DK2350026T3 - Sulfoximinsubstituerede anilinopyrimidinderativer som cdk-inhibitorer, fremstilling og anvendelse heraf som lægemiddel - Google Patents

Sulfoximinsubstituerede anilinopyrimidinderativer som cdk-inhibitorer, fremstilling og anvendelse heraf som lægemiddel

Info

Publication number: DK2350026T3
Authority: DK; Denmark
Prior art keywords: anilinopyrimide; sulfoximin; ingredients; medicine; substituted
Prior art date: 2008-10-21

Application number

DK09778874.9T

Other languages

English (en)

Inventor

Gerhard Siemeister

Julia Schulze

Philip Lienau

Ulrich Lücking

Rolf Jautelat

Original Assignee

Bayer Ip Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-21

Filing date

2009-10-09

Publication date

2014-09-15

2009-10-09 Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh

2014-09-15 Application granted granted Critical

2014-09-15 Publication of DK2350026T3 publication Critical patent/DK2350026T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK09778874.9T 2008-10-21 2009-10-09 Sulfoximinsubstituerede anilinopyrimidinderativer som cdk-inhibitorer, fremstilling og anvendelse heraf som lægemiddel DK2350026T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08167113A EP2179991A1 (de)	2008-10-21	2008-10-21	Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
PCT/EP2009/007247 WO2010046035A1 (de)	2008-10-21	2009-10-09	Sulfoximinsubstituierte anilinopyrimidinderative als cdk-inhibitoren, deren herstellung und verwendung als arzeinmittel

Publications (1)

Publication Number	Publication Date
DK2350026T3 true DK2350026T3 (da)	2014-09-15

Family

ID=40282208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09778874.9T DK2350026T3 (da)	2008-10-21	2009-10-09	Sulfoximinsubstituerede anilinopyrimidinderativer som cdk-inhibitorer, fremstilling og anvendelse heraf som lægemiddel

Country Status (38)

Country	Link
US (1)	US8735412B2 (da)
EP (2)	EP2179991A1 (da)
JP (1)	JP5564054B2 (da)
KR (1)	KR20110069115A (da)
CN (1)	CN102197029B (da)
AR (1)	AR074053A1 (da)
AU (1)	AU2009306733C1 (da)
BR (1)	BRPI0920112A2 (da)
CA (1)	CA2739739C (da)
CO (1)	CO6361926A2 (da)
CR (1)	CR20110210A (da)
CU (1)	CU24052B1 (da)
CY (1)	CY1115590T1 (da)
DK (1)	DK2350026T3 (da)
DO (1)	DOP2011000107A (da)
EA (1)	EA019230B1 (da)
EC (1)	ECSP11010992A (da)
ES (1)	ES2499028T3 (da)
HN (1)	HN2011001019A (da)
HR (1)	HRP20140830T1 (da)
IL (1)	IL211713A (da)
MA (1)	MA32723B1 (da)
MX (1)	MX2011004238A (da)
MY (1)	MY155230A (da)
NZ (1)	NZ592314A (da)
PA (1)	PA8846201A1 (da)
PE (1)	PE20110546A1 (da)
PL (1)	PL2350026T3 (da)
PT (1)	PT2350026E (da)
RS (1)	RS53523B1 (da)
SA (1)	SA109300632B1 (da)
SI (1)	SI2350026T1 (da)
TN (1)	TN2011000199A1 (da)
TW (2)	TWI458716B (da)
UA (1)	UA103500C2 (da)
UY (1)	UY32190A (da)
WO (1)	WO2010046035A1 (da)
ZA (1)	ZA201103727B (da)

Families Citing this family (13)

