DK2170857T3 - 3',4',5-trimethoxyflavonderivater som stimulerende middel ved slimafsondring, tilsvarende fremgangsmåde og farmaceutisk præparat, der indeholder disse - Google Patents
3',4',5-trimethoxyflavonderivater som stimulerende middel ved slimafsondring, tilsvarende fremgangsmåde og farmaceutisk præparat, der indeholder disseInfo
- Publication number
- DK2170857T3 DK2170857T3 DK08766040.3T DK08766040T DK2170857T3 DK 2170857 T3 DK2170857 T3 DK 2170857T3 DK 08766040 T DK08766040 T DK 08766040T DK 2170857 T3 DK2170857 T3 DK 2170857T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical composition
- trimethoxyflavone
- stimulants
- derivatives
- composition containing
- Prior art date
Links
- IIOQEHSFZUYICM-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-methoxychromen-4-one Chemical class C1=C(OC)C(OC)=CC=C1C1=CC(=O)C2=C(OC)C=CC=C2O1 IIOQEHSFZUYICM-UHFFFAOYSA-N 0.000 title abstract 3
- 210000003097 mucus Anatomy 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000021 stimulant Substances 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 2
- 206010013774 Dry eye Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000028006 Corneal injury Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 210000000795 conjunctiva Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020070055427A KR100930467B1 (ko) | 2007-06-07 | 2007-06-07 | 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도 |
| PCT/KR2008/003078 WO2008150085A2 (en) | 2007-06-07 | 2008-06-02 | 3',4',5-trimethoxy flavone derivatives as stimulant of mucus secretion, method of the same, and pharmaceutical composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2170857T3 true DK2170857T3 (da) | 2011-12-05 |
Family
ID=40094296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08766040.3T DK2170857T3 (da) | 2007-06-07 | 2008-06-02 | 3',4',5-trimethoxyflavonderivater som stimulerende middel ved slimafsondring, tilsvarende fremgangsmåde og farmaceutisk præparat, der indeholder disse |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8203011B2 (da) |
| EP (1) | EP2170857B1 (da) |
| JP (1) | JP5295230B2 (da) |
| KR (1) | KR100930467B1 (da) |
| CN (1) | CN101679341B (da) |
| AT (1) | ATE529417T1 (da) |
| AU (1) | AU2008260829B2 (da) |
| BR (1) | BRPI0812494A2 (da) |
| CA (1) | CA2689136C (da) |
| DK (1) | DK2170857T3 (da) |
| ES (1) | ES2375184T3 (da) |
| MX (1) | MX2009013062A (da) |
| PT (1) | PT2170857E (da) |
| WO (1) | WO2008150085A2 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2182801A4 (en) * | 2007-07-31 | 2011-04-13 | Limerick Biopharma Inc | COMPOSITIONS OF PYRONE ANALOGS AND METHODS |
| WO2010129138A2 (en) * | 2009-04-27 | 2010-11-11 | Limerick Biopharma | Phosphorylated and phosphonated pyrone analogs for therapeutic treatment |
| CN102796066B (zh) * | 2012-08-31 | 2014-09-03 | 云南民族大学 | 一种黄酮类化合物及其制备方法与应用 |
| CN103059005B (zh) * | 2012-11-22 | 2015-04-22 | 中南民族大学 | 白杨素酰胺衍生物及其医药用途 |
| WO2017033060A1 (en) * | 2015-08-24 | 2017-03-02 | University Of Macau | Composition for treating dry eye diseases and sjögren's syndrome |
| CN107373745B (zh) * | 2017-07-28 | 2020-04-03 | 云南中烟工业有限责任公司 | 一种防止烟草料液腐败变质的添加剂及其应用 |
| KR102040810B1 (ko) * | 2018-01-31 | 2019-11-05 | 인제대학교 산학협력단 | 알파-휴물렌을 유효성분으로 함유하는 안구 건조증 예방 또는 치료용 조성물 |
| KR102685191B1 (ko) * | 2021-07-26 | 2024-07-15 | 동아제약 주식회사 | 레코플라본 또는 이의 염을 포함하는 피부개선용 화장료 조성물 |
| JP2024528234A (ja) | 2021-08-05 | 2024-07-26 | ジーエル・ファームテック・コーポレイション | レコフラボン（ｒｅｃｏｆｌａｖｏｎｅ）を含有するドライアイ症候群を処置するための点眼組成物及びそれを製造するための方法 |
