[go: up one dir, main page]

DK1824475T3 - Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol - Google Patents

Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol

Info

Publication number
DK1824475T3
DK1824475T3 DK05807597.9T DK05807597T DK1824475T3 DK 1824475 T3 DK1824475 T3 DK 1824475T3 DK 05807597 T DK05807597 T DK 05807597T DK 1824475 T3 DK1824475 T3 DK 1824475T3
Authority
DK
Denmark
Prior art keywords
delta9
tetrahydrocannabinol
trans
purification
Prior art date
Application number
DK05807597.9T
Other languages
English (en)
Inventor
Arie L Gutman
Gennady A Nisnevich
Igor Rukhman
Boris Tishin
Marina Etinger
Irina Fedotev
Boris Pertsikov
Ram Khanolkar
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35789123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1824475(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of DK1824475T3 publication Critical patent/DK1824475T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/658Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4875Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK05807597.9T 2004-11-22 2005-11-18 Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol DK1824475T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63055604P 2004-11-22 2004-11-22
PCT/EP2005/012378 WO2006053766A1 (en) 2004-11-22 2005-11-18 Methods for purifying trans-(-)-δ9-tetrahydrocannabinol and trans-(+)-δ9-tetrahydrocannabinol

Publications (1)

Publication Number Publication Date
DK1824475T3 true DK1824475T3 (da) 2011-06-06

Family

ID=35789123

Family Applications (3)

Application Number Title Priority Date Filing Date
DK05807597.9T DK1824475T3 (da) 2004-11-22 2005-11-18 Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
DK10179360.2T DK2289509T3 (da) 2004-11-22 2005-11-18 Fremgangsmåder til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
DK10179374.3T DK2356987T3 (da) 2004-11-22 2005-11-18 Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10179360.2T DK2289509T3 (da) 2004-11-22 2005-11-18 Fremgangsmåder til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
DK10179374.3T DK2356987T3 (da) 2004-11-22 2005-11-18 Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol

Country Status (30)

