DK1907374T3 - Til behandling af gastrointestinale sygdomme anvendelige benzylpiperazin-derivater - Google Patents

Til behandling af gastrointestinale sygdomme anvendelige benzylpiperazin-derivater

Info

Publication number: DK1907374T3
Authority: DK; Denmark
Prior art keywords: treatment; gastrointestinal disorders; derivatives useful; benzylpiperazine derivatives; benzylpiperazine
Prior art date: 2005-07-26

Application number

DK06776430.8T

Other languages

English (en)

Inventor

Christopher Norbert Johnson

David Timothy Macpherson

Steven James Stanway

Geoffrey Stemp

Mervyn Thompson

Susan Marie Westaway

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-26

Filing date

2006-07-24

Publication date

2012-10-15

2005-07-26 Priority claimed from GB0515381A external-priority patent/GB0515381D0/en

2006-06-09 Priority claimed from GB0611469A external-priority patent/GB0611469D0/en

2006-07-24 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2012-10-15 Application granted granted Critical

2012-10-15 Publication of DK1907374T3 publication Critical patent/DK1907374T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Epidemiology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

DK06776430.8T 2005-07-26 2006-07-24 Til behandling af gastrointestinale sygdomme anvendelige benzylpiperazin-derivater DK1907374T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0515381A GB0515381D0 (en)	2005-07-26	2005-07-26	Compounds
GB0611469A GB0611469D0 (en)	2006-06-09	2006-06-09	Compounds
PCT/EP2006/007390 WO2007012479A2 (en)	2005-07-26	2006-07-24	Benzylpiperazine derivates and their medical use

Publications (1)

Publication Number	Publication Date
DK1907374T3 true DK1907374T3 (da)	2012-10-15

Family

ID=37560776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06776430.8T DK1907374T3 (da)	2005-07-26	2006-07-24	Til behandling af gastrointestinale sygdomme anvendelige benzylpiperazin-derivater

Country Status (28)

Country	Link
US (2)	US8536182B2 (da)
EP (2)	EP1907374B1 (da)
JP (1)	JP4938777B2 (da)
KR (1)	KR101281435B1 (da)
AR (1)	AR054508A1 (da)
AU (1)	AU2006274212B2 (da)
BR (1)	BRPI0613987A2 (da)
CA (1)	CA2616513C (da)
CR (1)	CR9722A (da)
CY (1)	CY1113257T1 (da)
DK (1)	DK1907374T3 (da)
EA (1)	EA014061B1 (da)
EG (1)	EG26235A (da)
ES (1)	ES2390812T3 (da)
HR (1)	HRP20120833T1 (da)
IL (1)	IL188854A (da)
JO (1)	JO2747B1 (da)
MA (1)	MA29723B1 (da)
MX (1)	MX2008001211A (da)
MY (1)	MY150098A (da)
NO (1)	NO340489B1 (da)
NZ (1)	NZ565062A (da)
PE (1)	PE20070180A1 (da)
PL (1)	PL1907374T3 (da)
PT (1)	PT1907374E (da)
SI (1)	SI1907374T1 (da)
TW (1)	TWI376375B (da)
WO (1)	WO2007012479A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0611907D0 (en) *	2006-06-15	2006-07-26	Glaxo Group Ltd	Compounds
EP1907374B1 (en) *	2005-07-26	2012-08-22	Glaxo Group Limited	Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders
GB0524814D0 (en) *	2005-12-05	2006-01-11	Glaxo Group Ltd	Compounds
CN101448503B (zh)	2006-01-27	2011-04-13	株式会社爱慕知科学	哌啶和哌嗪衍生物
HRP20100284T1 (hr) *	2006-06-28	2010-06-30	Glaxo Group Limited	Derivati piperazinila korisni u liječenju bolesti posredovanih receptorom gpr38
GB0723317D0 (en)	2007-11-28	2008-01-09	Glaxo Group Ltd	Compounds
CA2750699C (en)	2009-02-27	2015-12-29	Raqualia Pharma Inc.	Oxyindole derivatives with motilin receptor agonistic activity
CN102762572A (zh)	2010-02-01	2012-10-31	诺瓦提斯公司	作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
WO2011092293A2 (en)	2010-02-01	2011-08-04	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
CN102753527B (zh)	2010-02-02	2014-12-24	诺华股份有限公司	用作crf受体拮抗剂的环己基酰胺衍生物
CN113292485B (zh) *	2021-06-08	2023-10-27	河南大学	苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5385912A (en) *	1991-03-08	1995-01-31	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
TW355711B (en)	1992-11-04	1999-04-11	Chugai Pharmaceutical Co Ltd	Erythromycin derivatives
JP3449766B2 (ja)	1993-11-19	2003-09-22	中外製薬株式会社	モチリンアンタゴニスト
US5593994A (en) *	1994-09-29	1997-01-14	The Dupont Merck Pharmaceutical Company	Prostaglandin synthase inhibitors
JP3901239B2 (ja)	1996-03-13	2007-04-04	大正製薬株式会社	アリールアルカン誘導体
US5965578A (en) *	1996-04-03	1999-10-12	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5734012A (en)	1996-05-16	1998-03-31	Ohmeda Pharmaceutical Products Division Inc.	Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity
DE19644195A1 (de) *	1996-10-24	1998-04-30	Solvay Pharm Gmbh	10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AU4968997A (en)	1996-11-26	1998-06-22	Chugai Seiyaku Kabushiki Kaisha	13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
US6060491A (en) *	1997-06-19	2000-05-09	Dupont Pharmaceuticals	6-membered aromatics as factor Xa inhibitors
JP3583928B2 (ja) *	1997-08-15	2004-11-04	中外製薬株式会社	フェネチルアミン誘導体
US5972939A (en)	1997-10-28	1999-10-26	Ortho-Mcneil Pharmaceutical, Inc.	Cyclopentene derivatives useful as antagonists of the motilin receptor
DE19805822B4 (de)	1998-02-13	2009-02-05	Solvay Pharmaceuticals Gmbh	11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en)	1998-02-13	2000-12-26	Solvay Pharmaceuticals Gmbh	11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
GB9804734D0 (en) *	1998-03-05	1998-04-29	Pfizer Ltd	Compounds
JP2002517507A (ja) *	1998-06-12	2002-06-18	メルク・アンド・カンパニー・インコーポレーテッド	モチリン受容体のクローニングと同定
JP2000191700A (ja) *	1998-12-28	2000-07-11	Kyowa Hakko Kogyo Co Ltd	持続型消化管運動ペプチド
