DK2257618T3 - Fremstilling af glykosylerede polypeptider i mikroalger - Google Patents
Fremstilling af glykosylerede polypeptider i mikroalger Download PDFInfo
- Publication number
- DK2257618T3 DK2257618T3 DK09710039.0T DK09710039T DK2257618T3 DK 2257618 T3 DK2257618 T3 DK 2257618T3 DK 09710039 T DK09710039 T DK 09710039T DK 2257618 T3 DK2257618 T3 DK 2257618T3
- Authority
- DK
- Denmark
- Prior art keywords
- microalges
- glycosyled
- polypeptides
- preparation
- glycosyled polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01052—Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase (3.5.1.52), i.e. glycopeptidase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08300090A EP2090648A1 (en) | 2008-02-12 | 2008-02-12 | Production of glycosylated polypeptides in microalgae |
| PCT/EP2009/051672 WO2009101160A1 (en) | 2008-02-12 | 2009-02-12 | Production of glycosylated polypeptides in microalgae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2257618T3 true DK2257618T3 (da) | 2019-07-22 |
Family
ID=39590460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09710039.0T DK2257618T3 (da) | 2008-02-12 | 2009-02-12 | Fremstilling af glykosylerede polypeptider i mikroalger |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8728761B2 (da) |
| EP (2) | EP2090648A1 (da) |
| JP (1) | JP5628689B2 (da) |
| AU (1) | AU2009214077B2 (da) |
| CA (1) | CA2715107C (da) |
| DK (1) | DK2257618T3 (da) |
| ES (1) | ES2734276T3 (da) |
| HR (1) | HRP20191222T1 (da) |
| HU (1) | HUE044328T2 (da) |
| IL (1) | IL207381A (da) |
| PL (1) | PL2257618T3 (da) |
| PT (1) | PT2257618T (da) |
| WO (1) | WO2009101160A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI377253B (en) | 2001-04-16 | 2012-11-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| TWI548648B (zh) | 2009-03-16 | 2016-09-11 | Ｄｓｍ智慧財產有限公司 | 於網黏菌門微生物中生產蛋白質之技術 |
| CN103068984B (zh) * | 2009-12-28 | 2017-12-01 | Dsm Ip资产公司 | 微藻中血凝素‑神经氨酸酶蛋白的生产 |
| MX351643B (es) * | 2009-12-28 | 2017-10-23 | Merial Ltd | Antigeno ndv recombinante y usos del mismo. |
| AU2010343095B2 (en) * | 2009-12-28 | 2017-01-05 | Sanofi Vaccine Technologies, S.A.S. | Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof |
| EP2412815A1 (en) * | 2010-07-27 | 2012-02-01 | Universite De Rouen | N-glycosylation in transformed Phaeodactylum tricornutum |
| EP2444495A1 (en) * | 2010-10-20 | 2012-04-25 | Algenics | Secretion of recombinant polypeptides in the extracellular medium of diatoms |
| EP2471929A1 (en) * | 2010-12-29 | 2012-07-04 | Algenics | Production of high mannose glycosylated proteins stored in the plastid of microalgae |
| US20150368655A1 (en) * | 2012-12-26 | 2015-12-24 | Osaka Prefecture University Public Corporation | Transformed euglena and process for producing same |
| JP2014193154A (ja) * | 2013-02-28 | 2014-10-09 | Euglena Co Ltd | ユーグレナの形質転換体 |
| BR112015020827A2 (pt) * | 2013-02-28 | 2017-10-10 | Euglena Co Ltd | método para a introdução de gene em euglena, e transformante do mesmo |
| JP2014193153A (ja) * | 2013-02-28 | 2014-10-09 | Euglena Co Ltd | ユーグレナへの遺伝子導入方法 |
| US9441020B2 (en) | 2013-12-31 | 2016-09-13 | Synthetic Genomics, Inc. | Biomass productivity regulator |
| CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
