DK2125026T3 - Sammensætninger baseret på broforbundne polycykliske forbindelser til hæmning og lindring af sygdomme - Google Patents
Sammensætninger baseret på broforbundne polycykliske forbindelser til hæmning og lindring af sygdomme Download PDFInfo
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- DK2125026T3 DK2125026T3 DK08730417.6T DK08730417T DK2125026T3 DK 2125026 T3 DK2125026 T3 DK 2125026T3 DK 08730417 T DK08730417 T DK 08730417T DK 2125026 T3 DK2125026 T3 DK 2125026T3
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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Claims (15)
1. Kemisk sammensætning, der omfatter: en kemisk forbindelse, hvor den kemiske forbindelse omfatter en generel struktur (la) eller (I): (Ia)og/elle
(i) hvor hvert R1 uafhængigt af hinanden er en alkyl-aryl-gruppe, en substitueret alkyl-aryl-gruppe, en alkylgruppe, en substitueret alkylgruppe, en arylgruppe, en substitueret arylgruppe, N, N+H, N+R3, en heterocykelgruppe eller en substitueret heterocykelgruppe; hvor hvert R2 uafhængigt af hinanden er en alkyl-aryl-gruppe, en substitueret alkyl-aryl-gruppe, en alkylgruppe, en substitueret alkylgruppe, en arylgruppe, en substitueret arylgruppe, en heterocykelgruppe eller en substitueret heterocykelgruppe, en kovalent binding eller en alken; hvor hvert R3 uafhængigt af hinanden er hydrogen, et farmaceutisk aktivt middel, en alkyl-aryl-gruppe, en substitueret alkyl-aryl-gruppe, en alkylgruppe, en substitueret alkylgruppe, en arylgruppe, en substitueret arylgruppe, en heterocykelgruppe, en substitueret heterocykelgruppe, en alken, en æter, en guanidindel, en PEG, en PEI eller en hvilken som helst kombination af disse, hvor i det mindste to R3 er farmaceutisk aktive midler, og hvor det farmaceutisk aktive middel er konfigureret til at hæmme og/eller lindre i det mindste en sygdom; hvor hvert R4 uafhængigt af hinanden er en alkyl-aryl-gruppe, en substitueret alkyl-aryl-gruppe, en alkylgruppe, en substitueret alkylgruppe, en arylgruppe, en substitueret arylgruppe, en heterocykelgruppe eller en substitueret heterocykelgruppe, en æter, et amid, en alkohol, et sulfonamid, et sulfanilamid eller en alken; hvor Z omfatter i det mindste en bro, hvor i det mindste en af broerne er -R2 - N+R32 - R4 - N+R32-R2-, -R2-NR3-R4-N+R32-R2-, -R2-NR3-R4-NR3-R2-eller -R2-N=R4=N-R2-, og hvor hver bro uafhængigt af hinanden forbinder R1 med R1; og hvor X omfatter i det mindste en modion.
2. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, der yderligere omfatter en eller flere af det følgende: en eller flere polymeriserbare forbindelser; en prepolymer eller en polymer, for eksempel poly(vinylacetat-co-crotonsyre); i det mindste et opløsningsmiddel, for eksempel vand eller alkohol, for eksempel ætanol; og en farmaceutisk acceptabel viskøs væske, for eksempel glycerin.
3. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, der yderligere omfatter en eller flere polymeriserbare forbindelser, hvor den kemiske sammensætning er konfigureret således, at når den kemiske sammensætning påføres en overflade og hærdes, danner i det mindste en del af sammensætningen en antimikrobiel belægning eller barriere over i det mindste en del af overfladen.
4. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den kemiske forbindelse er et salt af den kemiske forbindelse, der omfatter i det mindste en modion, for eksempel en acetation eller en glukonation.
5. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den kemiske forbindelse har følgende generelle struktur:
6. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav 1 til 4, hvor den kemiske forbindelse har følgende generelle struktur:
1 104b hvor R1 er N, R2 er -(CH2)2-, R4 er -CH2-C6H4-CH2- og R3 er et farmaceutisk aktivt middel, der er:
hvor n er 0 til 12, og X omfatter et sukker eller et kulhydrat.
7. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor i det mindste et R4 er
8. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor i det mindste et R3 omfatter en halogeneret aryldel.
9. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor i det mindste et X er en polymer, en monomer, en anion, et halogen, indeholder bor eller indeholder for eksempel kvælstof, hvor i det mindste et X er et hexafluorfosfat, et bis(trifluormethansulfonyl)imid, et nitrat eller et borat, for eksempel et tetrafluorborat.
10. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor i det mindste et af de farmaceutisk aktive midler er et antiviralt middel, et antiinflammatorisk middel eller et antimikrobielt middel, for eksempel et middel mod periodontal sygdom, en hæmmer mod ophobning af periodontale bakterier, en hæmmer mod en periodontal sygdoms enzym, en hæmmer mod ophobning afen periodontal sygdoms enzym.
11. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor i det mindste et af de farmaceutisk aktive midler er en FORL-hæmmer (FORL = feline odontoklastiske resorptionslæsioner) eller en hæmmer af periodontal stomatitis.
12. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den kemiske forbindelse omfatter en generel struktur
hvor R3=
13. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav til anvendelse som et medikament til behandling af en oral sygdom eller en øresygdom eller en topisk sygdom hos en patient.
14. Kemisk sammensætning ifølge krav 13, hvor den kemiske sammensætning er konfigureret til at påføres, som i det mindste en del af en farmaceutisk acceptabel formulering, på en overflade, der er: en oral overflade, såsom i det mindste en del af en tandoverflade, i det mindste en del af et tandkød, i det mindste en del af blødvæv og/eller i det mindste en del af en dentalfikstur, såsom en fyldning og/eller i det mindste en del afen bro og/eller i det mindste en del af tandprotese, hvor medikamentet anvendes til behandlingen afen oral sygdom; en øreoverflade, hvor medikamentet anvendes til behandlingen afen øresygdom, for eksempel øremider eller øreinfektioner; eller en topisk overflade, hvor medikamentet eller den medicinske anordning anvendes til behandlingen af en sygdom, for eksempel til behandling af bakterieinfektion, svampeinfektion eller virusinfektion.
15. Kemisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den orale sygdom, øresygdommen eller den topiske sygdom er en svampeinfektion, en infektion, en virusinfektion, en sygdom, der er bakteriebaseret, mikrobebaseret, skimmelsvampbaseret, gærbaseret og/eller hidrører fra et parasitangreb på en patient. 7
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90257707P | 2007-02-21 | 2007-02-21 | |
| US96431207P | 2007-08-10 | 2007-08-10 | |
| US96515407P | 2007-08-17 | 2007-08-17 | |
| US2933208P | 2008-02-16 | 2008-02-16 | |
| PCT/US2008/054611 WO2008103847A2 (en) | 2007-02-21 | 2008-02-21 | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2125026T3 true DK2125026T3 (da) | 2014-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08730417.6T DK2125026T3 (da) | 2007-02-21 | 2008-02-21 | Sammensætninger baseret på broforbundne polycykliske forbindelser til hæmning og lindring af sygdomme |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8222239B2 (da) |
| EP (1) | EP2125026B1 (da) |
| AU (1) | AU2008218275B2 (da) |
| CA (1) | CA2683383C (da) |
| DK (1) | DK2125026T3 (da) |
| ES (1) | ES2522908T3 (da) |
| NZ (1) | NZ579785A (da) |
| WO (1) | WO2008103847A2 (da) |
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| WO2008103847A2 (en) | 2007-02-21 | 2008-08-28 | Allaccem, Incorporated | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease |
| US8188068B2 (en) | 2007-08-10 | 2012-05-29 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in pets |
| US8153618B2 (en) | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for topical applications for pets |
| US8153617B2 (en) | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in humans |
| US8766004B2 (en) | 2010-01-13 | 2014-07-01 | The Research Foundation Of State University Of New York | Green synthesis of aryl aldimines using ethyl lactate |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CH707030B1 (de) | 2011-10-21 | 2015-03-13 | Abbvie Inc | Kombinationsbehandlung von DAAs zur Verwendung in der Behandlung von HCV |
| ES2529143B1 (es) | 2011-10-21 | 2015-10-26 | Abbvie Inc. | Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| EP3448392A4 (en) | 2016-04-28 | 2020-01-15 | Emory University | ALKYNOUS THERAPEUTIC NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND RELATED APPLICATIONS |
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2008
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- 2008-02-21 AU AU2008218275A patent/AU2008218275B2/en active Active
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|---|---|
| CA2683383A1 (en) | 2008-08-28 |
| CA2683383C (en) | 2016-01-05 |
| AU2008218275B2 (en) | 2013-06-20 |
| EP2125026A2 (en) | 2009-12-02 |
| US20080275141A1 (en) | 2008-11-06 |
| US8222239B2 (en) | 2012-07-17 |
| AU2008218275A1 (en) | 2008-08-28 |
| NZ579785A (en) | 2012-06-29 |
| EP2125026B1 (en) | 2014-09-24 |
| US20130040924A1 (en) | 2013-02-14 |
| WO2008103847A2 (en) | 2008-08-28 |
| US9994444B2 (en) | 2018-06-12 |
| WO2008103847A3 (en) | 2008-11-20 |
| ES2522908T3 (es) | 2014-11-19 |
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