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DK1959981T3 - Anti-connexin 43 forbindelser til behandling af kroniske sår - Google Patents

Anti-connexin 43 forbindelser til behandling af kroniske sår Download PDF

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Publication number
DK1959981T3
DK1959981T3 DK06795121.0T DK06795121T DK1959981T3 DK 1959981 T3 DK1959981 T3 DK 1959981T3 DK 06795121 T DK06795121 T DK 06795121T DK 1959981 T3 DK1959981 T3 DK 1959981T3
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Prior art keywords
connexin
compounds
treatment
scars
chronic
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DK06795121.0T
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English (en)
Inventor
Colin R Green
David L Becker
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Coda Therapeutics Ltd
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  • Urology & Nephrology (AREA)
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DK06795121.0T 2005-02-03 2006-02-03 Anti-connexin 43 forbindelser til behandling af kroniske sår DK1959981T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65007505P 2005-02-03 2005-02-03
PCT/IB2006/001961 WO2006134494A2 (en) 2005-02-03 2006-02-03 Anti-connexin compounds and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
DK1959981T3 true DK1959981T3 (da) 2020-01-27

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DK06795121.0T DK1959981T3 (da) 2005-02-03 2006-02-03 Anti-connexin 43 forbindelser til behandling af kroniske sår

Country Status (12)

