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DK1824775T3 - Bromelain debridement composition and methods of preparation thereof - Google Patents

Bromelain debridement composition and methods of preparation thereof

Info

Publication number
DK1824775T3
DK1824775T3 DK05804486.8T DK05804486T DK1824775T3 DK 1824775 T3 DK1824775 T3 DK 1824775T3 DK 05804486 T DK05804486 T DK 05804486T DK 1824775 T3 DK1824775 T3 DK 1824775T3
Authority
DK
Denmark
Prior art keywords
bromelain
preparation
methods
debridement composition
debridement
Prior art date
Application number
DK05804486.8T
Other languages
Danish (da)
Inventor
Marian Gorecki
Amir Toren
Original Assignee
Mediwound Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediwound Ltd filed Critical Mediwound Ltd
Application granted granted Critical
Publication of DK1824775T3 publication Critical patent/DK1824775T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK05804486.8T 2004-11-22 2005-11-22 Bromelain debridement composition and methods of preparation thereof DK1824775T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL16533404A IL165334A0 (en) 2004-11-22 2004-11-22 Debriding composition from bromelain and methods of producing same
PCT/IL2005/001236 WO2006054309A2 (en) 2004-11-22 2005-11-22 Debriding composition from bromelain

Publications (1)

Publication Number Publication Date
DK1824775T3 true DK1824775T3 (en) 2012-09-24

Family

ID=36407550

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05804486.8T DK1824775T3 (en) 2004-11-22 2005-11-22 Bromelain debridement composition and methods of preparation thereof

Country Status (17)

Country Link
US (2) US8119124B2 (en)
EP (1) EP1824775B1 (en)
JP (1) JP5053096B2 (en)
KR (1) KR101235544B1 (en)
CN (1) CN101297033B (en)
AU (1) AU2005305461B2 (en)
BR (1) BRPI0518050A (en)
CA (1) CA2587951C (en)
DK (1) DK1824775T3 (en)
ES (1) ES2389810T3 (en)
IL (2) IL165334A0 (en)
MX (1) MX2007006074A (en)
NO (1) NO337096B1 (en)
PL (1) PL1824775T3 (en)
PT (1) PT1824775E (en)
WO (1) WO2006054309A2 (en)
ZA (1) ZA200704821B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2588130T (en) * 2010-06-25 2016-11-25 Shire Human Genetic Therapies Cns delivery of therapeutic agents
US20140154235A1 (en) 2011-05-12 2014-06-05 Smith & Nephew Orthopaedics Ag Wound debridement compositions containing seaprose and methods of wound treatment using same
GB201110783D0 (en) 2011-06-24 2011-08-10 Aqua Bio Technology Asa Methods and uses
GB201110777D0 (en) * 2011-06-24 2011-08-10 Aqua Bio Technology Asa Methods and uses
RU2625726C2 (en) 2011-07-20 2017-07-18 Медиваунд Лтд. Bromelain extract with proteolytic activity to treat connective tissue diseases
WO2013096337A1 (en) 2011-12-20 2013-06-27 Kci Licensing, Inc. Composition for enzymatic debridement
AU2013259360B2 (en) 2012-05-11 2017-07-13 Smith & Nephew, Inc. Use of Seaprose to remove bacterial biofilm
JP6306036B2 (en) * 2012-11-14 2018-04-04 スミス アンド ネフュー インコーポレイテッド Stable thermolysin hydrogel
US10238719B2 (en) 2014-10-10 2019-03-26 Rochal Industries, Llc Compositions and kits for enzymatic debridement and methods of using the same
US9592280B2 (en) 2014-10-10 2017-03-14 Rochal Industries Llc Compositions and kits for enzymatic debridement and methods of using the same
LT6177B (en) 2014-10-10 2015-07-27 Uab "Biocentras" ISOLATION OF ENZYME COMPLEXES FROM Streptomyces gougerotii 101, PREPARATION AND APPLICATION OF MULTIENZYME BIOPREPARATIONS
US20160101166A1 (en) 2014-10-10 2016-04-14 Rochal Industries, Llp Compositions and kits for treating pruritus and methods of using the same
CN104857187A (en) * 2015-04-28 2015-08-26 李正 Bromelain burn tissue healing medicine
KR102376345B1 (en) * 2016-01-31 2022-03-18 메디운드 리미티드 Necrotic tissue removal composition for wound treatment
WO2017183018A1 (en) * 2016-04-18 2017-10-26 Mediwound Ltd Methods of debridement of chronic wounds
US11628207B2 (en) 2016-07-27 2023-04-18 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
CN107913401A (en) * 2016-10-08 2018-04-17 江阴市本特塞缪森生命科学研究院有限公司 Trypsase product and the application for treating gynaecological imflammation
US11413300B2 (en) 2017-01-30 2022-08-16 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
WO2020072982A1 (en) 2018-10-05 2020-04-09 Xenotherapeutics, Inc. Xenotransplantation products and methods
EP3945799A1 (en) 2019-03-25 2022-02-09 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same
WO2021255625A1 (en) * 2020-06-16 2021-12-23 Anatara Lifesciences Limited Protease composition
CA3210372A1 (en) * 2021-03-01 2022-09-09 Mediwound Ltd. Proteolytic enzyme mixture for treating psoriasis
WO2023159123A1 (en) * 2022-02-16 2023-08-24 Guild Associates Inc. Immobilized enzyme-based wound debridement

