DK1887359T3 - Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K - Google Patents
Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3KInfo
- Publication number
- DK1887359T3 DK1887359T3 DK06016205T DK06016205T DK1887359T3 DK 1887359 T3 DK1887359 T3 DK 1887359T3 DK 06016205 T DK06016205 T DK 06016205T DK 06016205 T DK06016205 T DK 06016205T DK 1887359 T3 DK1887359 T3 DK 1887359T3
- Authority
- DK
- Denmark
- Prior art keywords
- pi3k
- phenylthiazole ligand
- immobilized
- phenylthiazole
- ligand
- Prior art date
Links
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 title abstract 20
- 108091007960 PI3Ks Proteins 0.000 title abstract 20
- 238000000034 method Methods 0.000 title abstract 5
- WYKHSBAVLOPISI-UHFFFAOYSA-N 2-phenyl-1,3-thiazole Chemical compound C1=CSC(C=2C=CC=CC=2)=N1 WYKHSBAVLOPISI-UHFFFAOYSA-N 0.000 abstract 15
- 239000003446 ligand Substances 0.000 abstract 15
- 150000001875 compounds Chemical class 0.000 abstract 9
- 238000002360 preparation method Methods 0.000 abstract 7
- 102000004169 proteins and genes Human genes 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 230000015572 biosynthetic process Effects 0.000 abstract 5
- 239000007787 solid Substances 0.000 abstract 5
- 238000003306 harvesting Methods 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Vending Machines For Individual Products (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06016205A EP1887359B1 (en) | 2006-08-03 | 2006-08-03 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1887359T3 true DK1887359T3 (da) | 2009-03-02 |
Family
ID=37635850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06016205T DK1887359T3 (da) | 2006-08-03 | 2006-08-03 | Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8153389B2 (da) |
| EP (1) | EP1887359B1 (da) |
| JP (1) | JP5234668B2 (da) |
| CN (1) | CN101563612B (da) |
| AT (1) | ATE414281T1 (da) |
| AU (1) | AU2007280631B2 (da) |
| CA (1) | CA2658904A1 (da) |
| DE (1) | DE602006003651D1 (da) |
| DK (1) | DK1887359T3 (da) |
| ES (1) | ES2317382T3 (da) |
| WO (1) | WO2008015013A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0716239A2 (pt) | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| CA2706578A1 (en) | 2007-11-27 | 2009-06-04 | Cellzome Limited | Amino triazoles as pi3k inhibitors |
| CA2713276A1 (en) | 2008-02-04 | 2009-08-13 | Cellzome Ag | Selectivity profiling of pi3k interacting molecules against multiple targets |
| WO2009138229A1 (en) * | 2008-05-16 | 2009-11-19 | Cellzome Ag | Methods for the identification of parp interacting molecules and for purification of parp proteins |
| WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
| US8785457B2 (en) | 2009-03-13 | 2014-07-22 | Cellzome Limited | Pyrimidine derivatives as mTOR inhibitors |
| ES2423804T3 (es) | 2009-04-03 | 2013-09-24 | Cellzome Gmbh | Métodos para la identificación de moléculas que interaccionan con cinasas y para la purificación de proteínas de cinasa |
| US8367830B2 (en) | 2009-05-20 | 2013-02-05 | Cellzome Ag | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins |
| ES2535116T3 (es) | 2010-03-04 | 2015-05-05 | Cellzome Limited | Derivados de urea sustituida con morfolino como inhibidores de mtor |
| US20140163023A1 (en) | 2011-04-04 | 2014-06-12 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
| RU2616619C2 (ru) | 2011-09-21 | 2017-04-18 | Селлзоум Лимитед | Морфолино-замещенные производные мочевины или карбамата в качестве ингибиторов mtor |
| BR112014008241A2 (pt) | 2011-10-07 | 2017-04-18 | Cellzome Ltd | composto, composição farmacêutica, métodos para tratar, controlar, retardar ou prevenir doenças e distúrbios, e para preparar um composto, e, uso de um composto |
| US20160022757A1 (en) * | 2013-03-15 | 2016-01-28 | Icahn School Of Medicine At Mount Sinai | Therapeutic methods for treating solid tumors and related diagnostic methods |
| CN115754306A (zh) * | 2022-12-02 | 2023-03-07 | 中国科学院生态环境研究中心 | 化合物下拉靶点蛋白的方法 |
| CN116773823A (zh) * | 2023-06-25 | 2023-09-19 | 济宁医学院附属医院 | 一种快速鉴定与蛋白相互作用的小分子代谢物配体的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4952512A (en) * | 1984-06-22 | 1990-08-28 | Loskutoff David J | Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators |
| US5994082A (en) * | 1994-08-26 | 1999-11-30 | Mach; Bernard | Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity |
| CA2239463A1 (en) * | 1996-11-01 | 1998-05-14 | Onyx Pharmaceuticals, Inc. | Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof |
| AR038703A1 (es) * | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| US7138401B2 (en) * | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | 2-aminopurine analogs having HSP90-inhibiting activity |
| SE0402735D0 (sv) * | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
| PL1891446T3 (pl) | 2005-06-14 | 2013-08-30 | Cellzome Gmbh | Sposób identyfikacji nowych związków oddziałujących z enzymami |
| CA2713276A1 (en) | 2008-02-04 | 2009-08-13 | Cellzome Ag | Selectivity profiling of pi3k interacting molecules against multiple targets |
-
2006
- 2006-08-03 DK DK06016205T patent/DK1887359T3/da active
- 2006-08-03 ES ES06016205T patent/ES2317382T3/es active Active
- 2006-08-03 EP EP06016205A patent/EP1887359B1/en not_active Not-in-force
- 2006-08-03 AT AT06016205T patent/ATE414281T1/de active
- 2006-08-03 DE DE602006003651T patent/DE602006003651D1/de active Active
-
2007
- 2007-08-03 WO PCT/EP2007/006887 patent/WO2008015013A1/en not_active Ceased
- 2007-08-03 JP JP2009522180A patent/JP5234668B2/ja not_active Expired - Fee Related
- 2007-08-03 US US12/375,979 patent/US8153389B2/en not_active Expired - Fee Related
- 2007-08-03 AU AU2007280631A patent/AU2007280631B2/en not_active Ceased
- 2007-08-03 CN CN2007800344464A patent/CN101563612B/zh not_active Expired - Fee Related
- 2007-08-03 CA CA002658904A patent/CA2658904A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1887359B1 (en) | 2008-11-12 |
| JP2010500870A (ja) | 2010-01-14 |
| US8153389B2 (en) | 2012-04-10 |
| CN101563612B (zh) | 2013-05-29 |
| CA2658904A1 (en) | 2008-02-07 |
| US20100055711A1 (en) | 2010-03-04 |
| DE602006003651D1 (de) | 2008-12-24 |
| JP5234668B2 (ja) | 2013-07-10 |
| HK1111218A1 (en) | 2008-08-01 |
| CN101563612A (zh) | 2009-10-21 |
| WO2008015013A1 (en) | 2008-02-07 |
| AU2007280631B2 (en) | 2013-02-21 |
| ES2317382T3 (es) | 2009-04-16 |
| EP1887359A1 (en) | 2008-02-13 |
| AU2007280631A1 (en) | 2008-02-07 |
| ATE414281T1 (de) | 2008-11-15 |
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