アミノ−４−ピリミジニル）−２−ピリジニル）オキシ）フェニル）−４−（４−メチル−２−チエニル）−１−フタラジンアミンの薬学的に許容される塩の結晶形態及びその使用 |
| CA2940237C (en) * | 2014-02-21 | 2023-03-07 | Frost Biologic, Inc. | Antimitotic amides for the treatment of cancer and proliferative disorders |
| EP3443351A4 (en) * | 2016-04-15 | 2019-12-18 | Felicitex Therapeutics, Inc. | COMBINATIONS FOR THE TREATMENT OF NEOPLASIA BY TARGETING RESTING CELLS AND INHIBITORS OF MITOSIS |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| EP3679040B1 (en) | 2017-09-08 | 2022-08-03 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| AU2019262589B2 (en) | 2018-05-04 | 2022-07-07 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| CA3100390A1 (en) | 2018-06-12 | 2020-03-12 | Amgen Inc. | Kras g12c inhibitors encompassing piperazine ring and use thereof in the treatment of cancer |
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| CN101405282B (zh) * | 2006-01-23 | 2015-03-25 | 安姆根有限公司 | 极光激酶调节剂和使用方法 |
| MY161884A (en) | 2006-01-23 | 2017-05-15 | Amgen Inc | Aurora kinase modulators and method of use |
| GB0609621D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Novel co-crystal |
| GB0609619D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Combination |
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