DK2129685T3 - Overekspression af foldaser og chaperoner forbedrer proteinfremstilling - Google Patents
Overekspression af foldaser og chaperoner forbedrer proteinfremstillingInfo
- Publication number
- DK2129685T3 DK2129685T3 DK08727098.9T DK08727098T DK2129685T3 DK 2129685 T3 DK2129685 T3 DK 2129685T3 DK 08727098 T DK08727098 T DK 08727098T DK 2129685 T3 DK2129685 T3 DK 2129685T3
- Authority
- DK
- Denmark
- Prior art keywords
- overpression
- chaperones
- protein preparation
- improve protein
- folding axes
- Prior art date
Links
- 102000005431 Molecular Chaperones Human genes 0.000 title 1
- 108010006519 Molecular Chaperones Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6483—Chymosin (3.4.23.4), i.e. rennin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
- C12Y304/23004—Chymosin (3.4.23.4), i.e. rennin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91933207P | 2007-03-21 | 2007-03-21 | |
| PCT/US2008/003802 WO2008115596A2 (en) | 2007-03-21 | 2008-03-21 | Over expression of foldases and chaperones improves protein production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2129685T3 true DK2129685T3 (da) | 2014-02-10 |
Family
ID=39710887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08727098.9T DK2129685T3 (da) | 2007-03-21 | 2008-03-21 | Overekspression af foldaser og chaperoner forbedrer proteinfremstilling |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8546126B2 (da) |
| EP (1) | EP2129685B1 (da) |
| DK (1) | DK2129685T3 (da) |
| WO (1) | WO2008115596A2 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8093016B2 (en) | 2007-05-21 | 2012-01-10 | Danisco Us Inc. | Use of an aspartic protease (NS24) signal sequence for heterologous protein expression |
| MX2010004325A (es) * | 2007-11-01 | 2010-05-20 | Danisco Us Inc | Secuencias de señal y chaperones co-expresados para mejorar produccion de proteinas en una celula hospedera. |
| US9315565B2 (en) | 2009-02-10 | 2016-04-19 | Ucb Pharma, S.A. | Method for producing protein |
| GB0902180D0 (en) * | 2009-02-10 | 2009-03-25 | Ucb Pharma Sa | Method for producing protein |
| GB201018664D0 (en) | 2010-11-05 | 2010-12-22 | Msd Biolog Uk Ltd | Expression process |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| WO2014164727A1 (en) * | 2013-03-12 | 2014-10-09 | Wisconsin Alumni Research Foundation | A method of treating fungal infection |
| CN104694560A (zh) * | 2013-12-04 | 2015-06-10 | 中国科学院天津工业生物技术研究所 | 一种源于里氏木霉的二硫键异构酶基因Trpdi2及其用途 |
| EP4399295A1 (en) * | 2021-09-09 | 2024-07-17 | International N&H Denmark ApS | Over expression of foldases and chaperones improves protein production |
| KR20240094203A (ko) * | 2022-12-15 | 2024-06-25 | 씨제이제일제당 (주) | 트리코더마 속 균주 유래 pdi를 이용하여 재조합 단백질을 생산하는 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1266018T3 (da) * | 2000-03-24 | 2008-09-01 | Genencor Int | Fremstilling af udskilte proteiner af rekombinante, eukaryotiske celler |
| JP2006512891A (ja) * | 2002-04-18 | 2006-04-20 | ジェネンコー・インターナショナル・インク | 糸状菌における機能性抗体の生産 |
| US7226781B1 (en) * | 2003-07-24 | 2007-06-05 | Belyaev Alexander S | Chaperone expression genomes |
| FI120045B (fi) * | 2005-12-22 | 2009-06-15 | Roal Oy | Selluloosamateriaalin käsittely ja siinä käyttökelpoiset entsyymit |
-
2008
- 2008-03-21 WO PCT/US2008/003802 patent/WO2008115596A2/en not_active Ceased
- 2008-03-21 EP EP08727098.9A patent/EP2129685B1/en active Active
- 2008-03-21 DK DK08727098.9T patent/DK2129685T3/da active
- 2008-03-21 US US12/531,030 patent/US8546126B2/en active Active
-
2013
- 2013-08-27 US US14/011,506 patent/US20140087443A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US8546126B2 (en) | 2013-10-01 |
| WO2008115596A2 (en) | 2008-09-25 |
| US20140087443A1 (en) | 2014-03-27 |
| WO2008115596A3 (en) | 2008-11-13 |
| US20100144013A1 (en) | 2010-06-10 |
| EP2129685B1 (en) | 2013-11-20 |
| EP2129685A2 (en) | 2009-12-09 |
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