DK1796663T3 - Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer - Google Patents

Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer

Info

Publication number: DK1796663T3
Authority: DK; Denmark
Prior art keywords: azetidines; pyrrolidines; piperazines; receptor modulators; serotonin receptor
Prior art date: 2004-09-03

Application number

DK05794345.8T

Other languages

English (en)

Inventor

Michael J Robarge

Youssef L Bennani

David C Bom

Original Assignee

Athersys Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-03

Filing date

2005-09-01

Publication date

2011-08-15

2005-09-01 Application filed by Athersys Inc filed Critical Athersys Inc

2011-08-15 Application granted granted Critical

2011-08-15 Publication of DK1796663T3 publication Critical patent/DK1796663T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Obesity (AREA)
Hematology (AREA)
Addiction (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK05794345.8T 2004-09-03 2005-09-01 Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer DK1796663T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60714204P	2004-09-03	2004-09-03
PCT/US2005/031306 WO2006028961A2 (en)	2004-09-03	2005-09-01	Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

Publications (1)

Publication Number	Publication Date
DK1796663T3 true DK1796663T3 (da)	2011-08-15

Family

ID=36036866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05794345.8T DK1796663T3 (da)	2004-09-03	2005-09-01	Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer

Country Status (9)

Country	Link
US (2)	US7423056B2 (da)
EP (1)	EP1796663B1 (da)
JP (1)	JP4960235B2 (da)
AR (1)	AR050624A1 (da)
AT (1)	ATE507832T1 (da)
DE (1)	DE602005027861D1 (da)
DK (1)	DK1796663T3 (da)
TW (1)	TWI406866B (da)
WO (1)	WO2006028961A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1796663T3 (da) *	2004-09-03	2011-08-15	Athersys Inc	Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer
JP5007988B2 (ja) *	2005-10-27	2012-08-22	国立大学法人名古屋大学	多環縮環化合物およびそれらの製造法ならびに多環縮環化合物を用いる有機電界発光素子
EP2018863B9 (en)	2006-05-16	2015-02-18	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound and use thereof
CN101230058A (zh)	2007-01-23	2008-07-30	上海恒瑞医药有限公司	双环氮杂烷类衍生物、其制备方法及其在医药上的用途
JP5520051B2 (ja)	2007-11-15	2014-06-11	武田薬品工業株式会社	縮合ピリジン誘導体およびその用途
BRPI0822143A2 (pt)	2008-01-23	2019-09-24	Jiangsu Hansoh Pharmaceutical Cio Ltd	derivados de dicicloaza-alcano, processos de preparação e usos médicos dos mesmos
US8546377B2 (en)	2009-04-23	2013-10-01	Abbvie Inc.	Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en)	2009-04-23	2013-08-27	Abbvie Inc.	Modulators of 5-HT receptors and methods of use thereof
WO2011071136A1 (ja)	2009-12-11	2011-06-16	アステラス製薬株式会社	線維筋痛症治療剤
US9937002B2 (en)	2011-03-08	2018-04-10	Nexus Control Systems, Llc	Ablation catheter system with safety features
EP2683700B1 (de)	2011-03-08	2015-02-18	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de)	2011-03-08	2012-09-13	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8710050B2 (en)	2011-03-08	2014-04-29	Sanofi	Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (de)	2011-03-08	2012-09-13	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
KR101273566B1 (ko) *	2011-09-05	2013-06-11	한국과학기술연구원	신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물
CN102827064B (zh) *	2012-08-14	2014-01-29	华东师范大学	一种氮杂双环[3.3.0]辛烷衍生物的合成方法
WO2019131902A1 (ja)	2017-12-27	2019-07-04	武田薬品工業株式会社	腹圧性尿失禁および便失禁の治療薬
CN116283899A (zh) *	2022-12-28	2023-06-23	南京林业大学	一种3-全氟烷基苯并噻吩[b]环戊烯酮化合物及其合成方法
CN116813532A (zh) *	2023-06-29	2023-09-29	上海柯君医药科技有限公司	一种哌啶化合物的制备方法

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GB8800891D0 (en) *	1988-01-15	1988-02-17	Lilly Industries Ltd	Pharmaceutical compounds
EP0596125A4 (en)	1991-12-26	1994-10-05	Yoshitomi Pharmaceutical	Condensed thiophene compound and pharmaceutical use thereof.
FR2725792A1 (fr)	1994-10-13	1996-04-19	Centre Nat Etd Spatiales	Procede pour evaluer des effets non-euclidiens affectant une image obtenue avec un radar spatial, et satellite pour sa mise en oeuvre
AU742735B2 (en)	1997-01-08	2002-01-10	F. Hoffmann-La Roche Ag	Tricyclic benzo{e}isoindoles and benzo{h}isoquinolines
AU727654B2 (en) *	1997-06-13	2000-12-21	Yamanouchi Pharmaceutical Co., Ltd.	Tricyclic pyrazole derivative
AU3880399A (en)	1998-06-16	2000-01-05	Ortho-Mcneil Pharmaceutical, Inc.	Octahydropyrrolo-(3,4-c)carbazoles useful as analgesic agents
WO2002074746A1 (en) *	2001-03-16	2002-09-26	Yamanouchi Pharmaceutical Co., Ltd.	Benzazepine derivatives
GB0118892D0 (en) *	2001-08-02	2001-09-26	Vernalis Res Ltd	Method of treatment
WO2003051883A1 (en)	2001-12-18	2003-06-26	Kyowa Hakko Kogyo Co., Ltd.	Indole derivative
US6953787B2 (en) *	2002-04-12	2005-10-11	Arena Pharmaceuticals, Inc.	5HT2C receptor modulators
DK1796663T3 (da) *	2004-09-03	2011-08-15	Athersys Inc	Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer

2005
- 2005-09-01 DK DK05794345.8T patent/DK1796663T3/da active
- 2005-09-01 AT AT05794345T patent/ATE507832T1/de not_active IP Right Cessation
- 2005-09-01 EP EP05794345A patent/EP1796663B1/en not_active Expired - Lifetime
- 2005-09-01 JP JP2007530395A patent/JP4960235B2/ja not_active Expired - Fee Related
- 2005-09-01 DE DE602005027861T patent/DE602005027861D1/de not_active Expired - Lifetime
- 2005-09-01 US US11/217,991 patent/US7423056B2/en not_active Expired - Fee Related
- 2005-09-01 WO PCT/US2005/031306 patent/WO2006028961A2/en not_active Ceased
- 2005-09-02 AR ARP050103681A patent/AR050624A1/es not_active Application Discontinuation
- 2005-09-05 TW TW094130443A patent/TWI406866B/zh not_active IP Right Cessation
2008
- 2008-08-05 US US12/221,668 patent/US7981919B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2006028961A2 (en)	2006-03-16
TW200621787A (en)	2006-07-01
EP1796663A4 (en)	2009-08-05
US20060079567A1 (en)	2006-04-13
JP2008512377A (ja)	2008-04-24
DE602005027861D1 (de)	2011-06-16
JP4960235B2 (ja)	2012-06-27
US7981919B2 (en)	2011-07-19
US20090069365A1 (en)	2009-03-12
EP1796663B1 (en)	2011-05-04
EP1796663A2 (en)	2007-06-20
WO2006028961A3 (en)	2006-12-28
AR050624A1 (es)	2006-11-08
US7423056B2 (en)	2008-09-09
ATE507832T1 (de)	2011-05-15
TWI406866B (zh)	2013-09-01

Publication	Publication Date	Title
DK1796663T3 (da)	2011-08-15	Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer
LTPA2017005I1 (lt)	2017-03-27	Nauji junginiai, kaip opioido receptoriaus moduliatoriai
NO20070494L (no)	2007-03-23	Substituerte azepinderivater som serotoninreseptormodulatorer
NO20055135D0 (no)	2005-11-02	Fenylguinoliner og deres anvendelse som ostrogenreseptormodulatorer
DK1735286T3 (da)	2012-04-02	Tetrahydroindazoler som cannabinoidmodulatorer
GB0400440D0 (en)	2004-02-11	Receptor modulators
ATE439357T1 (de)	2009-08-15	Indolylderivate als liver-x-rezeptormodulatoren
DK1668014T3 (da)	2009-04-20	Kondenserede heterocykliske forbindelser som serotoninreceptormodulatorer
NO20051042L (no)	2005-03-31	Pyrimidylsulfonamidderivater som kemokinreseptormodulatorer
DK1802307T3 (da)	2008-06-30	Pyrrolidinderivater som histamin-receptor-ligander
IL181120A0 (en)	2008-03-20	Tricyclic ?? -opioid modulators
AP2314A (en)	2011-10-31	3- 4-heteroarylcyclohexylamino cyclopentanecarboxamides as modulators of chemokine receptors.
DE602004014773D1 (de)	2008-08-14	Pyrrol-2,5-dionderivate als modulatoren des liver-x-rezeptors
DE602004014772D1 (de)	2008-08-14	Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors
DK2099784T3 (da)	2013-01-14	1,5-diphenyl-3-pyridinylamino-1,5-dihydrioyrrolidin-2-on som cb1-receptor-modulatorer
IL180637A0 (en)	2007-06-03	Tricyclic pyrazole derivatives as cannabinoid receptor modulators
EP1831743A4 (en)	2009-09-02	Gain-assisted electroabsorption modulators
DK2447252T3 (da)	2020-03-16	Theramuteinmodulatorer
IL177729A0 (en)	2006-12-31	N-piperidine derivatives as ccr3 modulators
ATE396998T1 (de)	2008-06-15	Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren
DE602005002986D1 (de)	2007-12-06	Call-Agent-Apparat, IP-basiertes Fernsprechgerät und IP-basiertes Fernsprechsystem
DE602006020489D1 (de)	2011-04-14	Cb1-rezeptormodulatoren
ZA200607353B (en)	2008-04-30	N-Piperidine derivatives as CCR3 modulators
HK1111349A (en)	2008-08-08	Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
DE602005003564D1 (de)	2008-01-10	Progesteronrezeptormodulatoren