US20020010184A1 (en) *	2000-02-18	2002-01-24	Dinsmore Christopher J.	Inhibitors of prenyl-protein transferase
US20020052380A1 (en) *	2000-02-18	2002-05-02	Dinsmore Christopher J.	Inhibitors of prenyl-protein transferase
US6384031B2 (en) *	2000-03-13	2002-05-07	Ortho-Mcneil Pharmaceutical, Inc.	Cyclobutene derivatives useful as antagonists of the motilin receptor
WO2001068620A1 (en)	2000-03-13	2001-09-20	Ortho-Mcneil Pharmaceutical, Inc.	Novel cyclopentene derivatives useful as antagonists of the motilin receptor
US6423714B2 (en) *	2000-03-13	2002-07-23	Ortho Mcneil-Pharmaceutical, Inc..	Cyclohexene derivatives useful as antagonists of the motilin receptor
US6511980B2 (en) *	2000-05-05	2003-01-28	Ortho Mcneil Pharmaceutical, Inc.	Substituted diamine derivatives useful as motilin antagonists
US7102009B2 (en)	2001-01-12	2006-09-05	Amgen Inc.	Substituted amine derivatives and methods of use
JP2004529184A (ja) *	2001-05-10	2004-09-24	ゾルファイ　ファーマスーティカルズ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング	新規１−アミドメチルカルボニル−ピペリジン誘導体、該誘導体を製造するための方法及び中間体並びにこれらの化合物を含有している医薬
US6977264B2 (en) *	2001-07-25	2005-12-20	Amgen Inc.	Substituted piperidines and methods of use
PA8575901A1 (es)	2002-07-18	2004-07-20	Pfizer Prod Inc	Derivados de piperidina novedosos
US7223788B2 (en) *	2003-02-14	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
ATE490264T1 (de) *	2003-07-31	2010-12-15	Tranzyme Pharma Inc	Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7262195B2 (en) *	2003-09-17	2007-08-28	Bristol-Myers Squibb Company	Compounds useful as motilin agonists and method
US7338954B2 (en) *	2003-09-17	2008-03-04	Bristol-Myers Squibb Company	Compounds useful as motilin agonists and method
WO2005063720A1 (ja)	2003-12-25	2005-07-14	Nippon Shinyaku Co., Ltd.	アミド誘導体及び医薬
WO2005077345A1 (en)	2004-02-03	2005-08-25	Astrazeneca Ab	Compounds for the treatment of gastro-esophageal reflux disease
WO2005077368A2 (en)	2004-02-03	2005-08-25	Astrazeneca Ab	Treatment of gastro-esophageal reflux disease (gerd)
WO2005077373A2 (en)	2004-02-03	2005-08-25	Astrazeneca Ab	Treatment of gastro-esophageal reflux disease (gerd)
EP1744751A4 (en) *	2004-03-18	2010-03-10	Brigham & Womens Hospital	METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
JP2007538004A (ja) *	2004-03-18	2007-12-27	ザブライハムアンドウイメンズホスピタル，インコーポレイテッド	シヌクレイノパチーを治療する方法
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
US20050272722A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
EP1732549A4 (en) *	2004-03-18	2009-11-11	Brigham & Womens Hospital	METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
PE20060315A1 (es)	2004-05-24	2006-05-15	Irm Llc	Compuestos de tiazol como moduladores de ppar
SE0401345D0 (sv)	2004-05-25	2004-05-25	Astrazeneca Ab	Therapeutic compounds: Pyridine as scaffold
GB0611907D0 (en)	2006-06-15	2006-07-26	Glaxo Group Ltd	Compounds
US20080312209A1 (en) *	2005-07-12	2008-12-18	Glaxo Group Limited	Piperazine Heteroaryl Derivatives as Gpr38 Agonists
EP1907374B1 (en) *	2005-07-26	2012-08-22	Glaxo Group Limited	Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders
GB0524814D0 (en)	2005-12-05	2006-01-11	Glaxo Group Ltd	Compounds
HRP20100284T1 (hr)	2006-06-28	2010-06-30	Glaxo Group Limited	Derivati piperazinila korisni u liječenju bolesti posredovanih receptorom gpr38
GB0723317D0 (en)	2007-11-28	2008-01-09	Glaxo Group Ltd	Compounds