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Publication number	Priority date	Publication date	Assignee	Title
WO2011018517A1 (en)	2009-08-14	2011-02-17	Boehringer Ingelheim International Gmbh	Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en)	2009-08-14	2015-01-13	Boehringer Ingelheim International Gmbh	Selective synthesis of functionalized pyrimidines
DE102010014427A1 (de)	2010-04-01	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010014426A1 (de) *	2010-04-01	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010046720A1 (de)	2010-09-23	2012-03-29	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung
TWI555737B (zh)	2011-05-24	2016-11-01	拜耳知識產權公司	含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
DE102011080991A1 (de) *	2011-08-16	2013-02-21	Bayer Pharma AG	Verwendung von CCNE2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren
DE102011080992A1 (de) *	2011-08-16	2013-02-21	Bayer Pharma AG	Verwendung von MAD2L2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren
EP2755948B1 (en)	2011-09-16	2016-05-25	Bayer Intellectual Property GmbH	Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group
KR20140135215A (ko) *	2012-03-21	2014-11-25	바이엘 인텔렉쳐 프로퍼티 게엠베하	특정한 종양의 치료를 위한 (rs)-s-시클로프로필-s-(4-｛[4-｛[(1r, 2r)-2-히드록시-1-메틸프로필]옥시｝-5-(트리플루오로메틸)피리미딘-2-일]아미노｝페닐)술폭시미드의 용도
CA2964696C (en) *	2014-10-16	2022-09-06	Bayer Pharma Aktiengesellschaft	Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
PT3849537T (pt)	2018-09-10	2025-01-22	Mirati Therapeutics Inc	Terapêuticas de combinação
WO2021138391A1 (en)	2019-12-30	2021-07-08	Tyra Biosciences, Inc.	Indazole compounds

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Publication number	Priority date	Publication date	Assignee	Title
DE4029650A1 (de)	1990-09-19	1992-03-26	Hoechst Ag	2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
ES2253821T3 (es)	1997-07-12	2006-06-01	Cancer Research Technology Limited	Derivados de purina inhibidores de quinasa que depende de ciclina.
US6440965B1 (en)	1997-10-15	2002-08-27	Krenitsky Pharmaceuticals, Inc.	Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
ES2270612T3 (es)	1998-08-29	2007-04-01	Astrazeneca Ab	Compuestos de pirimidina.
GB9828511D0 (en)	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
IL159120A0 (en)	2001-05-29	2004-05-12	Schering Ag	Cdk inhibiting pyrimidines, production thereof and their use as medicaments
EP1483260A1 (de) *	2002-03-11	2004-12-08	Schering Aktiengesellschaft	Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel
WO2004048343A1 (en)	2002-11-28	2004-06-10	Schering Aktiengesellschaft	Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
DE10349423A1 (de)	2003-10-16	2005-06-16	Schering Ag	Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
JP2008514571A (ja) *	2004-09-29	2008-05-08	バイエル・シエーリング・ファーマアクチエンゲゼルシャフト	細胞周期−キナーゼまたはレセプター−チロシン−キナーゼインヒビターとしての置換２−置換アニリノピリミジン類、それらの製造および薬剤としての使用
DE102005062742A1 (de)	2005-12-22	2007-06-28	Bayer Schering Pharma Ag	Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
DE102006027156A1 (de) *	2006-06-08	2007-12-13	Bayer Schering Pharma Ag	Sulfimide als Proteinkinaseinhibitoren
EP2179992A1 (de) *	2008-10-21	2010-04-28	Bayer Schering Pharma Aktiengesellschaft	Sulfonsubstituierte Anlinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel

2008
- 2008-10-21 EP EP08167113A patent/EP2179991A1/de not_active Withdrawn
2009
- 2009-10-09 HR HRP20140830AT patent/HRP20140830T1/hr unknown
- 2009-10-09 RS RSP20140466 patent/RS53523B1/sr unknown
- 2009-10-09 US US13/125,066 patent/US8735412B2/en not_active Expired - Fee Related
- 2009-10-09 UA UAA201106183A patent/UA103500C2/uk unknown
- 2009-10-09 NZ NZ592314A patent/NZ592314A/xx not_active IP Right Cessation
- 2009-10-09 AU AU2009306733A patent/AU2009306733C1/en not_active Ceased
- 2009-10-09 CA CA2739739A patent/CA2739739C/en not_active Expired - Fee Related
- 2009-10-09 DK DK09778874.9T patent/DK2350026T3/da active
- 2009-10-09 PL PL09778874T patent/PL2350026T3/pl unknown
- 2009-10-09 BR BRPI0920112A patent/BRPI0920112A2/pt not_active IP Right Cessation
- 2009-10-09 MX MX2011004238A patent/MX2011004238A/es active IP Right Grant
- 2009-10-09 EP EP09778874.9A patent/EP2350026B1/de active Active
- 2009-10-09 EA EA201100623A patent/EA019230B1/ru not_active IP Right Cessation
- 2009-10-09 ES ES09778874.9T patent/ES2499028T3/es active Active
- 2009-10-09 KR KR1020117009024A patent/KR20110069115A/ko not_active Abandoned
- 2009-10-09 JP JP2011532519A patent/JP5564054B2/ja not_active Expired - Fee Related
- 2009-10-09 CN CN200980141978.7A patent/CN102197029B/zh not_active Expired - Fee Related
- 2009-10-09 SI SI200931004T patent/SI2350026T1/sl unknown
- 2009-10-09 WO PCT/EP2009/007247 patent/WO2010046035A1/de not_active Ceased
- 2009-10-09 MY MYPI2011001632A patent/MY155230A/en unknown
- 2009-10-09 PE PE2011000917A patent/PE20110546A1/es not_active Application Discontinuation
- 2009-10-09 PT PT97788749T patent/PT2350026E/pt unknown
- 2009-10-19 PA PA20098846201A patent/PA8846201A1/es unknown
- 2009-10-20 SA SA109300632A patent/SA109300632B1/ar unknown
- 2009-10-20 UY UY0001032190A patent/UY32190A/es not_active Application Discontinuation
- 2009-10-21 TW TW098135674A patent/TWI458716B/zh not_active IP Right Cessation
- 2009-10-21 TW TW103126302A patent/TWI496774B/zh not_active IP Right Cessation
- 2009-10-21 AR ARP090104043A patent/AR074053A1/es not_active Application Discontinuation
2011
- 2011-03-14 IL IL211713A patent/IL211713A/en not_active IP Right Cessation
- 2011-04-15 HN HN2011001019A patent/HN2011001019A/es unknown
- 2011-04-20 CU CU2011000088A patent/CU24052B1/es active IP Right Grant
- 2011-04-20 MA MA33786A patent/MA32723B1/fr unknown
- 2011-04-20 TN TN2011000199A patent/TN2011000199A1/fr unknown
- 2011-04-20 DO DO2011000107A patent/DOP2011000107A/es unknown
- 2011-04-20 EC EC2011010992A patent/ECSP11010992A/es unknown
- 2011-04-20 CO CO11049624A patent/CO6361926A2/es active IP Right Grant
- 2011-04-25 CR CR20110210A patent/CR20110210A/es unknown
- 2011-05-20 ZA ZA2011/03727A patent/ZA201103727B/en unknown
2014
- 2014-09-05 CY CY20141100717T patent/CY1115590T1/el unknown

Also Published As

Publication number	Publication date
TWI496774B (zh)	2015-08-21
BRPI0920112A2 (pt)	2015-12-22
JP2012506391A (ja)	2012-03-15
PE20110546A1 (es)	2011-08-12
HN2011001019A (es)	2013-07-01
CN102197029A (zh)	2011-09-21
CU20110088A7 (es)	2011-12-28
TWI458716B (zh)	2014-11-01
NZ592314A (en)	2013-02-22
IL211713A (en)	2015-04-30
TW201020237A (en)	2010-06-01
PA8846201A1 (es)	2010-05-26
MY155230A (en)	2015-09-30
US20110294838A1 (en)	2011-12-01
AU2009306733A1 (en)	2010-04-29
CN102197029B (zh)	2014-05-14
WO2010046035A1 (de)	2010-04-29
ES2499028T3 (es)	2014-09-26
SA109300632B1 (ar)	2013-07-04
IL211713A0 (en)	2011-06-30
ZA201103727B (en)	2014-11-26
MA32723B1 (fr)	2011-10-02
CR20110210A (es)	2011-06-08
MX2011004238A (es)	2011-05-23
PT2350026E (pt)	2014-09-12
KR20110069115A (ko)	2011-06-22
CY1115590T1 (el)	2017-01-04
ECSP11010992A (es)	2011-05-31
AR074053A1 (es)	2010-12-22
TN2011000199A1 (en)	2012-12-17
CA2739739C (en)	2016-12-20
EP2350026A1 (de)	2011-08-03
PL2350026T3 (pl)	2014-11-28
UA103500C2 (uk)	2013-10-25
CO6361926A2 (es)	2012-01-20
HRP20140830T1 (hr)	2014-11-21
EA201100623A1 (ru)	2011-12-30
UY32190A (es)	2010-05-31
AU2009306733B2 (en)	2015-11-12
RS53523B1 (sr)	2015-02-27
DOP2011000107A (es)	2011-05-15
TW201444803A (zh)	2014-12-01
AU2009306733C1 (en)	2016-07-14
CU24052B1 (es)	2014-12-26
EA019230B1 (ru)	2014-02-28
EP2350026B1 (de)	2014-06-18
EP2179991A1 (de)	2010-04-28
JP5564054B2 (ja)	2014-07-30
SI2350026T1 (sl)	2014-10-30
US8735412B2 (en)	2014-05-27
CA2739739A1 (en)	2010-04-29