| CN117794515A (zh) | 2021-08-05 | 2024-03-29 | 格里医药科技公司 | 用于治疗干眼综合征的包含瑞可黄酮的滴眼剂组合物及其制备方法 |
| KR102356603B1 (ko) | 2021-08-05 | 2022-02-08 | 지엘팜텍주식회사 | 안구건조증 치료를 위한 레코플라본 함유 점안 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA873745B (en) | 1986-06-04 | 1988-10-26 | Daiichi Seiyaku Co | Benzopyran derivatives |
| DE3628590A1 (de) * | 1986-08-22 | 1988-02-25 | Musikon Gmbh | Raumeinheit fuer die aufnahme und/oder wiedergabe von akustischen signalen |
| US5006550A (en) * | 1989-12-29 | 1991-04-09 | Allergan, Inc. | Chroman esters of phenols and benzoic acids having retinoid-like activity |
| KR100447918B1 (ko) * | 1996-07-25 | 2005-09-28 | 동아제약주식회사 | 대장을포함한위장관보호작용을갖는플라본및플라바논화합물 |
| FR2753969B1 (fr) * | 1996-09-27 | 1998-10-30 | Adir | Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP3957795B2 (ja) | 1996-10-04 | 2007-08-15 | 興和株式会社 | フラボン誘導体及びこれを含有する医薬 |
| JPH11279062A (ja) * | 1998-01-30 | 1999-10-12 | Fujisawa Pharmaceut Co Ltd | 眼科用剤 |
| KR100327621B1 (ko) | 1999-09-22 | 2002-03-15 | 유충식 | 7-카르복시메틸옥시-3',4',5-트리메톡시플라본의 제조방법 |
| JP2001233775A (ja) * | 2000-02-28 | 2001-08-28 | Cci Corp | 涙液分泌促進剤 |
| KR20050024121A (ko) * | 2003-09-04 | 2005-03-10 | 동아제약주식회사 | 7-카르복시메틸옥시-3',4',5-트리메톡시 플라본.일수화물, 이의 제조방법 및 용도 |
| US8017649B2 (en) | 2005-03-11 | 2011-09-13 | Howard Florey Institute Of Experimental Physiology And Medicine | Flavonoid compounds and uses thereof |
| EP2444079B1 (en) * | 2005-05-17 | 2016-11-30 | SARcode Bioscience Inc. | Compositions and Methods for Treatment of Eye Disorders |
-
2007
- 2007-06-07 KR KR1020070055427A patent/KR100930467B1/ko active Active
-
2008
- 2008-06-02 DK DK08766040.3T patent/DK2170857T3/da active
- 2008-06-02 US US12/451,902 patent/US8203011B2/en not_active Expired - Fee Related
- 2008-06-02 CA CA2689136A patent/CA2689136C/en not_active Expired - Fee Related
- 2008-06-02 PT PT08766040T patent/PT2170857E/pt unknown
- 2008-06-02 CN CN2008800190634A patent/CN101679341B/zh not_active Expired - Fee Related
- 2008-06-02 EP EP08766040A patent/EP2170857B1/en active Active
- 2008-06-02 AT AT08766040T patent/ATE529417T1/de active
- 2008-06-02 JP JP2010511105A patent/JP5295230B2/ja not_active Expired - Fee Related
- 2008-06-02 BR BRPI0812494-9A patent/BRPI0812494A2/pt not_active IP Right Cessation
- 2008-06-02 AU AU2008260829A patent/AU2008260829B2/en not_active Ceased
- 2008-06-02 WO PCT/KR2008/003078 patent/WO2008150085A2/en not_active Ceased
- 2008-06-02 MX MX2009013062A patent/MX2009013062A/es active IP Right Grant
- 2008-06-02 ES ES08766040T patent/ES2375184T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0812494A2 (pt) | 2015-06-16 |
| CA2689136C (en) | 2012-11-13 |
| EP2170857A4 (en) | 2010-06-23 |
| US8203011B2 (en) | 2012-06-19 |
| ATE529417T1 (de) | 2011-11-15 |
| JP5295230B2 (ja) | 2013-09-18 |
| KR100930467B1 (ko) | 2009-12-08 |
| PT2170857E (pt) | 2011-12-12 |
| AU2008260829B2 (en) | 2012-11-08 |
| WO2008150085A2 (en) | 2008-12-11 |
| CA2689136A1 (en) | 2008-12-11 |
| CN101679341B (zh) | 2012-06-06 |
| US20100130448A1 (en) | 2010-05-27 |
| EP2170857B1 (en) | 2011-10-19 |
| KR20080107542A (ko) | 2008-12-11 |
| ES2375184T3 (es) | 2012-02-27 |
| CN101679341A (zh) | 2010-03-24 |
| JP2010529112A (ja) | 2010-08-26 |
| AU2008260829A1 (en) | 2008-12-11 |
| MX2009013062A (es) | 2010-01-18 |
| WO2008150085A3 (en) | 2009-02-26 |
| EP2170857A2 (en) | 2010-04-07 |
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