[go: up one dir, main page]

DK1709159T3 - Definitiv endoderm - Google Patents

Definitiv endoderm Download PDF

Info

Publication number
DK1709159T3
DK1709159T3 DK04815710.1T DK04815710T DK1709159T3 DK 1709159 T3 DK1709159 T3 DK 1709159T3 DK 04815710 T DK04815710 T DK 04815710T DK 1709159 T3 DK1709159 T3 DK 1709159T3
Authority
DK
Denmark
Prior art keywords
definitive endoderm
endoderm
definitive
Prior art date
Application number
DK04815710.1T
Other languages
English (en)
Inventor
Kevin Allen D'amour
Alan D Agulnick
Emmanuel E Baetge
Original Assignee
Viacyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34743694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1709159(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viacyte Inc filed Critical Viacyte Inc
Application granted granted Critical
Publication of DK1709159T3 publication Critical patent/DK1709159T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0679Cells of the gastro-intestinal tract
    • C12N5/068Stem cells; Progenitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/415Wnt; Frizzeled
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK04815710.1T 2003-12-23 2004-12-23 Definitiv endoderm DK1709159T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53200403P 2003-12-23 2003-12-23
US58656604P 2004-07-09 2004-07-09
US58794204P 2004-07-14 2004-07-14
PCT/US2004/043696 WO2005063971A2 (en) 2003-12-23 2004-12-23 Definitive endoderm

Publications (1)

Publication Number Publication Date
DK1709159T3 true DK1709159T3 (da) 2019-07-29

Family

ID=34743694

Family Applications (2)

Application Number Title Priority Date Filing Date
DK13186231.0T DK2722387T3 (da) 2003-12-23 2004-12-23 Definitiv endoderm
DK04815710.1T DK1709159T3 (da) 2003-12-23 2004-12-23 Definitiv endoderm

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK13186231.0T DK2722387T3 (da) 2003-12-23 2004-12-23 Definitiv endoderm

Country Status (15)

