[go: up one dir, main page]

DK2158331T3 - Nye polymorfier i ABCB1 i sammenhæng med mangel på klinisk respons over for lægemidler - Google Patents

Nye polymorfier i ABCB1 i sammenhæng med mangel på klinisk respons over for lægemidler

Info

Publication number
DK2158331T3
DK2158331T3 DK08759217T DK08759217T DK2158331T3 DK 2158331 T3 DK2158331 T3 DK 2158331T3 DK 08759217 T DK08759217 T DK 08759217T DK 08759217 T DK08759217 T DK 08759217T DK 2158331 T3 DK2158331 T3 DK 2158331T3
Authority
DK
Denmark
Prior art keywords
abcb1
drugs
lack
context
clinical response
Prior art date
Application number
DK08759217T
Other languages
English (en)
Inventor
Florian Holsboer
Manfred Uhr
Bertram Mueller-Myhsok
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK2158331T3 publication Critical patent/DK2158331T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK08759217T 2007-06-12 2008-06-12 Nye polymorfier i ABCB1 i sammenhæng med mangel på klinisk respons over for lægemidler DK2158331T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94333507P 2007-06-12 2007-06-12
PCT/EP2008/004737 WO2008151803A2 (en) 2007-06-12 2008-06-12 New polymorphisms in abcb1 associated with a lack of clinical response to medicaments

Publications (1)

Publication Number Publication Date
DK2158331T3 true DK2158331T3 (da) 2012-12-17

Family

ID=39735268

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12179060T DK2520670T3 (da) 2007-06-12 2008-06-12 Nye polymorphier i ABCB1 forbundet med en mangel på klinisk respons over for lægemidler
DK08759217T DK2158331T3 (da) 2007-06-12 2008-06-12 Nye polymorfier i ABCB1 i sammenhæng med mangel på klinisk respons over for lægemidler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK12179060T DK2520670T3 (da) 2007-06-12 2008-06-12 Nye polymorphier i ABCB1 forbundet med en mangel på klinisk respons over for lægemidler

Country Status (6)

Country Link
US (2) US9115398B2 (da)
EP (2) EP2520670B1 (da)
DK (2) DK2520670T3 (da)
ES (2) ES2456919T3 (da)
PL (2) PL2520670T3 (da)
WO (1) WO2008151803A2 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110016546A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Porcine genome editing with zinc finger nucleases
US20110023144A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
US20110023143A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of neurodevelopmental genes in animals
US20110023154A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Silkworm genome editing with zinc finger nucleases
US20110023147A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of prion disorder-related genes in animals
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
US20110016540A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
US20110023139A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in cardiovascular disease
US20110023148A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of addiction-related genes in animals
US20110023141A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved with parkinson's disease
US20110023145A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in autism spectrum disorders
US20110023149A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in tumor suppression in animals
US20110023140A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Rabbit genome editing with zinc finger nucleases
US20110023151A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of abc transporters
US20110023158A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Bovine genome editing with zinc finger nucleases
US20110016541A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genome editing of sensory-related genes in animals
US20110023153A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in alzheimer's disease
US20110023152A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of cognition related genes in animals
US20110023150A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of genes associated with schizophrenia in animals
US20110030072A1 (en) * 2008-12-04 2011-02-03 Sigma-Aldrich Co. Genome editing of immunodeficiency genes in animals
US20110023146A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in secretase-associated disorders
US20110016539A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genome editing of neurotransmission-related genes in animals
US20110023156A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Feline genome editing with zinc finger nucleases
US20130316391A1 (en) * 2010-12-29 2013-11-28 Sigmaaldrich Co., LLC Cells having disrupted expression of proteins involved in adme and toxicology processes
WO2012103060A1 (en) * 2011-01-27 2012-08-02 Glaxo Wellcome Manufacturing Pte Ltd Method of administration and treatment
CN102912003A (zh) * 2011-08-02 2013-02-06 广州益善生物技术有限公司 一种abcb1基因多态性检测特异性引物和液相芯片
GB201210686D0 (en) * 2012-06-15 2012-08-01 Holsboermaschmeyer Neurochemie Gmbh V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
US11694539B2 (en) * 2020-06-16 2023-07-04 Heartware, Inc. Notification system for low-level preventative LVAD alerts
CN113584160A (zh) * 2021-06-15 2021-11-02 湖南菲思特精准医疗科技有限公司 一种昂司丹琼代谢标志物检测试剂盒及其检测方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2002329A3 (cs) 1999-07-30 2002-07-17 Epidauros Biotechnologie Aktiengesellschaft Polymorfismy v lidském genu MDR-1 a jejich pouľití v diagnostických a terapeutických aplikacích
US7034036B2 (en) 2000-10-30 2006-04-25 Pain Therapeutics, Inc. Inhibitors of ABC drug transporters at the blood-brain barrier
EP1756310B1 (en) 2004-05-12 2012-12-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for detecting polymorphisms in the ABCB1 gene associated with a lack of response to a CNS-active medicament and medicament comprising an ABCB1 inhibitor for use in the treatment of CNS related diseases.

