DK2343362T4 - Forbedret fremgangsmåde til dyrkning af celler - Google Patents

Forbedret fremgangsmåde til dyrkning af celler Download PDF

Info

Publication number: DK2343362T4
Authority: DK; Denmark
Prior art keywords: improved procedure; cultivating cells; cultivating; cells; procedure
Prior art date: 2006-07-14

Application number

DK10183677.3T

Other languages

English (en)

Other versions

DK2343362T3 (da

Inventor

Gerben Meile Zijlstra

Robert Patrick Hof

Jacob Schilder

Original Assignee

Patheon Holdings I B V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-14

Filing date

2007-07-04

Publication date

2024-07-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38441437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2343362(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-07-04 Application filed by Patheon Holdings I B V filed Critical Patheon Holdings I B V

2016-07-18 Publication of DK2343362T3 publication Critical patent/DK2343362T3/da

2024-07-08 Application granted granted Critical

2024-07-08 Publication of DK2343362T4 publication Critical patent/DK2343362T4/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/99—Serum-free medium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Sustainable Development (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Cell Biology (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Developmental Biology & Embryology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Clinical Laboratory Science (AREA)
Immunology (AREA)
Water Supply & Treatment (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Peptides Or Proteins (AREA)

DK10183677.3T 2006-07-14 2007-07-04 Forbedret fremgangsmåde til dyrkning af celler DK2343362T4 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP06014671		2006-07-14
EP07002571		2007-02-06
EP07765049.7A EP2041259B2 (en)	2006-07-14	2007-07-04	Improved process for the culturing of cells

Publications (2)

Publication Number	Publication Date
DK2343362T3 DK2343362T3 (da)	2016-07-18
DK2343362T4 true DK2343362T4 (da)	2024-07-08

Family

ID=38441437

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK07765049.7T DK2041259T3 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler
DK13169685.8T DK2634242T3 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler
DK10183677.3T DK2343362T4 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler
DK13169693.2T DK2634243T4 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK07765049.7T DK2041259T3 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler
DK13169685.8T DK2634242T3 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK13169693.2T DK2634243T4 (da)	2006-07-14	2007-07-04	Forbedret fremgangsmåde til dyrkning af celler

Country Status (22)

