DK1954264T3 - Fremgangsmåde til fremstilling af epoxybutanol-mellemprodukter - Google Patents
Fremgangsmåde til fremstilling af epoxybutanol-mellemprodukterInfo
- Publication number
- DK1954264T3 DK1954264T3 DK06804890T DK06804890T DK1954264T3 DK 1954264 T3 DK1954264 T3 DK 1954264T3 DK 06804890 T DK06804890 T DK 06804890T DK 06804890 T DK06804890 T DK 06804890T DK 1954264 T3 DK1954264 T3 DK 1954264T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- intermediates
- preparation
- ethyl
- prg
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 title 2
- 239000004593 Epoxy Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 abstract 1
- QUGUFLJIAFISSW-UHFFFAOYSA-N 1,4-difluorobenzene Chemical compound FC1=CC=C(F)C=C1 QUGUFLJIAFISSW-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Chemical group 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05026163 | 2005-12-01 | ||
| PCT/CH2006/000671 WO2007062542A2 (en) | 2005-12-01 | 2006-11-29 | Process for the manufacture of epoxybutanol intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1954264T3 true DK1954264T3 (da) | 2010-01-11 |
Family
ID=36178579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06804890T DK1954264T3 (da) | 2005-12-01 | 2006-11-29 | Fremgangsmåde til fremstilling af epoxybutanol-mellemprodukter |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7816537B2 (pl) |
| EP (2) | EP2133345A1 (pl) |
| JP (1) | JP5329969B2 (pl) |
| KR (1) | KR101191682B1 (pl) |
| CN (1) | CN101321522B (pl) |
| AT (1) | ATE444747T1 (pl) |
| AU (2) | AU2006319657B2 (pl) |
| BR (1) | BRPI0619120B1 (pl) |
| CA (2) | CA2629092C (pl) |
| CY (1) | CY1110588T1 (pl) |
| DE (1) | DE602006009698D1 (pl) |
| DK (1) | DK1954264T3 (pl) |
| ES (1) | ES2333258T3 (pl) |
| HR (1) | HRP20090675T1 (pl) |
| PL (1) | PL1954264T3 (pl) |
| PT (1) | PT1954264E (pl) |
| SI (1) | SI1954264T1 (pl) |
| WO (1) | WO2007062542A2 (pl) |
| ZA (1) | ZA200804218B (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012006180A2 (pt) | 2009-09-21 | 2015-09-08 | Gilead Sciences Inc | processos e intermediários para a preparação de análogos de 1'-substituido carba-nucleosídeo |
| SG186830A1 (en) | 2010-07-22 | 2013-02-28 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
| KR102129150B1 (ko) | 2012-08-07 | 2020-07-02 | 바실리어 파마슈티카 아게 | 이사부코나졸 또는 라부코나졸의 제조 방법 |
| WO2015150947A1 (en) | 2014-03-29 | 2015-10-08 | Wockhardt Limited | A process for the preparation of isavuconazole and its intermediates |
| TWI687432B (zh) | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| BR122020020217B1 (pt) | 2015-09-16 | 2021-08-17 | Gilead Sciences, Inc | Uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por arenaviridae |
| CN105367528A (zh) * | 2015-11-10 | 2016-03-02 | 南通诺泰生物医药技术有限公司 | 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法 |
| EP4331677A3 (en) | 2017-03-14 | 2024-05-29 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| CA3178212A1 (en) | 2017-05-01 | 2018-11-08 | Gilead Sciences, Inc. | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| PL3651734T3 (pl) | 2017-07-11 | 2025-03-31 | Gilead Sciences, Inc. | Kompozycje zawierające inhibitor polimerazy rna i cyklodekstrynę do leczenia infekcji wirusowych |
| WO2019031240A1 (ja) | 2017-08-10 | 2019-02-14 | 住友化学株式会社 | エポキシアルコール化合物の製造方法 |
