DK1719774T3 - Terapeutisk middel mod diabetisk makulaødem - Google Patents
Terapeutisk middel mod diabetisk makulaødemInfo
- Publication number
- DK1719774T3 DK1719774T3 DK05704239.2T DK05704239T DK1719774T3 DK 1719774 T3 DK1719774 T3 DK 1719774T3 DK 05704239 T DK05704239 T DK 05704239T DK 1719774 T3 DK1719774 T3 DK 1719774T3
- Authority
- DK
- Denmark
- Prior art keywords
- diabetic
- prophylactic
- diabetic maculopathy
- therapeutic agent
- hydrogen atom
- Prior art date
Links
- 206010012688 Diabetic retinal oedema Diseases 0.000 title 1
- 201000011190 diabetic macular edema Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 4
- 208000035719 Maculopathy Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 208000002780 macular degeneration Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- WAAPEIZFCHNLKK-UFBFGSQYSA-N (2s,4s)-6-fluoro-2',5'-dioxospiro[2,3-dihydrochromene-4,4'-imidazolidine]-2-carboxamide Chemical compound C([C@H](OC1=CC=C(F)C=C11)C(=O)N)[C@@]21NC(=O)NC2=O WAAPEIZFCHNLKK-UFBFGSQYSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 210000002189 macula lutea Anatomy 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 230000002207 retinal effect Effects 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/106—Primate
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004022547 | 2004-01-30 | ||
| PCT/JP2005/001187 WO2005072066A2 (ja) | 2004-01-30 | 2005-01-28 | 糖尿病黄斑症の予防又は治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1719774T3 true DK1719774T3 (da) | 2012-07-16 |
Family
ID=34823835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05704239.2T DK1719774T3 (da) | 2004-01-30 | 2005-01-28 | Terapeutisk middel mod diabetisk makulaødem |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7910615B2 (da) |
| EP (1) | EP1719774B1 (da) |
| JP (2) | JP4014053B2 (da) |
| KR (1) | KR101111411B1 (da) |
| CN (1) | CN100537574C (da) |
| AT (1) | ATE555117T1 (da) |
| AU (1) | AU2005207906B2 (da) |
| CA (1) | CA2554679C (da) |
| DK (1) | DK1719774T3 (da) |
| ES (1) | ES2386094T3 (da) |
| PL (1) | PL1719774T3 (da) |
| WO (1) | WO2005072066A2 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006325947B2 (en) * | 2005-12-16 | 2011-09-01 | Hirosaki University | Agent for prevention and treatment of acute renal failure |
| CN101389332A (zh) * | 2006-02-20 | 2009-03-18 | 株式会社三和化学研究所 | 脑卒中中的脑缺血或脑缺血再灌注损伤的预防或治疗剂 |
| KR20090104014A (ko) | 2007-01-31 | 2009-10-05 | 가부시키가이샤산와카가쿠켄큐쇼 | 망막신경 또는 시신경의 보호제 |
| BRPI0808267A2 (pt) * | 2007-03-07 | 2014-07-22 | Kyorin Phamaceutical Co., Ltd | "composto representado pela formula geral (1) ou um sal farmeceuticamente aceitável do mesmo; método para o tratamento ou prevenção de diabetes ; uso do composto; composição farmacêutica e composto representado pela formula geral (3)". |
| JP5212849B2 (ja) * | 2010-01-14 | 2013-06-19 | 株式会社三和化学研究所 | 眼内血管新生及び／又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬 |
| CA2791360A1 (en) | 2010-04-28 | 2011-11-03 | Sanwa Kagaku Kenkyusho Co., Ltd. | A pharmaceutical for preventing or treating an inner ear disorder |
| RU2438637C1 (ru) * | 2010-07-13 | 2012-01-10 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО "НижГМА Росздрава") | Способ лечения диабетического макулярного отека |
| EP2671589A4 (en) * | 2011-02-02 | 2014-11-19 | Public Univ Corp Nagoya City Univ | MEDICAMENT FOR PREVENTING OR TREATING DISEASES RELATED TO INTRAOCULAR NEOVASCULARIZATION AND / OR INTRAOCULAR VASCULAR HYPERPERMEABILITY |
| JP2015110525A (ja) * | 2012-04-02 | 2015-06-18 | 株式会社三和化学研究所 | 歯肉炎の予防又は治療のための医薬 |
| JP6187985B2 (ja) * | 2015-07-14 | 2017-08-30 | 国立大学法人佐賀大学 | ノックアウト非ヒト動物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61200991A (ja) * | 1985-03-04 | 1986-09-05 | Sanwa Kagaku Kenkyusho:Kk | スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤 |
| JP2672949B2 (ja) | 1987-10-20 | 1997-11-05 | 株式会社芝浦製作所 | エミッションコントロール装置 |
| JP2976230B2 (ja) * | 1989-12-20 | 1999-11-10 | 大塚製薬株式会社 | 糖尿病ラット |
| JP3025917B2 (ja) * | 1990-12-19 | 2000-03-27 | 大塚製薬株式会社 | インシュリン非依存性糖尿病ラット |
| US5639482A (en) * | 1993-11-10 | 1997-06-17 | Crary; Ely J. | Composition for control and prevention of diabetic retinopathy |
| JPH07242547A (ja) * | 1994-03-02 | 1995-09-19 | Sanwa Kagaku Kenkyusho Co Ltd | 糖尿病性単純網膜症の進行阻止剤乃至治療剤 |
| JP3072226B2 (ja) * | 1994-06-20 | 2000-07-31 | 日本原子力研究所 | デカボランガス供給システムにおけるデカボラン供給方法 |
| JP3603129B2 (ja) * | 1994-12-28 | 2004-12-22 | 株式会社三和化学研究所 | 糖尿病性角膜症の治療剤 |
| EP0719556B1 (en) | 1994-12-28 | 2000-10-25 | Sanwa Kagaku Kenkyusho Co., Ltd. | Use of (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazoline]-2-carboxamide for treating diabetic keratopathy |
| JPH09301861A (ja) * | 1996-05-13 | 1997-11-25 | Showa Denko Kk | ラジカル疾患用注射・点滴薬剤 |
| WO1998019523A1 (fr) * | 1996-11-01 | 1998-05-14 | Shionogi & Co., Ltd. | Souris modele pour maladies affectant l'homme |
| US6479729B1 (en) | 1998-02-06 | 2002-11-12 | The Johns Hopkins University | Mouse model for ocular neovascularization |
| CA2319798C (en) * | 1998-02-06 | 2009-09-29 | Cci Corporation | Agent for preventing and curing hindrance of ischemic reperfusion |
| JP2000270713A (ja) * | 1999-03-23 | 2000-10-03 | Kennetto:Kk | 糖尿病態モデル動物及びその製造方法並びに糖尿病態モデル動物の選定方法 |
| US6426341B1 (en) * | 1999-06-30 | 2002-07-30 | Pfizer Inc. | Treatment for diabetic complications |
| EP1106210A3 (en) * | 1999-12-07 | 2003-12-03 | Pfizer Products Inc. | Combination of aldose reductase inhibitors and antihypertensive agents for the treatment of diabetic complications |
-
2005
- 2005-01-28 WO PCT/JP2005/001187 patent/WO2005072066A2/ja not_active Ceased
- 2005-01-28 PL PL05704239T patent/PL1719774T3/pl unknown
- 2005-01-28 ES ES05704239T patent/ES2386094T3/es not_active Expired - Lifetime
- 2005-01-28 AT AT05704239T patent/ATE555117T1/de active
- 2005-01-28 KR KR1020067015812A patent/KR101111411B1/ko not_active Expired - Fee Related
- 2005-01-28 CA CA2554679A patent/CA2554679C/en not_active Expired - Fee Related
- 2005-01-28 JP JP2005517502A patent/JP4014053B2/ja not_active Expired - Fee Related
- 2005-01-28 AU AU2005207906A patent/AU2005207906B2/en not_active Ceased
- 2005-01-28 US US10/587,320 patent/US7910615B2/en not_active Expired - Fee Related
- 2005-01-28 CN CNB2005800036591A patent/CN100537574C/zh not_active Expired - Fee Related
- 2005-01-28 DK DK05704239.2T patent/DK1719774T3/da active
- 2005-01-28 EP EP05704239A patent/EP1719774B1/en not_active Expired - Lifetime
-
2007
- 2007-08-03 JP JP2007203191A patent/JP2008029346A/ja active Pending
-
2010
- 2010-07-23 US US12/842,391 patent/US8097640B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008029346A (ja) | 2008-02-14 |
| ES2386094T3 (es) | 2012-08-08 |
| US8097640B2 (en) | 2012-01-17 |
| US20100305177A1 (en) | 2010-12-02 |
| CN1914211A (zh) | 2007-02-14 |
| AU2005207906B2 (en) | 2009-10-22 |
| EP1719774B1 (en) | 2012-04-25 |
| KR20060126547A (ko) | 2006-12-07 |
| ATE555117T1 (de) | 2012-05-15 |
| US7910615B2 (en) | 2011-03-22 |
| AU2005207906A1 (en) | 2005-08-11 |
| US20070293556A1 (en) | 2007-12-20 |
| CA2554679C (en) | 2012-09-25 |
| EP1719774A2 (en) | 2006-11-08 |
| JP4014053B2 (ja) | 2007-11-28 |
| EP1719774A4 (en) | 2009-05-06 |
| JPWO2005072066A1 (ja) | 2007-09-06 |
| WO2005072066A2 (ja) | 2005-08-11 |
| PL1719774T3 (pl) | 2012-09-28 |
| KR101111411B1 (ko) | 2012-03-13 |
| CN100537574C (zh) | 2009-09-09 |
| CA2554679A1 (en) | 2005-08-11 |
| WO2005072066A3 (ja) | 2005-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0314761A (pt) | Composto de adenina e seu uso | |
| TWI350170B (en) | Treating agent for glaucoma comprising rho kinase inhibitor and prostaglandin | |
| BRPI0515488A (pt) | derivados de heterocìclicos e seu uso como agentes terapêuticos | |
| BRPI0507984A (pt) | composto ou um sal do mesmo, processo para produzir um composto, medicamento, métodos para antagonizar angiotensina ii em um mamìfero, para melhorar a resistência de insulina em um mamìfero e para prevenir ou tratar doenças circulatórias em um mamìfero, e, uso do composto | |
| EP1614676A4 (en) | CONNECTION TO INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICAMENT CONTAINING THEREOF | |
| BRPI0515482A (pt) | derivados heterocìclicos e seus usos como agentes terapêuticos | |
| WO2007044085A3 (en) | Heteroaryl compounds and their uses as therapeutic agents | |
| NZ530782A (en) | Aminoisoxazole derivatives active as kinase inhibitors | |
| AR044543A1 (es) | Derivados de pirazolo-quinazolina, un procedimiento para su preparacion y su uso como inhibidor de quinasa | |
| DK1719774T3 (da) | Terapeutisk middel mod diabetisk makulaødem | |
| BRPI0412343A (pt) | derivados de piridazina e seu uso como agentes terapêuticos | |
| EP1792927A4 (en) | NEW BLOCK COPOLYMER, MICELLA PREPARATION AND ANTICROPHIDE CONTAINING THIS AS ACTIVE INGREDIENTS | |
| NO20076425L (no) | Fremgangsmater for behandling av drug-resistent cancer | |
| RU2012134639A (ru) | Фармацевтический препарат для предупреждения и лечения нарушений, сопровождающихся глазным ангиогенезом и/или повышенной проницаемостью сосудов глаза | |
| NO20072089L (no) | Benzimidazolderivater, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav | |
| US6436944B1 (en) | Combination effective for the treatment of impotence | |
| WO2007046867A3 (en) | Piperidine derivatives and their uses as therapeutic agents | |
| DK1778680T3 (da) | Spirocykliske cyclohexaderivater | |
| WO2008008701A3 (en) | Substituted cyclopentane derivatives as therapeutic agents | |
| CA2673751A1 (en) | Protective agent for retinal nerve or optic nerve | |
| NZ597866A (en) | Therapeutic lactams | |
| WO2005072066A1 (ja) | 糖尿病黄斑症の予防又は治療剤 | |
| RU2008114048A (ru) | Комбинации, включающие ингибитор рецептора сэфр (сосудистого эндотелиального фактора роста) и агент, увеличивающий проницаемость | |
| AR054272A1 (es) | Derivados de 3- aminopirrilidinas tri, tetra - sustituidos | |
| BR112019000290B1 (pt) | Prófármacos de fósforo dos estimuladores da sgc |