DK163435C - Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf - Google Patents
Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater derafInfo
- Publication number
- DK163435C DK163435C DK452188A DK452188A DK163435C DK 163435 C DK163435 C DK 163435C DK 452188 A DK452188 A DK 452188A DK 452188 A DK452188 A DK 452188A DK 163435 C DK163435 C DK 163435C
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- aralkyl
- aryl
- alkyl
- acid residue
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 2
- 108090000371 Esterases Proteins 0.000 abstract 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001414 amino alcohols Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 108700023418 Amidases Proteins 0.000 abstract 1
- 102000005367 Carboxypeptidases Human genes 0.000 abstract 1
- 108010006303 Carboxypeptidases Proteins 0.000 abstract 1
- 150000007650 D alpha amino acids Chemical group 0.000 abstract 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 abstract 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 abstract 1
- 150000007649 L alpha amino acids Chemical class 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 102000005922 amidase Human genes 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK452188A DK163435C (da) | 1988-08-12 | 1988-08-12 | Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf |
| JP1508952A JPH04501056A (ja) | 1988-08-12 | 1989-08-14 | ジペプチドまたは構造関連化合物の酵素的製造方法 |
| AU40792/89A AU4079289A (en) | 1988-08-12 | 1989-08-14 | A process for enzymatic production of dipeptides or structurally related compounds |
| EP89308232A EP0359399B1 (en) | 1988-08-12 | 1989-08-14 | Process for the enzymatic production of dipeptides |
| DE68913880T DE68913880T2 (de) | 1988-08-12 | 1989-08-14 | Verfahren zur enzymatischen Herstellung von Dipeptiden. |
| PCT/DK1989/000193 WO1990001555A1 (en) | 1988-08-12 | 1989-08-14 | A process for enzymatic production of dipeptides or structurally related compounds |
| AT89308232T ATE103003T1 (de) | 1988-08-12 | 1989-08-14 | Verfahren zur enzymatischen herstellung von dipeptiden. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK452188A DK163435C (da) | 1988-08-12 | 1988-08-12 | Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf |
| DK452188 | 1988-08-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK452188D0 DK452188D0 (da) | 1988-08-12 |
| DK452188A DK452188A (da) | 1990-02-13 |
| DK163435B DK163435B (da) | 1992-03-02 |
| DK163435C true DK163435C (da) | 1992-07-20 |
Family
ID=8134301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK452188A DK163435C (da) | 1988-08-12 | 1988-08-12 | Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0359399B1 (da) |
| JP (1) | JPH04501056A (da) |
| AT (1) | ATE103003T1 (da) |
| AU (1) | AU4079289A (da) |
| DE (1) | DE68913880T2 (da) |
| DK (1) | DK163435C (da) |
| WO (1) | WO1990001555A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930002966B1 (ko) * | 1990-11-24 | 1993-04-16 | 주식회사 미 원 | 디펩티드의 제조방법 |
| US5508182A (en) * | 1991-02-13 | 1996-04-16 | Schneider; Manfred P. | Esterification of hydrophilic polyols by adsorption onto a solid support and employing a substrate-immiscible solvent |
| DK53191D0 (da) * | 1991-03-25 | 1991-03-25 | Carlbiotech Ltd As | Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse |
| AU7338294A (en) * | 1993-07-20 | 1995-02-20 | Bionebraska, Inc. | Method for endomodification of proteins |