| US11660307B2 (en) | 2020-01-27 | 2023-05-30 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
| TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
| EP4132651A1 (en) | 2020-04-06 | 2023-02-15 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| TW202532084A (zh) | 2020-05-29 | 2025-08-16 | 美商基利科學股份有限公司 | 瑞德西韋之治療方法 |
| WO2021262826A2 (en) | 2020-06-24 | 2021-12-30 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
| PT4204421T (pt) | 2020-08-27 | 2024-06-25 | Gilead Sciences Inc | Compostos e métodos para o tratamento de infeções virais |
| JP2025508942A (ja) | 2022-03-02 | 2025-04-10 | ギリアード サイエンシーズ， インコーポレイテッド | ウイルス感染症の治療のための化合物及び方法 |
| CN115536643A (zh) * | 2022-12-05 | 2022-12-30 | 南京桦冠生物技术有限公司 | 一种艾沙康唑类药物关键中间体的制备方法 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| CN119264078B (zh) * | 2024-12-09 | 2025-08-01 | 浙江世佳科技股份有限公司 | 一种(5s,6r)-5,6-环氧-2-十七碳炔-1-醇的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3452213B2 (ja) * | 1994-07-05 | 2003-09-29 | エーザイ株式会社 | 抗真菌剤及びその製造方法 |
| WO1999045008A1 (en) * | 1998-03-06 | 1999-09-10 | F. Hoffmann-La Roche Ag | 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity |
| US6133485A (en) * | 1998-04-15 | 2000-10-17 | Synphar Laboratories, Inc. | Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols |
| US6391903B1 (en) * | 1999-09-09 | 2002-05-21 | Sankyo Company, Limited | Triazole derivatives having antifungal activity |
| US6884892B2 (en) * | 2002-06-20 | 2005-04-26 | Sumitomo Chemical Company, Limited | Production methods of epoxytriazole derivative and intermediate therefor |
| JP4627413B2 (ja) * | 2003-05-06 | 2011-02-09 | 三井化学株式会社 | １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法 |
-
2006
- 2006-11-29 CN CN2006800449743A patent/CN101321522B/zh active Active
- 2006-11-29 WO PCT/CH2006/000671 patent/WO2007062542A2/en not_active Ceased
- 2006-11-29 BR BRPI0619120-7A patent/BRPI0619120B1/pt not_active IP Right Cessation
- 2006-11-29 CA CA2629092A patent/CA2629092C/en active Active
- 2006-11-29 SI SI200630502T patent/SI1954264T1/sl unknown
- 2006-11-29 US US12/085,617 patent/US7816537B2/en active Active
- 2006-11-29 EP EP09168177A patent/EP2133345A1/en not_active Withdrawn
- 2006-11-29 ES ES06804890T patent/ES2333258T3/es active Active
- 2006-11-29 EP EP06804890A patent/EP1954264B1/en active Active
- 2006-11-29 KR KR1020087015976A patent/KR101191682B1/ko active Active
- 2006-11-29 AU AU2006319657A patent/AU2006319657B2/en not_active Ceased
- 2006-11-29 PT PT06804890T patent/PT1954264E/pt unknown
- 2006-11-29 CA CA2711852A patent/CA2711852C/en active Active
- 2006-11-29 HR HR20090675T patent/HRP20090675T1/hr unknown
- 2006-11-29 AT AT06804890T patent/ATE444747T1/de active
- 2006-11-29 PL PL06804890T patent/PL1954264T3/pl unknown
- 2006-11-29 DE DE602006009698T patent/DE602006009698D1/de active Active
- 2006-11-29 DK DK06804890T patent/DK1954264T3/da active
- 2006-11-29 JP JP2008542575A patent/JP5329969B2/ja active Active
-
2008
- 2008-05-15 ZA ZA200804218A patent/ZA200804218B/xx unknown
-
2009
- 2009-12-29 CY CY20091101343T patent/CY1110588T1/el unknown
-
2010
- 2010-07-23 AU AU2010203301A patent/AU2010203301B2/en not_active Ceased
- 2010-08-31 US US12/872,599 patent/US8076494B2/en active Active
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