Country Link
US (6) US8383842B2 (da)
EP (3) EP1824475B1 (da)
JP (3) JP4995728B2 (da)
KR (1) KR100919719B1 (da)
CN (2) CN102151259A (da)
AR (1) AR054989A1 (da)
AT (1) ATE500824T1 (da)
AU (2) AU2005305944B2 (da)
BR (1) BRPI0519803A2 (da)
CA (2) CA2921590C (da)
CY (1) CY1111471T1 (da)
DE (1) DE602005026852D1 (da)
DK (3) DK1824475T3 (da)
EA (1) EA012299B1 (da)
ES (3) ES2556802T3 (da)
HR (3) HRP20110385T1 (da)
HU (2) HUE025904T2 (da)
IL (1) IL183306A (da)
ME (2) ME02306B (da)
MX (1) MX2007006104A (da)
NO (1) NO331831B1 (da)
NZ (1) NZ556038A (da)
PL (3) PL1824475T3 (da)
PT (2) PT1824475E (da)
RS (3) RS54537B1 (da)
SI (3) SI2289509T1 (da)
TW (2) TWI369203B (da)
UA (1) UA88491C2 (da)
WO (1) WO2006053766A1 (da)
ZA (1) ZA200706837B (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI369203B (en) * 2004-11-22 2012-08-01 Euro Celtique Sa Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol
TWI366460B (en) * 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
CN101316832A (zh) 2005-09-29 2008-12-03 Amr科技公司 δ-9-四氢大麻酚的生成方法
US8039509B2 (en) 2006-11-10 2011-10-18 Johnson Matthey Public Limited Company Composition comprising (−)-Δ9-trans-tetrahydrocannabinol
US8980940B2 (en) 2006-11-10 2015-03-17 Johnson Matthey Public Limited Company Stable cannabinoid compositions and methods for making and storing them
GB0702895D0 (en) * 2007-02-14 2007-03-28 Resolution Chemicals Ltd Delta 9 tetrahydrocannabinol derivatives
GB0703284D0 (en) * 2007-02-20 2007-03-28 Resolution Chemicals Ltd Delta 9 - tetrahydrocannabinol processing
WO2009099868A1 (en) * 2008-02-06 2009-08-13 Mallinckrodt Inc. Process for the preparation of (-) -delta 9-tetrahydrocannabinol
WO2014030053A1 (en) 2012-08-20 2014-02-27 Rhodes Technologies Systems and methods for increasing stability of dronabinol compositions
EP3160445B1 (en) 2014-06-26 2021-10-20 Island Breeze Systems Ca, LLC Mdi related products and methods of use
US10207198B2 (en) 2015-01-22 2019-02-19 Phytoplant Research S.L. Methods of purifying cannabinoids using liquid:liquid chromatography
US11034639B2 (en) 2015-01-22 2021-06-15 Phytoplant Research S.L. Methods of purifying cannabinoids using liquid:liquid chromatography
US10155708B2 (en) * 2015-01-22 2018-12-18 Phytoplant Research S.L. Methods of purifying cannabinoids, compositions and kits thereof
CN106268657A (zh) * 2015-05-14 2017-01-04 株式会社大赛璐 光学异构体用分离剂
US20170008869A1 (en) * 2015-07-10 2017-01-12 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
WO2017194173A1 (en) * 2016-05-13 2017-11-16 Symrise Ag Method for purifying cannabinoid compounds
US10499584B2 (en) 2016-05-27 2019-12-10 New West Genetics Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles
US10399920B2 (en) 2016-06-01 2019-09-03 S&B Pharma, Inc. Crystalline form of cannabidiol
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
CN106810426B (zh) * 2016-12-29 2020-05-08 暨明医药科技(苏州)有限公司 一种大麻二酚的合成方法
US11213558B2 (en) 2017-05-17 2022-01-04 Orochem Technologies, Inc. CBX extraction-isolation process
US10189762B1 (en) 2017-07-07 2019-01-29 Orochem Technologies, Inc. Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves
CA3074173A1 (en) * 2017-09-01 2019-03-07 Pureform Global, Inc. Synthetic cannabidiol compositions and methods of making the same
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
WO2019173582A1 (en) * 2018-03-07 2019-09-12 Socati Technologies Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
US11192870B2 (en) 2018-03-07 2021-12-07 Socati Technologies—Oregon, Llc Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
US11851415B2 (en) 2018-03-07 2023-12-26 Cleen Technology Inc. Continuous isolation of cannabidiol and cannabinoids and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol
WO2020001770A1 (en) * 2018-06-28 2020-01-02 Symrise Ag Synthesis of (+)-cannabinoids and their therapeutic effects
CA3073093A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
WO2020089424A1 (en) 2018-10-31 2020-05-07 Enantia, S.L. Solid compositions of cocrystals of cannabinoids
EP3653596A1 (en) * 2018-11-14 2020-05-20 Indena S.p.A. Continuous flow synthesis of cannabidiol
CN109734554B (zh) * 2019-02-25 2021-11-23 江苏暨明医药科技有限公司 一种反式-薄荷基-2,8-二烯-1-醇的合成工艺
CN111943813B (zh) * 2019-05-17 2023-04-14 上海特化医药科技有限公司 大麻二酚类化合物的制备方法
WO2020248062A1 (en) * 2019-06-11 2020-12-17 Canopy Growth Corporation Improved methods for cannabinoid isomerization
WO2020248058A1 (en) 2019-06-11 2020-12-17 Canopy Growth Corporation Improved methods for converting cannabidiol into delta 8-tetrahydrocannabinol
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
US11542243B1 (en) 2019-09-26 2023-01-03 FusionFarms, LLC Method of converting delta9-THC to delta10-THC and the purification of the delta10-THC by crystallization
AU2020370165A1 (en) * 2019-10-21 2022-04-21 Esolate Ltd Compositions comprising superfine compounds and production thereof
GB2588455B (en) * 2019-10-25 2022-12-21 Gw Res Ltd Cannabinoid compound
GB2588457B (en) * 2019-10-25 2022-12-21 Gw Res Ltd Cannabinoid compound
GB2588456B (en) * 2019-10-25 2023-02-01 Gw Res Ltd Cannabinoid compound
WO2021181420A1 (en) 2020-03-12 2021-09-16 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Process for the synthesis of cannabidiol and intermediates thereof
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
US12195438B2 (en) 2020-12-10 2025-01-14 Kazmira Llc. Process for removing THC from cannabinoids
CN113336705B (zh) * 2021-08-09 2021-12-10 中国农业科学院农产品加工研究所 一种大麻二酚-2-咪唑-1-甲酸酯及其应用
CA3263937A1 (en) 2022-08-05 2024-02-08 Salud & Semillas, S.L. SYNTHESIS OF CANNABINOIDS FROM OLIVETOL AND TERPENE IN DICHLOROMETHANE WITH FECL3 * 6H2O AS A CATALYST
CN115583933B (zh) * 2022-10-31 2024-02-06 暨明医药科技(苏州)有限公司 一种高纯度四氢大麻素同系物的制备方法
CN115784836A (zh) * 2022-12-08 2023-03-14 南京康立瑞生物科技有限公司 一种高选择性的制备反式-薄荷基-2,8-二烯-1-醇的方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507885A (en) * 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
CH481911A (de) 1967-05-19 1969-11-30 Theodor Dr Petrzilka Verfahren zur Herstellung von tricyclischen Verbindungen
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3668224A (en) * 1970-07-02 1972-06-06 Theodor Petrzilka PROCESS OF PRODUCING 6a, 10a-TRANS-6a,7,8,10a-TETRAHYDRODIBENZO (b,d)-PYRANS
US4025516A (en) 1975-06-23 1977-05-24 The John C. Sheehan Institute For Research, Inc. Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans
US4381399A (en) 1981-12-21 1983-04-26 Aerojet-General Corporation Purification of tetrahydrodibenzo[b,d]pyrans from crude synthetic mixtures
US4861598A (en) * 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4970075A (en) * 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
DE4100441A1 (de) * 1991-01-09 1992-07-16 Mack Chem Pharm Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol
US6703418B2 (en) * 1991-02-26 2004-03-09 Unimed Pharmaceuticals, Inc. Appetite stimulation and induction of weight gain in patients suffering from symptomatic HIV infection
US5389375A (en) 1993-05-21 1995-02-14 University Of Mississippi Stable suppository formulations effecting bioavailability of Δ9 -thc
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
AU6111796A (en) * 1995-06-12 1997-01-09 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
US6328992B1 (en) * 1997-03-03 2001-12-11 Lawrence L. Brooke Cannabinoid patch and method for cannabis transdermal delivery