| FR2708938B1 (fr) * | 1993-08-09 | 1995-11-03 | Bioeurope | Procédé enzymatique perfectionné de préparation d'oligomères de L-lysine. |
| DE19834308C2 (de) * | 1998-07-30 | 2002-11-07 | Univ Leipzig | Verfahren zur Herstellung von Säureamiden |
| CN101982546A (zh) * | 2001-07-26 | 2011-03-02 | 味之素株式会社 | 二肽的制备方法 |
| KR20030080439A (ko) * | 2002-04-08 | 2003-10-17 | 새롬시엠에스 주식회사 | 인쇄매체를 이용한 홀로그램 부분 정착, 박리방법 및 그에의해 형성된 플라스틱 필름 |
| EP1553171A4 (en) * | 2002-07-26 | 2005-09-21 | Ajinomoto Kk | NEW ENZYM-FORMING PEPTIDE, THIS PRODUCING MICRO-ORGANISM AND METHOD FOR PRODUCING DIPEPTIDE USING THE SAME |
| ATE458056T1 (de) | 2002-07-26 | 2010-03-15 | Ajinomoto Kk | Verfahren zur herstellung eines tripeptids oder höheren peptids |
| EP2298907B1 (en) | 2002-07-26 | 2014-08-20 | Ajinomoto Co., Inc. | Novel peptide-forming enzyme gene |
| JP2005040037A (ja) * | 2003-07-25 | 2005-02-17 | Ajinomoto Co Inc | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
| JP2005168405A (ja) * | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| JP5754682B2 (ja) * | 2010-01-27 | 2015-07-29 | 国立大学法人鳥取大学 | Ｄ−，ｌ−ペプチドの立体選択的合成法 |
| WO2013051685A1 (ja) | 2011-10-07 | 2013-04-11 | 味の素株式会社 | 変異型γ－グルタミルトランスフェラーゼ、及び、γ-グルタミルバリルグリシン又はその塩の製造法 |
| CN107936089B (zh) * | 2017-11-07 | 2021-01-29 | 重庆大学 | 一种合成苯丙氨酰-赖氨酸二肽的方法 |
| SG11202010069SA (en) * | 2018-04-26 | 2020-11-27 | Zeria Pharmaceutical Co Ltd | Dipeptide and pharmaceutical composition containing same |
| WO2024216030A1 (en) * | 2023-04-13 | 2024-10-17 | Ohio State Innovation Foundation | Phosphonoalanine oligopeptides and methods of making and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU545416B2 (en) * | 1979-04-06 | 1985-07-11 | Carlsberg Biotechnology Ltd. A/S | A process for enzymatic production of peptides |
| US4506011A (en) * | 1981-09-05 | 1985-03-19 | Toyo Soda Manufacturing Co., Ltd. | Process for preparation of aspartylphenylalanine alkyl esters |
| DE3573614D1 (en) * | 1984-03-07 | 1989-11-16 | Ajinomoto Kk | Process for the production of l-aspartyl-l-phenylalanine ester |
| NZ217813A (en) * | 1985-10-21 | 1991-01-29 | Grace W R & Co | Dipeptides and process for their preparation using an enzyme coupling agent |
| DE3787155T2 (de) * | 1986-11-21 | 1994-03-03 | Genencor Int | Enzymatische Herstellung von L-Aspartyl-L-Phenylalanin-Alkylester. |
| DK72587D0 (da) * | 1987-02-13 | 1987-02-13 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk fremstilling af dipeptider |
-
1988
- 1988-08-12 DK DK452188A patent/DK163435C/da not_active IP Right Cessation
-
1989
- 1989-08-14 AU AU40792/89A patent/AU4079289A/en not_active Abandoned
- 1989-08-14 JP JP1508952A patent/JPH04501056A/ja active Pending
- 1989-08-14 AT AT89308232T patent/ATE103003T1/de not_active IP Right Cessation
- 1989-08-14 WO PCT/DK1989/000193 patent/WO1990001555A1/en not_active Ceased
- 1989-08-14 EP EP89308232A patent/EP0359399B1/en not_active Expired - Lifetime
- 1989-08-14 DE DE68913880T patent/DE68913880T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4079289A (en) | 1990-03-05 |
| EP0359399A1 (en) | 1990-03-21 |
| DE68913880D1 (de) | 1994-04-21 |
| DK452188A (da) | 1990-02-13 |
| JPH04501056A (ja) | 1992-02-27 |
| DE68913880T2 (de) | 1994-09-22 |
| ATE103003T1 (de) | 1994-04-15 |
| EP0359399B1 (en) | 1994-03-16 |
| WO1990001555A1 (en) | 1990-02-22 |
| DK163435B (da) | 1992-03-02 |
| DK452188D0 (da) | 1988-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |