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DK2134339T3 - Præparater, der omfatter (s)-2-amino-1-(4-chlorphenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol som modulator af proteinkinaser - Google Patents

Præparater, der omfatter (s)-2-amino-1-(4-chlorphenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol som modulator af proteinkinaser

Info

Publication number
DK2134339T3
DK2134339T3 DK08719025.2T DK08719025T DK2134339T3 DK 2134339 T3 DK2134339 T3 DK 2134339T3 DK 08719025 T DK08719025 T DK 08719025T DK 2134339 T3 DK2134339 T3 DK 2134339T3
Authority
DK
Denmark
Prior art keywords
chlorphenyl
pyrazol
modulator
phenyl
ethanol
Prior art date
Application number
DK08719025.2T
Other languages
English (en)
Inventor
Steven John Woodhead
David Charles Rees
Martyn Frederickson
Kyla Merriom Grimshaw
Original Assignee
Astex Therapeutics Ltd
Inst Of Cancer Res The Royal Cancer Hospital
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd, Inst Of Cancer Res The Royal Cancer Hospital, Cancer Rec Tech Ltd filed Critical Astex Therapeutics Ltd
Application granted granted Critical
Publication of DK2134339T3 publication Critical patent/DK2134339T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
    • C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK08719025.2T 2007-03-14 2008-03-14 Præparater, der omfatter (s)-2-amino-1-(4-chlorphenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol som modulator af proteinkinaser DK2134339T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89475207P 2007-03-14 2007-03-14
GBGB0704932.3A GB0704932D0 (en) 2007-03-14 2007-03-14 Pharmaceutical compounds
PCT/GB2008/050180 WO2008110846A2 (en) 2007-03-14 2008-03-14 Compositions comprising (s)-2-amino-1-(4-chlorophenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases

Publications (1)

Publication Number Publication Date
DK2134339T3 true DK2134339T3 (da) 2014-11-03

Family

ID=38008428

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08719025.2T DK2134339T3 (da) 2007-03-14 2008-03-14 Præparater, der omfatter (s)-2-amino-1-(4-chlorphenyl)-1-[4-(1h-pyrazol-4-yl)-phenyl]-ethanol som modulator af proteinkinaser

Country Status (23)

Country Link
US (2) US20100113551A1 (da)
EP (2) EP2433632A1 (da)
JP (2) JP2010521446A (da)
KR (1) KR20100014720A (da)
CN (1) CN101686965B (da)
AU (1) AU2008224657B2 (da)
BR (1) BRPI0808802A2 (da)
CA (1) CA2679878A1 (da)
CY (1) CY1115877T1 (da)
DK (1) DK2134339T3 (da)
ES (1) ES2511817T3 (da)
GB (1) GB0704932D0 (da)
HR (1) HRP20141034T1 (da)
IL (1) IL200822A (da)
MX (1) MX2009009874A (da)
NZ (1) NZ579341A (da)
PL (1) PL2134339T3 (da)
PT (1) PT2134339E (da)
RS (1) RS53580B1 (da)
RU (1) RU2527151C2 (da)
SI (1) SI2134339T1 (da)
WO (1) WO2008110846A2 (da)
ZA (1) ZA200906303B (da)

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RU2657832C1 (ru) * 2017-06-07 2018-06-15 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" Антидиабетическое средство
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CN111707830B (zh) * 2020-07-16 2023-08-15 首都医科大学附属北京朝阳医院 Rock激酶活性在辅助诊断肺损害中的应用
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WO2025069008A1 (en) 2023-09-28 2025-04-03 Graviton Bioscience Bv Therapy for treating type 1 diabetes using rock2 and dyrk1 inhibitors
WO2025069009A1 (en) 2023-09-29 2025-04-03 Graviton Bioscience Bv Rock2 inhibitors in the treatment of obesity

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Also Published As

Publication number Publication date
US20110269808A1 (en) 2011-11-03
AU2008224657B2 (en) 2014-06-26
SI2134339T1 (sl) 2014-12-31
JP2015028033A (ja) 2015-02-12
ES2511817T3 (es) 2014-10-23
ZA200906303B (en) 2015-08-26
EP2134339A2 (en) 2009-12-23
MX2009009874A (es) 2009-09-24
US20100113551A1 (en) 2010-05-06
KR20100014720A (ko) 2010-02-10
PL2134339T3 (pl) 2015-04-30
CA2679878A1 (en) 2008-09-18
US8497294B2 (en) 2013-07-30
CN101686965B (zh) 2014-09-17
RU2527151C2 (ru) 2014-08-27
GB0704932D0 (en) 2007-04-25
WO2008110846A2 (en) 2008-09-18
EP2433632A1 (en) 2012-03-28
PT2134339E (pt) 2014-11-03
NZ579341A (en) 2012-08-31
JP2010521446A (ja) 2010-06-24
HRP20141034T1 (hr) 2014-12-19
AU2008224657A1 (en) 2008-09-18
CN101686965A (zh) 2010-03-31
EP2134339B1 (en) 2014-09-17
RS53580B1 (sr) 2015-02-27
HK1133828A1 (en) 2010-04-09
IL200822A0 (en) 2010-05-17
WO2008110846A3 (en) 2009-03-05
RU2009137779A (ru) 2011-05-10
BRPI0808802A2 (pt) 2017-05-02
IL200822A (en) 2016-09-29
CY1115877T1 (el) 2017-01-25

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