DK1824479T3 - Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering - Google Patents

Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering

Info

Publication number: DK1824479T3
Authority: DK; Denmark
Prior art keywords: serotonin reuptake; combination; reuptake inhibition; phenylpiperazine derivatives; receptor agonism
Prior art date: 2004-12-08

Application number

DK05816322T

Other languages

Danish (da)

English (en)

Inventor

Roelof W Feenstra

Axel Stoit

Jan-Willem Terpstra

Maria L Pras-Raves

Andrew C Mccreary

Vliet Bernard J Van

Mayke B Hesselink

Cornelis G Kruse

Scharrenburg G J M Van

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-08

Filing date

2005-12-06

Publication date

2009-03-09

2005-12-06 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2009-03-09 Application granted granted Critical

2009-03-09 Publication of DK1824479T3 publication Critical patent/DK1824479T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK05816322T 2004-12-08 2005-12-06 Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering DK1824479T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63407404P	2004-12-08	2004-12-08
EP04106394		2004-12-08
PCT/EP2005/056507 WO2006061378A1 (fr)	2004-12-08	2005-12-06	Derives de phenylpiperazine avec combinaison d'agonisme partiel de recepteurs de dopamine-d2 et inhibition de reabsorption de serotonine

Publications (1)

Publication Number	Publication Date
DK1824479T3 true DK1824479T3 (da)	2009-03-09

Family

ID=35744728

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK05816322T DK1824479T3 (da)	2004-12-08	2005-12-06	Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering
DK05850037T DK1827427T3 (da)	2004-12-08	2005-12-06	Aryloxyethylaminderivater med en kombination af partiel dopamin-D2 receptoragonisme og inhibition af genoptag af serotonin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK05850037T DK1827427T3 (da)	2004-12-08	2005-12-06	Aryloxyethylaminderivater med en kombination af partiel dopamin-D2 receptoragonisme og inhibition af genoptag af serotonin

Country Status (18)

Country	Link
EP (4)	EP1827426A1 (fr)
JP (4)	JP2008523031A (fr)
KR (4)	KR20070085975A (fr)
AT (2)	ATE401883T1 (fr)
AU (4)	AU2005313311A1 (fr)
BR (1)	BRPI0518613A2 (fr)
CA (4)	CA2587381A1 (fr)
DE (2)	DE602005008471D1 (fr)
DK (2)	DK1824479T3 (fr)
ES (2)	ES2311245T3 (fr)
HR (2)	HRP20080538T3 (fr)
IL (4)	IL183062A0 (fr)
NO (4)	NO20072981L (fr)
PL (2)	PL1827427T3 (fr)
PT (2)	PT1827427E (fr)
RU (4)	RU2007125659A (fr)
SI (2)	SI1827427T1 (fr)
WO (4)	WO2006061378A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2641120A1 (fr) *	2006-01-30	2007-08-02	Speedel Experimenta Ag	Procede de preparation de composes organiques
US8063062B2 (en)	2006-12-20	2011-11-22	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
US8138174B2 (en)	2007-01-10	2012-03-20	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
KR20090103932A (ko) *	2007-01-10	2009-10-01	솔베이 파마슈티칼스 비. 브이	카나비노이드-ｃｂ1 길항작용과 세로토닌 재흡수 억제가 조합된 화합물
EP2148872A1 (fr) *	2007-04-23	2010-02-03	Janssen Pharmaceutica, N.V.	Dérivés de pyridine comme antagonistes des récepteurs d2 de la dopamine à dissociation rapide
CA2682671C (fr) *	2007-04-23	2015-11-17	Janssen Pharmaceutica N.V.	Thia(dia)zoles en tant qu'antagonistes du recepteur de la dopamine a dissociation rapide
PL2148873T3 (pl) *	2007-04-23	2013-01-31	Janssen Pharmaceutica Nv	Pochodne 4-alkoksypirydazynowe jako szybko dysocjujący antagoniści receptora dopaminowego 2
CN103360342B (zh) *	2012-04-09	2015-12-16	江苏恩华药业股份有限公司	3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) *	2012-08-01	2016-08-03	江苏恩华药业股份有限公司	用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) *	2013-03-15	2014-09-16	Dipharma Francis Srl	Sintesi di un inibitore della ricaptazione della serotonina
EP3010586A1 (fr)	2013-06-21	2016-04-27	Lupin Limited	Composés hétérocycliques substitués utiles en tant que modulateurs de crac
AU2014300629A1 (en)	2013-06-24	2015-12-24	Lupin Limited	Chromane and chromene derivatives and their use as CRAC modulators
US9598401B2 (en)	2013-07-29	2017-03-21	Sunshine Lake Pharma Co., Ltd.	Substituted heteroaryl compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2692264B1 (fr) *	1992-06-12	1994-08-05	Adir	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (fr) *	1997-09-02	2003-10-29	Duphar International Research B.V	Dérivés de pipéridine et de pipérazine comme agonistes du récepteur 5-HT1
JP2002510675A (ja) *	1998-04-08	2002-04-09	アメリカン・ホーム・プロダクツ・コーポレイション	うつ病治療用のｎ−アリールオキシエチル−インドリル−アルキルアミン（５−ｈｔ１ａ受容体活性薬）
HUP0101475A3 (en) *	1998-06-19	2003-01-28	Lundbeck & Co As H	4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR022303A1 (es) *	1999-01-22	2002-09-04	Lundbeck & Co As H	Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
SK287018B6 (sk) *	1999-08-23	2009-09-07	Solvay Pharmaceuticals B. V.	Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
MXPA05006076A (es) *	2002-12-10	2005-08-16	Merck Patent Gmbh	Derivados de indol y su uso como ligandos 5-ht.