Country	Link
US (7)	US8119368B2 (da)
EP (5)	EP2634243B2 (da)
JP (4)	JP5092129B2 (da)
KR (3)	KR20120009530A (da)
CN (2)	CN104263700A (da)
AR (1)	AR062072A1 (da)
AU (1)	AU2007272054C1 (da)
BR (1)	BRPI0714347A2 (da)
CA (1)	CA2657040C (da)
CL (1)	CL2007002060A1 (da)
DK (4)	DK2041259T3 (da)
EA (2)	EA016451B1 (da)
ES (5)	ES2579957T5 (da)
FI (1)	FI2343362T4 (da)
HU (5)	HUE028593T2 (da)
IL (2)	IL196322A0 (da)
MX (2)	MX340242B (da)
PL (5)	PL2041259T3 (da)
PT (5)	PT2634243T (da)
SI (5)	SI2634242T1 (da)
TW (3)	TWI512102B (da)
WO (1)	WO2008006494A1 (da)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1720972B1 (en)	2004-03-05	2014-01-08	DSM IP Assets B.V.	Process for cell culturing by continuous perfusion and alternating tangential flow
US8585594B2 (en) *	2006-05-24	2013-11-19	Phoenix Biomedical, Inc.	Methods of assessing inner surfaces of body lumens or organs
PT2634243T (pt)	2006-07-14	2017-12-18	Patheon Holdings I B V	Método para melhorar a cultura de células
US9109193B2 (en)	2007-07-30	2015-08-18	Ge Healthcare Bio-Sciences Corp.	Continuous perfusion bioreactor system
US8623650B2 (en)	2007-10-19	2014-01-07	Viacyte, Inc.	Methods and compositions for feeder-free pluripotent stem cell media containing human serum
US9238792B2 (en) *	2009-09-15	2016-01-19	E I Du Pont De Nemours And Company	Compartmentalized simultaneous saccharification and fermentation of biomass
ES2472429T3 (es)	2009-10-15	2014-07-01	Crucell Holland B.V.	Método para la purificación de partículas de adenovirus a partir de cultivos de alta densidad celular
KR101805938B1 (ko)	2009-10-15	2018-01-10	얀센 백신스 앤드 프리벤션 비.브이.	고밀도 세포 배양액에서 아데노바이러스의 정제 방법
WO2012030512A1 (en)	2010-09-03	2012-03-08	Percivia Llc.	Flow-through protein purification process
EP2625262B1 (en) *	2010-10-05	2015-09-23	Novo Nordisk Health Care AG	Process for protein production
PL2673072T3 (pl)	2011-02-10	2015-04-30	Crucell Holland Bv	System pneumatycznej zmiennociśnieniowej membranowej separacji komórek
RU2580020C2 (ru) *	2011-04-29	2016-04-10	Биокон Рисерч Лимитед	Способ снижения гетерогенности антител и способ получения соответствующих антител
AU2012257736B2 (en)	2011-05-13	2015-12-10	Octapharma Ag	A method of increasing the productivity of eucaryotic cells in the production of recombinant FVIII
JP5897708B2 (ja)	2011-07-01	2016-03-30	アムジエン・インコーポレーテツド	哺乳類細胞培養物
TWI637057B (zh)	2012-11-09	2018-10-01	拜爾沙納有限公司	具交替生物反應器用途之不連續進料批次製程
WO2014085034A1 (en) *	2012-11-29	2014-06-05	Emd Millipore Corporation	Container having magnetic impeller assembly with hood
KR20210095233A (ko) *	2013-03-15	2021-07-30	젠자임 코포레이션	고-밀도 세포 뱅킹 방법
US10316282B2 (en)	2013-03-19	2019-06-11	Cmc Biologics A/S	Method for producing a product (e.g. polypeptide) in a continuous cell culture fermentation process
HUE055888T2 (hu) *	2013-09-16	2022-01-28	Genzyme Corp	Eljárások és összeállítások sejttenyészet feldolgozására
KR102245547B1 (ko) *	2013-09-30	2021-04-28	얀센 백신스 앤드 프리벤션 비.브이.	고밀도의 미정제 세포 배양 수거물의 정화를 위한 방법
JP6695814B2 (ja)	2014-06-04	2020-05-20	アムジエン・インコーポレーテツド	哺乳類細胞培養物を回収するための方法
US10829539B2 (en)	2014-06-13	2020-11-10	Csl Limited	Production of recombinant von Willebrand factor in a bioreactor
BR112017001177B1 (pt)	2014-07-24	2022-05-24	Janssen Vaccines & Prevention B.V	Método de purificação e de potenciação da liberação de poliovírus a partir de uma colheita de cultura celular bruta contendo poliovírus e uso de um detergente catiônico