Also Published As

Publication number Publication date
EP2520670A1 (en) 2012-11-07
WO2008151803A3 (en) 2009-02-26
PL2158331T3 (pl) 2013-01-31
EP2520670B1 (en) 2014-02-26
DK2520670T3 (da) 2014-05-26
EP2158331A2 (en) 2010-03-03
US20100184742A1 (en) 2010-07-22
PL2520670T3 (pl) 2014-07-31
US9901582B2 (en) 2018-02-27
ES2456919T3 (es) 2014-04-24
US20160067262A1 (en) 2016-03-10
ES2394529T3 (es) 2013-02-01
US9115398B2 (en) 2015-08-25
WO2008151803A2 (en) 2008-12-18
EP2158331B1 (en) 2012-08-29

Similar Documents

Publication Publication Date Title
DK2158331T3 (da) Nye polymorfier i ABCB1 i sammenhæng med mangel på klinisk respons over for lægemidler
CY2020008I2 (el) Φαρμακοτεχνικες μορφες διστρωματικου δισκιου
MA30236B1 (fr) Nouvelle composition pharmaceutique
DK3470077T3 (da) Fremgangsmåde til forudsigelse af respons på behandling af sygdomme med farmakologiske chaperoner
EP2191826A4 (en) PHARMACEUTICAL COMPOSITION
DK2236598T3 (da) Mikroorganismer til forbedring af helbredet hos individer med lidelser i forbindelse med fordøjelse af gluten
EP2132133A4 (en) RELEASE OF PARTICULATE ACTIVE SUBSTANCES
BRPI1009324A2 (pt) compostos e/ou farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e respectivos usos
ATE553084T1 (de) Polycyclische säureverbindungen als crth2- antagonisten und antiallergika
DK2442790T3 (da) Vandige farmaceutiske sammensætninger, indeholdende borat-polyolkomplekser
DK2421879T3 (da) Nye 7-deazapurinnukleotider til terapeutiske anvendelser
EP2620154A4 (en) MEDICAMENT AGAINST IGNITION OF THE CENTRAL NERVOUS SYSTEM
EP2116242A4 (en) NEW PHARMACEUTICAL COMPOSITION
EP2323515A4 (en) CONTAINER HOLDER WITH FIXING AGENTS
EP2301525A4 (en) TOPICAL IBUPROFEN FORMULATION
EE201300007A (et) Kombineeritud ravimkoostis diabeedi ning ainevahetush„irete raviks
EP2069541A4 (en) POLYMORPHISMS IN GENES WITH INFLUENCE ON DISEASES OF THE CENTRAL NERVOUS SYSTEM AND ITS APPLICATIONS
EP2627427A4 (en) THINNING / DETERGENT CHEST WITH SPIRAL PERIPHERALS
EP2394648A4 (en) PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
FR2933987B1 (fr) Procede d'hydrogenation du benzene
DE06722936T8 (de) Isomerisation pharmazeutischer zwischenprodukte
ATE512137T1 (de) Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors
EP2465512A4 (en) PAIN-SUBJECTIVE PHARMACEUTICAL COMPOSITION
EP2411542A4 (en) POLYMORPHISM IN THE CYP3A4 GENE WITH EFFECT ON THE ACTIVE METABOLISM AND ITS USE
BRPI1010256A2 (pt) "aplicações terapêuticas no domínio cardiovascular de derivados de quinazolina diona."