2005
- 2005-12-06 SI SI200530416T patent/SI1827427T1/sl unknown
- 2005-12-06 DE DE602005008471T patent/DE602005008471D1/de not_active Expired - Fee Related
- 2005-12-06 EP EP05813645A patent/EP1827426A1/fr not_active Withdrawn
- 2005-12-06 JP JP2007544897A patent/JP2008523031A/ja not_active Withdrawn
- 2005-12-06 KR KR1020077013041A patent/KR20070085975A/ko not_active Withdrawn
- 2005-12-06 KR KR1020077013063A patent/KR20070085988A/ko not_active Withdrawn
- 2005-12-06 KR KR1020077012935A patent/KR20070085916A/ko not_active Withdrawn
- 2005-12-06 PT PT05850037T patent/PT1827427E/pt unknown
- 2005-12-06 AU AU2005313311A patent/AU2005313311A1/en not_active Abandoned
- 2005-12-06 ES ES05850037T patent/ES2311245T3/es not_active Expired - Lifetime
- 2005-12-06 WO PCT/EP2005/056507 patent/WO2006061378A1/fr not_active Ceased
- 2005-12-06 ES ES05816322T patent/ES2317335T3/es not_active Expired - Lifetime
- 2005-12-06 WO PCT/EP2005/056505 patent/WO2006061376A1/fr not_active Ceased
- 2005-12-06 JP JP2007544898A patent/JP2008537725A/ja not_active Withdrawn
- 2005-12-06 EP EP05850037A patent/EP1827427B1/fr not_active Expired - Lifetime
- 2005-12-06 BR BRPI0518613-7A patent/BRPI0518613A2/pt not_active IP Right Cessation
- 2005-12-06 EP EP05816324A patent/EP1824480A1/fr not_active Withdrawn
- 2005-12-06 AU AU2005313391A patent/AU2005313391A1/en not_active Abandoned
- 2005-12-06 WO PCT/EP2005/056506 patent/WO2006061377A1/fr not_active Ceased
- 2005-12-06 RU RU2007125659/04A patent/RU2007125659A/ru not_active Application Discontinuation
- 2005-12-06 DE DE602005010902T patent/DE602005010902D1/de not_active Expired - Fee Related
- 2005-12-06 SI SI200530566T patent/SI1824479T1/sl unknown
- 2005-12-06 JP JP2007544895A patent/JP2008523029A/ja not_active Withdrawn
- 2005-12-06 CA CA002587381A patent/CA2587381A1/fr not_active Abandoned
- 2005-12-06 RU RU2007125661/04A patent/RU2007125661A/ru not_active Application Discontinuation
- 2005-12-06 JP JP2007544896A patent/JP2008523030A/ja not_active Withdrawn
- 2005-12-06 PL PL05850037T patent/PL1827427T3/pl unknown
- 2005-12-06 CA CA002587202A patent/CA2587202A1/fr not_active Abandoned
- 2005-12-06 RU RU2007125660/04A patent/RU2007125660A/ru not_active Application Discontinuation
- 2005-12-06 WO PCT/EP2005/056508 patent/WO2006061379A1/fr not_active Ceased
- 2005-12-06 RU RU2007125658/04A patent/RU2007125658A/ru not_active Application Discontinuation
- 2005-12-06 HR HR20080538T patent/HRP20080538T3/xx unknown
- 2005-12-06 EP EP05816322A patent/EP1824479B1/fr not_active Expired - Lifetime
- 2005-12-06 AU AU2005313390A patent/AU2005313390A1/en not_active Abandoned
- 2005-12-06 HR HR20090015T patent/HRP20090015T3/xx unknown
- 2005-12-06 DK DK05816322T patent/DK1824479T3/da active
- 2005-12-06 CA CA002587559A patent/CA2587559A1/fr not_active Abandoned
- 2005-12-06 KR KR1020077013015A patent/KR20070085959A/ko not_active Withdrawn
- 2005-12-06 PT PT05816322T patent/PT1824479E/pt unknown
- 2005-12-06 PL PL05816322T patent/PL1824479T3/pl unknown
- 2005-12-06 AU AU2005313312A patent/AU2005313312A1/en not_active Abandoned
- 2005-12-06 CA CA002587357A patent/CA2587357A1/fr not_active Abandoned
- 2005-12-06 AT AT05850037T patent/ATE401883T1/de not_active IP Right Cessation
- 2005-12-06 DK DK05850037T patent/DK1827427T3/da active
- 2005-12-06 AT AT05816322T patent/ATE413173T1/de not_active IP Right Cessation
2007
- 2007-05-08 IL IL183062A patent/IL183062A0/en unknown
- 2007-05-08 IL IL183064A patent/IL183064A0/en unknown
- 2007-05-08 IL IL183061A patent/IL183061A0/en unknown
- 2007-05-08 IL IL183063A patent/IL183063A0/en unknown
- 2007-06-11 NO NO20072981A patent/NO20072981L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072974A patent/NO20072974L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072977A patent/NO20072977L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072969A patent/NO20072969L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2008523029A (ja)	2008-07-03
NO20072969L (no)	2007-08-31
CA2587559A1 (fr)	2006-06-15
DE602005010902D1 (de)	2008-12-18
JP2008537725A (ja)	2008-09-25
KR20070085959A (ko)	2007-08-27
AU2005313391A1 (en)	2006-06-15
PT1827427E (pt)	2008-11-03
ATE413173T1 (de)	2008-11-15
KR20070085988A (ko)	2007-08-27
EP1824479A1 (fr)	2007-08-29
JP2008523031A (ja)	2008-07-03
JP2008523030A (ja)	2008-07-03
ES2317335T3 (es)	2009-04-16
CA2587202A1 (fr)	2006-06-15
CA2587381A1 (fr)	2006-06-15
NO20072974L (no)	2007-08-23
KR20070085975A (ko)	2007-08-27
AU2005313312A1 (en)	2006-06-15
KR20070085916A (ko)	2007-08-27
EP1827427A1 (fr)	2007-09-05
RU2007125660A (ru)	2009-01-20
IL183063A0 (en)	2007-09-20
IL183064A0 (en)	2007-09-20
EP1824480A1 (fr)	2007-08-29
WO2006061376A1 (fr)	2006-06-15
HRP20080538T3 (en)	2008-12-31
NO20072981L (no)	2007-09-05
ES2311245T3 (es)	2009-02-01
EP1827427B1 (fr)	2008-07-23
WO2006061379A1 (fr)	2006-06-15
IL183062A0 (en)	2007-09-20
CA2587357A1 (fr)	2006-06-15
SI1827427T1 (sl)	2008-12-31
RU2007125661A (ru)	2009-01-20
RU2007125659A (ru)	2009-01-20
WO2006061378A1 (fr)	2006-06-15
PT1824479E (pt)	2009-01-30
PL1827427T3 (pl)	2009-01-30
PL1824479T3 (pl)	2009-04-30
DK1827427T3 (da)	2008-11-24
WO2006061377A1 (fr)	2006-06-15
AU2005313311A1 (en)	2006-06-15
RU2007125658A (ru)	2009-01-20
SI1824479T1 (sl)	2009-04-30
NO20072977L (no)	2007-09-05
DE602005008471D1 (de)	2008-09-04
HRP20090015T3 (en)	2009-02-28
BRPI0518613A2 (pt)	2008-11-25
ATE401883T1 (de)	2008-08-15
EP1827426A1 (fr)	2007-09-05
AU2005313390A1 (en)	2006-06-15
EP1824479B1 (fr)	2008-11-05
IL183061A0 (en)	2007-09-20

