DK2213664T3 - Fremgangsmåde til fremstillingen af cyclopenta[g]quinazolinderivater - Google Patents
Fremgangsmåde til fremstillingen af cyclopenta[g]quinazolinderivaterInfo
- Publication number
- DK2213664T3 DK2213664T3 DK10003257.2T DK10003257T DK2213664T3 DK 2213664 T3 DK2213664 T3 DK 2213664T3 DK 10003257 T DK10003257 T DK 10003257T DK 2213664 T3 DK2213664 T3 DK 2213664T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclopenta
- procedure
- preparation
- quinazoline derivatives
- formula
- Prior art date
Links
- BCCZFOXKKDTUTF-UHFFFAOYSA-N 5h-cyclopenta[g]quinazoline Chemical class C1=NC=C2CC3=CC=CC3=CC2=N1 BCCZFOXKKDTUTF-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Paints Or Removers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121214.1A GB0121214D0 (en) | 2001-08-31 | 2001-08-31 | Synthetic method |
| US34024401P | 2001-12-18 | 2001-12-18 | |
| EP02755271A EP1421069B1 (en) | 2001-08-31 | 2002-08-30 | Process for the preparation of cyclopenta[g]quinazoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2213664T3 true DK2213664T3 (da) | 2014-07-21 |
Family
ID=9921361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02755271.0T DK1421069T3 (da) | 2001-08-31 | 2002-08-30 | Fremgangsmåde til fremstilling af cyclopenta[G]-quinazolinderivater |
| DK10003257.2T DK2213664T3 (da) | 2001-08-31 | 2002-08-30 | Fremgangsmåde til fremstillingen af cyclopenta[g]quinazolinderivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02755271.0T DK1421069T3 (da) | 2001-08-31 | 2002-08-30 | Fremgangsmåde til fremstilling af cyclopenta[G]-quinazolinderivater |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7250511B2 (da) |
| EP (2) | EP1421069B1 (da) |
| JP (2) | JP4405798B2 (da) |
| AT (1) | ATE519747T1 (da) |
| CY (1) | CY1112711T1 (da) |
| DK (2) | DK1421069T3 (da) |
| ES (1) | ES2371334T3 (da) |
| GB (1) | GB0121214D0 (da) |
| PT (1) | PT1421069E (da) |
| WO (1) | WO2003020706A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1556705B (zh) * | 2002-07-09 | 2010-04-28 | 埃科特莱茵药品有限公司 | 7,8,9,10-四氢-6H-氮杂卓并、6,7,8,9-四氢-吡啶并和2,3-二氢-2H-吡咯并[2,1-b]-喹唑啉酮衍生物 |
| US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| AU2007288253B2 (en) | 2006-08-23 | 2013-05-02 | Xenon Pharmaceuticals Inc. | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| WO2008066900A1 (en) * | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| AU2011280235A1 (en) * | 2010-07-19 | 2013-03-07 | Onyx Pharmaceuticals, Inc. | Synthesis of cyclopentaquinazolines |
| EP2655398B1 (en) * | 2010-12-22 | 2016-08-24 | BTG International Limited | Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta (g) quinazoline trisodium salt |
| US9717797B2 (en) | 2013-12-05 | 2017-08-01 | International Business Machines Corporation | Polycarbonates bearing aromatic N-heterocycles for drug delivery |
| GB201707864D0 (en) | 2017-05-16 | 2017-06-28 | Inst Of Cancer Research: Royal Cancer Hospital | Platinum-reistant cancer treatment |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| GEAP202415942A (en) | 2019-11-08 | 2024-10-28 | Xenon Pharmaceuticals Inc | Methods of treating depressive disorders |
| GEAP202416348A (en) | 2021-02-09 | 2024-01-10 | Xenon Pharmaceuticals Inc | Methods and uses for treating anhedonia |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223352D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
| GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| EP1259484B1 (en) * | 2000-01-18 | 2005-05-18 | Novartis AG | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion |
-
2001
- 2001-08-31 GB GBGB0121214.1A patent/GB0121214D0/en not_active Ceased
-
2002
- 2002-08-30 DK DK02755271.0T patent/DK1421069T3/da active
- 2002-08-30 EP EP02755271A patent/EP1421069B1/en not_active Expired - Lifetime
- 2002-08-30 PT PT02755271T patent/PT1421069E/pt unknown
- 2002-08-30 WO PCT/GB2002/003967 patent/WO2003020706A1/en not_active Ceased
- 2002-08-30 DK DK10003257.2T patent/DK2213664T3/da active
- 2002-08-30 US US10/487,863 patent/US7250511B2/en not_active Expired - Lifetime
- 2002-08-30 JP JP2003524977A patent/JP4405798B2/ja not_active Expired - Lifetime
- 2002-08-30 AT AT02755271T patent/ATE519747T1/de active
- 2002-08-30 EP EP10003257.2A patent/EP2213664B1/en not_active Expired - Lifetime
- 2002-08-30 ES ES02755271T patent/ES2371334T3/es not_active Expired - Lifetime
-
2009
- 2009-08-21 JP JP2009192490A patent/JP5275945B2/ja not_active Expired - Lifetime
-
2011
- 2011-11-07 CY CY20111101068T patent/CY1112711T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003020706A1 (en) | 2003-03-13 |
| HK1145321A1 (en) | 2011-04-15 |
| DK1421069T3 (da) | 2011-11-21 |
| US7250511B2 (en) | 2007-07-31 |
| EP1421069B1 (en) | 2011-08-10 |
| GB0121214D0 (en) | 2001-10-24 |
| EP2213664A1 (en) | 2010-08-04 |
| ES2371334T3 (es) | 2011-12-29 |
| EP2213664B1 (en) | 2014-04-30 |
| JP4405798B2 (ja) | 2010-01-27 |
| JP5275945B2 (ja) | 2013-08-28 |
| JP2009280609A (ja) | 2009-12-03 |
| CY1112711T1 (el) | 2016-02-10 |
| EP1421069A1 (en) | 2004-05-26 |
| ATE519747T1 (de) | 2011-08-15 |
| US20040266798A1 (en) | 2004-12-30 |
| JP2005507384A (ja) | 2005-03-17 |
| PT1421069E (pt) | 2011-11-21 |
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