2006
- 2006-07-24 EP EP06776430A patent/EP1907374B1/en active Active
- 2006-07-24 TW TW095126884A patent/TWI376375B/zh not_active IP Right Cessation
- 2006-07-24 CA CA2616513A patent/CA2616513C/en not_active Expired - Fee Related
- 2006-07-24 EP EP12150635A patent/EP2441763A1/en not_active Withdrawn
- 2006-07-24 NZ NZ565062A patent/NZ565062A/en not_active IP Right Cessation
- 2006-07-24 MX MX2008001211A patent/MX2008001211A/es active IP Right Grant
- 2006-07-24 US US11/996,650 patent/US8536182B2/en not_active Expired - Fee Related
- 2006-07-24 WO PCT/EP2006/007390 patent/WO2007012479A2/en not_active Ceased
- 2006-07-24 AU AU2006274212A patent/AU2006274212B2/en not_active Ceased
- 2006-07-24 PT PT06776430T patent/PT1907374E/pt unknown
- 2006-07-24 KR KR1020087002102A patent/KR101281435B1/ko not_active Expired - Fee Related
- 2006-07-24 PL PL06776430T patent/PL1907374T3/pl unknown
- 2006-07-24 BR BRPI0613987-6A patent/BRPI0613987A2/pt not_active Application Discontinuation
- 2006-07-24 SI SI200631440T patent/SI1907374T1/sl unknown
- 2006-07-24 DK DK06776430.8T patent/DK1907374T3/da active
- 2006-07-24 JO JO2006248A patent/JO2747B1/en active
- 2006-07-24 HR HRP20120833TT patent/HRP20120833T1/hr unknown
- 2006-07-24 ES ES06776430T patent/ES2390812T3/es active Active
- 2006-07-24 JP JP2008523238A patent/JP4938777B2/ja not_active Expired - Fee Related
- 2006-07-24 EA EA200800421A patent/EA014061B1/ru not_active IP Right Cessation
- 2006-07-24 MY MYPI20063524A patent/MY150098A/en unknown
- 2006-07-24 PE PE2006000888A patent/PE20070180A1/es not_active Application Discontinuation
- 2006-07-25 AR ARP060103206A patent/AR054508A1/es not_active Application Discontinuation
2008
- 2008-01-17 IL IL188854A patent/IL188854A/en not_active IP Right Cessation
- 2008-01-20 EG EG2008010090A patent/EG26235A/en active
- 2008-01-25 MA MA30595A patent/MA29723B1/fr unknown
- 2008-02-11 CR CR9722A patent/CR9722A/es unknown
- 2008-02-26 NO NO20081014A patent/NO340489B1/no not_active IP Right Cessation
2012
- 2012-10-26 CY CY20121101022T patent/CY1113257T1/el unknown
2013
- 2013-08-05 US US13/959,018 patent/US20130317041A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2390812T3 (es)	2012-11-16
PL1907374T3 (pl)	2012-12-31
MA29723B1 (fr)	2008-09-01
EP1907374B1 (en)	2012-08-22
EP1907374A2 (en)	2008-04-09
HK1116477A1 (en)	2008-12-24
EG26235A (en)	2013-05-07
MX2008001211A (es)	2008-03-24
TWI376375B (en)	2012-11-11
AU2006274212B2 (en)	2011-06-09
EA200800421A1 (ru)	2008-06-30
BRPI0613987A2 (pt)	2011-03-01
CY1113257T1 (el)	2016-04-13
IL188854A (en)	2013-08-29
SI1907374T1 (sl)	2012-11-30
JO2747B1 (en)	2014-03-15
CA2616513A1 (en)	2007-02-01
NZ565062A (en)	2011-02-25
NO340489B1 (no)	2017-05-02
US20130317041A1 (en)	2013-11-28
AR054508A1 (es)	2007-06-27
US8536182B2 (en)	2013-09-17
US20090054456A1 (en)	2009-02-26
EP2441763A1 (en)	2012-04-18
EA014061B1 (ru)	2010-08-30
HRP20120833T1 (hr)	2012-11-30
CR9722A (es)	2008-04-10
TW200745081A (en)	2007-12-16
JP2009502842A (ja)	2009-01-29
IL188854A0 (en)	2008-04-13
MY150098A (en)	2013-11-29
JP4938777B2 (ja)	2012-05-23
AU2006274212A1 (en)	2007-02-01
KR20080037663A (ko)	2008-04-30
KR101281435B1 (ko)	2013-07-02
WO2007012479A2 (en)	2007-02-01
CA2616513C (en)	2013-02-19
PT1907374E (pt)	2012-11-05
NO20081014L (no)	2008-04-10
PE20070180A1 (es)	2007-04-25
WO2007012479A3 (en)	2007-04-26

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