GB9726916D0 (en) * 1997-12-19 1998-02-18 Danbiosyst Uk Nasal formulation
US20020039795A1 (en) * 1998-10-26 2002-04-04 Elsohly Et Al Method of preparing delta-9-tetrahydrocannabinol
US6730519B2 (en) 1998-10-26 2004-05-04 The University Of Mississippi Method of preparing delta-9-tetrahydrocannabinol
US6509005B1 (en) * 1998-10-27 2003-01-21 Virginia Commonwealth University Δ9 Tetrahydrocannabinol (Δ9 THC) solution metered dose inhaler
FI990915A0 (fi) * 1999-04-23 1999-04-23 Orion Yhtymae Oyj Jauheinhalaattori
US6403126B1 (en) * 1999-05-26 2002-06-11 Websar Innovations Inc. Cannabinoid extraction method
US6555139B2 (en) * 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6747058B1 (en) * 1999-08-20 2004-06-08 Unimed Pharmaceuticals, Inc. Stable composition for inhalation therapy comprising delta-9-tetrahydrocannabinol and semiaqueous solvent therefor
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
GB2368061B (en) * 2000-10-20 2005-05-11 Gw Pharmaceuticals Ltd Dose dispensing apparatus
BR0115382A (pt) * 2000-10-30 2003-09-16 Euro Celtique Sa Formulações para liberação controlada de hidrocodona, método de produzir analgesia efetiva, processo de preparação de uma forma farmacêutica de um sólido oral de liberação controlada, liberação controlada da forma farmacêutica oral e uso da forma farmacêutica
US6730330B2 (en) * 2001-02-14 2004-05-04 Gw Pharma Limited Pharmaceutical formulations
CH695661A5 (de) * 2001-03-06 2006-07-31 Forsch Hiscia Ver Fuer Krebsfo Pharmazeutische Zusammensetzung.
EP1409473A2 (en) * 2001-03-07 2004-04-21 Websar Innovations Inc. CONVERSION OF CBD TO $g(D)?8 -THC AND $g(D)?9 -THC
US20030050334A1 (en) * 2001-04-30 2003-03-13 Murty Ram B. Process for extraction of Delta-9-Tetrahydrocannabinol and other related cannabinoids and preparation of specific strength marijuana cigarettes
GB0112752D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
BR0307330A (pt) * 2002-02-01 2004-12-07 Resolution Chemicals Ltd Produção do delta-9-tetraidrocanabinol
WO2003070506A1 (fr) 2002-02-21 2003-08-28 Biel Timothee Dispositif d'entraînement pour vehicules a moteur, notamment avec propulsion hybride
UA79281C2 (en) * 2002-04-03 2007-06-11 Solvay Pharm Bv Stabilized composition comprising a natural cannabinoid compound and process for the preparation thereof
US6946150B2 (en) * 2002-08-14 2005-09-20 Gw Pharma Limited Pharmaceutical formulation
GB0222077D0 (en) 2002-09-23 2002-10-30 Gw Pharma Ltd Methods of preparing cannabinoids from plant material
CN100455576C (zh) 2002-11-12 2009-01-28 马林克罗特公司 大麻素的结晶衍生物及大麻素的纯化方法
US20040229939A1 (en) * 2003-02-14 2004-11-18 Chowdhury Dipak K. Tetrahydrocannabinol compositions and methods of manufacture and use thereof
AU2004287495A1 (en) 2003-11-05 2005-05-19 Unimed Pharmaceuticals, Inc. Delta-9- the treatment of multiple sclerosis
GB0329635D0 (en) * 2003-12-23 2004-01-28 Johnson Matthey Plc Process for purifying trans-tetrahydrocannabinol
EP1773801A1 (de) * 2004-07-19 2007-04-18 Cilag Ltd. Verfahren zur gewinnung von reinem tetrahydrocannabinol
GB0425445D0 (en) * 2004-11-18 2004-12-22 Smithkline Beecham Corp Novel compositions
TWI369203B (en) * 2004-11-22 2012-08-01 Euro Celtique Sa Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol
TWI366460B (en) * 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
DK2176208T3 (da) 2007-07-30 2015-04-27 Zynerba Pharmaceuticals Inc Prodrugs for cannabidiol, sammensætninger indeholdende prodrugs for cannabidiol og fremgangsmåder til anvendelse deraf
US8642645B2 (en) * 2011-05-20 2014-02-04 Brooks Kelly Research, LLC. Pharmaceutical composition comprising Cannabinoids

