DK1704230T3 - Avanceret mikroorganisme til produktion af 1,2-propandiol - Google Patents
Avanceret mikroorganisme til produktion af 1,2-propandiolInfo
- Publication number
- DK1704230T3 DK1704230T3 DK05717405T DK05717405T DK1704230T3 DK 1704230 T3 DK1704230 T3 DK 1704230T3 DK 05717405 T DK05717405 T DK 05717405T DK 05717405 T DK05717405 T DK 05717405T DK 1704230 T3 DK1704230 T3 DK 1704230T3
- Authority
- DK
- Denmark
- Prior art keywords
- strain
- propanediol
- production
- gene
- methylglyoxal
- Prior art date
Links
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 4
- 235000013772 propylene glycol Nutrition 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 101150080369 tpiA gene Proteins 0.000 abstract 2
- ABVQGNDUHAQLBS-UHFFFAOYSA-N 2-oxopropanal propanal Chemical compound CCC=O.CC(=O)C=O ABVQGNDUHAQLBS-UHFFFAOYSA-N 0.000 abstract 1
- 101100280051 Brucella abortus biovar 1 (strain 9-941) eryH gene Proteins 0.000 abstract 1
- 101100235161 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) lerI gene Proteins 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400214A FR2864967B1 (fr) | 2004-01-12 | 2004-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
| PCT/FR2005/000070 WO2005073364A2 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1704230T3 true DK1704230T3 (da) | 2009-11-02 |
Family
ID=34684930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05717405T DK1704230T3 (da) | 2004-01-12 | 2005-01-12 | Avanceret mikroorganisme til produktion af 1,2-propandiol |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8252579B2 (da) |
| EP (2) | EP2192180A1 (da) |
| JP (1) | JP4613177B2 (da) |
| KR (1) | KR101229525B1 (da) |
| CN (1) | CN1910278B (da) |
| AT (1) | ATE440135T1 (da) |
| BR (1) | BRPI0506790B1 (da) |
| CA (1) | CA2547695C (da) |
| DE (1) | DE602005016073D1 (da) |
| DK (1) | DK1704230T3 (da) |
| ES (1) | ES2329914T3 (da) |
| FR (1) | FR2864967B1 (da) |
| PL (1) | PL1704230T3 (da) |
| PT (1) | PT1704230E (da) |
| RU (1) | RU2407793C2 (da) |
| SI (1) | SI1704230T1 (da) |
| WO (1) | WO2005073364A2 (da) |
| ZA (1) | ZA200605440B (da) |
Families Citing this family (96)
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| US20110020888A1 (en) * | 2006-12-15 | 2011-01-27 | Biofuelchem Co., Ltd. | METHOD FOR PREPARING BUTANOL THROUGH BUTYRYL-CoA AS AN INTERMEDIATE USING BACTERIA |
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| MY156388A (en) * | 2007-02-08 | 2016-02-15 | Biofuelchem Co Ltd | Method for preparing butanol through butyryl-coa as an intermediate using yeast |
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| WO2008124523A1 (en) * | 2007-04-04 | 2008-10-16 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
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| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| PT3328997T (pt) | 2015-07-27 | 2021-03-15 | Centre Nat Rech Scient | Novo polipéptido com actividade de ferredoxina-nadp+ redutase, polinucleótido codificador do mesmo e suas utilizações |
| US20180223319A1 (en) | 2015-08-07 | 2018-08-09 | Evonik Degussa Gmbh | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| WO2017042602A1 (en) | 2015-09-10 | 2017-03-16 | Metabolic Explorer | New lactaldehyde reductases for the production of 1,2-propanediol |
| US10801050B2 (en) | 2015-10-23 | 2020-10-13 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
| CN108291243A (zh) | 2015-11-27 | 2018-07-17 | 赢创德固赛有限公司 | 生产l-甲硫氨酸的方法 |
| WO2017211883A1 (en) * | 2016-06-07 | 2017-12-14 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to polyols |
| JP7321089B2 (ja) * | 2016-07-08 | 2023-08-04 | メタボリック エクスプローラー | 糖ホスホトランスフェラーゼ系（ｐｔｓ）をコードする遺伝子を含んでなる微生物による目的分子の発酵生産法 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3342873A1 (en) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof |
| EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
| WO2019092495A1 (en) * | 2017-11-09 | 2019-05-16 | Braskem S.A. | Process for the recovery of ketones and glycols from fermentation |
| CN115261292B (zh) * | 2021-04-29 | 2023-06-09 | 中国科学院上海高等研究院 | 改造的克雷伯氏菌属细菌及其生产1,2-丙二醇的应用和方法 |
| CN115125263B (zh) * | 2022-05-31 | 2024-01-23 | 中国科学院天津工业生物技术研究所 | 解除pts依赖碳源对相关启动子阻遏的方法及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
| RU2175351C2 (ru) * | 1998-12-30 | 2001-10-27 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") | Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот |
| DK1204755T3 (da) | 1999-08-18 | 2006-12-11 | Du Pont | Proces til biologisk produktion af 1,3-propandiol |
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- 2005-01-12 CN CN2005800023110A patent/CN1910278B/zh not_active Expired - Fee Related
- 2005-01-12 CA CA2547695A patent/CA2547695C/fr not_active Expired - Lifetime
- 2005-01-12 WO PCT/FR2005/000070 patent/WO2005073364A2/fr not_active Ceased
- 2005-01-12 PL PL05717405T patent/PL1704230T3/pl unknown
- 2005-01-12 DE DE602005016073T patent/DE602005016073D1/de not_active Expired - Lifetime
- 2005-01-12 RU RU2006129295/10A patent/RU2407793C2/ru active
- 2005-01-12 PT PT05717405T patent/PT1704230E/pt unknown
- 2005-01-12 EP EP20090167750 patent/EP2192180A1/fr not_active Ceased
- 2005-01-12 DK DK05717405T patent/DK1704230T3/da active
- 2005-01-12 EP EP05717405A patent/EP1704230B1/fr not_active Expired - Lifetime
- 2005-01-12 AT AT05717405T patent/ATE440135T1/de active
- 2005-01-12 SI SI200530761T patent/SI1704230T1/sl unknown
- 2005-01-12 US US10/585,040 patent/US8252579B2/en not_active Expired - Fee Related
- 2005-01-12 JP JP2006548349A patent/JP4613177B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| PL1704230T3 (pl) | 2010-01-29 |
| CA2547695C (fr) | 2015-03-10 |
| EP1704230B1 (fr) | 2009-08-19 |
| DE602005016073D1 (de) | 2009-10-01 |
| BRPI0506790B1 (pt) | 2020-12-22 |
| US8252579B2 (en) | 2012-08-28 |
| WO2005073364A2 (fr) | 2005-08-11 |
| FR2864967A1 (fr) | 2005-07-15 |
| EP1704230A2 (fr) | 2006-09-27 |
| JP4613177B2 (ja) | 2011-01-12 |
| BRPI0506790A (pt) | 2007-05-22 |
| KR20060123490A (ko) | 2006-12-01 |
| PT1704230E (pt) | 2009-10-14 |
| CA2547695A1 (fr) | 2005-08-11 |
| RU2407793C2 (ru) | 2010-12-27 |
| US20070072279A1 (en) | 2007-03-29 |
| ATE440135T1 (de) | 2009-09-15 |
| JP2007517517A (ja) | 2007-07-05 |
| SI1704230T1 (sl) | 2009-12-31 |
| CN1910278A (zh) | 2007-02-07 |
| WO2005073364A3 (fr) | 2005-09-29 |
| ZA200605440B (en) | 2007-04-25 |
| KR101229525B1 (ko) | 2013-02-04 |
| RU2006129295A (ru) | 2008-02-20 |
| FR2864967B1 (fr) | 2006-05-19 |
| CN1910278B (zh) | 2010-05-26 |
| ES2329914T3 (es) | 2009-12-02 |
| EP2192180A1 (fr) | 2010-06-02 |
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