Country Link
US (2) US9248141B2 (da)
EP (5) EP2510938A1 (da)
JP (6) JP5964538B2 (da)
KR (4) KR102073629B1 (da)
CN (2) CN101573131B (da)
AU (2) AU2006257283A1 (da)
CA (1) CA2596412A1 (da)
DK (1) DK1959981T3 (da)
ES (1) ES2766549T3 (da)
HK (1) HK1258903A1 (da)
HU (1) HUE047335T2 (da)
WO (1) WO2006134494A2 (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9408381B2 (en) 2004-12-21 2016-08-09 Musc Foundation For Research Development Alpha Connexin c-Terminal (ACT) peptides for use in transplant
PL2289535T3 (pl) 2004-12-21 2018-12-31 Musc Foundation For Research Development Kompozycje i sposoby wspomagania gojenia ran oraz regeneracji tkanek
AU2006257283A1 (en) 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and uses thereof
US8247384B2 (en) 2006-11-15 2012-08-21 Coda Therapeutics, Inc. Methods and compositions for wound healing
EP2543377A1 (en) 2006-12-11 2013-01-09 Coda Therapeutics, INC. Anticonnexin polynucleotides as impaired wound healing compositions
AU2014204482B2 (en) * 2006-12-11 2016-07-07 Coda Therapeutics, Inc. Anticonnexin polynucleotides as impaired wound healing compositions
JP5552048B2 (ja) * 2007-06-21 2014-07-16 ムスク ファンデーション フォー リサーチ ディベロップメント 加齢性黄斑変性を治療するためのアルファコネキシンｃ末端（ａｃｔ）ペプチド
EP2190455A4 (en) * 2007-09-07 2010-11-24 Australian Meat & Live Stock AGENTS HAVING ANGIOGENIC AND WOUND HEALING ACTIVITY
CN102920996A (zh) * 2007-12-11 2013-02-13 科达治疗公司 受损伤口愈合的药物组合物
JP2011506446A (ja) * 2007-12-11 2011-03-03 コーダ セラピューティクス， インコーポレイテッド 損傷した創傷治癒組成物および治療
JP2011507861A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 線維症性の状態の治療のための抗コネキシンポリヌクレオチド剤と組み合わせた抗コネキシンポリペプチド剤の使用
WO2009085273A2 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polynucleotides for the treatment of surgical adhesions
JP2011507856A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用
AU2008343842A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions
JP2011507855A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
AU2008343841A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of inhibitors of connexin43 for treatment of fibrotic conditions
US9035037B2 (en) 2007-12-21 2015-05-19 Coda Therapeutics, Inc. Medical devices
WO2009134967A2 (en) 2008-04-30 2009-11-05 Kci Licensing, Inc. Use of nucleic acids with reduced pressure therapy
WO2009148552A2 (en) * 2008-06-02 2009-12-10 Kansas State University Research Foundation Methods and compositions for treating disease
CN102099475A (zh) * 2008-06-04 2011-06-15 科达治疗公司 用间隙连接调节化合物治疗疼痛
ITCH20080021A1 (it) * 2008-09-25 2010-03-26 Saverio Alberti Usi in diagnosi e terapia dei tumori di un rna di fusione tra ciclina d1 e trop2
WO2013073968A2 (en) * 2011-09-12 2013-05-23 Industrial Research Limited Agents for modulation of cell signalling
MX351881B (es) 2012-03-01 2017-11-01 Firststring Res Inc Geles tópicos que contienen péptidos de alfa-conexina c- terminal (act).
US9345744B2 (en) 2012-04-25 2016-05-24 Musc Foundation For Research Development Peptide-based collagen modulators for wound healing and tissue repair
HUE036623T2 (hu) 2012-05-08 2018-07-30 Ishihara Sangyo Kaisha Eljárás szubsztituált benzoesav vegyület elõállítására
EP2897632A4 (en) 2012-05-30 2016-10-12 Univ Andres Bello COMPOUNDS FOR MODULATING THE ASTROCYTIC RELEASE OF SUBSTANCES BY CONNEXINE AND PANNEXINE AND TREATMENT OF PSYCHIATRIC DISEASES
US9156896B2 (en) 2013-03-15 2015-10-13 Coda Therapeutics, Inc. Wound healing compositions and treatments
WO2015027120A1 (en) 2013-08-21 2015-02-26 Jiang Jean X Compositions and methods for targeting connexin hemichannels
CA2951721C (en) 2014-06-12 2023-09-26 The Research Foundation For The State University Of New York Methods of using gap junctions as therapeutic targets for the treatment of degenerative disorders of the retina
JP7185655B2 (ja) * 2014-08-22 2022-12-07 オークランド ユニサービシーズ リミティド チャネル調節剤
US10465188B2 (en) 2014-08-22 2019-11-05 Auckland Uniservices Limited Channel modulators
EP3193865B1 (en) 2014-09-19 2019-11-06 Memorial Sloan-Kettering Cancer Center Methods for treating brain metastasis
EP3322412B1 (en) 2015-07-15 2021-04-07 Theranexus Use of amitriptyline for blocking brain hemichannels and method for potentiating its effect in vivo
CA2994943C (en) * 2015-08-06 2021-10-12 The Feinstein Institute For Medical Research Hemichannel extracellular domain-specific agents for treating sepsis
AU2016309948B2 (en) * 2015-08-14 2021-05-20 The University Of Sydney Connexin 45 inhibition for therapy
CN105566495B (zh) * 2016-01-27 2019-10-22 上海科技大学 一种特异性抑制连接蛋白26的全人抗体
CN116672445A (zh) 2016-02-26 2023-09-01 德克萨斯大学体系董事会 连接蛋白(Cx)43半通道结合抗体及其用途
WO2017180896A1 (en) * 2016-04-14 2017-10-19 Cedars-Sinai Medical Center Gja1 isoforms protect against metabolic stress
CA3022763A1 (en) * 2016-05-03 2017-11-09 University Of Auckland Novel peptides and peptidomimetics
WO2018039302A1 (en) * 2016-08-23 2018-03-01 The Cleveland Clinic Foundation Cancer treatment using cx26 blocking peptides
JP6778756B2 (ja) 2016-09-30 2020-11-04 富士フイルム株式会社 水溶液、着色組成物、インクジェット記録用インク、インクジェット記録方法、及びインクカートリッジ
WO2018199777A1 (en) 2017-04-28 2018-11-01 Auckland Uniservices Limited Methods of treatment and novel constructs
WO2019018691A1 (en) 2017-07-19 2019-01-24 Auckland Uniservices Limited MODULATION OF CYTOKINE
US12098385B2 (en) 2017-09-20 2024-09-24 The Regents Of The University Of California Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy
WO2019060619A1 (en) * 2017-09-20 2019-03-28 The Regents Of The University Of California STRATEGY OF GENE THERAPY FOR RESTORING ELECTRICAL AND CARDIAC FUNCTION AND CARDIAC STRUCTURE IN ARYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY
CN107469071B (zh) * 2017-09-29 2021-01-26 河南大学 Connexin模拟肽在制备预防或治疗急性肺损伤药物中的应用
CN108066744A (zh) * 2017-12-29 2018-05-25 于海龙 细胞连接蛋白43模拟肽Gap19在制备治疗脑出血药物中的用途
CA3095897A1 (en) 2018-04-02 2019-10-10 Alamab Therapeutics, Inc. Connexin 43 antibodies and use thereof
CN108588075A (zh) * 2018-05-03 2018-09-28 天德悦（北京）生物科技有限责任公司 人Cx43基因干扰序列、shRNA-Cx43病毒及低表达Cx43蛋白的细胞系
WO2019222800A1 (en) * 2018-05-21 2019-11-28 Hudson Institute of Medical Research Methods for the treatment or prevention of autoimmune or autoinflammatory diseases
IL285369B2 (en) 2019-02-04 2025-10-01 Alamab Therapeutics Inc Connexin 43 antibodies and their use
CN111484981B (zh) * 2020-04-26 2021-02-02 四川省人民医院 一种用于构建视网膜新生血管疾病模型的方法和应用
JP7036158B2 (ja) * 2020-07-08 2022-03-15 株式会社リコー 表示画像作成装置および画像表示装置
CN116234576A (zh) 2020-07-31 2023-06-06 阿拉玛布治疗学股份有限公司 抗-连接蛋白抗体制剂
AU2021364900A1 (en) 2020-10-22 2023-06-08 Xequel Bio, Inc. Peptide formulations and ophthalmic uses thereof
CN114859057A (zh) * 2022-04-13 2022-08-05 江苏省中医院 人结直肠癌或人结直肠癌转移的预测性生物标志物及其应用
US20250059264A1 (en) * 2023-08-14 2025-02-20 Alamab Therapeutics, Inc. Method of treating stroke

