DK1824482T3 - AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof - Google Patents

AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof Download PDF

Info

Publication number: DK1824482T3
Authority: DK; Denmark
Prior art keywords: mmol; thiazolo; amino; pyrimidin; mixture
Prior art date: 2004-12-17

Application number

DK05854334.9T

Other languages

Danish (da)

English (en)

Inventor

Stephen E Webber

Gregory J Haley

Joseph R Lennox

Alan Xin Xiang

Erik J Rueden

Original Assignee

Anadys Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-17

Filing date

2005-12-16

Publication date

2014-03-24

2005-12-16 Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc

2014-03-24 Application granted granted Critical

2014-03-24 Publication of DK1824482T3 publication Critical patent/DK1824482T3/en

Links

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229940002612 prodrug Drugs 0.000 title description 61
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GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical group C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1
229940051021 yellow-fever virus Drugs 0.000 description 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
229960005332 zileuton Drugs 0.000 description 1
229960002791 zimeldine Drugs 0.000 description 1
OYPPVKRFBIWMSX-SXGWCWSVSA-N zimeldine Chemical compound C=1C=CN=CC=1C(=C/CN(C)C)\C1=CC=C(Br)C=C1 OYPPVKRFBIWMSX-SXGWCWSVSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
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- C07—ORGANIC CHEMISTRY
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- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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DK05854334.9T 2004-12-17 2005-12-16 AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof DK1824482T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63663304P	2004-12-17	2004-12-17
US63663404P	2004-12-17	2004-12-17
PCT/US2005/045589 WO2006066080A1 (fr)	2004-12-17	2005-12-16	Composes de 3h-oxazolo et 3h-thiazolo [4,5-d]pyrimidine-2-one disubstitues en 3, 5 et trisubstitues en 3, 5, 7 et promedicaments associes

Publications (1)

Publication Number	Publication Date
DK1824482T3 true DK1824482T3 (en)	2014-03-24

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Application Number	Title	Priority Date	Filing Date
DK05854334.9T DK1824482T3 (en)	2004-12-17	2005-12-16	AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof
DK12193759.3T DK2561872T3 (en)	2004-12-17	2005-12-16	3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED 3H-OXAZOLO- [4,5-d] PYRIMIDIN-2-ON COMPOUNDS AND PRODRUGS THEREOF

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DK12193759.3T DK2561872T3 (en)	2004-12-17	2005-12-16	3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED 3H-OXAZOLO- [4,5-d] PYRIMIDIN-2-ON COMPOUNDS AND PRODRUGS THEREOF

Country Status (28)

Country	Link
US (4)	US7560544B2 (fr)
EP (2)	EP1824482B1 (fr)
JP (1)	JP5303149B2 (fr)
KR (1)	KR101320008B1 (fr)
CN (1)	CN102504001B (fr)
AR (1)	AR052995A1 (fr)
AU (1)	AU2005316397B2 (fr)
BR (1)	BRPI0518861B8 (fr)
CA (1)	CA2589529C (fr)
DK (2)	DK1824482T3 (fr)
EA (1)	EA013594B1 (fr)
EG (1)	EG25920A (fr)
ES (2)	ES2459368T3 (fr)
GT (1)	GT200500374A (fr)
IL (2)	IL183512A (fr)
MX (1)	MX2007007263A (fr)
MY (1)	MY176938A (fr)
NO (1)	NO20073615L (fr)
NZ (1)	NZ555723A (fr)
PA (1)	PA8657201A1 (fr)
PE (1)	PE20060837A1 (fr)
PL (2)	PL2561872T3 (fr)
PT (2)	PT1824482E (fr)
SI (2)	SI1824482T1 (fr)
TN (1)	TNSN07208A1 (fr)
TW (1)	TWI407956B (fr)
UY (1)	UY29265A1 (fr)
WO (1)	WO2006066080A1 (fr)

