DK2035548T3 - Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse - Google Patents
Vurdering af embryokvalitet på basis af blastomer deling og bevævgelseInfo
- Publication number
- DK2035548T3 DK2035548T3 DK07722668.6T DK07722668T DK2035548T3 DK 2035548 T3 DK2035548 T3 DK 2035548T3 DK 07722668 T DK07722668 T DK 07722668T DK 2035548 T3 DK2035548 T3 DK 2035548T3
- Authority
- DK
- Denmark
- Prior art keywords
- determining
- division period
- embryo quality
- inter
- extent
- Prior art date
Links
- 210000001161 mammalian embryo Anatomy 0.000 title abstract 4
- 230000032823 cell division Effects 0.000 abstract 4
- 230000001413 cellular effect Effects 0.000 abstract 3
- 210000003463 organelle Anatomy 0.000 abstract 3
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Pregnancy & Childbirth (AREA)
- Surgery (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Computer Hardware Design (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81411506P | 2006-06-16 | 2006-06-16 | |
| DKPA200600821 | 2006-06-16 | ||
| PCT/DK2006/000581 WO2007042044A1 (en) | 2005-10-14 | 2006-10-16 | Determination of a change in a cell population |
| DKPA200700571 | 2007-04-19 | ||
| PCT/DK2007/000291 WO2007144001A2 (en) | 2006-06-16 | 2007-06-15 | Embryo quality assessment based on blastomere division and movement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2035548T3 true DK2035548T3 (da) | 2010-11-22 |
Family
ID=43414894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07722668.6T DK2035548T3 (da) | 2006-06-16 | 2007-06-15 | Vurdering af embryokvalitet på basis af blastomer deling og bevævgelse |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20100041090A1 (da) |
| EP (2) | EP2282210A1 (da) |
| JP (2) | JP5731748B2 (da) |
| CN (2) | CN103074410B (da) |
| AT (1) | ATE477499T1 (da) |
| DE (1) | DE602007008419D1 (da) |
| DK (1) | DK2035548T3 (da) |
| WO (1) | WO2007144001A2 (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102254150A (zh) | 2005-10-14 | 2011-11-23 | 尤尼森斯繁殖技术公司 | 细胞群的变化的测定 |
| CN101802166B (zh) | 2007-06-29 | 2013-12-11 | 尤尼森斯繁殖技术公司 | 用于监测和/或培养显微对象的设备、系统和方法 |
| GB0719037D0 (en) | 2007-09-28 | 2007-11-07 | Vitrolife Sweden Ab | Sampling needle |
| ES2664744T3 (es) * | 2008-07-05 | 2018-04-23 | Unisense Fertilitech A/S | Sistema de identificación individual |
| NZ598293A (en) | 2009-08-22 | 2014-06-27 | Univ Leland Stanford Junior | Imaging and evaluating embryos, oocytes, and stem cells |
| GB201006046D0 (en) * | 2010-04-12 | 2010-05-26 | Ge Healthcare Uk Ltd | System and method for determining motion of a biological object |
| JP5962828B2 (ja) * | 2010-06-30 | 2016-08-03 | 大日本印刷株式会社 | 体外培養による胚の製造方法、並びに胚を選別するための方法、装置、及びシステム |
| JP5807288B2 (ja) * | 2010-06-30 | 2015-11-10 | 大日本印刷株式会社 | 体外培養による胚の製造方法、並びに胚を選別するための方法、装置、及びシステム |
| WO2012047678A2 (en) | 2010-09-27 | 2012-04-12 | Auxogyn, Inc. | Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes, and stem cells |
| RU2441243C1 (ru) * | 2010-11-12 | 2012-01-27 | Федеральное государственное учреждение "Ивановский научно-исследовательский институт материнства и детства имени В.Н. Городкова" Министерства здравоохранения и социального развития Российской Федерации | Способ прогнозирования качества эмбриона при проведении эко у женщин с бесплодием |
| GR1007617B (el) * | 2011-01-24 | 2012-06-20 | Ιδρυμα Τεχνολογιας Και Ερευνας - Ιτε, | Χρηση μη-γραμμικων απεικονιστικων τεχνικων για την αξιολογηση της ποιοτητας εμβρυων προεμφυτευτικου σταδιου και την προωθηση επιτυχους εγκυμοσυνης |