Publication	Publication Date	Title
DK2350026T3 (da)	2014-09-15	Sulfoximinsubstituerede anilinopyrimidinderativer som cdk-inhibitorer, fremstilling og anvendelse heraf som lægemiddel
DK2024347T3 (da)	2012-10-29	Phenylamino-benzoxazol substituerede carboxylsyrer, fremgangsmåde til deres fremstilling og deres anvendelse som lægemiddel
DK2051975T3 (da)	2012-10-15	Substituerede prolinamider, fremstilling deraf og anvendelse deraf som lægemiddel.
DK2242740T3 (da)	2013-03-25	SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler
IL204442A (en)	2015-05-31	Inhibitors of atpase-0fif, medicinal preparations containing them and their use
DK2240017T3 (da)	2019-06-17	Ketonlegemer og ketonlegemsestere som blodlipid-sænkende midler
IL210843A0 (en)	2011-04-28	Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
BRPI0907036A2 (pt)	2015-07-07	Conjunto de máscara para fornecer gás para um paciente, e, kit de conjunto de máscara para fornecer um gás para um paciente.
BRPI0910503A2 (pt)	2015-09-29	compostos, composições farmacêuticas e respectivos usos.
HUE059635T2 (hu)	2022-12-28	Citidin-analógokat tartalmazó orális készítmények, és eljárások azok alkalmazására
DK1711494T3 (da)	2010-10-11	Arylsubstituerede heterocykler, fremgangsmåde til deres fremstilling og deres anvendelse som lægemiddel
EA201200550A1 (ru)	2012-12-28	Фармацевтические композиции, включающие bi-1356 и метформин
BRPI0906962A2 (pt)	2015-07-14	Composto, e, composição farmacêutica
BRPI0906556A2 (pt)	2015-07-07	Composto, e, composição farmacêutica
ATE496849T1 (de)	2011-02-15	Getränkeinhaltstoffkapsel
CR10571A (es)	2009-05-14	Vacuna virica recombinante
BRPI0909770A2 (pt)	2015-08-11	Vacina, e, kit
IL211018A (en)	2015-11-30	Inhibitors, processes for making them, medicinal preparations containing them and their use
BRPI0807078A2 (pt)	2014-04-08	Composto, e, formulação farmacêutica
BRPI0917681A2 (pt)	2015-08-04	Composto, e, composição farmacêutica
IL210514A0 (en)	2011-03-31	Pyridino-pyridinone derivatives, preparation thereof, and therapeutic use thereof
IL192442A0 (en)	2008-12-29	Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
IL209840A0 (en)	2011-02-28	Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors
BRPI0909818A2 (pt)	2015-10-06	métodos, formas de dosagem e conjunto para administrar ziprasidona sem alimentos
DK2448927T3 (da)	2014-06-16	Hidtil ukendte (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amidderivater, fremstilling deraf og farmaceutisk anvendelse deraf som akt-phosphoryleringshæmmere