Publication	Publication Date	Title
NO20072977L (no)	2007-09-05	Aryloksyetylaminderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
DOP2010000047A (es)	2010-04-15	Compuestos de pirazol y su uso como inhibidores de raf
EA200601686A1 (ru)	2007-02-27	Замещенные производные морфолина и тиоморфолина
ES2338590T3 (es)	2010-05-10	Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos.
HRP20090235A2 (hr)	2009-08-31	Karbonilirani (aza) cikloheksani kao ligandi dopaminskog receptora d<sub>3</sub>
CY1111733T1 (el)	2015-10-07	Παραγωγα 2-(1η-ινδολυλοσουλφανυλ)-βενζυλαμινης ως ssri
CR11463A (es)	2010-08-13	Compuestos de piridilmetil-sulfonamida
NO20084301L (no)	2008-12-12	Tetrahydronaftalenderivater, fremgangsmate for deres fremstilling og anvendelse derav som anti-inflammatoriske midler
EA200700365A1 (ru)	2007-06-29	Производные индол-2-карбоксамидина как антагонисты nmda рецептора
EA200801366A1 (ru)	2008-10-30	Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
EA200701676A1 (ru)	2008-02-28	Производные дигидроимидазотиазола
TW200634009A (en)	2006-10-01	Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
TW200631952A (en)	2006-09-16	Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
TW200633987A (en)	2006-10-01	Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
EA200970116A1 (ru)	2009-08-28	Кристаллический гидрохлорид неморубицина
EA200900982A1 (ru)	2009-12-30	Новый способ синтеза прамипексола и его фармацевтически приемлемых солей
UY31668A1 (es)	2009-09-30	"ligando de receptor d2-078"
EA200802000A1 (ru)	2009-02-27	Фармацевтически приемлемые соли и полиморфные формы
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NO20073390L (no)	2007-07-05	Fenylpiperaziner med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter
EA200700254A1 (ru)	2007-06-29	Димерные производные пипередина
UA84947C2 (en)	2008-12-10	Use of 2,4(6)-dinitroaniline derivatives as synergists of gramicides