| CN103460038A (zh) | 2011-02-23 | 2013-12-18 | 里兰斯坦福初级大学理事会 | 检测人类胚胎中的非整倍性的方法 |
| WO2012163363A1 (en) | 2011-05-31 | 2012-12-06 | Unisense Fertilitech A/S | Embryo quality assessment based on blastomere cleavage and morphology |
| WO2013004239A1 (en) | 2011-07-02 | 2013-01-10 | Unisense Fertilitech A/S | Adaptive embryo selection criteria optimized through iterative customization and collaboration |
| US20140017717A1 (en) * | 2012-05-31 | 2014-01-16 | Auxogyn, Inc. | In vitro embryo blastocyst prediction methods |
| AU2013269608B2 (en) | 2012-05-31 | 2016-05-05 | Unisense Fertilitech A/S | Embryo quality assessment based on blastocyst development |
| US20150169842A1 (en) * | 2012-06-25 | 2015-06-18 | Unisense Fertilitech A/S | Method and apparatus |
| CN110688985A (zh) * | 2012-08-30 | 2020-01-14 | 尤尼森斯繁殖技术公司 | 体外培养胚胎的自动化监控 |
| WO2014121200A1 (en) | 2013-02-01 | 2014-08-07 | Auxogyn, Inc. | Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential |
| US9542591B2 (en) | 2013-02-28 | 2017-01-10 | Progyny, Inc. | Apparatus, method, and system for automated, non-invasive cell activity tracking |
| JP2014193145A (ja) * | 2013-03-01 | 2014-10-09 | Naoki Yamashita | 胚盤胞培養液中のノルエピネフリン量によるヒト胚盤胞の評価方法 |
| EP3011047B1 (en) * | 2013-06-18 | 2018-08-01 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for determining the quality of an embryo |
| US10942170B2 (en) | 2014-03-20 | 2021-03-09 | Ares Trading S.A. | Quantitative measurement of human blastocyst and morula morphology developmental kinetics |
| WO2015192352A1 (zh) * | 2014-06-19 | 2015-12-23 | 湖南光琇高新生命科技有限公司 | 一种根据分裂行为对体外受精治疗胚胎进行评估的等级分类方法 |
| US10510143B1 (en) | 2015-09-21 | 2019-12-17 | Ares Trading S.A. | Systems and methods for generating a mask for automated assessment of embryo quality |
| US11494578B1 (en) * | 2015-09-21 | 2022-11-08 | Ares Trading S.A. | Systems and methods for automated assessment of embryo quality using image based features |
| JP2018014991A (ja) * | 2016-07-13 | 2018-02-01 | ソニー株式会社 | 情報処理装置、情報処理方法及び情報処理システム |
| JP2018022216A (ja) * | 2016-08-01 | 2018-02-08 | ソニー株式会社 | 情報処理装置、情報処理方法、及びプログラム |
| US11282201B2 (en) | 2016-11-02 | 2022-03-22 | Sony Corporation | Information processing device, information processing method and information processing system |
| JP6977293B2 (ja) * | 2017-03-31 | 2021-12-08 | ソニーグループ株式会社 | 情報処理装置、情報処理方法、プログラム及び観察システム |
| JP7100431B2 (ja) * | 2017-07-14 | 2022-07-13 | 株式会社ニコン | 受精卵判定装置、受精卵判定システム、及び受精卵判定プログラム |
| US20210198605A1 (en) | 2017-10-26 | 2021-07-01 | Sony Corporation | Information processing apparatus, information processing method, program, and observation system |
| JP6732722B2 (ja) * | 2017-12-11 | 2020-08-05 | 憲隆 福永 | 胚選抜システム |
| JP2020036580A (ja) * | 2018-06-20 | 2020-03-12 | Jcrファーマ株式会社 | 初期胚を選別するための解析ソフトウエア及び装置 |
| GB201810634D0 (en) | 2018-06-28 | 2018-08-15 | Vitrolife As | Methods and apparatus for assessing embryo development |
| CN109214437A (zh) * | 2018-08-22 | 2019-01-15 | 湖南自兴智慧医疗科技有限公司 | 一种基于机器学习的ivf-et早孕胚胎发育预测系统 |
| EP4636688A2 (en) * | 2019-09-06 | 2025-10-22 | The Brigham and Women's Hospital, Inc. | Automated evaluation of quality assurance metrics for assisted reproduction procedures |
| CN116323915A (zh) * | 2020-08-03 | 2023-06-23 | 爱慕基因系统有限公司 | 基于实时视频的胚胎评价 |
| JP2024054578A (ja) | 2022-10-05 | 2024-04-17 | 株式会社アステック | タイムラプス撮影機能付き培養装置および培養方法 |