JP6530171B2 (ja) *	2014-09-09	2019-06-12	旭化成メディカル株式会社	培養産生物の回収方法
WO2017147536A1 (en)	2016-02-24	2017-08-31	The Rockefeller University	Embryonic cell-based therapeutic candidate screening systems, models for huntington's disease and uses thereof
EP3442688A4 (en)	2016-04-12	2019-11-20	Artemis Biosystems, Inc.	FILTRATION SYSTEMS FOR INFUSION
WO2018159847A1 (ja) *	2017-03-03	2018-09-07	富士フイルム株式会社	細胞培養装置及び細胞培養方法
IL273549B2 (en)	2017-10-06	2023-10-01	Lonza Ag	Automated control of cell culture using Raman spectroscopy
ES2919850T3 (es)	2017-10-16	2022-07-28	Regeneron Pharma	Procedimientos de perfusión
WO2019084410A1 (en)	2017-10-26	2019-05-02	Repligen Corporation	MICRO-ALTERNATIVE TANGENTIALLY FLOWING INFUSION FILTER, TREATMENT CONTAINER, AND METHODS OF USING THE SAME
CN111315780A (zh) *	2017-12-11	2020-06-19	安进公司	双特异性抗体产品的连续制造工艺
AU2019231885B2 (en) *	2018-03-08	2022-03-24	Repligen Corporation	Tangential flow depth filtration systems and methods of filtration using same
CN111868249B (zh) *	2018-03-19	2024-06-18	富士胶片株式会社	生产物的制造方法
US11958018B2 (en)	2018-05-25	2024-04-16	Repligen Corporation	Tangential flow filtration systems and methods
CN109157690A (zh) *	2018-06-15	2019-01-08	翁炳焕	猴-人细胞融合母胎血型不合治疗杂交株的制备
EP3647405A1 (en) *	2018-11-02	2020-05-06	Microfluidx	Cell culture device and method of using the same
US20220364034A1 (en) *	2018-11-02	2022-11-17	WuXi Biologics Ireland Limited	Cell culture process by intensified perfusion with continuous harvest and without cell bleeding
CN113924355B (zh) *	2019-05-28	2024-04-02	上海药明生物技术有限公司	用于监测和自动控制灌流细胞培养的拉曼光谱集成灌流细胞培养系统
EP4055136A1 (en)	2019-11-07	2022-09-14	Merck Patent GmbH	Methods and systems for performing perfusion cell culture
US12157119B2 (en)	2020-03-10	2024-12-03	Cellares Corporation	Systems and methods for cell processing
US12252678B2 (en)	2021-12-01	2025-03-18	Microfluidx Ltd	Systems and methods for bioprocessing
CA3266599A1 (en)	2022-09-07	2024-11-07	Quantitative Biosciences, Inc.	UNIQUE VARIABLE DOMAIN ANTIBODIES SPECIFIC TO FENTANYL AND USE IN A CONTINUOUS AGGLUTINATION TEST
WO2024072444A1 (en) *	2022-09-26	2024-04-04	Upside Foods, Inc.	Harvesting cell-based meat
US11898127B1 (en)	2022-09-26	2024-02-13	Upside Foods, Inc.	Harvesting cell-based meat
US12180453B2 (en)	2023-03-21	2024-12-31	Cellares Corporation	Systems, devices, and methods for electroporation within a cell processing system
WO2024226439A1 (en)	2023-04-24	2024-10-31	Quantitative Biosciences, Inc.	Engineered biosensor strains of e. coli for continuous aerobic detection of analytes
US12399193B2 (en)	2023-05-05	2025-08-26	Cellares Corporation	Systems, devices, and methods for combined cell processes
WO2025041047A1 (en)	2023-08-21	2025-02-27	Cellares Corporation	Bioreactors and methods of their use in automatic cell processing systems
WO2025041064A2 (en)	2023-08-21	2025-02-27	Cellares Corporation	Systems, devices, and methods for automatic cell sorting
WO2025041046A1 (en)	2023-08-21	2025-02-27	Cellares Corporation	Systems, devices, and methods for fluid control in a cell processing system
WO2025128343A1 (en)	2023-12-11	2025-06-19	Just-Evotec Biologics, Inc.	Protein expression using trans-splicing and split selectable markers
US12492368B2 (en)	2024-03-11	2025-12-09	Cellares Corporation	Monitoring air pressure within a cell processing system

