DK1851214T3 - Isoxazolinderivat samt hidtil ukendt fremgangsmåde til dets fremstilling - Google Patents
Isoxazolinderivat samt hidtil ukendt fremgangsmåde til dets fremstillingInfo
- Publication number
- DK1851214T3 DK1851214T3 DK06716026.7T DK06716026T DK1851214T3 DK 1851214 T3 DK1851214 T3 DK 1851214T3 DK 06716026 T DK06716026 T DK 06716026T DK 1851214 T3 DK1851214 T3 DK 1851214T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- novel process
- isoxazoline derivative
- isoxazoline
- derivative
- Prior art date
Links
- 150000002547 isoxazolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20050016203 | 2005-02-26 | ||
| PCT/KR2006/000576 WO2006090997A1 (en) | 2005-02-26 | 2006-02-21 | Isoxazoline derivative and novel process for its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1851214T3 true DK1851214T3 (da) | 2012-10-15 |
Family
ID=36927605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06716026.7T DK1851214T3 (da) | 2005-02-26 | 2006-02-21 | Isoxazolinderivat samt hidtil ukendt fremgangsmåde til dets fremstilling |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8044080B2 (da) |
| EP (1) | EP1851214B1 (da) |
| JP (1) | JP4961357B2 (da) |
| KR (1) | KR100774999B1 (da) |
| CN (1) | CN101128459B (da) |
| AP (1) | AP2374A (da) |
| AR (1) | AR055314A1 (da) |
| AU (1) | AU2006217293B2 (da) |
| BR (1) | BRPI0607330B1 (da) |
| CA (1) | CA2598347C (da) |
| DK (1) | DK1851214T3 (da) |
| EA (1) | EA013005B1 (da) |
| ES (1) | ES2394480T3 (da) |
| IL (1) | IL185226A0 (da) |
| MA (1) | MA29311B1 (da) |
| MX (1) | MX2007010338A (da) |
| MY (1) | MY149181A (da) |
| NO (1) | NO341347B1 (da) |
| NZ (1) | NZ560805A (da) |
| PE (1) | PE20061076A1 (da) |
| PL (1) | PL1851214T3 (da) |
| PT (1) | PT1851214E (da) |
| SG (1) | SG156689A1 (da) |
| SI (1) | SI1851214T1 (da) |
| TW (1) | TWI377205B (da) |
| UA (1) | UA94395C2 (da) |
| WO (1) | WO2006090997A1 (da) |
| ZA (1) | ZA200707202B (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101299720B1 (ko) * | 2006-08-16 | 2013-08-28 | 주식회사 엘지생명과학 | 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법 |
| KR20090099886A (ko) * | 2008-03-18 | 2009-09-23 | 주식회사 엘지생명과학 | 캐스파제 저해제의 프로드럭 |
| AR072181A1 (es) * | 2008-07-11 | 2010-08-11 | Gilead Sciences Inc | Metodo de tratamiento y composiciones farmaceuticas que comprenden (r)-n-((2s,3s)-2-(fluorometil)-2-hidroxi-5-oxo-tetrahidrofuran-3-il)-5-isopropil-3-(isoquinolin-1-il)-4,5-dihidroisoxazol-5-carboxamida y uso |
| TW201012816A (en) * | 2008-07-11 | 2010-04-01 | Gilead Sciences Inc | Method of treatment and pharmaceutical compositions |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| CN104812751B (zh) * | 2012-09-28 | 2018-06-05 | 拜尔农作物科学股份公司 | 用于植物疾病防治的含氮杂环化合物 |
| JP2017095353A (ja) * | 2014-03-27 | 2017-06-01 | 日本曹達株式会社 | イソオキサゾリン−5−カルボキサミド化合物および有害生物防除剤 |
| TWI764977B (zh) * | 2017-01-23 | 2022-05-21 | 大陸商正大天晴藥業集團股份有限公司 | 作爲caspase抑制劑的聯環化合物、含有其的藥物組合物及其應用 |
| JP2022529973A (ja) * | 2019-04-19 | 2022-06-27 | エルジー・ケム・リミテッド | カスパーゼ阻害剤のプロドラッグ |
| WO2020222541A1 (ko) * | 2019-04-30 | 2020-11-05 | 주식회사 엘지화학 | 캐스파제 저해제의 프로드럭 |
| KR102366226B1 (ko) * | 2019-05-31 | 2022-02-22 | 주식회사 엘지화학 | 캐스파제 저해제 프로드럭을 함유하는 주사용 조성물 및 이의 제조 방법 |