| CN107810271B (zh) * | 2014-11-20 | 2021-09-28 | 耶路撒冷希伯来大学伊萨姆研发公司 | 用于在植物细胞中生产具有改变的糖基化模式的多肽的组合物和方法 |
| PT3271453T (pt) | 2015-03-17 | 2021-11-29 | eleva GmbH | Proteínas lisossomais glicosiladas, método de produção e usos |
| EP3908302A1 (en) | 2019-01-10 | 2021-11-17 | Expres2ion Biotechnologies ApS | Glyco-engineered immunization antigens |
| KR20240008322A (ko) * | 2021-04-16 | 2024-01-18 | 인바이오스 엔.브이. | 발효 생산 |
| US20240294959A1 (en) * | 2021-04-16 | 2024-09-05 | Inbiose N.V. | Cellular production of bioproducts |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6027900A (en) * | 1996-04-12 | 2000-02-22 | Carnegie Institution Of Washington | Methods and tools for transformation of eukaryotic algae |
| JP2001095588A (ja) * | 1998-12-04 | 2001-04-10 | Research Institute Of Innovative Technology For The Earth | 緑藻のω３脂肪酸不飽和化酵素遺伝子及びその利用 |
| KR20000075076A (ko) * | 1999-05-28 | 2000-12-15 | 최태진 | 형질전환된 미세조류를 이용하여 외래 단백질을 생산하는 방법 |
| AU2001253699B2 (en) * | 2000-04-21 | 2006-04-27 | Martek Biosciences Corporation | Trophic conversion of obligate phototrophic algae through metabolic engineering |
| US7863020B2 (en) * | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
| US8936930B2 (en) * | 2004-08-05 | 2015-01-20 | Ben-Gurion University Of The Negev Research And Development Authority | Red microalgae expressing exogenous polypeptides and methods of generating and utilizing same |
| JP2010517558A (ja) * | 2007-02-09 | 2010-05-27 | サントル ナショナル ドゥ ラ ルシェルシュ スィヤンティフィック（セーエヌエルエス） | オストレオコッカス（Ｏｓｔｒｅｏｃｏｃｃｕｓ）種の核ゲノムからのポリペプチドの発現 |
-
2008
- 2008-02-12 EP EP08300090A patent/EP2090648A1/en not_active Withdrawn
-
2009
- 2009-02-12 JP JP2010545510A patent/JP5628689B2/ja active Active
- 2009-02-12 US US12/867,279 patent/US8728761B2/en active Active
- 2009-02-12 AU AU2009214077A patent/AU2009214077B2/en active Active
- 2009-02-12 CA CA2715107A patent/CA2715107C/en active Active
- 2009-02-12 PL PL09710039T patent/PL2257618T3/pl unknown
- 2009-02-12 HU HUE09710039 patent/HUE044328T2/hu unknown
- 2009-02-12 WO PCT/EP2009/051672 patent/WO2009101160A1/en not_active Ceased
- 2009-02-12 DK DK09710039.0T patent/DK2257618T3/da active
- 2009-02-12 HR HRP20191222TT patent/HRP20191222T1/hr unknown
- 2009-02-12 EP EP09710039.0A patent/EP2257618B1/en active Active
- 2009-02-12 PT PT09710039T patent/PT2257618T/pt unknown
- 2009-02-12 ES ES09710039T patent/ES2734276T3/es active Active
-
2010
- 2010-08-03 IL IL207381A patent/IL207381A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2090648A1 (en) | 2009-08-19 |
| CA2715107C (en) | 2021-03-09 |
| PT2257618T (pt) | 2019-07-16 |
| AU2009214077B2 (en) | 2014-10-23 |
| WO2009101160A1 (en) | 2009-08-20 |
| PL2257618T3 (pl) | 2020-04-30 |
| IL207381A (en) | 2013-11-28 |
| AU2009214077A1 (en) | 2009-08-20 |
| US20110045533A1 (en) | 2011-02-24 |
| EP2257618B1 (en) | 2019-04-17 |
| IL207381A0 (en) | 2010-12-30 |
| US8728761B2 (en) | 2014-05-20 |
| CA2715107A1 (en) | 2009-08-20 |
| ES2734276T3 (es) | 2019-12-05 |
| HRP20191222T1 (hr) | 2019-10-04 |
| HUE044328T2 (hu) | 2019-10-28 |
| EP2257618A1 (en) | 2010-12-08 |
| JP5628689B2 (ja) | 2014-11-19 |
| JP2011512128A (ja) | 2011-04-21 |
| AU2009214077A2 (en) | 2010-08-26 |
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