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226854A (en) 1974-01-08 1980-10-07 Gerold K. V. Klein Debridement of devitalized tissue with hydrolytic enzyme product
US4307081A (en) 1974-01-08 1981-12-22 Gerold K. V. Klein Enzyme mixture
US4197291A (en) 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
US4329430A (en) * 1979-06-04 1982-05-11 Klein Gerold K V Enzyme mixture
US4320120A (en) 1979-10-22 1982-03-16 Zenyaku Kogyo Kabushiki Kaisha Extracts of Marsdenia cundurango Reichenbach fil
US4361551A (en) 1979-11-05 1982-11-30 Riker Laboratories, Inc. Method of enzymatic debridement
US4286064A (en) * 1979-11-05 1981-08-25 Riker Laboratories, Inc. Process for isolating active debriding agent from bromelain
AU543965B2 (en) 1979-11-05 1985-05-09 Riker Laboratories, Inc. Method of enzymatic debridement
GB8724728D0 (en) 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
CA2046802C (en) 1990-08-15 2007-05-22 Donald Zane Fortney Compositions containing protease produced by vibrio and method of use in debridement and wound healing
JP3255643B2 (en) * 1991-12-03 2002-02-12 クライン，マーガレット エル． Proteolytic mixture containing escalase and its separation method
IL103969A (en) * 1991-12-03 1997-01-10 Gerold K V Klein Proteolytic mixture containing escharase and method of isolating same
JPH08503691A (en) * 1992-06-30 1996-04-23 コーテックス リミテッド Use of enzymes, especially bromelain, in the treatment of diarrhea
GB9313188D0 (en) * 1993-06-25 1993-08-11 Cortecs Ltd Medical use of enzymes
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
US5858964A (en) 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
US5830793A (en) 1995-12-28 1998-11-03 Micron Technology, Inc. Method of selective texfturing for patterned polysilicon electrodes
US20020102253A1 (en) * 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
EP1012305A1 (en) * 1997-02-25 2000-06-28 Cortecs (UK) Limited Component of bromelain
US6803038B1 (en) * 1998-07-15 2004-10-12 Ursapharm Arzneimittel Gmbh Use of bromelaine proteases for inhibiting blood coagulation
GB9819138D0 (en) * 1998-09-02 1998-10-28 Cortecs Uk Ltd Nucleic acids and proteins from pineapple stem
US20030026794A1 (en) 2001-07-31 2003-02-06 Howard Fein Selective enzyme treatment of skin conditions
US7678908B2 (en) 2002-04-15 2010-03-16 Sun Pharmaceutical Industries Limited Process of preparing desaloratadine
AU2003222418B2 (en) * 2002-04-23 2008-10-23 Mediwound, Ltd. Apparatus and methods for enzymatic escharotomy in burn induced compartment syndrome
WO2008021543A2 (en) * 2006-08-17 2008-02-21 Monsanto Technology, Llc Transgenic plants with enhanced agronomic traits
EP2036978A1 (en) * 2007-09-14 2009-03-18 URSAPHARM Arzneimittel GmbH & Co. KG Recombinant preparation of selected bromelain fractions

Also Published As

Publication number Publication date
IL183184A (en) 2015-09-24
AU2005305461B2 (en) 2011-01-27
CA2587951C (en) 2015-03-31
AU2005305461A1 (en) 2006-05-26
WO2006054309A3 (en) 2009-04-30
ZA200704821B (en) 2008-11-26
KR20070091285A (en) 2007-09-10
BRPI0518050A (en) 2008-10-28
CN101297033A (en) 2008-10-29
NO337096B1 (en) 2016-01-18
JP2008520651A (en) 2008-06-19
US8119124B2 (en) 2012-02-21
PL1824775T3 (en) 2012-12-31
HK1124639A1 (en) 2009-07-17
EP1824775B1 (en) 2012-06-13
WO2006054309A2 (en) 2006-05-26
IL165334A0 (en) 2006-01-15
IL183184A0 (en) 2007-09-20
CA2587951A1 (en) 2006-05-26
JP5053096B2 (en) 2012-10-17
ES2389810T3 (en) 2012-10-31
MX2007006074A (en) 2007-10-04
KR101235544B1 (en) 2013-02-21
US20120171187A1 (en) 2012-07-05
NO20073115L (en) 2007-08-13
CN101297033B (en) 2012-05-30
EP1824775A4 (en) 2011-01-26
PT1824775E (en) 2012-09-19
EP1824775A2 (en) 2007-08-29
US8540983B2 (en) 2013-09-24
US20090148429A1 (en) 2009-06-11

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