Also Published As

Publication number Publication date
US9675581B2 (en) 2017-06-13
IL183306A (en) 2012-06-28
US8383842B2 (en) 2013-02-26
SI2289509T1 (sl) 2016-01-29
WO2006053766A1 (en) 2006-05-26
BRPI0519803A2 (pt) 2009-03-17
DE602005026852D1 (de) 2011-04-21
CA2587957A1 (en) 2006-05-26
PL2356987T3 (pl) 2016-09-30
PL1824475T3 (pl) 2011-09-30
CA2921590A1 (en) 2006-05-26
NO331831B1 (no) 2012-04-16
NO20072964L (no) 2007-08-17
HUE027197T2 (en) 2016-10-28
HK1154796A1 (en) 2012-05-04
JP4995728B2 (ja) 2012-08-08
WO2006053766A8 (en) 2006-12-14
US9278083B2 (en) 2016-03-08
CY1111471T1 (el) 2015-08-05
RS51706B (sr) 2011-10-31
ES2556802T3 (es) 2016-01-20
KR20070086529A (ko) 2007-08-27
US9744151B2 (en) 2017-08-29
DK2289509T3 (da) 2015-11-23
JP2012180350A (ja) 2012-09-20
PT2289509E (pt) 2015-12-23
DK2356987T3 (da) 2016-03-21
MX2007006104A (es) 2007-07-11
ES2362288T3 (es) 2011-06-30
TWI436991B (zh) 2014-05-11
HRP20110385T1 (hr) 2011-06-30
SI1824475T1 (sl) 2011-06-30
UA88491C2 (ru) 2009-10-26
JP5048448B2 (ja) 2012-10-17
HK1159500A1 (en) 2012-08-03
ME02306B (me) 2016-06-20
PL2289509T3 (pl) 2016-04-29
PT1824475E (pt) 2011-06-01
US20160184261A1 (en) 2016-06-30
HUE025904T2 (en) 2016-05-30
ME02403B (me) 2016-09-20
NZ556038A (en) 2009-12-24
CN101076329A (zh) 2007-11-21
AU2005305944B2 (en) 2010-03-04
JP2008101000A (ja) 2008-05-01
EA012299B1 (ru) 2009-08-28
EP2289509B1 (en) 2015-10-14
KR100919719B1 (ko) 2009-10-06
TWI369203B (en) 2012-08-01
EP2289509A2 (en) 2011-03-02
JP2008520608A (ja) 2008-06-19
TW201302722A (zh) 2013-01-16
SI2356987T1 (sl) 2016-04-29
RS54537B1 (sr) 2016-06-30
ATE500824T1 (de) 2011-03-15
EP2356987A1 (en) 2011-08-17
CN101076329B (zh) 2011-08-10
US20150126596A1 (en) 2015-05-07
EP1824475A1 (en) 2007-08-29
US20160199344A1 (en) 2016-07-14
EP1824475B1 (en) 2011-03-09
HRP20151301T1 (hr) 2016-01-01
EP2289509A3 (en) 2011-08-10
HK1109058A1 (en) 2008-05-30
IL183306A0 (en) 2007-09-20
TW200633695A (en) 2006-10-01
US20160184260A1 (en) 2016-06-30
ES2566480T3 (es) 2016-04-13
AU2010200227A1 (en) 2010-02-11
CA2587957C (en) 2016-05-03
CN102151259A (zh) 2011-08-17
EP2356987B1 (en) 2016-01-06
RS54338B1 (sr) 2016-02-29
AU2005305944A1 (en) 2006-05-26
US20130171259A1 (en) 2013-07-04
HRP20160300T1 (hr) 2016-04-22
ZA200706837B (en) 2008-04-30
US8937097B2 (en) 2015-01-20
US20090298930A1 (en) 2009-12-03
EA200701123A1 (ru) 2007-12-28
AR054989A1 (es) 2007-08-01
CA2921590C (en) 2019-09-24

Similar Documents

Publication Publication Date Title
DK1824475T3 (da) Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
DK1667986T3 (da) Acetonesolvat af dimethoxydocetaxel og fremgangsmåde til fremstilling heraf
DK3121169T3 (da) Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser
DK1888033T3 (da) Fremgangsmåde og sammensætning til behandling af inflammatoriske sygdomme
DK1805312T3 (da) Fremgangsmåder og midler til fremstilling af hyaluronan
DK1934179T3 (da) Fremgangsmåder og mellemprodukter
DK1644021T3 (da) Fremgangsmåder og sammensætninger til behandlingen af gastrointestinale sygdomme
DK1828164T3 (da) Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider
DK1778668T3 (da) Fremgangsmåde til fremstilling af dihydropteridion
DK1948852T3 (da) Hovedelektrode og fremgangsmåde til dannelse af hovedelektroden
DE602005012267D1 (de) N von geräten
DK1720866T3 (da) Fremgangsmåde
DK1647529T3 (da) Fremgangsmåde til oprensing af spildevand
DK3321359T3 (da) Variante former af uratoxidase og anvendelse deraf
DK1858488T4 (da) Tigecyclinsammensætninger og fremgangsmåder til fremstilling deraf
DK3403657T3 (da) Anvendelse af oligouronater til behandling af slimhyperviskositet
DE602006004463D1 (de) Kristallform von asenapinmaleat
DK1750713T3 (da) Anvendelse af imatinib til behandling af leversygdomme og vi-rusinfektioner
DK1896077T3 (da) Fremgangsmåder og sammensætninger til forebyggelse og behandling af inflammatoriske sygdomme
PT1763520E (pt) Utilização de benzopiranonas trissubstituídas
DK1745844T3 (da) System og fremgangsmåde til bortskaffelse af urenheder
DK1919290T3 (da) Fremgangsmåder og produkter til behandling af sygdomme
DK3332789T3 (da) Cladribinkur til behandling af multipel sklerose
DK1831223T3 (da) Fremgangsmåde til fremstilling af L-biopterin
DK1740534T3 (da) Fremgangsmåde til rensning af mesotrion