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4477342A (en)	1982-08-31	1984-10-16	Becton, Dickinson And Company	Apparatus and method for controlling ultrafiltration during hemodialysis
US4885166A (en) *	1985-06-11	1989-12-05	Ciba-Geigy Corporation	Hybrid interferons
US5286646A (en) *	1985-11-25	1994-02-15	Boehringer Mannheim Gmbh	Method for mammalian cell culture
PT84991B (pt) *	1986-06-06	1990-03-08	Genentech Inc	Processo para a producao de actividador do plasminogenio biologicamente activo
JPH0642905B2 (ja)	1986-06-13	1994-06-08	東レ株式会社	血液透析膜
GB8617646D0 (en)	1986-07-18	1986-08-28	Manchester Inst Science Tech	Recovery of biological material
US6022742A (en) *	1986-11-26	2000-02-08	Kopf; Henry B.	Culture device and method
US4806484A (en) *	1987-08-07	1989-02-21	Igb Products, Ltd.	Perfusion airlift bioreactor
JPH0797982B2 (ja) *	1987-09-24	1995-10-25	東洋紡績株式会社	細胞培養装置
US4921792A (en)	1987-11-27	1990-05-01	Miles Inc.	Continuous cell dispersion, cultivation and substance recovery process
JPH01243985A (ja)	1988-03-25	1989-09-28	P C C Technol:Kk	植物器官の培養法及びその培養槽
US5595909A (en)	1988-05-23	1997-01-21	Regents Of The University Of Minnesota	Filter device
JPH02119772A (ja) *	1988-10-29	1990-05-07	Shimadzu Corp	細胞培養装置
JP2625990B2 (ja) *	1988-11-19	1997-07-02	株式会社島津製作所	細胞培養装置
US5019512A (en)	1989-03-17	1991-05-28	Baxter International Inc.	Spin filter for removing substantially cell-free culture medium from suspension cell culture system
JP2690144B2 (ja) *	1989-04-24	1997-12-10	哲哉峠	膜型細胞培養装置
JPH0793874B2 (ja) *	1989-04-27	1995-10-11	日本碍子株式会社	バイオリアクタ
US5256294A (en)	1990-09-17	1993-10-26	Genentech, Inc.	Tangential flow filtration process and apparatus
JP2948675B2 (ja) *	1991-03-20	1999-09-13	日本碍子株式会社	発酵液中の有価物を回収するクロスフロー濾過方法
JPH0531332A (ja) *	1991-07-30	1993-02-09	Toto Ltd	微生物の膜分離方法
GB9118664D0 (en)	1991-08-30	1991-10-16	Celltech Ltd	Cell culture
JPH07123972A (ja) *	1993-11-01	1995-05-16	Fumio Yamauchi	膜型バイオリアクター
JPH07298871A (ja) *	1994-05-06	1995-11-14	Fumio Yamauchi	膜型バイオリアクター
US6204000B1 (en)	1995-04-28	2001-03-20	The United States Of America As Represented By The Department Of Health And Human Services	Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1
KR100470180B1 (ko)	1995-06-15	2005-02-04	크루셀 홀란드 비.브이.	유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템
US5994728A (en)	1995-11-15	1999-11-30	Matsushita Electronics Corporation	Field effect transistor and method for producing the same
JPH1015357A (ja) *	1996-07-01	1998-01-20	Nitto Denko Corp	排水の処理方法
JPH1033671A (ja) *	1996-07-24	1998-02-10	Jms Co Ltd	中空糸型人工肝臓とその灌流及び培養システム
JP3346996B2 (ja)	1996-09-18	2002-11-18	金剛株式会社	免震自立棚
JPH10108673A (ja) *	1996-10-04	1998-04-28	Asahi Medical Co Ltd	中空糸型培養器を用いた動物細胞の培養方法
JPH10108666A (ja) *	1996-10-04	1998-04-28	Asahi Medical Co Ltd	中空糸型培養器
US6001585A (en)	1997-11-14	1999-12-14	Cellex Biosciences, Inc.	Micro hollow fiber bioreactor
US8026096B1 (en)	1998-10-08	2011-09-27	Protein Sciences Corporation	In vivo active erythropoietin produced in insect cells
JP4475819B2 (ja)	1999-01-26	2010-06-09	シェーリング−プラウ・リミテッド	チャイニーズハムスター卵巣細胞中でのウシコロナウイルスの増殖
EP1533380B1 (en)	1999-04-15	2009-11-04	Crucell Holland B.V.	Recombinant protein production in a human cell comprising at least one E1 protein of adenovirus
US6855544B1 (en) *	1999-04-15	2005-02-15	Crucell Holland B.V.	Recombinant protein production in a human cell
EP1103610A1 (en)	1999-11-26	2001-05-30	Introgene B.V.	Production of vaccines from immortalised mammalian cell lines
JP2001149099A (ja)	1999-11-26	2001-06-05	Olympus Optical Co Ltd	染色体異常解析のための有核細胞の標本作製方法
