DK2220082T3 - Stabilt krystallinsk salt af (R)-3-fluorphenyl-3,4,5-trifluorbenzylcarbaminsyre-1-azabicyclo[2.2.2]oct-3-ylester - Google Patents
Stabilt krystallinsk salt af (R)-3-fluorphenyl-3,4,5-trifluorbenzylcarbaminsyre-1-azabicyclo[2.2.2]oct-3-ylesterInfo
- Publication number
- DK2220082T3 DK2220082T3 DK08854867.2T DK08854867T DK2220082T3 DK 2220082 T3 DK2220082 T3 DK 2220082T3 DK 08854867 T DK08854867 T DK 08854867T DK 2220082 T3 DK2220082 T3 DK 2220082T3
- Authority
- DK
- Denmark
- Prior art keywords
- azabicyclo
- fluorophenyl
- oct
- ester
- crystalline salt
- Prior art date
Links
- UXZDMXYRRQJIBJ-IBGZPJMESA-N [(3r)-1-azabicyclo[2.2.2]octan-3-yl] n-(3-fluorophenyl)-n-[(3,4,5-trifluorophenyl)methyl]carbamate Chemical compound FC1=CC=CC(N(CC=2C=C(F)C(F)=C(F)C=2)C(=O)O[C@@H]2C3CCN(CC3)C2)=C1 UXZDMXYRRQJIBJ-IBGZPJMESA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07384038A EP2065385A1 (en) | 2007-11-28 | 2007-11-28 | Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester |
| PCT/EP2008/010012 WO2009068253A2 (en) | 2007-11-28 | 2008-11-26 | Stable crystalline salt of (r)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-yl ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2220082T3 true DK2220082T3 (da) | 2014-10-06 |
Family
ID=39401152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08854867.2T DK2220082T3 (da) | 2007-11-28 | 2008-11-26 | Stabilt krystallinsk salt af (R)-3-fluorphenyl-3,4,5-trifluorbenzylcarbaminsyre-1-azabicyclo[2.2.2]oct-3-ylester |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8492402B2 (da) |
| EP (2) | EP2065385A1 (da) |
| JP (1) | JP5336509B2 (da) |
| KR (1) | KR101557832B1 (da) |
| CN (1) | CN101925600B (da) |
| AU (1) | AU2008329181B2 (da) |
| BR (1) | BRPI0819607A2 (da) |
| CA (1) | CA2706565C (da) |
| DK (1) | DK2220082T3 (da) |
| EA (1) | EA017483B1 (da) |
| ES (1) | ES2498819T3 (da) |
| IL (1) | IL206032A (da) |
| MX (1) | MX2010005850A (da) |
| NZ (1) | NZ585833A (da) |
| PL (1) | PL2220082T3 (da) |
| UA (1) | UA102083C2 (da) |
| WO (1) | WO2009068253A2 (da) |
| ZA (1) | ZA201003718B (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1345937B1 (en) | 2000-12-22 | 2005-09-28 | Almirall Prodesfarma AG | Quinuclidine carbamate derivatives and their use as m3 antagonists |
| JP5745283B2 (ja) | 2010-02-12 | 2015-07-08 | ファイザー・インク | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| KR101978364B1 (ko) | 2017-06-15 | 2019-05-14 | 크리스탈지노믹스(주) | 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 또는 그 유도체의 약학적으로 허용 가능한 염 및 그 제조방법 |
| KR102678356B1 (ko) * | 2018-10-29 | 2024-06-26 | 씨지인바이츠 주식회사 | 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 인산염, 타르타르산염 또는 이들의 조합을 포함하는 약제학적 조성물 및 그 제조방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE510305C2 (sv) * | 1997-05-30 | 1999-05-10 | Astra Ab | Nytt salt |
| KR100751981B1 (ko) * | 2000-06-27 | 2007-08-28 | 라보라토리오스 살바트, 에스.에이. | 아릴알킬아민으로부터 유도된 카바메이트 |
| EP1345937B1 (en) * | 2000-12-22 | 2005-09-28 | Almirall Prodesfarma AG | Quinuclidine carbamate derivatives and their use as m3 antagonists |