Country Link
US (8) US7704738B2 (da)
EP (2) EP2722387B1 (da)
JP (7) JP4819697B2 (da)
KR (1) KR101221302B1 (da)
CN (2) CN103898045B (da)
AU (2) AU2004309421B2 (da)
CA (2) CA2807342C (da)
DK (2) DK2722387T3 (da)
EA (1) EA200601231A1 (da)
HK (3) HK1197082A1 (da)
IL (1) IL176336A (da)
MX (2) MX2009009225A (da)
NZ (1) NZ547920A (da)
SG (1) SG149061A1 (da)
WO (1) WO2005063971A2 (da)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014313A2 (en) * 2001-08-06 2003-02-20 Bresagen, Ltd. Alternative compositions and methods for the culture of stem cells
GB2415432B (en) * 2001-12-07 2006-09-06 Geron Corp Islet cells from human embryonic stem cells
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
EP1543110A4 (en) 2002-05-17 2006-09-06 Sinai School Medicine POPULATION OF DEFINITIVE ENDODERMIC CELLS AND MESODERMAL
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2005063971A2 (en) 2003-12-23 2005-07-14 Cythera, Inc Definitive endoderm
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
EP2377922B1 (en) * 2004-04-27 2020-04-08 Viacyte, Inc. PDX1 expressing endoderm
US20090010900A1 (en) * 2004-07-07 2009-01-08 The University Of North Carlolina At Chapel Hill Embryonic Stem Cell Derivatives, and Methods of Making and Using the Same
CA2573354C (en) * 2004-07-09 2015-02-24 Cythera, Inc. Preprimitive streak and mesendoderm cells
WO2006020919A2 (en) * 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
AU2005322007B2 (en) * 2004-12-23 2011-06-30 Viacyte, Inc. Expansion of definitive endoderm cells
JP4824036B2 (ja) * 2004-12-23 2011-11-24 ヴィアサイト,インコーポレイテッド 胚体内胚葉細胞の増殖
EP1859026A2 (en) * 2005-01-31 2007-11-28 ES Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
US7642091B2 (en) 2005-02-24 2010-01-05 Jau-Nan Lee Human trophoblast stem cells and use thereof
ES2400916T3 (es) 2005-06-08 2013-04-15 Janssen Biotech, Inc. Una terapia celular para degeneración ocular
US8460928B2 (en) 2005-10-24 2013-06-11 Agency For Science, Technology And Research Methods of specifying mesodermal, endodermal and mesoendodermal cell fates
DK1957636T3 (da) 2005-10-27 2018-10-01 Viacyte Inc Pdx1-udtrykkende dorsal og ventral for-tarm-endoderm
JP4463189B2 (ja) 2005-11-22 2010-05-12 Nec東芝スペースシステム株式会社 探索機能付きモバイル装置
AU2007220759A1 (en) * 2006-02-23 2007-09-07 Viacyte, Inc. Compositions and methods useful for culturing differentiable cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
DK2650360T3 (da) * 2006-03-02 2019-10-07 Viacyte Inc Endokrine prekursorceller, pancreatiske hormon udtrykkende celler og fremgangsmåder til fremstilling
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
GB0615327D0 (en) * 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US7989204B2 (en) * 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
CA2650561C (en) * 2006-05-02 2014-02-25 Wisconsin Alumni Research Foundation Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
US20090298169A1 (en) * 2006-06-02 2009-12-03 The University Of Georgia Research Foundation Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems
US8415153B2 (en) * 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US8874380B2 (en) 2010-12-09 2014-10-28 Rutgers, The State University Of New Jersey Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs
WO2008013664A2 (en) 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
US20100323442A1 (en) * 2006-10-17 2010-12-23 Emmanuel Edward Baetge Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2179034A1 (en) 2007-07-20 2010-04-28 Cellartis AB A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts stem cells
EP2610336A1 (en) 2007-07-31 2013-07-03 Lifescan, Inc. Differentiation of human embryonic stem cells
US7695963B2 (en) * 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
MX2010005805A (es) 2007-11-27 2010-06-09 Lifescan Inc Diferenciacion de celulas madre embrionarias humanas.
EP2227487A1 (en) 2007-12-28 2010-09-15 Novo Nordisk A/S Ddr1-mediated cell purification of pancreatic endocrine cells through their progenitors
MX2010009251A (es) 2008-02-21 2010-11-25 Centocor Ortho Biotech Inc Metodos, placas de superficie modificada y composiciones para la fijacion, el cultivo y el desprendimiento celular.
CN101983336A (zh) 2008-04-03 2011-03-02 诺沃-诺迪斯克有限公司 Dner介导的胰腺内分泌前祖细胞及其子代的细胞纯化
AU2008355123B2 (en) 2008-04-21 2014-12-04 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
DK2993226T3 (da) 2008-06-03 2021-02-22 Viacyte Inc Vækstfaktorer til fremstilling af en definitiv endoderm
ES2697798T3 (es) 2008-06-30 2019-01-28 Janssen Biotech Inc Diferenciación de células madre pluripotentes
AU2009267167A1 (en) * 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
KR102025158B1 (ko) 2008-10-31 2019-09-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 계통으로의 분화
RU2522001C2 (ru) 2008-10-31 2014-07-10 Сентокор Орто Байотек Инк. Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
ES2743204T3 (es) 2008-11-04 2020-02-18 Viacyte Inc Composiciones de suspensión de agregados de células madre y métodos para su diferenciación
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
ES2667493T3 (es) * 2008-11-14 2018-05-11 Viacyte, Inc. Encapsulación de células pancreáticas derivadas de células madre humanas pluripotentes
CA2744227C (en) 2008-11-20 2018-10-02 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
JP2012509085A (ja) 2008-11-20 2012-04-19 ヤンセン バイオテツク,インコーポレーテツド マイクロキャリア上での多能性幹細胞の培養
WO2010065679A1 (en) * 2008-12-03 2010-06-10 International Stem Cell Corporation Methods of deriving differentiated cells from stem cells
WO2010091241A2 (en) 2009-02-06 2010-08-12 President And Fellows Of Harvard College Compositions and methods for promoting the generation of definitive endoderm
EP2233566A1 (en) 2009-03-17 2010-09-29 Vrije Universiteit Brussel Generation of pancreatic progenitor cells
US20100272695A1 (en) * 2009-04-22 2010-10-28 Alan Agulnick Cell compositions derived from dedifferentiated reprogrammed cells
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
EP2435471A2 (en) * 2009-05-29 2012-04-04 Novo Nordisk A/S INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM
GB0911060D0 (en) 2009-06-26 2009-08-12 Ge Healthcare Uk Ltd Methods for predicting the toxicity of a chemical
EP2456862A4 (en) 2009-07-20 2013-02-27 Janssen Biotech Inc DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
KR101893021B1 (ko) 2009-07-20 2018-08-29 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
GB2485113B (en) 2009-07-20 2016-12-28 Janssen Biotech Inc Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage
CA2778817A1 (en) * 2009-10-29 2011-05-19 Janssen Biotech, Inc. Pluripotent stem cells
DK2516625T3 (da) * 2009-12-23 2024-09-09 Janssen Biotech Inc Differentiering af humane embryonale stamceller
KR101841271B1 (ko) * 2009-12-23 2018-03-22 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
WO2011100291A1 (en) * 2010-02-09 2011-08-18 The Regents Of The University Of California Method for identifying pancreatic progenitor cells
AU2011223900A1 (en) * 2010-03-01 2012-09-13 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
US20120100110A1 (en) * 2010-04-20 2012-04-26 International Stem Cell Corporation Physiological methods for isolation of high purity cell populations
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
WO2011143299A2 (en) 2010-05-12 2011-11-17 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
US9181528B2 (en) 2010-08-31 2015-11-10 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
SG187946A1 (en) * 2010-08-31 2013-03-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
ES2659393T3 (es) * 2010-08-31 2018-03-15 Janssen Biotech, Inc. Diferenciación de células madre embrionarias humanas
CA2821562A1 (en) 2010-11-02 2012-05-10 National University Corporation Kumamoto University Method of producing intestinal cells
CA2818234C (en) 2010-11-15 2023-03-07 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
US9433557B2 (en) 2011-02-21 2016-09-06 Viacyte, Inc. Loading system for an encapsulation device
US20140234963A1 (en) 2011-06-21 2014-08-21 Novo Nordisk A/S Efficient induction of definitive endoderm from pluripotent stem cells
KR102090751B1 (ko) 2011-12-22 2020-03-19 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
EP2823037A4 (en) 2012-03-07 2015-09-16 Janssen Biotech Inc DEFINED MEDIA FOR THE EXPANSION AND CARE OF PLURIPOTENTAL STEM CELLS
US20140162359A1 (en) 2012-05-07 2014-06-12 Janssen Biotech, Inc. Differentiation of Human Embryonic Stem Cells into Pancreatic Endoderm
JP6161603B2 (ja) 2012-05-25 2017-07-12 学校法人 埼玉医科大学 膵臓ホルモン産生細胞の生産方法及び膵臓ホルモン産生細胞、並びに分化誘導促進剤
CN108034633B (zh) 2012-06-08 2022-08-02 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
CN104995294A (zh) * 2012-10-19 2015-10-21 新加坡科技研究局 使干细胞分化成一种或多种细胞谱系的方法
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
GB2523696B (en) 2012-11-30 2017-12-27 Accelerated Biosciences Corp Methods of differentiating stem cells to pancreatic progenitor cells by modulating miR-124
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
RU2018116647A (ru) 2012-12-31 2018-10-24 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
CN105705634A (zh) 2012-12-31 2016-06-22 詹森生物科技公司 用于分化成胰腺内分泌细胞的人多能细胞的悬浮和群集
MX2015008578A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
CA2902857C (en) 2013-02-27 2022-11-29 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
JP6234485B2 (ja) 2013-03-07 2017-11-22 ヴィアサイト インコーポレイテッド 3次元大収容力細胞封入デバイスアセンブリー
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
AU2014248167B2 (en) 2013-04-03 2019-10-10 FUJIFILM Cellular Dynamics, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
EP2988699B1 (en) 2013-04-24 2020-05-27 Société des Produits Nestlé S.A. Encapsulation device
EP3006564B1 (en) 2013-05-24 2019-10-02 Saitama Medical University New peptide and application thereof
KR102580225B1 (ko) 2013-06-11 2023-09-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
US11051900B2 (en) 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
CN117821369A (zh) 2014-05-16 2024-04-05 詹森生物科技公司 小分子增强胰腺内分泌细胞中的mafa表达的用途
US10174289B2 (en) 2014-05-28 2019-01-08 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
SG10202009095VA (en) 2014-11-26 2020-10-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
WO2016100909A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF
CN113234661A (zh) 2014-12-18 2021-08-10 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
EP3234109A4 (en) 2014-12-19 2018-06-27 Janssen Biotech, Inc. Suspension culturing of pluripotent stem cells
US10494608B2 (en) 2015-04-24 2019-12-03 University Of Copenhagen Isolation of bona fide pancreatic progenitor cells
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
CA3016641A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
MA45502A (fr) 2016-06-21 2019-04-24 Janssen Biotech Inc Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases
AU2017353982B2 (en) 2016-11-04 2021-05-06 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP4595951A3 (en) 2016-11-10 2025-08-27 ViaCyte, Inc. Pdx1 pancreatic endoderm cells in cell delivery devices
WO2018106628A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
JP6485883B2 (ja) * 2017-03-01 2019-03-20 株式会社大一商会 遊技機
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
IL313825B2 (en) 2017-06-14 2025-07-01 Vertex Pharma Devices and methods for administering medications
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
AU2018370029B2 (en) 2017-11-15 2024-11-07 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
KR20250163421A (ko) 2018-07-26 2025-11-20 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
CA3108275A1 (en) 2018-08-10 2020-02-13 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
CN112823012A (zh) 2018-09-12 2021-05-18 儿童医院医学中心 用于产生造血干细胞及其衍生物的类器官组合物
KR20220033465A (ko) 2019-05-06 2022-03-16 액셀러레이티드 바이오사이언시스 코포레이션 전구 조절성 세포영양막 세포 및 그의 용도
CA3257300A1 (en) 2019-05-31 2025-06-12 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
AU2020283056B2 (en) 2019-05-31 2023-06-08 Viacyte, Inc. A biocompatible membrane composite
WO2020243663A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
EP3976066A4 (en) 2019-05-31 2023-06-28 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
US20220233298A1 (en) 2019-05-31 2022-07-28 W. L. Gore & Associates, Inc. A biocompatible membrane composite
JP7753197B2 (ja) 2019-09-05 2025-10-14 クリスパー セラピューティクス アクチェンゲゼルシャフト ユニバーサルドナー細胞
EP4025224A1 (en) 2019-09-05 2022-07-13 CRISPR Therapeutics AG Universal donor cells
US12188051B2 (en) 2020-05-27 2025-01-07 The Regents Of The University Of Michigan Compositions and methods for obtaining vascularized human intestinal organoid tissue, and related uses thereof
CN115843381A (zh) * 2020-06-19 2023-03-24 富士胶片株式会社 信息处理装置、信息处理装置的工作方法、信息处理装置的工作程序
AU2021328501A1 (en) 2020-08-15 2023-04-13 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (CALCR)
KR20230146007A (ko) 2020-12-31 2023-10-18 크리스퍼 테라퓨틱스 아게 범용 공여자 세포
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1234567A (en) * 1915-09-14 1917-07-24 Edward J Quigley Soft collar.
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5869620A (en) 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6165993A (en) 1992-03-23 2000-12-26 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US7153684B1 (en) * 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
JP3945846B2 (ja) 1995-11-09 2007-07-18 武田薬品工業株式会社 膵臓機能改善剤
JP2001517927A (ja) 1996-02-28 2001-10-09 バンダービルト ユニバーシティ 胚幹細胞を作製する組成物および方法
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
AU6909298A (en) 1996-10-28 1998-05-22 Novartis Ag Method for the oligomerisation of peptides
JP2001508302A (ja) 1997-01-10 2001-06-26 ライフ テクノロジーズ,インコーポレイテッド 胚性幹細胞血清置換
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5866366A (en) 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
BR9813202B1 (pt) 1997-09-15 2011-11-01 complexo de administração de genes; processo de transdução de células com material genético estranho, composição útil para administração de material genético e uso de um complexo de administração de genes.
WO1999020741A1 (en) 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
US6117986A (en) 1998-06-10 2000-09-12 Intergen Company, L.P. Pyrimidines linked to a quencher
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19852800C1 (de) 1998-11-16 2000-04-13 Univ Albert Ludwigs Freiburg Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist
GB9903804D0 (en) 1999-02-20 1999-04-14 Univ Sheffield Pluripotential cells-2
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
US7795026B2 (en) 2000-01-21 2010-09-14 The Johns Hopkins University School Of Medicine Methods for obtaining human embryoid body-derived cells
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7256042B2 (en) * 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
JP4426064B2 (ja) 2000-05-31 2010-03-03 独立行政法人科学技術振興機構 脊椎動物の膵臓のインビトロ形成方法
JP2004504834A (ja) 2000-08-01 2004-02-19 イスム リサーチ ディベロップメント カンパニー 胚性細胞の定方向分化
WO2002034880A2 (en) 2000-10-23 2002-05-02 University Of Kansas Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion
JP2004532648A (ja) 2000-11-30 2004-10-28 ステムロン インコーポレイテッド 単離されたホモ接合性幹細胞、これ由来の分化細胞、ならびにこれを作製及び使用するための材料及び方法
WO2002059278A2 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America, As Represented By The Secretary Of Department Of Health & Human Services Differentiation of stem cells to pancreatic endocrine cells
EP1393066A4 (en) 2001-05-15 2006-01-25 Rappaport Family Inst For Res INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
US20030032183A1 (en) 2001-05-25 2003-02-13 Sheridan Steven D. Stem cell differentiation
AU2002345691C1 (en) 2001-06-13 2008-07-24 Massachusetts Institute Of Technology In vivo bioreactors
WO2002102982A2 (en) 2001-06-14 2002-12-27 Regents Of The University Of California Hoxd3 compositions ad methods for improved wound healing
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
AU2002360424A1 (en) * 2001-11-26 2003-06-10 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
GB2415432B (en) * 2001-12-07 2006-09-06 Geron Corp Islet cells from human embryonic stem cells
US20030138949A1 (en) 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US20030162290A1 (en) 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
EP1497435A4 (en) * 2002-04-19 2005-07-27 Univ Pittsburgh STEM CELLS DERIVED FROM PLAZENTA AND THEIR USES
US20060003446A1 (en) * 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
EP1543110A4 (en) * 2002-05-17 2006-09-06 Sinai School Medicine POPULATION OF DEFINITIVE ENDODERMIC CELLS AND MESODERMAL
EP1507848A4 (en) * 2002-05-28 2005-11-23 Becton Dickinson Co EXPANSION AND TRANSDIFFERENCING OF HUMAN AZINUS CELLS
WO2003100026A2 (en) 2002-05-28 2003-12-04 Novocell, Inc. Methods, compositions, and growth and differentiation factors for insulin-producing cells
AU2003302702B2 (en) 2002-12-05 2008-08-07 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
FR2849043B1 (fr) 2002-12-24 2005-07-08 Gemac Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu
AU2004211654B2 (en) 2003-02-07 2009-03-05 Wisconsin Alumni Research Foundation Directed genetic modifications of human stem cells
US20070155661A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Standord Junior University Methods and compositions for modulating the development of stem cells
WO2005045001A2 (en) 2003-02-14 2005-05-19 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
AU2004241380A1 (en) 2003-05-20 2004-12-02 Riken Preparation of endodermal stem cells
WO2005017131A2 (en) 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
US7091082B2 (en) * 2003-08-22 2006-08-15 The Board Of Trustees Of The University Of Illinois Semiconductor method and device
WO2005033294A2 (en) 2003-09-30 2005-04-14 Regents Of The University Of California Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage
US7985585B2 (en) * 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
WO2005063971A2 (en) 2003-12-23 2005-07-14 Cythera, Inc Definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
WO2005097977A2 (en) 2004-04-01 2005-10-20 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
EP1740612B1 (en) 2004-04-27 2019-08-07 Viacyte, Inc. Pdx1 expressing endoderm
CA2573354C (en) 2004-07-09 2015-02-24 Cythera, Inc. Preprimitive streak and mesendoderm cells
CA2573283C (en) 2004-07-09 2023-03-14 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
WO2006020919A2 (en) 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
EP1797171A1 (en) 2004-09-29 2007-06-20 Cellartis AB Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hbs)
EP1859026A2 (en) 2005-01-31 2007-11-28 ES Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
WO2007002210A2 (en) 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
NZ567082A (en) 2005-10-14 2012-08-31 Univ Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
DK1957636T3 (da) 2005-10-27 2018-10-01 Viacyte Inc Pdx1-udtrykkende dorsal og ventral for-tarm-endoderm
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
WO2008013664A2 (en) 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
DK2993226T3 (da) * 2008-06-03 2021-02-22 Viacyte Inc Vækstfaktorer til fremstilling af en definitiv endoderm

Also Published As

Publication number Publication date
AU2011201552A1 (en) 2011-04-28
US20070154984A1 (en) 2007-07-05
JP6356021B2 (ja) 2018-07-11
US8623645B2 (en) 2014-01-07
CA2549605C (en) 2013-05-07
HK1199740A1 (en) 2015-07-17
HK1197082A1 (en) 2015-01-02
WO2005063971A2 (en) 2005-07-14
AU2004309421B2 (en) 2011-04-21
JP2014230551A (ja) 2014-12-11
WO2005063971A3 (en) 2005-12-15
US7704738B2 (en) 2010-04-27
US20190376028A1 (en) 2019-12-12
JP4819697B2 (ja) 2011-11-24
JP2015163081A (ja) 2015-09-10
EP2722387A3 (en) 2016-08-17
JP7045407B2 (ja) 2022-03-31
EP1709159B1 (en) 2019-05-15
US20050158853A1 (en) 2005-07-21
AU2004309421A1 (en) 2005-07-14
MXPA06007252A (es) 2007-01-23
JP2020078342A (ja) 2020-05-28
EP2722387B1 (en) 2019-12-11
KR101221302B1 (ko) 2013-01-11
US20090253202A1 (en) 2009-10-08
US20170159011A1 (en) 2017-06-08
EA200601231A1 (ru) 2007-06-29
CN103898047A (zh) 2014-07-02
IL176336A0 (en) 2006-10-05
JP2007516728A (ja) 2007-06-28
CA2549605A1 (en) 2005-07-14
JP2017038625A (ja) 2017-02-23
EP2722387A2 (en) 2014-04-23
IL176336A (en) 2011-07-31
DK2722387T3 (da) 2020-01-20
US20100151568A1 (en) 2010-06-17
EP1709159A2 (en) 2006-10-11
JP2011250794A (ja) 2011-12-15
CN103898047B (zh) 2020-03-03
CN103898045A (zh) 2014-07-02
US20140134727A1 (en) 2014-05-15
US7510876B2 (en) 2009-03-31
CA2807342A1 (en) 2005-07-14
CN103898045B (zh) 2019-02-01
MX2009009225A (es) 2009-09-28
JP6574158B2 (ja) 2019-09-11
JP5669688B2 (ja) 2015-02-12
KR20060114355A (ko) 2006-11-06
CA2807342C (en) 2022-11-08
HK1199741A1 (en) 2015-07-17
SG149061A1 (en) 2009-01-29
US10421942B2 (en) 2019-09-24
NZ547920A (en) 2009-06-26
JP2018171071A (ja) 2018-11-08
AU2011201552B2 (en) 2012-11-15
US20220056405A1 (en) 2022-02-24

Similar Documents

Publication Publication Date Title
DK1709159T3 (da) Definitiv endoderm
DK2377922T3 (da) PDX1-eksprimerende endoderm
DE602004018654D1 (de) Se
ATE363383T1 (de) Schlingenware
ATE354631T1 (de) Nuancierungsmittel
AT502792A5 (de) Düsenanpressvorrichtung
ATE417648T1 (de) Stifte zusammensetzungen
ATE442044T1 (de) Herbizid-safener-kombination
DE112004000620D2 (de) Struktoguss
DE112004002671D2 (de) Diode
DE10355350A8 (de) Elektromodul
ATA662003A (de) Trink-mundstück
ATE446959T1 (de) Chromenonindole
DK1633719T3 (da) Substituerede spirobenzazepiner
DE10394329D2 (de) Mäanderstent
ATE406350T1 (de) Prolinylarylacetamide
DE10329218B4 (de) Hotflue
DE112004002110D2 (de) Behälter-Deckel-Kombination
DE112004001561D2 (de) Getriebene-Antreibseinheit
EP1597265A4 (en) GLYCOSYLATED ENKEPHALINE AGENTS
AT500001B8 (de) Münzscheideeinrichtung
ATA1802003A (de) Verbundhonring
FR2858028B1 (fr) Fermoir
DE50307365D1 (de) Etui
DE10316511B4 (de) Teigportionierer