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4861757A (en) * 1986-11-14 1989-08-29 Institute Of Molecular Biology Wound healing and bone regeneration using PDGF and IGF-I
JPH0539594Y2 (da) * 1988-08-05 1993-10-07
US5004810A (en) 1988-09-30 1991-04-02 Schering Corporation Antiviral oligomers
US5166195A (en) * 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
FR2692265B1 (fr) 1992-05-25 1996-11-08 Centre Nat Rech Scient Composes biologiquement actifs de type phosphotriesters.
GB2273932A (en) 1992-11-24 1994-07-06 Stiefel Laboratories Stable oligonucleotides
GB9425930D0 (en) 1994-12-22 1995-02-22 Procter & Gamble Silicone compositions
US6752987B1 (en) * 1995-02-28 2004-06-22 The Regents Of The University Of California Adenovirus encoding human adenylylcyclase (AC) VI
US20030148968A1 (en) 1995-02-28 2003-08-07 Hammond H. Kirk Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
JP2001505432A (ja) 1996-12-02 2001-04-24 ダイヤド ファーマシューティカル コーポレイション ヒト接着分子のアンチセンス阻害
WO1999007844A2 (en) * 1997-08-07 1999-02-18 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods and compositions for treatment of restenosis
WO1999029858A1 (en) * 1997-12-09 1999-06-17 Children's Medical Center Corporation Soluble inhibitors of vascular endothelial growth factor and use thereof
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AU776512B2 (en) * 1999-01-27 2004-09-09 David Laurence Becker Formulations comprising antisense nucleotides to connexins
US5998148A (en) * 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
EP2298333A3 (en) * 1999-12-20 2012-05-02 Immunex Corporation Tweak receptor
WO2002032940A2 (en) * 2000-10-18 2002-04-25 Children's Medical Center Corporation Osteopontin-coated surfaces and methods of use
CN1911965B (zh) 2001-01-17 2013-05-29 新兴产品开发西雅图有限公司 结合域-免疫球蛋白融合蛋白
US20050119211A1 (en) * 2001-05-18 2005-06-02 Sirna Therapeutics, Inc. RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
JP2005509621A (ja) * 2001-10-17 2005-04-14 ユニバーシティ オブ ウェールズ カレッジ オブ メディスン ギャップ結合ならびにｅｄｈｆ
EA006860B1 (ru) * 2002-01-29 2006-04-28 Уайт Композиции и способы модулирования гемиканалов коннексина
JP2003238441A (ja) * 2002-02-08 2003-08-27 英行 ▲高▼野 血管新生抑制剤
US20030215424A1 (en) * 2002-05-15 2003-11-20 Seul Kyung Hwan Method of modulating angiogenesis
JP2004073182A (ja) * 2002-05-24 2004-03-11 Takeda Chem Ind Ltd インスリン抵抗性改善剤
US8809504B2 (en) * 2002-09-03 2014-08-19 Vit Lauermann Inhibitor which is deactivatable by a reagent produced by a target cell
WO2006006948A2 (en) * 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
ES2327409T3 (es) * 2003-03-26 2009-10-29 Apogenix Gmbh Proteinas de fusion fc mejoradas.
EP1514929A1 (en) 2003-09-12 2005-03-16 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Antisense oligonucleotides for prevention of metastasis formation of cancer cells
DK1699924T3 (da) * 2003-12-03 2019-10-21 Ocunexus Therapeutics Inc Connexin 43-målrettede hæmmende forbindelser og fremgangsmåder til anvendelse deraf i behandling af hornhindetraume
DE102004027422A1 (de) 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
PL2289535T3 (pl) * 2004-12-21 2018-12-31 Musc Foundation For Research Development Kompozycje i sposoby wspomagania gojenia ran oraz regeneracji tkanek
AU2006257283A1 (en) 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and uses thereof
CA2632876A1 (en) * 2005-12-16 2007-06-21 Arla Foods Amba Bovine osteopontin formulations for the improvement of the wound healing process
US8247384B2 (en) 2006-11-15 2012-08-21 Coda Therapeutics, Inc. Methods and compositions for wound healing
EP2543377A1 (en) 2006-12-11 2013-01-09 Coda Therapeutics, INC. Anticonnexin polynucleotides as impaired wound healing compositions
AU2008223817A1 (en) * 2007-03-02 2008-09-12 National University Of Ireland, Galway Osteopontin for the prediction and treatment of cardiovascular diseases
CA2688415C (en) 2007-05-31 2015-11-10 Anterios, Inc. Nucleic acid nanoparticles and uses therefor
CN102920996A (zh) 2007-12-11 2013-02-13 科达治疗公司 受损伤口愈合的药物组合物
JP2011506446A (ja) 2007-12-11 2011-03-03 コーダ セラピューティクス， インコーポレイテッド 損傷した創傷治癒組成物および治療
CA2710388A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polynucleotides for the treatment of abnormal or excessive scars
WO2009085273A2 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polynucleotides for the treatment of surgical adhesions
AU2008343842A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions
JP2011507856A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用
JP2011507861A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 線維症性の状態の治療のための抗コネキシンポリヌクレオチド剤と組み合わせた抗コネキシンポリペプチド剤の使用
JP2011507855A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
AU2008343841A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of inhibitors of connexin43 for treatment of fibrotic conditions
US9035037B2 (en) 2007-12-21 2015-05-19 Coda Therapeutics, Inc. Medical devices
CA2710232A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Treatment of abnormal or excessive scars
CA2711635A1 (en) 2008-01-07 2009-08-06 Coda Therapeutics, Inc. Wound healing compositions and treatments
CN102099475A (zh) 2008-06-04 2011-06-15 科达治疗公司 用间隙连接调节化合物治疗疼痛

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