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DK2003120T3 - Azapeptidderivater som HIV-proteaseinhibitorer - Google Patents

Azapeptidderivater som HIV-proteaseinhibitorer

Info

Publication number
DK2003120T3
DK2003120T3 DK08252023.0T DK08252023T DK2003120T3 DK 2003120 T3 DK2003120 T3 DK 2003120T3 DK 08252023 T DK08252023 T DK 08252023T DK 2003120 T3 DK2003120 T3 DK 2003120T3
Authority
DK
Denmark
Prior art keywords
protease inhibitors
hiv protease
azapeptide derivatives
azapeptide
derivatives
Prior art date
Application number
DK08252023.0T
Other languages
English (en)
Inventor
Scott L Harbeson
Roger D Tung
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2003120T3 publication Critical patent/DK2003120T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
DK08252023.0T 2007-06-12 2008-06-12 Azapeptidderivater som HIV-proteaseinhibitorer DK2003120T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93420107P 2007-06-12 2007-06-12
US6762708P 2008-02-29 2008-02-29

Publications (1)

Publication Number Publication Date
DK2003120T3 true DK2003120T3 (da) 2010-03-15

Family

ID=39730784

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08252023.0T DK2003120T3 (da) 2007-06-12 2008-06-12 Azapeptidderivater som HIV-proteaseinhibitorer

Country Status (25)

Country Link
US (4) US20090036357A1 (da)
EP (3) EP2116532B1 (da)
JP (1) JP2010529196A (da)
KR (2) KR20120029480A (da)
CN (2) CN101711237B (da)
AR (1) AR066972A1 (da)
AT (2) ATE447554T1 (da)
AU (1) AU2008267048C1 (da)
BR (2) BRPI0823520A2 (da)
CA (1) CA2692028C (da)
CO (1) CO6241121A2 (da)
CY (1) CY1109766T1 (da)
DE (1) DE602008000255D1 (da)
DK (1) DK2003120T3 (da)
ES (3) ES2395137T3 (da)
HR (1) HRP20100065T1 (da)
MX (1) MX2009013565A (da)
PL (1) PL2003120T3 (da)
PT (1) PT2003120E (da)
RS (1) RS51226B (da)
RU (2) RU2448958C2 (da)
SI (1) SI2003120T1 (da)
TW (1) TW200908970A (da)
WO (1) WO2008156632A1 (da)
ZA (1) ZA200909079B (da)

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WO2010132663A1 (en) * 2009-05-13 2010-11-18 Concert Pharmaceticals, Inc. Pegylated azapeptide derivatives as hiv protease inhibitors
WO2010135424A1 (en) * 2009-05-19 2010-11-25 Glaxosmithkline Llc Chemical compounds
ES2600878T3 (es) * 2009-12-21 2017-02-13 Janssen Sciences Ireland Uc Implante removible, degradable, para la liberación prolongada de un compuesto activo
WO2011080562A1 (en) 2009-12-29 2011-07-07 Hetero Research Foundation Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals
SI2720989T1 (sl) 2011-06-20 2016-11-30 H. Lundbeck A/S Devterirani 1-piperazino-3-fenil indani za zdravljenje shizofrenije
CN106543073A (zh) * 2015-09-17 2017-03-29 宁波杰尔盛化工有限公司 2-[4-（2-吡啶基）苄基]-肼羧酸叔丁酯的制备方法
CN108367008B (zh) * 2015-12-02 2021-04-30 默沙东公司 包含多拉韦林、富马酸替诺福韦二吡呋酯和拉米夫定的药物组合物
UA123785C2 (uk) 2016-03-28 2021-06-02 Інсайт Корпорейшн Сполуки піролотриазину як інгібітори tam
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
PL3687996T3 (pl) 2017-09-27 2022-02-21 Incyte Corporation Sole pochodnych pirolotriazyny użyteczne jako inhibitory tam
EP4606432A3 (en) * 2018-06-29 2025-10-29 Incyte Corporation Formulations of an axl/mer inhibitor
TWI766172B (zh) 2018-07-30 2022-06-01 美商基利科學股份有限公司 抗hiv化合物
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
EP4135740A4 (en) * 2020-04-16 2024-05-22 The Medical College of Wisconsin, Inc. AEROSOLATED FORMULATIONS OF HIV PROTEASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY TRACT REFLUX
CN115385983A (zh) * 2022-01-11 2022-11-25 嘉兴安谛康生物科技有限公司 氮杂双环类化合物及其制备方法、药物组合物和用途
CN116987024A (zh) * 2023-08-01 2023-11-03 浙江荣耀生物科技股份有限公司 一种阿扎那韦中间体的制备方法

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Also Published As

Publication number Publication date
US20110009355A1 (en) 2011-01-13
KR20100020033A (ko) 2010-02-19
SI2003120T1 (sl) 2010-03-31
US8258309B2 (en) 2012-09-04
CN102424668A (zh) 2012-04-25
EP2116532B1 (en) 2011-12-07
AR066972A1 (es) 2009-09-23
CN101711237B (zh) 2013-08-07
EP2322509A1 (en) 2011-05-18
BRPI0823520A2 (pt) 2013-12-17
CY1109766T1 (el) 2014-09-10
ATE447554T1 (de) 2009-11-15
EP2003120B9 (en) 2010-06-02
HK1136576A1 (en) 2010-07-02
ES2395137T3 (es) 2013-02-08
EP2322509B1 (en) 2012-08-22
ES2394952T3 (es) 2013-02-07
EP2003120B1 (en) 2009-11-04
RS51226B (sr) 2010-12-31
TW200908970A (en) 2009-03-01
ATE536343T1 (de) 2011-12-15
RU2448958C2 (ru) 2012-04-27
RU2012101881A (ru) 2013-07-27
AU2008267048B2 (en) 2012-05-31
DE602008000255D1 (de) 2009-12-17
PL2003120T3 (pl) 2010-04-30
US8158805B2 (en) 2012-04-17
CO6241121A2 (es) 2011-01-20
MX2009013565A (es) 2010-06-02
ES2356334T3 (es) 2011-04-07
KR101185899B1 (ko) 2012-09-27
CA2692028A1 (en) 2008-12-24
KR20120029480A (ko) 2012-03-26
HK1127345A1 (en) 2009-09-25
RU2010100821A (ru) 2011-07-20
WO2008156632A1 (en) 2008-12-24
EP2116532A1 (en) 2009-11-11
EP2003120A1 (en) 2008-12-17
CN101711237A (zh) 2010-05-19
AU2008267048C1 (en) 2013-01-17
AU2008267048A1 (en) 2008-12-24
CA2692028C (en) 2013-06-04
US20130041156A1 (en) 2013-02-14
PT2003120E (pt) 2010-02-11
HRP20100065T1 (hr) 2010-03-31
US20120165288A1 (en) 2012-06-28
ZA200909079B (en) 2011-05-25
JP2010529196A (ja) 2010-08-26
BRPI0813911A2 (pt) 2012-02-22
US20090036357A1 (en) 2009-02-05

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