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2005
- 2005-12-16 DK DK05854334.9T patent/DK1824482T3/en active
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Also Published As

Publication number	Publication date
EP2561872B1 (fr)	2014-09-10
US20110275589A1 (en)	2011-11-10
MX2007007263A (es)	2007-08-14
US7560544B2 (en)	2009-07-14
MY176938A (en)	2020-08-27
NZ555723A (en)	2010-07-30
EP2561872A1 (fr)	2013-02-27
US8097718B2 (en)	2012-01-17
HK1108377A1 (en)	2008-05-09
ES2459368T3 (es)	2014-05-09
EP1824482A1 (fr)	2007-08-29
SI1824482T1 (sl)	2014-06-30
JP5303149B2 (ja)	2013-10-02
PL1824482T3 (pl)	2014-07-31
EG25920A (en)	2012-10-15
EP1824482A4 (fr)	2009-08-26
NO20073615L (no)	2007-09-12
EA013594B1 (ru)	2010-06-30
ES2525567T3 (es)	2014-12-26
IL220759A0 (en)	2012-08-30
HK1175990A1 (en)	2013-07-19
US20120121541A1 (en)	2012-05-17
WO2006066080A1 (fr)	2006-06-22
GT200500374A (es)	2006-07-03
PT2561872E (pt)	2014-12-18
PA8657201A1 (es)	2006-12-07
CN102504001B (zh)	2015-02-25
BRPI0518861A2 (pt)	2009-03-24
US20060160830A1 (en)	2006-07-20
CN102504001A (zh)	2012-06-20
CA2589529A1 (fr)	2006-06-22
US8883758B2 (en)	2014-11-11
EP1824482B1 (fr)	2014-02-12
TNSN07208A1 (en)	2008-11-21
KR101320008B1 (ko)	2013-10-18
KR20070107005A (ko)	2007-11-06
CA2589529C (fr)	2013-09-10
IL183512A (en)	2013-04-30
US20130259831A1 (en)	2013-10-03
TW200635588A (en)	2006-10-16
AR052995A1 (es)	2007-04-18
JP2008534437A (ja)	2008-08-28
TWI407956B (zh)	2013-09-11
BRPI0518861B8 (pt)	2021-05-25
AU2005316397B2 (en)	2012-02-02
DK2561872T3 (en)	2014-12-08
PL2561872T3 (pl)	2015-03-31
BRPI0518861B1 (pt)	2021-03-09
PE20060837A1 (es)	2006-09-02
IL220759A (en)	2015-07-30
EA200701296A1 (ru)	2007-12-28
AU2005316397A1 (en)	2006-06-22
IL183512A0 (en)	2007-09-20
UY29265A1 (es)	2006-07-31
SI2561872T1 (sl)	2015-02-27
PT1824482E (pt)	2014-05-13

Publication	Publication Date	Title
DK1824482T3 (en)	2014-03-24	AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof
EP2040712B1 (fr)	2011-03-02	Promédicaments à groupes fonctionnels carbonate et carbamate de thiazolo [4,5-d] pyrimidines
US7943759B2 (en)	2011-05-17	3-β-D-ribofuranosylthiazolo[4-5-d]pyrimidine nucleosides and uses thereof
EP2034834B1 (fr)	2011-01-26	Promedicaments de la 5-amino-3-(3'-desoxy-beta-d-ribofurannosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
EP1758916B1 (fr)	2012-11-21	Nucleosides 3-beta-d-ribofuranosylthiazolo[4,5-d]pyridimine et leurs utilisations
HK1175990B (en)	2015-03-13	3, 5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo [4,5-d]pyrimidin-2-one compounds and prodrugs thereof
HK1108377B (en)	2014-06-27	3, 5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo and 3h-thiazolo [4,5-d]pyrimidin-2-one compounds and prodrugs thereof
HK1126353B (en)	2011-10-21	Prodrugs of 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione