DK1709161T3 - Humane terapeutiske celler, som udskiller nervevækstfaktor - Google Patents
Humane terapeutiske celler, som udskiller nervevækstfaktorInfo
- Publication number
- DK1709161T3 DK1709161T3 DK05707792T DK05707792T DK1709161T3 DK 1709161 T3 DK1709161 T3 DK 1709161T3 DK 05707792 T DK05707792 T DK 05707792T DK 05707792 T DK05707792 T DK 05707792T DK 1709161 T3 DK1709161 T3 DK 1709161T3
- Authority
- DK
- Denmark
- Prior art keywords
- growth factor
- nerve growth
- therapeutic cells
- human therapeutic
- ngf
- Prior art date
Links
- 102000015336 Nerve Growth Factor Human genes 0.000 title 1
- 108010025020 Nerve Growth Factor Proteins 0.000 title 1
- 229940053128 nerve growth factor Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000000975 bioactive effect Effects 0.000 abstract 2
- 210000005260 human cell Anatomy 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400064 | 2004-01-19 | ||
| US53703304P | 2004-01-20 | 2004-01-20 | |
| DKPA200400673 | 2004-04-30 | ||
| US57508704P | 2004-05-28 | 2004-05-28 | |
| PCT/EP2005/050180 WO2005068498A2 (en) | 2004-01-19 | 2005-01-18 | Human therapeutic cells secreting nerve growth factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1709161T3 true DK1709161T3 (da) | 2009-01-26 |
Family
ID=34799654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05707792T DK1709161T3 (da) | 2004-01-19 | 2005-01-18 | Humane terapeutiske celler, som udskiller nervevækstfaktor |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080286323A1 (da) |
| EP (1) | EP1709161B1 (da) |
| AT (1) | ATE409741T1 (da) |
| DE (1) | DE602005010047D1 (da) |
| DK (1) | DK1709161T3 (da) |
| ES (1) | ES2315842T3 (da) |
| WO (1) | WO2005068498A2 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1784486B1 (en) * | 2004-06-23 | 2011-10-05 | TissueGene, Inc. | Nerve regeneration |
| EP1940471A1 (en) * | 2005-10-28 | 2008-07-09 | NsGene A/S | IMPLANTABLE BIOCOMPATIBLE IMMtTNOISOLATORY VEHICLE FOR DELIVERY OF GDNF |
| CN102361971A (zh) * | 2009-01-23 | 2012-02-22 | Ns基因公司 | 改善的细胞系以及在胶囊化细胞生物递送中的用途 |
| WO2011079222A2 (en) | 2009-12-23 | 2011-06-30 | Boston Scientific Scimed, Inc. | Less traumatic method of delivery of mesh-based devices into human body |
| JP6093714B2 (ja) | 2011-01-18 | 2017-03-08 | ステムニオン，インコーポレイテッド | 創傷治癒デバイスおよび方法 |
| ES2939147T3 (es) | 2011-03-18 | 2023-04-19 | Microvascular Tissues Inc | Tejido microvascular alogénico para tratamientos de tejidos blandos |
| PL2672984T3 (pl) | 2011-12-19 | 2015-10-30 | Wacker Chemie Ag | Nowe mutanty PRONGF i ich zastosowanie do wytwarzania BETA-NGF |
| WO2013103936A1 (en) * | 2012-01-05 | 2013-07-11 | Beech Tree Labs, Inc. | Method of treating pain by administration of nerve growth factor |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US11819522B2 (en) | 2012-09-19 | 2023-11-21 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| EP3188712A1 (en) | 2014-09-04 | 2017-07-12 | Kemijski Institut | Cell-based device for local treatment with therapeutic protein |
| CN114671941B (zh) * | 2016-03-18 | 2023-09-26 | 舒泰神（北京）生物制药股份有限公司 | 神经生长因子突变体 |
| GB201610101D0 (en) * | 2016-06-09 | 2016-07-27 | Attenborough Dental Laboratories Ltd | Multicellular lay-up process |
| US20180147236A1 (en) * | 2016-11-25 | 2018-05-31 | National Taiwan University | Method of suppressing inflammation and promoting repair of injured neural tissues with carboxyl-functionalized polyurethane nanoparticles |
| KR20200099201A (ko) * | 2018-01-08 | 2020-08-21 | 마이크로배스큘러 티슈, 인코포레이티드 | 신경 손상을 치료하기 위한 조성물 및 방법 |
| EP4051169A1 (en) * | 2019-11-01 | 2022-09-07 | Neurotech USA, Inc. | System, apparatuses, devices, and methods for packaging an analyte diffusive implantable device |
| CN113845583B (zh) * | 2020-06-28 | 2023-08-11 | 江苏中新医药有限公司 | 一种修饰的重组人神经生长因子及其制备方法 |
| CN114933657B (zh) * | 2021-08-25 | 2024-02-02 | 上海交通大学医学院 | 神经生长因子突变体重组蛋白及其应用 |
| CN116216874B (zh) * | 2023-03-23 | 2024-04-30 | 重庆大学 | 一种控制蓝藻水华的水体修复剂、制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5156844A (en) * | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
| US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| DE3829766A1 (de) * | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| DE3829752A1 (de) * | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| ES2127458T3 (es) * | 1989-11-06 | 1999-04-16 | Cell Genesys Inc | Produccion de proteinas utilizando recombinacion homologa. |
| US5272071A (en) * | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5618531A (en) * | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| US5488099A (en) * | 1992-03-06 | 1996-01-30 | Persson, Deceased; Hakan B. | Multifunctional chimeric neurotrophic factors |
| EP0612831B1 (en) * | 1992-12-07 | 1998-03-25 | Idemitsu Kosan Company Limited | Flame retardant hydraulic oil |
| US5512600A (en) * | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
| EP0708670A4 (en) * | 1993-06-23 | 1998-07-01 | Cytotherapeutics Inc | METHOD AND APPARATUS FOR HERMETICALLY CLOSING IMPLANTABLE MEMBRANE ENCAPSULATING DEVICES |
| EP0802800B1 (en) * | 1993-08-12 | 2002-06-12 | Neurotech S.A. | Biocompatible immunoisolatory capsules containing genetically altered cells for the delivery of biologically active molecules |
| US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US5554146A (en) * | 1994-05-06 | 1996-09-10 | Minnesota Mining And Manufacturing Company | Mechanical fastener for disposable article |
| US6299895B1 (en) * | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
| US6054142A (en) * | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
| US6303136B1 (en) * | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
| US6197294B1 (en) * | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
| JP3508015B2 (ja) * | 1999-12-03 | 2004-03-22 | 住友電装株式会社 | コネクタ |
-
2005
- 2005-01-18 DK DK05707792T patent/DK1709161T3/da active
- 2005-01-18 US US10/585,811 patent/US20080286323A1/en not_active Abandoned
- 2005-01-18 EP EP05707792A patent/EP1709161B1/en not_active Expired - Lifetime
- 2005-01-18 WO PCT/EP2005/050180 patent/WO2005068498A2/en not_active Ceased
- 2005-01-18 DE DE602005010047T patent/DE602005010047D1/de not_active Expired - Lifetime
- 2005-01-18 ES ES05707792T patent/ES2315842T3/es not_active Expired - Lifetime
- 2005-01-18 AT AT05707792T patent/ATE409741T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2315842T3 (es) | 2009-04-01 |
| DE602005010047D1 (de) | 2008-11-13 |
| WO2005068498A2 (en) | 2005-07-28 |
| EP1709161B1 (en) | 2008-10-01 |
| WO2005068498A3 (en) | 2005-09-22 |
| ATE409741T1 (de) | 2008-10-15 |
| US20080286323A1 (en) | 2008-11-20 |
| EP1709161A2 (en) | 2006-10-11 |
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