DK1853581T3 - 2-Sulfinyl- og 2-sulfonyl-substituerede imidazolderivater og deres anvendelse som cytokininhibitorer - Google Patents
2-Sulfinyl- og 2-sulfonyl-substituerede imidazolderivater og deres anvendelse som cytokininhibitorerInfo
- Publication number
- DK1853581T3 DK1853581T3 DK06723133.2T DK06723133T DK1853581T3 DK 1853581 T3 DK1853581 T3 DK 1853581T3 DK 06723133 T DK06723133 T DK 06723133T DK 1853581 T3 DK1853581 T3 DK 1853581T3
- Authority
- DK
- Denmark
- Prior art keywords
- sulfinyl
- sulfonyl
- imidazole derivatives
- substituted imidazole
- cytokine inhibitors
- Prior art date
Links
- -1 2-sulfonyl-substituted imidazole Chemical class 0.000 title abstract 2
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65638905P | 2005-02-28 | 2005-02-28 | |
| EP05004369 | 2005-02-28 | ||
| PCT/EP2006/001801 WO2006089798A1 (en) | 2005-02-28 | 2006-02-27 | 2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives and their use as cytokine inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1853581T3 true DK1853581T3 (da) | 2010-09-27 |
Family
ID=34933989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06723133.2T DK1853581T3 (da) | 2005-02-28 | 2006-02-27 | 2-Sulfinyl- og 2-sulfonyl-substituerede imidazolderivater og deres anvendelse som cytokininhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100273833A1 (da) |
| EP (1) | EP1853581B1 (da) |
| JP (1) | JP2008531627A (da) |
| KR (1) | KR20070107082A (da) |
| CN (1) | CN101128453A (da) |
| AT (1) | ATE469893T1 (da) |
| AU (1) | AU2006218037B2 (da) |
| BR (1) | BRPI0608739A2 (da) |
| CA (1) | CA2599449A1 (da) |
| DE (1) | DE602006014657D1 (da) |
| DK (1) | DK1853581T3 (da) |
| ES (1) | ES2351308T3 (da) |
| IL (1) | IL184745A0 (da) |
| MX (1) | MX2007010496A (da) |
| NO (1) | NO20074912L (da) |
| NZ (1) | NZ560264A (da) |
| PT (1) | PT1853581E (da) |
| RU (1) | RU2007135955A (da) |
| WO (1) | WO2006089798A1 (da) |
| ZA (1) | ZA200708203B (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1894925A1 (en) * | 2006-08-24 | 2008-03-05 | Merckle Gmbh | Imidazole compounds having an antiinflammatory effect |
| US8143294B2 (en) | 2007-12-31 | 2012-03-27 | Michael Burnet | 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors |
| CN102249992A (zh) * | 2011-07-05 | 2011-11-23 | 广东工业大学 | 一种制备2-氨基异烟酸的方法 |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US11739078B2 (en) | 2019-02-22 | 2023-08-29 | Insilico Medicine Ip Limited | Methods of inhibiting kinases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL133766A0 (en) * | 1997-06-30 | 2001-04-30 | Ortho Mcneil Pharm Inc | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| GB9713726D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| JP2003503456A (ja) * | 1999-07-02 | 2003-01-28 | スチュアート エイ． リプトン | 神経傷害またはアポトーシスを軽減する方法 |
| DE10107683A1 (de) * | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10114775A1 (de) * | 2001-03-26 | 2002-10-10 | Gerhard Dannhardt | 2-Mercapto-4,5-diarylimidazolderivate und ihre Verwendung in der Pharmazie |
| KR20020009532A (ko) * | 2001-11-13 | 2002-02-01 | (주)쎌믹스 | 류코트리엔 합성 억제용 조성물 |
| DE10222103A1 (de) * | 2002-05-17 | 2003-11-27 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10238045A1 (de) * | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
-
2006
- 2006-02-27 NZ NZ560264A patent/NZ560264A/en not_active IP Right Cessation
- 2006-02-27 CN CNA2006800062247A patent/CN101128453A/zh active Pending
- 2006-02-27 DE DE602006014657T patent/DE602006014657D1/de active Active
- 2006-02-27 EP EP06723133A patent/EP1853581B1/en active Active
- 2006-02-27 BR BRPI0608739-6A patent/BRPI0608739A2/pt not_active IP Right Cessation
- 2006-02-27 ES ES06723133T patent/ES2351308T3/es active Active
- 2006-02-27 CA CA002599449A patent/CA2599449A1/en not_active Abandoned
- 2006-02-27 RU RU2007135955/04A patent/RU2007135955A/ru not_active Application Discontinuation
- 2006-02-27 MX MX2007010496A patent/MX2007010496A/es not_active Application Discontinuation
- 2006-02-27 DK DK06723133.2T patent/DK1853581T3/da active
- 2006-02-27 US US11/817,298 patent/US20100273833A1/en not_active Abandoned
- 2006-02-27 JP JP2007557404A patent/JP2008531627A/ja active Pending
- 2006-02-27 AU AU2006218037A patent/AU2006218037B2/en not_active Ceased
- 2006-02-27 WO PCT/EP2006/001801 patent/WO2006089798A1/en not_active Ceased
- 2006-02-27 PT PT06723133T patent/PT1853581E/pt unknown
- 2006-02-27 KR KR1020077019748A patent/KR20070107082A/ko not_active Ceased
- 2006-02-27 AT AT06723133T patent/ATE469893T1/de not_active IP Right Cessation
-
2007
- 2007-07-19 IL IL184745A patent/IL184745A0/en unknown
- 2007-09-26 ZA ZA200708203A patent/ZA200708203B/xx unknown
- 2007-09-27 NO NO20074912A patent/NO20074912L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0608739A2 (pt) | 2011-03-15 |
| ZA200708203B (en) | 2008-10-29 |
| ES2351308T3 (es) | 2011-02-02 |
| CN101128453A (zh) | 2008-02-20 |
| ATE469893T1 (de) | 2010-06-15 |
| DE602006014657D1 (de) | 2010-07-15 |
| US20100273833A1 (en) | 2010-10-28 |
| AU2006218037B2 (en) | 2012-04-05 |
| NZ560264A (en) | 2009-11-27 |
| NO20074912L (no) | 2007-11-28 |
| EP1853581B1 (en) | 2010-06-02 |
| WO2006089798A1 (en) | 2006-08-31 |
| IL184745A0 (en) | 2007-12-03 |
| RU2007135955A (ru) | 2009-04-10 |
| MX2007010496A (es) | 2007-11-07 |
| PT1853581E (pt) | 2010-09-09 |
| CA2599449A1 (en) | 2006-08-31 |
| JP2008531627A (ja) | 2008-08-14 |
| AU2006218037A1 (en) | 2006-08-31 |
| KR20070107082A (ko) | 2007-11-06 |
| EP1853581A1 (en) | 2007-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1483265T3 (da) | Purinderivater som kinaseinhibitorer | |
| NO20063925L (no) | Indazolderivater som inhibitorer av hormonsensitiv lipase | |
| NO20083427L (no) | Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse | |
| NO20083726L (no) | Spiroindolinon derivater | |
| CY1120741T1 (el) | Θεραπεια οζωδους σκληρυνσης | |
| EA200501928A1 (ru) | Пирролодигидроизохинолины как ингибиторы pde10 | |
| CY1113314T1 (el) | (3-αρυλ-πιπεραζιν-1-υλ) παραγωγα της 6,7-διαλκοξυκιναζολινης, 6,7-διαλκοξυφθαλαζινης και 6,7-διαλκοξυϊσοκινολινης | |
| NO20064976L (no) | Azanidoler som er nyttige som inhibitorer av rock og andre proteinkinaser | |
| NO20081454L (no) | Met-kinaseinhibitorer | |
| EA200801428A1 (ru) | Производные пиридиазинона для лечения опухолей | |
| NO20082026L (no) | Deazapuriner som er nyttige som inhibitorer for Janus-kinaser | |
| ATE517896T1 (de) | P38-kinase-inhibitoren | |
| DK1836169T5 (da) | Sammensætninger og fremgangsmåder til behandling af celleproliferationslidelser | |
| NO20083501L (no) | Azaindoler som er anvendelige som inhibitorer for Janus-kinaser | |
| NO20083923L (no) | Pyrazolkinoloner er potente parp-inhibitorer | |
| DK1682530T3 (da) | Pyrrolsubstituerede indoler som inhibitorer af PAI-1 | |
| UA102858C2 (ru) | Производные пиридино-пиридинонов, способ их получения и применения в терапии | |
| ATE553093T1 (de) | Indazolderivate zur hemmung von trpv1 und verwendungen davon | |
| NO20062020L (no) | 1-amino-2-oksysubstituerte tetrahydronaftalenderivater, fremgangsmate for fremstilling derav, og deres anvendelse som antiflogistika | |
| MY147649A (en) | Benzimidazole derivatives useful in treatment of vallinoid receptor trpv1 related disorders | |
| NO20054848L (no) | Substituerte p-diaminobenzenderivater | |
| WO2009061924A3 (en) | Aldh-2 inhibitors in the treatment of psychiatric disorders | |
| UA107689C2 (xx) | ПОХІДНІ 3,4,4A,10B-ТЕТРАГІДРО-1H-ТІОПІРАНО$4, 3-c]ІЗОХІНОЛІНУ | |
| ZA200708203B (en) | 2-Sulfinyl- and 2-sulfonyl-substituted imidazole derivatives and their use as cytokine inhibitors | |
| EA201000618A1 (ru) | 5-цианотиенопиридины для лечения опухолей |