| EP3970699A4 (en) * | 2019-05-31 | 2022-08-10 | LG Chem, Ltd. | COMPOSITION FOR CASPASE INHIBITOR PRODRUG INJECTION |
| TW202220655A (zh) * | 2020-08-05 | 2022-06-01 | 南韓商Lg化學股份有限公司 | 半胱天冬酶抑制劑於緩解或治療骨關節炎的用途 |
| KR20220076371A (ko) | 2020-11-30 | 2022-06-08 | 주식회사 엘지화학 | 캐스파제 저해제를 함유하는 주사용 조성물 및 이의 제조 방법 |
| KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
| CN118510496A (zh) * | 2022-01-24 | 2024-08-16 | 株式会社Lg化学 | 含有异𫫇唑啉衍生物的注射制剂 |
| US20250152576A1 (en) | 2022-02-23 | 2025-05-15 | Lg Chem, Ltd. | Injectable formulation comprising isoxazoline derivative and method for preparing same |
| CN118613251A (zh) | 2022-03-24 | 2024-09-06 | 株式会社Lg化学 | 包含异𫫇唑啉衍生物的注射制剂及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR19990079267A (ko) * | 1998-04-03 | 1999-11-05 | 성재갑 | 이소옥사졸(또는 이소옥사졸린) 구조를 갖는 파네실 전이효소억제제 |
| KR100373375B1 (ko) * | 1998-04-03 | 2003-06-12 | 주식회사 엘지생명과학 | 인터루킨-1b-컨버팅효소및아포파인/cpp-32에대한저해제 |
| AU5762899A (en) * | 1999-09-17 | 2001-04-24 | Lg Chemical Ltd. | Caspase inhibitor |
| CN1137888C (zh) | 1999-09-17 | 2004-02-11 | 株式会社Lgci | 半胱氨酰天冬氨酸蛋白酶抑制剂 |
| KR100594544B1 (ko) * | 2003-08-27 | 2006-06-30 | 주식회사 엘지생명과학 | 이소옥사졸린 구조를 갖는 캐스파제 저해제 |
| TWI256952B (en) * | 2003-08-27 | 2006-06-21 | Sk Corp | Chroman carboxylic acid derivatives for the treatment of diabetes and lipid disorders |
-
2006
- 2006-02-10 KR KR1020060013107A patent/KR100774999B1/ko active Active
- 2006-02-15 TW TW095105039A patent/TWI377205B/zh active
- 2006-02-21 EA EA200701810A patent/EA013005B1/ru unknown
- 2006-02-21 NZ NZ560805A patent/NZ560805A/en unknown
- 2006-02-21 EP EP06716026A patent/EP1851214B1/en active Active
- 2006-02-21 UA UAA200709610A patent/UA94395C2/ru unknown
- 2006-02-21 AU AU2006217293A patent/AU2006217293B2/en active Active
- 2006-02-21 JP JP2007556969A patent/JP4961357B2/ja active Active
- 2006-02-21 ES ES06716026T patent/ES2394480T3/es active Active
- 2006-02-21 DK DK06716026.7T patent/DK1851214T3/da active
- 2006-02-21 MX MX2007010338A patent/MX2007010338A/es active IP Right Grant
- 2006-02-21 SG SG200907192-9A patent/SG156689A1/en unknown
- 2006-02-21 PL PL06716026T patent/PL1851214T3/pl unknown
- 2006-02-21 CA CA2598347A patent/CA2598347C/en active Active
- 2006-02-21 WO PCT/KR2006/000576 patent/WO2006090997A1/en not_active Ceased
- 2006-02-21 CN CN2006800059846A patent/CN101128459B/zh active Active
- 2006-02-21 SI SI200631425T patent/SI1851214T1/sl unknown
- 2006-02-21 BR BRPI0607330-1A patent/BRPI0607330B1/pt active IP Right Grant
- 2006-02-21 PT PT06716026T patent/PT1851214E/pt unknown
- 2006-02-21 US US11/816,801 patent/US8044080B2/en active Active
- 2006-02-21 AP AP2007004103A patent/AP2374A/xx active
- 2006-02-22 MY MYPI20060748A patent/MY149181A/en unknown
- 2006-02-24 PE PE2006000221A patent/PE20061076A1/es active IP Right Grant
- 2006-02-24 AR ARP060100679A patent/AR055314A1/es active IP Right Grant
-
2007
- 2007-08-13 IL IL185226A patent/IL185226A0/en active IP Right Grant
- 2007-08-17 MA MA30152A patent/MA29311B1/fr unknown
- 2007-08-24 ZA ZA200707202A patent/ZA200707202B/xx unknown
- 2007-09-26 NO NO20074895A patent/NO341347B1/no unknown
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