DK2252688T3 - Syntetiske phosphodiester-oligonukleotider og terapeutiske anvendelser deraf - Google Patents

Syntetiske phosphodiester-oligonukleotider og terapeutiske anvendelser deraf

Info

Publication number: DK2252688T3
Authority: DK; Denmark
Prior art keywords: phosphodiests; oligonucleotides; synthetic; therapeutic applications; therapeutic
Prior art date: 2008-03-19

Application number

DK09721382.1T

Other languages

English (en)

Inventor

Aaron Cy Stein

Massimo Iacobelli

Original Assignee

Gentium S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-19

Filing date

2009-03-13

Publication date

2017-11-13

2009-03-13 Application filed by Gentium S R L filed Critical Gentium S R L

2017-11-13 Application granted granted Critical

2017-11-13 Publication of DK2252688T3 publication Critical patent/DK2252688T3/da

Links

JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Hematology (AREA)
Immunology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK09721382.1T 2008-03-19 2009-03-13 Syntetiske phosphodiester-oligonukleotider og terapeutiske anvendelser deraf DK2252688T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08425175A EP2103689A1 (en)	2008-03-19	2008-03-19	Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
US5108808P	2008-05-07	2008-05-07
PCT/EP2009/053002 WO2009115465A1 (en)	2008-03-19	2009-03-13	Synthetic phosphodiester oligonucleotides and therapeutical uses thereof

Publications (1)

Publication Number	Publication Date
DK2252688T3 true DK2252688T3 (da)	2017-11-13

Family

ID=39683815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09721382.1T DK2252688T3 (da)	2008-03-19	2009-03-13	Syntetiske phosphodiester-oligonukleotider og terapeutiske anvendelser deraf

Country Status (11)

Country	Link
US (1)	US20110092576A1 (da)
EP (2)	EP2103689A1 (da)
JP (1)	JP2011515357A (da)
KR (1)	KR20100124820A (da)
CN (2)	CN106361763A (da)
AU (1)	AU2009226906B2 (da)
CA (1)	CA2712705C (da)
DK (1)	DK2252688T3 (da)
ES (1)	ES2647772T3 (da)
IL (1)	IL207032A (da)
WO (1)	WO2009115465A1 (da)

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WO2020118165A1 (en)	2018-12-07	2020-06-11	Jazz Pharmaceuticals Ireland Limited	Subcutaneous delivery of high concentration formulations
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2008
- 2008-03-19 EP EP08425175A patent/EP2103689A1/en not_active Withdrawn
2009
- 2009-03-13 JP JP2011500164A patent/JP2011515357A/ja active Pending
- 2009-03-13 CN CN201610647404.9A patent/CN106361763A/zh active Pending
- 2009-03-13 CA CA2712705A patent/CA2712705C/en active Active
- 2009-03-13 WO PCT/EP2009/053002 patent/WO2009115465A1/en not_active Ceased
- 2009-03-13 ES ES09721382.1T patent/ES2647772T3/es active Active
- 2009-03-13 KR KR1020107023194A patent/KR20100124820A/ko not_active Ceased
- 2009-03-13 EP EP09721382.1A patent/EP2252688B1/en active Active
- 2009-03-13 AU AU2009226906A patent/AU2009226906B2/en not_active Ceased
- 2009-03-13 US US12/919,605 patent/US20110092576A1/en not_active Abandoned
- 2009-03-13 CN CN2009801097251A patent/CN101978059A/zh active Pending
- 2009-03-13 DK DK09721382.1T patent/DK2252688T3/da active
2010
- 2010-07-15 IL IL207032A patent/IL207032A/en active IP Right Grant

Also Published As

Publication number	Publication date
EP2252688B1 (en)	2017-08-16
IL207032A0 (en)	2010-12-30
IL207032A (en)	2016-08-31
AU2009226906B2 (en)	2015-05-07
CN106361763A (zh)	2017-02-01
EP2252688A1 (en)	2010-11-24
JP2011515357A (ja)	2011-05-19
CA2712705C (en)	2017-08-15
US20110092576A1 (en)	2011-04-21
CA2712705A1 (en)	2009-09-24
CN101978059A (zh)	2011-02-16
EP2103689A1 (en)	2009-09-23
AU2009226906A1 (en)	2009-09-24
WO2009115465A1 (en)	2009-09-24
ES2647772T3 (es)	2017-12-26
KR20100124820A (ko)	2010-11-29

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