US6544424B1 (en) *	1999-12-03	2003-04-08	Refined Technology Company	Fluid filtration system
US6168941B1 (en)	2000-04-07	2001-01-02	Genvec, Inc.	Method of producing adenoviral vector stocks
JP4138209B2 (ja)	2000-06-29	2008-08-27	エーザイ・アール・アンド・ディー・マネジメント株式会社	プラバスタチン含有組成物
JP2002113896A (ja)	2000-10-05	2002-04-16	Seiko Epson Corp	画像形成装置
US6733662B2 (en)	2001-02-23	2004-05-11	V.A.I. Ltd.	Methods and apparatus for biological treatment of waste waters
JP3547715B2 (ja) *	2001-03-06	2004-07-28	榮新垣	ベクター精製用装置及び方法
US6716354B2 (en)	2001-03-08	2004-04-06	Cdg Technology, Inc.	Methods of treating water using combinations of chlorine dioxide, chlorine and ammonia
WO2002086133A1 (fr)	2001-04-17	2002-10-31	Seiren Kabushiki Kaisha	Additifs de milieu et milieux de culture de cellules animales
DE10120835C2 (de)	2001-04-27	2003-04-10	Sifin Inst Fuer Immunpraeparat	Verfahren zur Herstellung von monoklonalen Antikörpern
DE10120838A1 (de)	2001-04-27	2002-10-31	Basf Ag	Stoffmischung zur UV-Stabilisierung von Kunststoffen und Herstellung davon
WO2003020919A2 (en)	2001-08-31	2003-03-13	Bayer Healthcare Ag	A unit and a process for carrying out high cell density fermentation
CA2459469A1 (en)	2001-09-05	2003-03-20	Yamasa Corporation	Pharmaceutical composition for diabetic neuropathy
WO2003025158A1 (en)	2001-09-14	2003-03-27	Medcell Biologics, Inc.	Oxygen enriched bioreactor and method of culturing cells
GB0123098D0 (en) *	2001-09-26	2001-11-14	Lonza Biologics Plc	Use of aminoglycoside resistance gene
WO2003041749A1 (de)	2001-11-15	2003-05-22	Aesculap Ag & Co. Kg	Sterilbehälter
JP2003219873A (ja)	2002-01-24	2003-08-05	Japan Science & Technology Corp	サケ科キングサーモン由来の不死化細胞
US20030186335A1 (en)	2002-03-28	2003-10-02	National Institute Of Advanced Industrial Science And Technology	Monoclonal antibodies, hybridomas, cell isolation method, isolated cells and immunological diagnostic method
US6902909B2 (en)	2002-07-09	2005-06-07	Synthecon, Inc.	Methods for efficient production of mammalian recombinant proteins
DE10237082B4 (de)	2002-08-09	2014-12-31	Sartorius Stedim Biotech Gmbh	Verfahren und Vorrichtung zur biotechnologischen Herstellung von Wertstoffen
DK1620549T3 (da) *	2003-05-01	2007-11-05	Dsm Ip Assets Bv	Fremgangsmåde til fremstilling af biologiske stoffer ved perfusionsdyrkning af suspenderede dyreceller
EP1623023B1 (en)	2003-05-09	2008-11-12	Crucell Holland B.V.	Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom
US20050054101A1 (en) *	2003-07-17	2005-03-10	Global Cell Solutions Llc	Automated cell culture system and process
JP2005041984A (ja)	2003-07-22	2005-02-17	Shin Kobe Electric Mach Co Ltd	水架橋ポリオレフィン製シートの製造法
EP1720972B1 (en)	2004-03-05	2014-01-08	DSM IP Assets B.V.	Process for cell culturing by continuous perfusion and alternating tangential flow
US20080230488A1 (en) *	2004-03-29	2008-09-25	Pall Corporation	Pleated, Crossflow Fluid Treatment Elements, Methods for Making Them, and Methods for Treating Cellular Solutions
JP4818936B2 (ja) *	2005-01-05	2011-11-16	中外製薬株式会社	細胞の培養方法およびその利用
CN100354408C (zh) *	2005-10-09	2007-12-12	南京工业大学	一种高密度细胞培养方法及其生物反应装置
JP2009519819A (ja) *	2005-12-17	2009-05-21	エアーインスペース・ビー．ブイ．	空気浄化装置
JP5031332B2 (ja)	2006-03-31	2012-09-19	旭化成ホームズ株式会社	線切断具
PT2634243T (pt) *	2006-07-14	2017-12-18	Patheon Holdings I B V	Método para melhorar a cultura de células
EP2014760A1 (en)	2007-06-13	2009-01-14	CMC Biopharmaceuticals A/S	A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
JP2008308560A (ja)	2007-06-13	2008-12-25	Tohcello Co Ltd	表面防汚性複合フィルムの製造方法
JP5426937B2 (ja) *	2009-06-19	2014-02-26	興和株式会社	光学的反応測定装置および光学的反応測定方法