| CN116091421A (zh) * | 2022-12-16 | 2023-05-09 | 中山大学 | 一种体外受精胚胎卵裂球图像自动分割及面积计算的方法 |
| CN116758539B (zh) * | 2023-08-17 | 2023-10-31 | 武汉互创联合科技有限公司 | 一种基于数据增强的胚胎图像卵裂球识别方法 |
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| JP2559760B2 (ja) * | 1987-08-31 | 1996-12-04 | 株式会社日立製作所 | 細胞搬送方法 |
| US5196168A (en) * | 1991-12-19 | 1993-03-23 | Eastman Kodak Company | Incubator with positioning device for slide elements |
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| US5968340A (en) * | 1997-04-07 | 1999-10-19 | Marine Biological Laboratory | Polarographic self-referencing probe and method for using |
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| DE19903506C2 (de) * | 1999-01-29 | 2002-04-04 | Inst Chemo Biosensorik | Verfahren, Gefäß und Vorrichtung zur Überwachung der Stoffwechselaktivität von Zellkulturen in flüssigen Medien |
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| EP1695080A1 (en) * | 2003-08-28 | 2006-08-30 | Coopersurgical, Inc. | Method for determining embryo quality |
| US20070015289A1 (en) * | 2003-09-19 | 2007-01-18 | Kao H P | Dispenser array spotting |
| JP3950972B2 (ja) * | 2003-11-14 | 2007-08-01 | 国立大学法人名古屋大学 | 生物試料の生物発光測定装置 |
| JP2007515958A (ja) * | 2003-12-19 | 2007-06-21 | ユニヴァーシティー オブ ウォータールー | 培養細胞、細胞培養の方法および機器 |
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| JP4333426B2 (ja) * | 2004-03-19 | 2009-09-16 | ソニー株式会社 | 化合物半導体の製造方法、及び半導体装置の製造方法 |
| CN102254150A (zh) * | 2005-10-14 | 2011-11-23 | 尤尼森斯繁殖技术公司 | 细胞群的变化的测定 |
| US20080056952A1 (en) * | 2006-08-25 | 2008-03-06 | Angros Lee H | Analytic plates with markable portions and methods of use |
-
2007
- 2007-06-15 DE DE602007008419T patent/DE602007008419D1/de active Active
- 2007-06-15 WO PCT/DK2007/000291 patent/WO2007144001A2/en not_active Ceased
- 2007-06-15 CN CN201210428780.0A patent/CN103074410B/zh not_active Expired - Fee Related
- 2007-06-15 JP JP2009514641A patent/JP5731748B2/ja active Active
- 2007-06-15 EP EP10172399A patent/EP2282210A1/en not_active Withdrawn
- 2007-06-15 AT AT07722668T patent/ATE477499T1/de not_active IP Right Cessation
- 2007-06-15 EP EP07722668A patent/EP2035548B1/en not_active Revoked
- 2007-06-15 US US12/304,905 patent/US20100041090A1/en not_active Abandoned
- 2007-06-15 DK DK07722668.6T patent/DK2035548T3/da active
- 2007-06-15 CN CN200780027901.8A patent/CN101495619B/zh not_active Expired - Fee Related
-
2012
- 2012-01-31 US US13/362,895 patent/US20120309043A1/en not_active Abandoned
- 2012-07-31 US US13/562,989 patent/US20130102837A1/en not_active Abandoned
- 2012-10-01 US US13/632,505 patent/US20130225917A1/en not_active Abandoned
-
2013
- 2013-07-05 JP JP2013141334A patent/JP5732110B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE477499T1 (de) | 2010-08-15 |
| WO2007144001A3 (en) | 2008-06-05 |
| EP2035548A2 (en) | 2009-03-18 |
| WO2007144001A2 (en) | 2007-12-21 |
| JP2013198503A (ja) | 2013-10-03 |
| EP2282210A1 (en) | 2011-02-09 |
| JP2009539387A (ja) | 2009-11-19 |
| DE602007008419D1 (de) | 2010-09-23 |
| US20130225917A1 (en) | 2013-08-29 |
| EP2035548B1 (en) | 2010-08-11 |
| CN101495619B (zh) | 2014-01-08 |
| US20120309043A1 (en) | 2012-12-06 |
| CN101495619A (zh) | 2009-07-29 |
| US20130102837A1 (en) | 2013-04-25 |
| JP5731748B2 (ja) | 2015-06-10 |
| US20100041090A1 (en) | 2010-02-18 |
| CN103074410A (zh) | 2013-05-01 |
| CN103074410B (zh) | 2016-12-07 |
| JP5732110B2 (ja) | 2015-06-10 |
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