| ES2425347T3 (es) * | 2001-12-20 | 2013-10-14 | Chiesi Farmaceutici S.P.A. | Derivados de carbamato de 1-alquil-1-azoniabiciclo[2.2.2]octano y su uso como antagonistas de receptores muscarínicos |
| ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2246170B1 (es) * | 2004-07-29 | 2007-04-01 | Almirall Prodesfarma, S.A. | Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio. |
-
2007
- 2007-11-28 EP EP07384038A patent/EP2065385A1/en not_active Withdrawn
-
2008
- 2008-11-26 WO PCT/EP2008/010012 patent/WO2009068253A2/en not_active Ceased
- 2008-11-26 UA UAA201007997A patent/UA102083C2/uk unknown
- 2008-11-26 CN CN2008801254506A patent/CN101925600B/zh not_active Expired - Fee Related
- 2008-11-26 NZ NZ585833A patent/NZ585833A/en not_active IP Right Cessation
- 2008-11-26 ES ES08854867.2T patent/ES2498819T3/es active Active
- 2008-11-26 EA EA201070651A patent/EA017483B1/ru not_active IP Right Cessation
- 2008-11-26 CA CA2706565A patent/CA2706565C/en not_active Expired - Fee Related
- 2008-11-26 AU AU2008329181A patent/AU2008329181B2/en not_active Ceased
- 2008-11-26 BR BRPI0819607A patent/BRPI0819607A2/pt not_active IP Right Cessation
- 2008-11-26 EP EP08854867.2A patent/EP2220082B1/en not_active Not-in-force
- 2008-11-26 PL PL08854867T patent/PL2220082T3/pl unknown
- 2008-11-26 DK DK08854867.2T patent/DK2220082T3/da active
- 2008-11-26 JP JP2010535281A patent/JP5336509B2/ja not_active Expired - Fee Related
- 2008-11-26 MX MX2010005850A patent/MX2010005850A/es active IP Right Grant
- 2008-11-26 US US12/744,493 patent/US8492402B2/en not_active Expired - Fee Related
- 2008-11-28 KR KR1020107013939A patent/KR101557832B1/ko not_active Expired - Fee Related
-
2010
- 2010-05-25 ZA ZA2010/03718A patent/ZA201003718B/en unknown
- 2010-05-27 IL IL206032A patent/IL206032A/en not_active IP Right Cessation
-
2013
- 2013-02-08 US US13/763,063 patent/US8871787B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0819607A2 (pt) | 2015-10-13 |
| WO2009068253A2 (en) | 2009-06-04 |
| CN101925600B (zh) | 2013-01-09 |
| US8492402B2 (en) | 2013-07-23 |
| WO2009068253A3 (en) | 2009-08-13 |
| AU2008329181A1 (en) | 2009-06-04 |
| IL206032A (en) | 2014-07-31 |
| EA201070651A1 (ru) | 2010-12-30 |
| JP5336509B2 (ja) | 2013-11-06 |
| HK1144192A1 (en) | 2011-02-02 |
| KR101557832B1 (ko) | 2015-10-06 |
| JP2011504890A (ja) | 2011-02-17 |
| US20140051721A1 (en) | 2014-02-20 |
| MX2010005850A (es) | 2010-09-03 |
| ZA201003718B (en) | 2011-08-31 |
| IL206032A0 (en) | 2010-11-30 |
| UA102083C2 (uk) | 2013-06-10 |
| PL2220082T3 (pl) | 2014-12-31 |
| US8871787B2 (en) | 2014-10-28 |
| CN101925600A (zh) | 2010-12-22 |
| KR20100103532A (ko) | 2010-09-27 |
| ES2498819T3 (es) | 2014-09-25 |
| EP2220082B1 (en) | 2014-06-25 |
| EP2220082A2 (en) | 2010-08-25 |
| NZ585833A (en) | 2011-05-27 |
| EP2065385A1 (en) | 2009-06-03 |
| AU2008329181B2 (en) | 2012-03-29 |
| US20110207769A1 (en) | 2011-08-25 |
| EA017483B1 (ru) | 2012-12-28 |
| CA2706565C (en) | 2015-04-28 |
| CA2706565A1 (en) | 2009-06-04 |
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