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Publication number	Publication date
CA2657040C (en)	2013-10-01
EP2041259B2 (en)	2024-10-09
KR101143796B1 (ko)	2012-05-21
JP2009543565A (ja)	2009-12-10
IL234890A (en)	2016-05-31
TWI627274B (zh)	2018-06-21
WO2008006494A1 (en)	2008-01-17
US9469865B2 (en)	2016-10-18
DK2634243T3 (da)	2017-12-11
EP2343362B8 (en)	2016-05-18
DK2343362T3 (da)	2016-07-18
US20100075413A1 (en)	2010-03-25
SI2343362T1 (sl)	2016-09-30
EP2634242A1 (en)	2013-09-04
JP2012165764A (ja)	2012-09-06
TWI413689B (zh)	2013-11-01
EA200900188A1 (ru)	2009-06-30
JP2011067222A (ja)	2011-04-07
TWI512102B (zh)	2015-12-11
US20140154745A1 (en)	2014-06-05
JP5092129B2 (ja)	2012-12-05
TW201341527A (zh)	2013-10-16
EP2343362B2 (en)	2024-04-03
ES2579957T5 (es)	2024-12-10
US8685731B2 (en)	2014-04-01
HUE034299T2 (en)	2018-02-28
KR20120009530A (ko)	2012-01-31
MX340242B (es)	2016-07-01
US8119368B2 (en)	2012-02-21
EP2634242B1 (en)	2017-04-05
EP2634250B1 (en)	2017-04-05
TW200813216A (en)	2008-03-16
DK2041259T3 (da)	2016-01-25
JP5448010B2 (ja)	2014-03-19
ES2559308T3 (es)	2016-02-11
CN102876628A (zh)	2013-01-16
SI2634242T1 (sl)	2017-07-31
CA2657040A1 (en)	2008-01-17
PL2634242T3 (pl)	2017-09-29
PL2343362T3 (pl)	2016-11-30
EP2041259A1 (en)	2009-04-01
US8440458B2 (en)	2013-05-14
EP2634243B2 (en)	2024-07-24
EA016451B1 (ru)	2012-05-30
HUE028365T2 (en)	2016-12-28
FI2343362T4 (fi)	2024-07-04
PL2634243T3 (pl)	2018-02-28
PT2343362T (pt)	2016-07-13
JP2014217395A (ja)	2014-11-20
KR101685246B1 (ko)	2016-12-09
SI2634250T1 (sl)	2017-06-30
PT2041259E (pt)	2016-02-15
KR20090031899A (ko)	2009-03-30
SI2634243T1 (en)	2018-01-31
AU2007272054C1 (en)	2014-08-28
HUE035109T2 (en)	2018-05-02
EP2634243A1 (en)	2013-09-04
PL2343362T5 (pl)	2024-12-02
BRPI0714347A2 (pt)	2013-05-07
CL2007002060A1 (es)	2008-04-18
ES2625062T3 (es)	2017-07-18
AU2007272054A1 (en)	2008-01-17
PT2634250T (pt)	2017-07-13
DK2634242T3 (da)	2017-05-22
KR20130014640A (ko)	2013-02-07
AU2007272054B2 (en)	2011-09-08
EP2343362A1 (en)	2011-07-13
SI2041259T1 (sl)	2016-04-29
US9670520B2 (en)	2017-06-06
TW201604277A (zh)	2016-02-01
US20130095527A1 (en)	2013-04-18
US20120064623A1 (en)	2012-03-15
PT2634243T (pt)	2017-12-18
CN104263700A (zh)	2015-01-07
IL196322A0 (en)	2009-09-22
AR062072A1 (es)	2008-10-15
ES2650042T3 (es)	2018-01-16
PL2634250T3 (pl)	2017-09-29
US20120149107A1 (en)	2012-06-14
PT2634242T (pt)	2017-07-12
DK2634243T4 (da)	2024-09-23
EA201101581A1 (ru)	2012-04-30
EP2634243B1 (en)	2017-09-06
ES2625066T3 (es)	2017-07-18
US20120149063A1 (en)	2012-06-14
MX2009000522A (es)	2009-01-27
HUE032608T2 (en)	2017-10-30
ES2579957T3 (es)	2016-08-17
EP2634250A1 (en)	2013-09-04
PL2041259T3 (pl)	2016-04-29
EP2343362B1 (en)	2016-03-30
EP2041259B1 (en)	2015-10-14
HUE028593T2 (en)	2016-12-28
US8222001B2 (en)	2012-07-17
US20160265017A1 (en)	2016-09-15

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