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DK1904504T3 - Inhibitorer af vegf-receptor- og hgf-receptorsignalering - Google Patents

Inhibitorer af vegf-receptor- og hgf-receptorsignalering

Info

Publication number
DK1904504T3
DK1904504T3 DK06842339.1T DK06842339T DK1904504T3 DK 1904504 T3 DK1904504 T3 DK 1904504T3 DK 06842339 T DK06842339 T DK 06842339T DK 1904504 T3 DK1904504 T3 DK 1904504T3
Authority
DK
Denmark
Prior art keywords
receptor
hgf
signal inhibitors
vegf
vegf receptor
Prior art date
Application number
DK06842339.1T
Other languages
English (en)
Inventor
Oscar Mario Saavedra
Stephen William Claridge
Lijie Zhan
Franck Raeppel
Arkadii Vaisburg
Stephane Raeppel
Robert Deziel
Michael Mannion
Nancy Z Zhou
Ljubomir Isakovic
Original Assignee
Methylgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc filed Critical Methylgene Inc
Application granted granted Critical
Publication of DK1904504T3 publication Critical patent/DK1904504T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK06842339.1T 2005-05-20 2006-05-19 Inhibitorer af vegf-receptor- og hgf-receptorsignalering DK1904504T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68303805P 2005-05-20 2005-05-20
PCT/IB2006/003903 WO2007054831A2 (en) 2005-05-20 2006-05-19 Inhibitors of vegf receptor and hgf receptor signaling

Publications (1)

Publication Number Publication Date
DK1904504T3 true DK1904504T3 (da) 2014-06-23

Family

ID=38023642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06842339.1T DK1904504T3 (da) 2005-05-20 2006-05-19 Inhibitorer af vegf-receptor- og hgf-receptorsignalering

Country Status (15)

Country Link
US (2) US7790729B2 (da)
EP (1) EP1904504B1 (da)
JP (1) JP5275792B2 (da)
KR (1) KR101078968B1 (da)
CN (1) CN101248080B (da)
AU (1) AU2006313456B2 (da)
BR (1) BRPI0610382A2 (da)
CA (1) CA2608726C (da)
DK (1) DK1904504T3 (da)
ES (1) ES2473341T3 (da)
IL (1) IL187422A0 (da)
MX (1) MX2007014617A (da)
NZ (1) NZ563774A (da)
WO (1) WO2007054831A2 (da)
ZA (1) ZA200709851B (da)

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WO2006010264A1 (en) 2004-07-30 2006-02-02 Methylgene, Inc. Inhibitors of vegf receptor and hgf receptor signaling
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
US8003662B2 (en) * 2006-01-30 2011-08-23 Array Biopharma, Inc. Heterobicyclic thiophene compounds and methods of use
EP2032538A2 (en) * 2006-06-08 2009-03-11 Array Biopharma, Inc. Quinoline compounds and methods of use
WO2008023159A1 (en) 2006-08-24 2008-02-28 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
EP2176238B1 (en) 2007-07-09 2012-04-18 AstraZeneca AB Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k
AU2008293038B2 (en) 2007-08-29 2013-08-29 Mirati Therapeutics, Inc. Inhibitors of protein tyrosine kinase activity
WO2009026720A1 (en) * 2007-08-29 2009-03-05 Methylgene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
EP2332536A1 (en) * 2008-03-05 2011-06-15 MethylGene Inc. Inhibitors of protein tyrosine kinase activity
KR20110099687A (ko) * 2008-10-29 2011-09-08 데시페라 파마슈티칼스, 엘엘씨. 항-암과 항-증식성 활성을 나타내는 시클로프로판 아미드와 유사체
JP5588458B2 (ja) 2008-12-05 2014-09-10 アッヴィ・バハマズ・リミテッド 癌の治療に使用するためのキナーゼ阻害剤としてのチエノ［３，２−ｃ］ピリジン誘導体
AU2010289353B2 (en) * 2009-09-03 2016-12-08 Allergan, Inc. Compounds as tyrosine kinase modulators
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
SG184883A1 (en) * 2010-04-16 2012-11-29 Methylgene Inc Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders
SA111320519B1 (ar) 2010-06-11 2014-07-02 Astrazeneca Ab مركبات بيريميدينيل للاستخدام كمثبطات atr
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
CN103209695A (zh) 2010-09-15 2013-07-17 弗·哈夫曼-拉罗切有限公司 氮杂苯并噻唑化合物、组合物及应用方法
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
BR112014000314A2 (pt) 2011-07-08 2017-01-10 Novartis Ag derivados de pirrolo pirimidina
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
WO2013111798A1 (ja) 2012-01-27 2013-08-01 国立大学法人 富山大学 セリンラセマーゼ阻害剤
GB2499666A (en) * 2012-02-27 2013-08-28 Nanyang Polytechnic Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders
TWI520962B (zh) * 2012-06-29 2016-02-11 As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
CN104507930B (zh) * 2012-06-29 2017-10-10 贝达药业股份有限公司 作为c‑Met酪氨酸激酶抑制剂的新型稠合吡啶衍生物
CN104936963B (zh) * 2012-11-20 2017-11-28 普罗齐纳斯有限公司 作为蛋白激酶抑制剂的硫醚衍生物
CN103396417B (zh) * 2013-08-14 2015-02-04 冯子侠 新型羟肟酸衍生物及其医疗应用
CN106995452B (zh) * 2016-12-22 2018-03-16 湖北民族学院 一种噻吩并[3，2‑d]嘧啶类EGFR/ErbB2双靶点抑制剂及其制备方法和用途
CN113874015B (zh) 2018-12-21 2024-05-24 细胞基因公司 Ripk2的噻吩并吡啶抑制剂
US10702525B1 (en) 2019-09-04 2020-07-07 United Arab Emirates University Pyrimidine derivatives as anti-diabetic agents
JP2024504587A (ja) * 2021-01-14 2024-02-01 ジョージタウン ユニバーシティ Ｕｓｐ１３阻害剤及びその使用方法

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US8003662B2 (en) 2006-01-30 2011-08-23 Array Biopharma, Inc. Heterobicyclic thiophene compounds and methods of use

Also Published As

Publication number Publication date
KR101078968B1 (ko) 2011-11-01
MX2007014617A (es) 2008-02-11
KR20080027782A (ko) 2008-03-28
BRPI0610382A2 (pt) 2010-06-15
EP1904504B1 (en) 2014-03-19
US20060287343A1 (en) 2006-12-21
US20100249145A1 (en) 2010-09-30
AU2006313456A1 (en) 2007-05-18
WO2007054831A2 (en) 2007-05-18
NZ563774A (en) 2010-04-30
CN101248080B (zh) 2012-09-05
CN101248080A (zh) 2008-08-20
AU2006313456B2 (en) 2011-06-23
JP5275792B2 (ja) 2013-08-28
EP1904504A4 (en) 2010-06-02
CA2608726A1 (en) 2007-05-18
EP1904504A2 (en) 2008-04-02
ZA200709851B (en) 2009-08-26
ES2473341T3 (es) 2014-07-04
US7790729B2 (en) 2010-09-07
JP2008540639A (ja) 2008-11-20
WO2007054831A3 (en) 2007-10-04
IL187422A0 (en) 2008-02-09
CA2608726C (en) 2013-07-09

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