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DK2178900T3 - Oprensning af pegylerede polypeptider - Google Patents

Oprensning af pegylerede polypeptider

Info

Publication number
DK2178900T3
DK2178900T3 DK08784775.2T DK08784775T DK2178900T3 DK 2178900 T3 DK2178900 T3 DK 2178900T3 DK 08784775 T DK08784775 T DK 08784775T DK 2178900 T3 DK2178900 T3 DK 2178900T3
Authority
DK
Denmark
Prior art keywords
pegyled
polypeptides
purification
pegyled polypeptides
Prior art date
Application number
DK08784775.2T
Other languages
English (en)
Inventor
Josef Burg
Klaus Reichert
Axel Schroth
Hartmut Schurig
Axel Wessner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40120288&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2178900(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK2178900T3 publication Critical patent/DK2178900T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK08784775.2T 2007-07-17 2008-07-15 Oprensning af pegylerede polypeptider DK2178900T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07013959 2007-07-17
PCT/EP2008/005767 WO2009010270A2 (en) 2007-07-17 2008-07-15 Reinigung pegylierter polypeptide

Publications (1)

Publication Number Publication Date
DK2178900T3 true DK2178900T3 (da) 2012-06-25

Family

ID=40120288

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08784775.2T DK2178900T3 (da) 2007-07-17 2008-07-15 Oprensning af pegylerede polypeptider

Country Status (21)

Country Link
US (2) US8138317B2 (da)
EP (1) EP2178900B1 (da)
JP (2) JP5307808B2 (da)
KR (1) KR101163297B1 (da)
CN (1) CN101889023B (da)
AR (2) AR067537A1 (da)
AT (1) ATE556086T1 (da)
AU (1) AU2008277887B2 (da)
BR (1) BRPI0813830A2 (da)
CA (1) CA2692612C (da)
CL (1) CL2008002053A1 (da)
DK (1) DK2178900T3 (da)
ES (1) ES2386323T3 (da)
IL (1) IL202940A (da)
PE (1) PE20090823A1 (da)
PL (1) PL2178900T3 (da)
PT (1) PT2178900E (da)
RU (1) RU2476439C2 (da)
TW (1) TWI363060B (da)
WO (1) WO2009010270A2 (da)
ZA (1) ZA201000283B (da)

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CL2008002053A1 (es) * 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
AR067536A1 (es) * 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
US20120172299A1 (en) * 2008-09-23 2012-07-05 F. Hoffmann-La Roche Ag Purification of erythropoietin
WO2011035282A1 (en) * 2009-09-21 2011-03-24 Ge Healthcare Bio-Sciences Ab Dual capture separation
ES2500048T3 (es) * 2010-09-14 2014-09-29 F. Hoffmann-La Roche Ag Procedimiento para purificar eritropoyetina pegilada
CN102816227A (zh) * 2012-08-30 2012-12-12 深圳赛保尔生物药业有限公司 回收促红细胞生成素的方法
CN105820232B (zh) * 2016-04-08 2019-05-17 昂德生物药业有限公司 单修饰聚乙二醇重组人促红素的制备方法及其制品和应用
CN109415427A (zh) * 2016-07-15 2019-03-01 豪夫迈·罗氏有限公司 用于纯化聚乙二醇化的促红细胞生成素的方法
US12208142B2 (en) 2017-12-29 2025-01-28 Hoffmann-La Roche Inc. Process for providing PEGylated protein composition
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CN113301922A (zh) * 2018-11-05 2021-08-24 百时美施贵宝公司 用于纯化聚乙二醇化蛋白的方法
WO2021072210A1 (en) * 2019-10-11 2021-04-15 Coherus Biosciences, Inc. Methods of purifying ranibizumab or a ranibizumab variant

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Also Published As

Publication number Publication date
ES2386323T3 (es) 2012-08-17
JP2013189457A (ja) 2013-09-26
KR20100072169A (ko) 2010-06-30
RU2476439C2 (ru) 2013-02-27
CN101889023B (zh) 2013-03-20
WO2009010270A3 (en) 2009-04-30
TW200914463A (en) 2009-04-01
RU2010105303A (ru) 2011-08-27
BRPI0813830A2 (pt) 2015-01-06
JP5307808B2 (ja) 2013-10-02
IL202940A (en) 2015-07-30
PT2178900E (pt) 2012-06-01
ZA201000283B (en) 2011-06-29
US20110118448A1 (en) 2011-05-19
EP2178900A2 (en) 2010-04-28
WO2009010270A2 (en) 2009-01-22
CL2008002053A1 (es) 2009-05-22
CA2692612A1 (en) 2009-01-22
JP5814978B2 (ja) 2015-11-17
CN101889023A (zh) 2010-11-17
KR101163297B1 (ko) 2012-07-05
ATE556086T1 (de) 2012-05-15
EP2178900B1 (en) 2012-05-02
TWI363060B (en) 2012-05-01
AU2008277887B2 (en) 2012-12-13
US8889837B2 (en) 2014-11-18
AR067537A1 (es) 2009-10-14
AU2008277887A1 (en) 2009-01-22
CA2692612C (en) 2015-02-10
WO2009010270A8 (en) 2010-04-29
US8138317B2 (en) 2012-03-20
PL2178900T3 (pl) 2012-10-31
US20090118476A1 (en) 2009-05-07
AR112300A2 (es) 2019-10-16
JP2010533664A (ja) 2010-10-28
PE20090823A1 (es) 2009-06-27

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